KEGG   Ovis canadensis (bighorn sheep): 138444295
Entry
138444295         CDS       T11679                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ocan  Ovis canadensis (bighorn sheep)
Pathway
ocan01521  EGFR tyrosine kinase inhibitor resistance
ocan01522  Endocrine resistance
ocan04010  MAPK signaling pathway
ocan04012  ErbB signaling pathway
ocan04014  Ras signaling pathway
ocan04015  Rap1 signaling pathway
ocan04022  cGMP-PKG signaling pathway
ocan04024  cAMP signaling pathway
ocan04062  Chemokine signaling pathway
ocan04066  HIF-1 signaling pathway
ocan04068  FoxO signaling pathway
ocan04071  Sphingolipid signaling pathway
ocan04072  Phospholipase D signaling pathway
ocan04114  Oocyte meiosis
ocan04140  Autophagy - animal
ocan04148  Efferocytosis
ocan04150  mTOR signaling pathway
ocan04151  PI3K-Akt signaling pathway
ocan04210  Apoptosis
ocan04218  Cellular senescence
ocan04270  Vascular smooth muscle contraction
ocan04370  VEGF signaling pathway
ocan04371  Apelin signaling pathway
ocan04380  Osteoclast differentiation
ocan04510  Focal adhesion
ocan04517  IgSF CAM signaling
ocan04519  Cadherin signaling
ocan04540  Gap junction
ocan04550  Signaling pathways regulating pluripotency of stem cells
ocan04613  Neutrophil extracellular trap formation
ocan04620  Toll-like receptor signaling pathway
ocan04650  Natural killer cell mediated cytotoxicity
ocan04660  T cell receptor signaling pathway
ocan04662  B cell receptor signaling pathway
ocan04664  Fc epsilon RI signaling pathway
ocan04666  Fc gamma R-mediated phagosome formation
ocan04668  TNF signaling pathway
ocan04720  Long-term potentiation
ocan04722  Neurotrophin signaling pathway
ocan04725  Cholinergic synapse
ocan04726  Serotonergic synapse
ocan04730  Long-term depression
ocan04810  Regulation of actin cytoskeleton
ocan04910  Insulin signaling pathway
ocan04912  GnRH signaling pathway
ocan04914  Progesterone-mediated oocyte maturation
ocan04915  Estrogen signaling pathway
ocan04916  Melanogenesis
ocan04917  Prolactin signaling pathway
ocan04919  Thyroid hormone signaling pathway
ocan04921  Oxytocin signaling pathway
ocan04926  Relaxin signaling pathway
ocan04928  Parathyroid hormone synthesis, secretion and action
ocan04929  GnRH secretion
ocan04934  Cushing syndrome
ocan04935  Growth hormone synthesis, secretion and action
ocan05010  Alzheimer disease
ocan05022  Pathways of neurodegeneration - multiple diseases
ocan05034  Alcoholism
ocan05132  Salmonella infection
ocan05135  Yersinia infection
ocan05160  Hepatitis C
ocan05161  Hepatitis B
ocan05163  Human cytomegalovirus infection
ocan05164  Influenza A
ocan05165  Human papillomavirus infection
ocan05166  Human T-cell leukemia virus 1 infection
ocan05167  Kaposi sarcoma-associated herpesvirus infection
ocan05170  Human immunodeficiency virus 1 infection
ocan05200  Pathways in cancer
ocan05205  Proteoglycans in cancer
ocan05206  MicroRNAs in cancer
ocan05207  Chemical carcinogenesis - receptor activation
ocan05208  Chemical carcinogenesis - reactive oxygen species
ocan05210  Colorectal cancer
ocan05211  Renal cell carcinoma
ocan05212  Pancreatic cancer
ocan05213  Endometrial cancer
ocan05214  Glioma
ocan05215  Prostate cancer
ocan05216  Thyroid cancer
ocan05218  Melanoma
ocan05219  Bladder cancer
ocan05220  Chronic myeloid leukemia
ocan05221  Acute myeloid leukemia
ocan05223  Non-small cell lung cancer
ocan05224  Breast cancer
ocan05225  Hepatocellular carcinoma
ocan05226  Gastric cancer
ocan05230  Central carbon metabolism in cancer
ocan05231  Choline metabolism in cancer
ocan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ocan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    138444295 (MAP2K1)
   04012 ErbB signaling pathway
    138444295 (MAP2K1)
   04014 Ras signaling pathway
    138444295 (MAP2K1)
   04015 Rap1 signaling pathway
    138444295 (MAP2K1)
   04370 VEGF signaling pathway
    138444295 (MAP2K1)
   04371 Apelin signaling pathway
    138444295 (MAP2K1)
   04668 TNF signaling pathway
    138444295 (MAP2K1)
   04066 HIF-1 signaling pathway
    138444295 (MAP2K1)
   04068 FoxO signaling pathway
    138444295 (MAP2K1)
   04072 Phospholipase D signaling pathway
    138444295 (MAP2K1)
   04071 Sphingolipid signaling pathway
    138444295 (MAP2K1)
   04024 cAMP signaling pathway
    138444295 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    138444295 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    138444295 (MAP2K1)
   04150 mTOR signaling pathway
    138444295 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    138444295 (MAP2K1)
   04519 Cadherin signaling
    138444295 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    138444295 (MAP2K1)
   04148 Efferocytosis
    138444295 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    138444295 (MAP2K1)
   04210 Apoptosis
    138444295 (MAP2K1)
   04218 Cellular senescence
    138444295 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138444295 (MAP2K1)
   04540 Gap junction
    138444295 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    138444295 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    138444295 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    138444295 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    138444295 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    138444295 (MAP2K1)
   04660 T cell receptor signaling pathway
    138444295 (MAP2K1)
   04662 B cell receptor signaling pathway
    138444295 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    138444295 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    138444295 (MAP2K1)
   04062 Chemokine signaling pathway
    138444295 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138444295 (MAP2K1)
   04929 GnRH secretion
    138444295 (MAP2K1)
   04912 GnRH signaling pathway
    138444295 (MAP2K1)
   04915 Estrogen signaling pathway
    138444295 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    138444295 (MAP2K1)
   04917 Prolactin signaling pathway
    138444295 (MAP2K1)
   04921 Oxytocin signaling pathway
    138444295 (MAP2K1)
   04926 Relaxin signaling pathway
    138444295 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    138444295 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    138444295 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    138444295 (MAP2K1)
   04916 Melanogenesis
    138444295 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    138444295 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    138444295 (MAP2K1)
   04726 Serotonergic synapse
    138444295 (MAP2K1)
   04720 Long-term potentiation
    138444295 (MAP2K1)
   04730 Long-term depression
    138444295 (MAP2K1)
   04722 Neurotrophin signaling pathway
    138444295 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    138444295 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138444295 (MAP2K1)
   05206 MicroRNAs in cancer
    138444295 (MAP2K1)
   05205 Proteoglycans in cancer
    138444295 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    138444295 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    138444295 (MAP2K1)
   05230 Central carbon metabolism in cancer
    138444295 (MAP2K1)
   05231 Choline metabolism in cancer
    138444295 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    138444295 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    138444295 (MAP2K1)
   05212 Pancreatic cancer
    138444295 (MAP2K1)
   05225 Hepatocellular carcinoma
    138444295 (MAP2K1)
   05226 Gastric cancer
    138444295 (MAP2K1)
   05214 Glioma
    138444295 (MAP2K1)
   05216 Thyroid cancer
    138444295 (MAP2K1)
   05221 Acute myeloid leukemia
    138444295 (MAP2K1)
   05220 Chronic myeloid leukemia
    138444295 (MAP2K1)
   05218 Melanoma
    138444295 (MAP2K1)
   05211 Renal cell carcinoma
    138444295 (MAP2K1)
   05219 Bladder cancer
    138444295 (MAP2K1)
   05215 Prostate cancer
    138444295 (MAP2K1)
   05213 Endometrial cancer
    138444295 (MAP2K1)
   05224 Breast cancer
    138444295 (MAP2K1)
   05223 Non-small cell lung cancer
    138444295 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    138444295 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    138444295 (MAP2K1)
   05161 Hepatitis B
    138444295 (MAP2K1)
   05160 Hepatitis C
    138444295 (MAP2K1)
   05164 Influenza A
    138444295 (MAP2K1)
   05163 Human cytomegalovirus infection
    138444295 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    138444295 (MAP2K1)
   05165 Human papillomavirus infection
    138444295 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    138444295 (MAP2K1)
   05135 Yersinia infection
    138444295 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138444295 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    138444295 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    138444295 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    138444295 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138444295 (MAP2K1)
   01522 Endocrine resistance
    138444295 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocan01001]
    138444295 (MAP2K1)
Enzymes [BR:ocan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     138444295 (MAP2K1)
Protein kinases [BR:ocan01001]
 Serine/threonine kinases: STE group
  STE7 family
   138444295 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 138444295
NCBI-ProteinID: XP_069453741
LinkDB
Position
7:25770176..25843725
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtattcaaggtctcccacaagccgtccggactcgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccgtacatcgtgggcttctacggggccttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactctttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacccaggccaaggacccccgggagacccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatctgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcagctggtgtctaa

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