Oryctolagus cuniculus (rabbit): 100340437
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Entry
100340437 CDS
T03373
Name
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04010
MAPK signaling pathway
ocu04012
ErbB signaling pathway
ocu04068
FoxO signaling pathway
ocu04270
Vascular smooth muscle contraction
ocu04650
Natural killer cell mediated cytotoxicity
ocu04720
Long-term potentiation
ocu04726
Serotonergic synapse
ocu04730
Long-term depression
ocu04810
Regulation of actin cytoskeleton
ocu04910
Insulin signaling pathway
ocu04914
Progesterone-mediated oocyte maturation
ocu04928
Parathyroid hormone synthesis, secretion and action
ocu05010
Alzheimer disease
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05034
Alcoholism
ocu05160
Hepatitis C
ocu05161
Hepatitis B
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05208
Chemical carcinogenesis - reactive oxygen species
ocu05210
Colorectal cancer
ocu05211
Renal cell carcinoma
ocu05212
Pancreatic cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05218
Melanoma
ocu05219
Bladder cancer
ocu05220
Chronic myeloid leukemia
ocu05221
Acute myeloid leukemia
ocu05223
Non-small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100340437
04012 ErbB signaling pathway
100340437
04068 FoxO signaling pathway
100340437
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100340437
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100340437
09152 Endocrine system
04910 Insulin signaling pathway
100340437
04914 Progesterone-mediated oocyte maturation
100340437
04928 Parathyroid hormone synthesis, secretion and action
100340437
09153 Circulatory system
04270 Vascular smooth muscle contraction
100340437
09156 Nervous system
04726 Serotonergic synapse
100340437
04720 Long-term potentiation
100340437
04730 Long-term depression
100340437
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100340437
05205 Proteoglycans in cancer
100340437
05208 Chemical carcinogenesis - reactive oxygen species
100340437
09162 Cancer: specific types
05210 Colorectal cancer
100340437
05212 Pancreatic cancer
100340437
05225 Hepatocellular carcinoma
100340437
05226 Gastric cancer
100340437
05214 Glioma
100340437
05221 Acute myeloid leukemia
100340437
05220 Chronic myeloid leukemia
100340437
05218 Melanoma
100340437
05211 Renal cell carcinoma
100340437
05219 Bladder cancer
100340437
05215 Prostate cancer
100340437
05213 Endometrial cancer
100340437
05224 Breast cancer
100340437
05223 Non-small cell lung cancer
100340437
09172 Infectious disease: viral
05161 Hepatitis B
100340437
05160 Hepatitis C
100340437
09164 Neurodegenerative disease
05010 Alzheimer disease
100340437
05022 Pathways of neurodegeneration - multiple diseases
100340437
09165 Substance dependence
05034 Alcoholism
100340437
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100340437
01522 Endocrine resistance
100340437
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100340437
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100340437
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100340437
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
zf-RING-like
Pkinase_fungal
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
100340437
NCBI-ProteinID:
XP_008270774
Ensembl:
ENSOCUG00000016449
UniProt:
G1TBN2
LinkDB
All DBs
Position
X:32615715..32630702
Genome browser
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVITVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTSRRQFYHSIQDLSGSSRQHEAPSSRPLNEPL
TPQGPSSCTQHHDPERFPFPAPANAPLQRIRSTSTPNVHMVSTAAPTDSSLMQLTAQSFG
TDAAGGRGGGDGAPRGSPSPASMSSGRKSPHSKSPSEQRERKSTADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccgccacgaggtccccctgccaacggggccgagccgtcccgggcagtgggcacc
gtgaaagtgtacctgcccaacaagcaacgcacggtgataactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaagtgcggggtctcaatcaggactgctgtgtg
gtgtaccgactcatcaaggggcgaaagacagtcactgcctgggacacggccatcgccccc
ctggatggcgaggagctcattgttgaggtccttgaagacgtcccgctgaccatgcacaat
tttgtgcgcaagaccttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggtttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtt
cccacagtgtgtgtggacatgagtaccagccgccgacagttctaccacagcatccaggat
ttgtccggaagctccaggcagcatgaggctccctccagccgccccctgaatgagccactc
accccccagggtcccagctcctgcacccagcaccatgacccggagcggttccccttccct
gccccggccaacgccccccttcagcgcatccgctccacgtccactcccaatgtccacatg
gtcagcaccgcagcccccacggactccagcctcatgcagctcactgcccagagtttcggc
actgatgctgctggtggtagaggtggtggtgatggagccccccggggaagccccagcccg
gccagcatgtcctcggggaggaagtccccacattccaagtcaccatcagagcaacgagag
cggaagtccacggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccccccagtgaggtgcagctgctgaagaggatcgggactggctca
tttggcaccgtgtttcgtggacggtggcatggcgacgtggccgtgaaggtgctcaaggtg
gcccagcccacagccgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaag
acacggcatgtcaacatcttgctattcatgggcttcatgacccgaccgggctttgccatc
atcacacagtggtgcgagggctccagcctctaccaccacctacatgtggccgacacgcgc
tttgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagacctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagatcggtgactttggcctggccaccgtgaagacgcggtggagcggggcc
cagcccttggagcagccttcaggctctgtgctttggatggcggctgaggtgatccgcatg
caggacccgaacccctacagcttccagtcggacgtctatgcctacggggttgtgctctac
gaactcatgaccggctcactgccttacagccacattggcagccgtgaccagatcatcttt
atggtgggccgtggctatctgtccccggacctcagtaaaatctccagcaactgccccaag
gccatgcggcgtctgctgtctgactgcctcaagttccagcgggaggagcggcctctcttc
ccccagatcctggccacgattgagctgctgcaacggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgacgagctgcctgcctgcctcctcagt
gcagcccgccttgtgccttag
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