KEGG   Oryctolagus cuniculus (rabbit): 100337822
Entry
100337822         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04081  Hormone signaling
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05020  Prion disease
ocu05100  Bacterial invasion of epithelial cells
ocu05132  Salmonella infection
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05146  Amoebiasis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05203  Viral carcinogenesis
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100337822
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100337822
   04014 Ras signaling pathway
    100337822
   04015 Rap1 signaling pathway
    100337822
   04370 VEGF signaling pathway
    100337822
   04630 JAK-STAT signaling pathway
    100337822
   04668 TNF signaling pathway
    100337822
   04066 HIF-1 signaling pathway
    100337822
   04068 FoxO signaling pathway
    100337822
   04070 Phosphatidylinositol signaling system
    100337822
   04072 Phospholipase D signaling pathway
    100337822
   04071 Sphingolipid signaling pathway
    100337822
   04024 cAMP signaling pathway
    100337822
   04151 PI3K-Akt signaling pathway
    100337822
   04152 AMPK signaling pathway
    100337822
   04150 mTOR signaling pathway
    100337822
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100337822
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100337822
  09143 Cell growth and death
   04210 Apoptosis
    100337822
   04218 Cellular senescence
    100337822
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100337822
   04550 Signaling pathways regulating pluripotency of stem cells
    100337822
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100337822
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100337822
   04613 Neutrophil extracellular trap formation
    100337822
   04620 Toll-like receptor signaling pathway
    100337822
   04625 C-type lectin receptor signaling pathway
    100337822
   04650 Natural killer cell mediated cytotoxicity
    100337822
   04660 T cell receptor signaling pathway
    100337822
   04662 B cell receptor signaling pathway
    100337822
   04664 Fc epsilon RI signaling pathway
    100337822
   04666 Fc gamma R-mediated phagocytosis
    100337822
   04670 Leukocyte transendothelial migration
    100337822
   04062 Chemokine signaling pathway
    100337822
  09152 Endocrine system
   04910 Insulin signaling pathway
    100337822
   04923 Regulation of lipolysis in adipocytes
    100337822
   04929 GnRH secretion
    100337822
   04915 Estrogen signaling pathway
    100337822
   04914 Progesterone-mediated oocyte maturation
    100337822
   04917 Prolactin signaling pathway
    100337822
   04926 Relaxin signaling pathway
    100337822
   04935 Growth hormone synthesis, secretion and action
    100337822
   04919 Thyroid hormone signaling pathway
    100337822
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100337822
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100337822
  09156 Nervous system
   04725 Cholinergic synapse
    100337822
   04722 Neurotrophin signaling pathway
    100337822
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100337822
  09158 Development and regeneration
   04360 Axon guidance
    100337822
   04380 Osteoclast differentiation
    100337822
  09149 Aging
   04211 Longevity regulating pathway
    100337822
   04213 Longevity regulating pathway - multiple species
    100337822
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100337822
   05206 MicroRNAs in cancer
    100337822
   05205 Proteoglycans in cancer
    100337822
   05207 Chemical carcinogenesis - receptor activation
    100337822
   05208 Chemical carcinogenesis - reactive oxygen species
    100337822
   05203 Viral carcinogenesis
    100337822
   05230 Central carbon metabolism in cancer
    100337822
   05231 Choline metabolism in cancer
    100337822
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100337822
  09162 Cancer: specific types
   05210 Colorectal cancer
    100337822
   05212 Pancreatic cancer
    100337822
   05225 Hepatocellular carcinoma
    100337822
   05226 Gastric cancer
    100337822
   05214 Glioma
    100337822
   05221 Acute myeloid leukemia
    100337822
   05220 Chronic myeloid leukemia
    100337822
   05218 Melanoma
    100337822
   05211 Renal cell carcinoma
    100337822
   05215 Prostate cancer
    100337822
   05213 Endometrial cancer
    100337822
   05224 Breast cancer
    100337822
   05222 Small cell lung cancer
    100337822
   05223 Non-small cell lung cancer
    100337822
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100337822
   05170 Human immunodeficiency virus 1 infection
    100337822
   05161 Hepatitis B
    100337822
   05160 Hepatitis C
    100337822
   05171 Coronavirus disease - COVID-19
    100337822
   05164 Influenza A
    100337822
   05162 Measles
    100337822
   05168 Herpes simplex virus 1 infection
    100337822
   05163 Human cytomegalovirus infection
    100337822
   05167 Kaposi sarcoma-associated herpesvirus infection
    100337822
   05169 Epstein-Barr virus infection
    100337822
   05165 Human papillomavirus infection
    100337822
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100337822
   05135 Yersinia infection
    100337822
   05100 Bacterial invasion of epithelial cells
    100337822
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100337822
   05142 Chagas disease
    100337822
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100337822
   05017 Spinocerebellar ataxia
    100337822
   05020 Prion disease
    100337822
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100337822
   05418 Fluid shear stress and atherosclerosis
    100337822
   05415 Diabetic cardiomyopathy
    100337822
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100337822
   04932 Non-alcoholic fatty liver disease
    100337822
   04931 Insulin resistance
    100337822
   04933 AGE-RAGE signaling pathway in diabetic complications
    100337822
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100337822
   01524 Platinum drug resistance
    100337822
   01522 Endocrine resistance
    100337822
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100337822
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100337822
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100337822
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1
Other DBs
NCBI-GeneID: 100337822
NCBI-ProteinID: XP_008264758
Ensembl: ENSOCUG00000010631
UniProt: U3KM40
LinkDB
Position
14:75694386..75792511
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ttagtagaatgtttactgccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaattactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaaggcgcctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctgaatcgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagagatctgaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgataagcagaagtataccctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaagaaaacccggagcatgttgctatcctctgaacaactaaaa
ctatgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcttagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccactgctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gctacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacctttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttctatatgctctgttaaaggccgaaagggtgctaaggaggaacactgt
ccactggcttggggaaatataaacttgtttgattacactgacactctggtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttactgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttt
agcagtgtggtaaagtttccagatatgtcagtgattgaggaacatgccaattggtctgta
tccagagaagcaggatttagttattcccatgcaggactgagtaacagactagcaagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatctgtacacgcgatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacattattgtgtaact
atcccagagattctacccaaattgcttctgtctgttaaatggaattctagagatgaagtt
gcccagatgtactgcttggtaaaagattggcctccaataaaacctgagcaggccatggag
ctcctggactgcaactacccagatccgatggttcgagcttttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtatctgattcagctagtacaggtcctaaaa
tatgaacagtatttggataaccttctcgtgagatttttactcaagaaagcattgactaac
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctactgccgggcatgtggaatgtatttgaag
cacctgaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacaaatgaagtttttagttgagcaaatgagg
caaccagatttcatggatgctctacagggctttctgtctcctttaaaccctgctcatcaa
ctgggaaatctcaggcttgaagagtgtcgaataatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactatcatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaatagccatacactgcatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacccgttca
tgtgctggctattgcgttgcaactttcatcttgggaattggagatcggcacaacagtaac
atcatggtgaaagatgatggacaactgtttcatatagatttcggacactttttggaccac
aagaagaaaaaatttggttataagcgagaacgtgtaccatttgttctgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaaaactagagaatttgagaggttt
caagagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgacattgca
tatattcgaaagaccctagccttagataaaactgagcaggaggctttggaatatttcatg
aaacaaatgaacgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

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