Oryctolagus cuniculus (rabbit): 100328811
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Entry
100328811 CDS
T03373
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu00230
Purine metabolism
ocu00670
One carbon pool by folate
ocu01100
Metabolic pathways
ocu01523
Antifolate resistance
Module
ocu_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
100328811 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
100328811 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100328811 (GART)
Enzymes [BR:
ocu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
100328811 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
100328811 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
100328811 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
CPSase_L_D2
ATP-grasp_3
ATP-grasp
ATP-grasp_2
ATP-grasp_4
Dala_Dala_lig_C
ATP-grasp_5
RimK
Motif
Other DBs
NCBI-GeneID:
100328811
NCBI-ProteinID:
NP_001164891
Ensembl:
ENSOCUG00000003857
UniProt:
B8K1B7
LinkDB
All DBs
AA seq
1010 aa
AA seq
DB search
MTARVLVIGNGGREHTLAWKLAQSIHVKQVLVAPGNAGTACSEKISNAAISVSDHTALAQ
FCKDENIELVVVGPEAPLAAGIVENLTSAGVRCFGPTAKAAQLESSKRFAKEFMDRHGIP
TARWRAFTTPEEACSFIMSADFPALVVKASGLAAGKGVIVAKNQEEACRAVQEIMQEKAF
GAAGETIVIEELLEGEEVSCLCFTDGSTVAPMPPAQDHKRLLEGDLGPNTGGMGAYCPAP
QVSKDLLLKIKNAVLQKTVDGMQQEGTPYVGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLFEVVQSTLDGQLCTSLPAWLENHAAVTVVMASKGYPGAYTTGMEITGFPEA
QALGLQVFHAGTALREGKVVTSGGRVLTVTAVQENLMSALEEAKKGLAALQFEGAVYRTD
IGSRALAFLRQPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCDVDLGDFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTAEAVVAGIAKACGQAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVIGIASSGLHSNGFSLVRKIVAQSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHLLLPVLRSGHVKAFAHITGGGLLENIPRVLPPKCGVDLDARTWRIPRIFSWLQQEG
QLSEEEMARTFNCGVGAALVVSKDQTERILRDIRQHQEEAWVIGSVVACPEGSPRVKVNN
LAEAMQMNGSVMENSSLKNHCSVQPTKARVAVLISGTGSNLQALIDSTQDPNSSSHIVVV
ISNKAAVAGLEKAERAGIPTRVINHKLYKNRVEFDNAVDQVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGANAHEQALEAGVTVTGCTVHFVSEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKVFPVALHLVACGAVRLGENGKICWVKEE
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atgacggcccgagtacttgtaattggcaatggaggcagggaacacacgctggcctggaaa
cttgcacagtccattcatgtcaagcaagtgttggttgcaccaggaaatgcaggaactgct
tgctctgaaaagatttcaaatgctgccatctcagtcagtgatcacactgcccttgctcaa
ttctgcaaagatgaaaacattgagttggtagttgttggacctgaggcgcctctggctgct
ggaattgttgagaacctaacatctgcaggagtgcgatgctttggccccacagcaaaagca
gctcagctggagtccagcaaaaggtttgccaaagagtttatggatcgacatggaatccca
actgcacggtggagagctttcaccacgcctgaagaggcctgcagcttcattatgagcgca
gacttccctgctttggtggtgaaggccagtggtctagcagctgggaaaggggtaattgtc
gcaaagaaccaagaagaggcctgcagggctgtccaggagatcatgcaggagaaggctttt
ggagcagctggagaaacaattgttattgaagaactccttgaaggagaagaagtatcttgt
ctgtgtttcactgatgggagtactgtggcccccatgcctccagcacaggaccacaagcga
ttactggagggggatcttggccccaacacaggggggatgggagcctattgtccagcacct
caggtttctaaggatttgttactgaaaattaaaaatgctgttcttcagaaaacagtagat
ggcatgcagcaggagggcactccttacgtaggaattctgtatgctggtataatgctgact
aaggatggcccaaaagttcttgagtttaattgtcgttttggtgatccagagtgccaggtt
atcctcccacttcttaaaagtgatctttttgaagtggttcagtccaccttagatggccag
ctctgcacctccttgcccgcctggctagaaaaccatgctgctgttaccgttgtcatggca
agtaaaggttatcctggagcctatacgacgggtatggagataacagggtttcctgaggct
caggctttaggactgcaggtgttccacgcaggcactgctctcagagagggcaaagtagtg
accagcggaggtagagtccttactgtgacagccgtccaggaaaatctcatgtcggccctt
gaggaagccaagaaaggactagctgctctccagttcgagggcgccgtttataggacggac
attggctctcgtgccctagctttcctccggcaacccagaggcctgacttacaaggactcg
ggggttgacattgcagctggaaatatgctggtcaaaaaaattcagcctttagcaaaagcc
acatctcgaccaggctgtgatgttgatcttggagattttgctggtctttttgatttgaaa
gcagctggcttcaaagatcctcttctggcctctggaacagatggcgttggaacaaaactg
aagattgctcagctgtgcaataaacatgataccattggtcaagatttggttgcaatgtgc
gtgaatgacattctggcacaaggagcagagcccctcttcttcctcgattacttctcctgt
gggaaacttgacctcagcacagccgaagccgttgttgctggcatcgcgaaagcttgtgga
caggctggatgtgctctgcttggaggtgaaacagcagaaatgcctgacatgtatcctcct
ggagagtacgaccttgctggttttgccgtcggcgccatggaacgagatcagaaactccct
cacctagaaagaatcaccgaaggggatgttgttattggaatagcttcatctggtctacac
agcaatggatttagccttgtgaggaaaattgtagcccagtcttcacttcagtactcctct
ccagcacctgatggttgtggtgaccagaccttaggggacctacttctgactccaacaaga
atctacagccatttgctgctgcctgtcctacggtcaggtcatgtcaaggcttttgcccac
attaccggtggaggattgctggaaaacatccccagagtcctccctccgaagtgtggtgtg
gatctagatgcccggacctggaggatccctaggatcttctcatggttacagcaggaaggg
cagctctctgaagaagagatggccagaacatttaactgtggggttggggctgccctcgtg
gtatcaaaggatcagacagagcggattctgagggacattcggcagcaccaggaagaagcc
tgggtgattggcagtgtggtcgcttgtcctgaaggttcccctcgtgtgaaagtcaacaat
ctggctgaagccatgcaaatgaatggctcagtaatggaaaacagctccctgaaaaatcat
tgctccgtccaacccaccaaggccagagtggctgtcttaatatccggaacaggttcaaat
ctccaggcactcatagacagtactcaggatccaaatagctcctcacacattgttgttgtc
atttccaataaagctgcggtggcgggcttagagaaagcagaaagagctggtattcccacc
agagtaattaatcataaattatataaaaatcgtgtagaatttgacaatgcagttgaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattctctct
ggtccctttgttagaaaatggaatgggaaaatgctcaacatccacccatccttactccct
tctttcaagggtgcgaatgcccacgagcaggctctggaagctggagtcacagtcaccggc
tgcaccgtgcacttcgtatcggaagatgtagacgccggacaaattattttacaagaagct
gttcccgtgaaaaggggtgacactgttgcaactctgtctgaaagagtaaaattagcagaa
cataaagtatttcctgtagccctccacctggtggcctgtggagctgtgcggcttggagaa
aatggcaagatctgttgggttaaagaggaataa
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