Oryctolagus cuniculus (rabbit): 100009536 Help Entry 100009536         CDS       T03373                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04020   Calcium signaling pathway ocu04024   cAMP signaling pathway ocu04260   Cardiac muscle contraction ocu04261   Adrenergic signaling in cardiomyocytes ocu04371   Apelin signaling pathway ocu04713   Circadian entrainment ocu04911   Insulin secretion ocu04921   Oxytocin signaling pathway ocu04972   Pancreatic secretion ocu05020   Prion disease ocu05022   Pathways of neurodegeneration - multiple diseases ocu05410   Hypertrophic cardiomyopathy ocu05412   Arrhythmogenic right ventricular cardiomyopathy ocu05414   Dilated cardiomyopathy ocu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100009536 (RYR2)    04020 Calcium signaling pathway     100009536 (RYR2)    04024 cAMP signaling pathway     100009536 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     100009536 (RYR2)    04921 Oxytocin signaling pathway     100009536 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     100009536 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     100009536 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     100009536 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     100009536 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     100009536 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     100009536 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     100009536 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     100009536 (RYR2)    05414 Dilated cardiomyopathy     100009536 (RYR2)    05415 Diabetic cardiomyopathy     100009536 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ocu04040]     100009536 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ocu04990]     100009536 (RYR2) Ion channels [BR:ocu04040]  Voltage-gated cation channels   Ryanodine receptor    100009536 (RYR2) Domain-containing proteins not elsewhere classified [BR:ocu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100009536 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  100009536 NCBI-ProteinID:  NP_001076226 Ensembl:  ENSOCUG00000002425 UniProt:  Q29621 LinkDB All DBs Position 16:complement(57808379..58578272) Genome browser AA seq 4968 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDGGVRKEVDGMGTSEIKYGDSI CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKASSVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTSGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVPG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKETTKAEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLRHILQLIEPSVFKDAATPEEE GDTLEEEPSVEDTKLEGAGEEEAKMGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQTEKPVESDSRKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNIIIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPRGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLNKHNI YSIYNTKSSRERAALSLPANVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPESNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPTPEAEELFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRNNIHLQGKLEDPAIRWQMALYKDLPNRTEE TSDPEKTVERVLDIANVLFHLEQKSKFIGRRYYNLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEVTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDTFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNETRLQTFLELAESVLNYFQPFLGRIEIMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSANKEESEKERPEEQGPKMGFFSVLTVRSALFALRYNILTLMRMLS LKSLKKQMKKMKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIVCSLLLGGSLVE GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPMETTLPSEDLTDLKELTEESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLMSNPVLIPEEQEKFQEQKTKEEEKEEKEETKSEPE KAEGEDGEKEEKVKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPSRSTSENAKVTTSLDSSSHRIIAVHY VLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITE QPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDF SDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDG DTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14907 nt NT seq  +upstreamnt  +downstreamnt atggctgatgggggcgaaggcgaggatgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcaccgcaaccatccacaaagaacaacagaagctatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtctacttccaattccaagaatgtccctccc gacctctccatctgtacctttgtgctggaacagtccctctcggtgcgggccctgcaggag atgctggctaacacggtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggccatcgaacactcctgtatggtcatgccatattg ctacgtcattcctatagtggcatgtatctgtgttgcctctccacctctcgatcttcaact gataaactggctttcgatgttggcttgcaagaggacaccacaggtgaggcttgttggtgg accatacatcctgcctcaaagcagcggtcagagggagaaaaagtacgagttggagatgac ctcatcttagtcagcgtgtcctctgaaaggtacctgcacctgtcttatggtaacggcagc ttgcatgtagatgccgccttccagcagacgctctggagcgtggcccccatcagctcagga agtgaagcagcccaagggtatctgattggcggtgatgtcctcaggctgctgcatggacac atggatgaatgtctcactgtcccttcgggagaacatggcgaagagcaacggaggactgtt cattatgaaggtggtgctgtatctgttcacgcacggtccctttggagactagagactcta agagttgcgtggagtggaagtcacataagatggggacagccattccgactacgtcatgtt acgacaggaaaatatttgagtctcatggaagacaaaaaccttcttctcatggataaagaa aaagctgatgtaaaatccacagcatttaccttccggtcttccaaggaaaagttggatgga ggggtgagaaaagaagttgatggcatgggaacatctgaaataaaatatggtgactcaata tgttatatacaacatgtagatacaggcctatggcttacatatcagtctgtggatgtgaaa tcagtgagaatgggatctatacaacgtaaggccattatgcaccatgaaggccacatggat gatggtttaaatttatctagatctcagcatgaagaatcacgcacagcacgagtcatccgg agcacagtcttccttttcaatagatttataaggggccttgatgctctcagcaagaaagcg aaggcttcctcagtagatttacccattgagtcggtgagtctgagtctgcaggacctgatc ggctacttccaccccccggatgaacacttggagcatgaggacaagcagaacagactgcgg gccctgaagaacaggcagaacctcttccaggaagagggaatgatcaacctcgtgcttgag tgcatagaccgactgcatgtctacagcagtgcagctcactttgccgatgtcgccgggaga gaagcgggggaatcttggaaatccattctgaattctctatatgagttgttggcggctcta attagaggaaatcgtaaaaactgtgctcagttttcgggctcccttgactggttgatcagc agattggagagactggaagcttcctcgggtattcttgaagttttacattgtgttttagta gaaagtccagaagctctaaatattattaaagaaggacatattaaatctattatctcactt ttagataagcatggaagaaatcacaaggtcctggatgtcttgtgctccctgtgtgtttgc cacggggttgcagtccgttctaaccagcatctcatttgtgacaacctcctgccaggaaga gatctgttattgcagacacgtcttgtaaaccacgttagcagcatgagacccaatatcttt ctgggagtcagcgaagggtctgctcagtataagaagtggtactatgaactcatggtggac cacacagagccgtttgtgactgctgaggccacgcacctgcgagtgggctgggcctccacc gaagggtactctccctaccctggagggggtgaagagtggggtggaaacggtgttggagat gacctcttctcctatggatttgatgggcttcacctctggtcaggttgcattgcacgtact gttagctcaccaaaccaacatctgttgagaactgatgacgtcatcagttgctgtttagat ctaagcgccccaagcatctcattccgaattaatggacaacccgttcaaggaatgtttgag aatttcaacatcgatggtctcttctttccagttgttagtttctctgcaggaatcaaggtg cgctttctgctcggggggcgacatggagagttcaagtttcttcctccacctggctatgct ccttgttatgaagctgttctgccaaaagaaaagttgaaagtggaacacagccgagaatac aagcaagaaagaacttacacacgagacctgcttggccccacagtttctttaacacaagcc gccttcacgccaatccctgtggataccagccagattgtgttgcctcctcacctagaaagg ataagagaaaaacttgcagagaatatccatgaactttgggttatgaataaaattgagctc ggctggcagtatggtccggttagagatgacaataagagacaacacccgtgtctggtggag ttctccaagttgcctgaacaggaacgcaattataatttacagatgtcacttgagaccttg aagactttgttggccctaggatgtcatgtgggtatatcagatgaacatgccgaagagaag gtgaaaaaaatgaagctgcctaagaattaccagctgacaagtggctacaagcctgcccca atggacttgagctttataaagcttaccccatctcaggaagcaatggtggacaagctggca gaaaatgctcacaatgtgtgggcccgagatcgaatccggcagggctggacgtatggcatc caacaggacgtaaagaacagaagaaaccctcgccttgttccttacactcttctagatgac cgaaccaagaaatcaaacaaggacagcctccgcgaggcggtgcgcacactgctgggctat ggttacaacctggaagctccagatcaagatcatgctgccagagccgaagtgtgcagtggc acaggggaacggttccggatcttccgtgctgagaagacctatgcagtgaaggcaggacgg tggtactttgaatttgaggctgtcacttctggagacatgagggttggctggagcaggcca ggttgtcagccggatcaggagcttggctcggatgaacgtgcctttgcttttgatggtttc aaggcccagcggtggcaccagggcaacgagcactatgggcgctcttggcaagcaggtgat gttgtagggtgtatggttgacatgaatgaacacaccatgatgttcacactaaatggagaa atccttcttgatgattctggttctgaattggctttcaaggactttgatgttggcgatgga ttcatacctgtgtgtagccttggtgtggctcaagtgggcaggatgaacttcgggaaagat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgagccatttgct gtgaatacaaatcgggacatcactatgtggttaagcaagaggcttcctcaatttctccaa gttccatcaaaccatgaacatatagaggtgactagaatagatggcaccatagacagttct ccatgtttgaaggtcactcagaagtcttttggttctcagaacagcaacaccgatatcatg ttttatcgtctgagcatgcccattgagtgtgcagaggtcttctccaagacggtgcctgga gggctacctggtgctggcctctttgggcccaagaatgatctggaggattacgatgcagat tctgactttgaggttctaatgaagacagctcatggtcatctggtacctgatcgtgttgac aaagataaagaaactacaaaagcagaatttaataaccacaaagattatgctcaggaaaag ccttctcgtctgaagcaaagatttttgcttagaaggacaaagccagattacagcacaagc cattctgcaagactcacagaagatgtcctggctgatgaccgggatgactatgatttcttg atgcaaacgtccacgtactattactcagtgaggatatttcctggacaagaacctgctaat gtctgggtgggctggattacatcagatttccatcaatatgatacaggcttcgacttggat agagttcgcacagtaacagttactctaggagatgaaaaaggaaaagtacatgagagcatc aaacgcagcaactgctatatggtgtgtgctggtgagagcatgagccctgggcaaggacgc aacaacaatggattggagattggctgtgtggtggatgctgccagtgggttgctcacattc attgccaatggcaaggaactgagcacatattatcaggtggagccaagtacaaaattattt cctgcagtttttgcacaagctacaagtcccaatgttttccagtttgaattgggaagaata aagaatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaaccctgtaccc caatgtccaccacgtctccatgtgcaattcctgtcacatgtcctgtggagcaggatgccc aaccagtttttgaaggtcgatgtttctcgaataagtgaacgacaaggctggctggtgcag tgtttggatcctctgcagttcatgtctcttcacatcccagaagagaacagatctgttgac atattagagttgacagagcaagaggagttgctgaaatttcactatcacacgctccgactc tactcagctgtctgtgcccttggcaatcaccgggtggcccatgccctgtgcagccacgtg gatgaacctcagctgctttatgccatcgagaacaagtacatgcccggtttgctgcgcacc ggctactacgacctgctcattgacatccacctcagctcctatgccactgccaggctcatg atgaacaatgagttcatcgtccccatgaccgaggagacgaagagcatcactctcttccct gatgagaacaagaagcacggcctcccaggaattggcctaagcacttccctcaggccacgg atgcagttttcctcccccagttttgtgagcattaataatgaatgttaccagtatagccca gagtttccactggacatcctaaaagccaaaaccattcagatgctgacagaagccgtgaaa gagggcagtctgcatgcccgggacccagtcggggggaccaccgaattcctctttgtgcct ctcatcaaacttttctatacgctgctcatcatgggcatcttccacaatgaggacctgagg cacatcttgcagttgatcgagcccagtgtgtttaaggatgctgccactccagaggaggag ggtgacacactggaggaagaacccagtgtggaagacacaaagctagaaggagcaggtgaa gaggaagccaaaatgggtaagaggcccaaggaaggcctgctccaaatgaaactgccagag ccagtaaaattgcagatgtgcctactacttcaatacctctgtgactgccaggtccggcac cggatagaagccattgtagccttttcagatgactttgtagctaagctccaagacaatcag cgcttccgatataatgaagttatgcaagccttaaacatgtcagctgcactcacagccagg aaaaccaaggaatttagatcaccacctcaagaacagattaatatgcttctcaattttaag gatgacaaaagtgagtgtccgtgtcctgaagaaattcgtgaccaacttttggatttccat gaagatttgatgacacactgtggaattgagctggatgaagatgggtctctggatggaaat agtgatctaacaattagaggacgactgctttcgttggtagaaaaggtgacatacctgaag aagaaacaaacagaaaagccagttgagagtgactccaggaagtcctccactcttcagcag ttgatttctgagaccatggttcgatgggcccaagagtctgtcattgaagaccctgagttg gtgagagccatgtttgtgctacttcatcggcagtacgatggcattgggggactggtccgg gccctgccgaagacctacactatcaatggcgtctctgtggaggacaccatcaacctgctg gcatctcttggtcaaattcgttctctgctgagtgtaagaatgggcaaagaggaagagaag cttatgattcgtggattgggagatatcatgaataataaagtgttttaccagcacccgaac ctcatgagggcacttggaatgcatgagacagtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcaccttcccgaagatggtggccaactgttgccgttttctc tgttatttctgtcgtataagtcggcagaatcaaaaagccatgtttgatcatctcagttac ttactggaaaacagtagtgttggtcttgcctcaccagctatgagaggttcaacaccactg gacgtggcagcagcctcagtgatggataataatgagttggccctagctttgcgtgagcca gatctggaaaaggtagttcgttatttggctggttgtggcctgcaaagctgccagatgttg gtgtcaaagggttatccagatattgggtggaatccagtcgaaggagaaagatatcttgac tttcttagatttgctgtcttctgtaatggggaaagtgtggaagagaatgcgaatgttgtg gttagattgctcattcggaggcctgagtgttttggtcctgctttgagaggggaaggtggg aatggtctccttgcagccatggaagaagccataaaaatagcggaggatccttcccgagat ggtccctcaccaactagtggatccagcaaaacacttgatacggaggaggaagaggatgac actatccacatggggaatgcaatcatgaccttttatgcagctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggagaagccatcagaatcagg tctattttgagatccctaattccattgggagatttggtgggtgtgatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggaacctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggtg caagatttcctcctccatcttcttgaggttggctttctgccagacctgcgggctgccgcc tctttagatacggctgctttgagtgctacagacatggcattggccctcaatcggtacctt tgcactgctgtcttgcctttgttaacaagatgtgctcctctttttgctggcacagagcac catgcttccctcattgactcattacttcataccgtgtataggctatctaagggctgctca cttaccaaagctcaacgggattccatagaagtttgtttactatctatttgtggccaattg cggccttctatgatgcagcacttactcagaagattagtatttgatgtcccgttactaaat gagcatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaactttggtgctgcctcagaagaggagcttcacttg tcaagaaagttgttctggggcatttttgatgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggaatcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatattataattcctgagaagttggaatacttc attaacaaatatgcagaacattctcatgacaaatggtcaatggacaagttagcaaatgga tggatttatggagaaatatattcagactcctccaagattcaacccttgatgaaaccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctctcaaa actatgttggcttggggttggaggattgaaagaacccgagaaggagacagcatggccctt tataaccgaactcgtcgtatttctcagacaagccaggtttctgtagatgctgcccatggt tatagtccccgagccattgacatgagcaatgttacactatccagagacctgcatgctatg gcagaaatgatggctgaaaactatcataacatatgggcaaagaaaaagaaactggagttg gagtctaaaggaggtggaaaccatcctctgctggtaccctatgatacgctgacagccaaa gagaaagccaaggatagggaaaaggcacaggacatcctcaagttcttgcagatcaatgga tatgctgtatccagaggattcaaggacctggaactggacacaccttccattgagaagcga ttcgcctatagtttcctccagcaacttatccgctatgtggatgaagctcatcagtacatc ctggagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgcaaaagtcgttctacctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagcagacctctctgctctggagggcatgcatcaaacaaagag aaggaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatctattgtcaactgtcttcatattttgggacagactttg gatgcaaggactgtgatgaagacaggcctggagagtgttaaaagtgctctcagagccttt ctggacaacgctgcggaggatctggagaagacgatggaaaaccttaagcagggccaattc acccacacccgaaaccaacccagaggtgtcactcagattatcaattacaccacagtggct ctgttgccaatgctgtcgtcattatttgaacatattggccaacatcagtttggagaagat ctaatattggaagatgtacaggtgtcttgttatagaatcctgactagtttgtatgctttg ggaaccagcaagagtatttatgtggagaggcaacgttctgcattaggagagtgtcttgct gcttttgctggtgcctttcctgtagcatttttggaaactcatctcaacaaacataatatt tactccatctacaatactaagtcttcacgagagcgagcagctctcagtttaccagccaat gtggaagatgtgtgtccaaatataccttctctggagaaactaatggaagaaattgtggag ttagctgagtctggcatccgctacactcaaatgccacatgtgatggaggtcatcctgccc atgctgtgtagctacatgtcccggtggtgggagcacgggcctgagagcaaccctggaagg gctgaaatgtgctgtactgctctgaactcggagcacatgaacacactgctagggaatata ctgaaaatcatatataataacttgggaattgatgagggagcctggatgaagagattagca gtgttttcccagcctattataaataaagtaaaacctcagctcttgaaaactcattttttg cccttaatggagaaactcaagaaaaaggcagccatggtggtgtctgaggaagaccacctg aaagccgaggcgaggggggatatgtcagaggctgagctgctcattctagatgaattcacc acgctggccagagatctttatgccttctaccctctcttgattagatttgtggactataac agggccaagtggctgaaggagcccaccccagaagcagaggagctcttccgaatggtggct gaagtgtttatctactggtcaaaatcccacaatttcaaaagagaagaacagaactttgtt gtacagaatgaaatcaacaacatgtccttccttattactgataccaagtcaaagatgtca aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggagatcggtattct atgcagacctctcttattgtggcagccctgaagcggttactacccattgggctgaacatc tgtgcccctggggaccaggagctcattgctctagccaaaaatcgatttagtctgaaagac actgaggatgaagtacgagatataatccgcaataatattcatttacaaggcaagttggag gatcctgctattagatggcaaatggcgttgtataaagacttacccaacaggactgaggaa acctctgatccagagaagacagtggaaagagtattggatatagcaaatgtgctttttcat ctggaacagaaatctaaatttattggccggcgatattacaatctggtggaacatcctcag aggtctaaaaaggccgtatggcacaagttactctccaagcaaaggaaaagggccgtggta gcctgcttccgaatggctcccttatataatttaccaaggcatcgagctgtcaatctcttc cttcagggatatgaaaagtcatggattgaaacagaagaacattactttgaagataaactg atagaagatttagcaaaacctggtgctgaacctccagaggaagatgaagtgactaagaga gttgaccctctacatcagctgattcttctgtttagtcgaacagctctaacagagaaatgc aaactagaggaagattttttatatatggcatatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagctttgaagaaaaagaaatggaa aagcaaaaacttctctaccagcaagccagactccatgaccgcggggccgccgagatggtg ctacagacaatcagtgccagcaaaggtgaaactgggccaatggtagctgccactttgaag cttggaattgcaatcttaaatggtgggaactccacagtacagcagaaaatgcttgactac ctcaaggagaaaaaggatgtgggcttctttcagagcctcgctggactgatgcagtcatgt agtgttcttgacttaaatgcatttgaacgacaaaacaaagctgaaggacttggaatggtg acagaggaaggatcaggtgaaaaggttctacaggatgacgagttcacctgtgacctgttc cgattcttgcaactactctgtgagggacacaactcagattttcagaattatctgagaact cagactggtaacaatacaactgtcaacattatcatctctactgtagactacctactaaga gttcaggaatctattagtgatttctattggtattactctgggaaagatgttattgatgaa caaggacaacgaaatttctccaaagctatacaagtagcaaaacaagtctttaacactctt actgaatatattcagggcccttgcactgggaatcagcagagtctggcacacagcaggcta tgggatgcagtggtgggttttcttcatgtgtttgcccacatgcaaatgaagctgtctcag gattcaagtcaaattgagctgttaaaagaattaatggatcttcagaaggatatggttgtc atgttgctatccatgttagaaggtaacgttgttaatggaacaattggcaaacagatggtt gacatgctcgtggaatcttccaataacgtggagatgattctcaaattctttgacatgttc ttaaaactaaaggatttgacctcttctgacacattcaaagaatatgaccccgacggtaag ggaatcatttccaagagggacttccacaaagccatggagagtcataagcactacacacaa tctgaaaccgagttcctcttgtcctgtgcggagacagatgagaatgaaacccttgactac gaggagtttgtcaaaaggttccacgaacccgccaaggacatcggcttcaacgtggctgtt ctgctgaccaatctctcggaacacatgcccaacgagacgcggctgcagactttcctagaa ctggcagagagtgtactgaactacttccagccctttctgggccgcattgagatcatggga agcgccaaacgcatcgagagggtttactttgaaatcagcgagtccagccgaacgcagtgg gagaagcctcaggtcaaagagtctaaaagacagttcatatttgatgtggtcaatgaggga ggagaaaaagagaagatggaactcttcgttaacttctgtgaggacacgatatttgaaatg cagctggcggctcagatctcagagtcggatttgaacgagagatcagcgaacaaagaagaa agtgagaaggagagaccggaagagcaggggcccaagatgggcttcttttcggtgctgacg gtcaggtcggccctgtttgcgctcaggtacaacatcttgaccctgatgcgaatgctcagt ctgaagagcctgaagaaacagatgaagaagatgaagaagatgaccgtgaaggacatggtc acggccttcttttcctcgtactggagcattttcatgaccctcctgcacttcgtggccagc gtcttcagaggctttttccgcatcgtgtgtagccttctgctgggagggagccttgtcgaa ggtgctaagaagatcaaagttgcagaactcttagccaacatgccggaccccactcaggat gaggtgaggggagatggagaggaaggggagaggaagcccatggagaccaccctgccctcg gaagacctcacagacctgaaggagctgacggaggaaagcgaccttctctccgacatattt ggcttggatctgaagagagaagggggacagtacaagctcattcctcataaccccaacgct ggccttagtgatctcatgagcaaccccgtcctcattcctgaggaacaagaaaagtttcag gaacagaagacaaaagaggaagaaaaggaagaaaaagaagaaaccaaatcggaacctgag aaagcagagggagaagatggagaaaaagaagagaaagtcaaggaagacaagggtaaacaa aagttgaggcagctccacacacatagatatggagaaccagaagttccagagtcagcattc tggaagaaaatcatagcatatcaacagaaacttctaaactattttgctcgcaacttttac aacatgagaatgttagccttatttgtcgcatttgcaatcaatttcatcttgctcttttat aaggtttccacttcttctgtggttgaaggaaaggagctcccctctcgaagtacaagtgaa aatgccaaagttaccaccagcctggacagcagctcacataggatcatcgctgttcactat gtcctggaagagagcagtggctacatggagcccactttgcgtatcttagcaattctccac acagtcatttctttcttctgcatcattggatactactgcttaaaagttccattggttatt tttaagcgagaaaaggaagtagcacgaaaattggaatttgatgggctttatattacagaa caaccttcagaagatgatattaaaggccagtgggatagacttgtaatcaacacacagtca tttcctaacaattactgggacaaatttgttaaaagaaaggttatggataaatatggagag ttctatggcagagatagaatcagtgagttactgggcatggacaaagcagcgctggacttc agtgatgccagagaaaagaagaaaccaaagaaagacagctctttatcagctgtattaaac tctattgatgtgaaatatcagatgtggaaactaggagttgttttcactgataattccttc ctctacctggcctggtatatgaccatgtccattcttggacactataacaacttttttttt gctgcacatcttcttgacatcgctatgggattcaaaacgttaagaaccatcttgtcatca gtaactcacaatggcaaacagcttgtattaactgttggcttattagctgttgttgtttac ctatatacggtggtggcattcaattttttccgaaaattctacaataaaagtgaagatggt gataccccagatatgaaatgtgatgatatgctgacgtgctatatgttccacatgtatgtt ggggtacgtgctggagggggtatcggtgatgaaattgaagacccagcaggagatgaatat gagatctatcgaatcatctttgacatcactttcttcttctttgtcattgtcatcctcttg gccataatacaaggtttaattattgatgcttttggagaactcagagaccagcaggaacaa gtcaaagaagacatggagaccaaatgcttcatctgtgggataggtaatgactattttgac acagtgccacatggctttgaaacccacaccttacaggagcacaacctggccaattacctg ttttttctgatgtacctcataaacaaagatgaaacagaacacacaggacaggaatcctat gtctggaaaatgtatcaagaaaggtgctgggaatttttcccggcaggggattgtttccgg aaacagtatgaagaccagctaaattaa

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