Oryctolagus cuniculus (rabbit): 100343394
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Entry
100343394 CDS
T03373
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu05012
Parkinson disease
ocu05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100343394
05022 Pathways of neurodegeneration - multiple diseases
100343394
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100343394
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ocu04131
]
100343394
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ocu04147
]
100343394
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100343394
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: TKL group
LRRK family
100343394
Membrane trafficking [BR:
ocu04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
100343394
Exosome [BR:
ocu04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
100343394
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
COR
LRR_8
LRR_4
Ras
LRR_14
WD40_CDC20-Fz
LRR_9
LRR_13
Beta-prop_RSE1_2nd
Arf
LRR_6
Ank_2
MMR_HSR1
AAA_22
AAA_16
T2SSE
Beta-prop_EML_2
nSTAND3
Kdo
NACHT
ABC_tran
AAA_7
Beta-prop_BBS7
G-alpha
TrwB_AAD_bind
GTP_EFTU
PduV-EutP
AAA_29
cobW
TniB
MobB
FtsK_SpoIIIE
Gtr1_RagA
AAA_23
NB-ARC
Septin
TsaE
AAA_33
PQQ_2
Motif
Other DBs
NCBI-GeneID:
100343394
NCBI-ProteinID:
XP_051706893
Ensembl:
ENSOCUG00000007857
LinkDB
All DBs
Position
8:105907563..106080635
Genome browser
AA seq
2523 aa
AA seq
DB search
MASGGGSNQGSDEDEESLKKLLVKLNNVQEGKQVETLVQTLEDLLVFTYSERASRLFRGK
SFHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPDTMQSLMGPQDVGSDWEVLGVHQLI
LRMLSVHSASVNLLTVGLKALDLLLTSGKITLLILEEESDIFLLIFDAMRTFPANDEIQK
LGCKALHVLFERVSEEQLTEFVENKDYMILLSALKNFKDEEEIVLHVLHCLHSLAIPCNN
VEVLMSGNVRCYNIVVEAMKAFPVSEKIQEVSCCLLHRLTLGNFFNILVLNEVHAFVVRA
VRRYPENAALQISALGCLALLTETIFLNQDLEEKSEAQSGEEEEEEDKLFWLEACYKALT
GHRKNRHVQEAACWSLNNLLMYHSSLHERIGDEDGQLPAHREVMLSMLMHSSSKEVFQAS
ANALSTLLEQNVNFRKILLSKGIYLNVLELMQRHAHSPEVAESGCKMLNHLFEGSHISLD
TVAAVVPKIITVMRSHEASLSVQLEALRAILHFMMPGMPEESREETESQRNLNVVRKQCF
RSDIHKLVLAALNRFIGNPGIQKCGLKVMASITQVPDALEVLSLEGAVDSVLHTLHMYPD
DQEIQCLGLSLVGRLIAKKNLCTGTGHLLAKILVSSLQRFKDAAEVQLEGFRTVLAILEL
SVSFSKLLVHHSFDSVIFHQMSSSITEQKDQQFLSLCCKCFAKLAMEDELKNAMLQRACD
QNNSIMVECLLLLGADANQTKEATSLICQVCEKESSPKLVELLLDSGSREQDVRKALAVS
IGKGDSQVISLLLKRLALDLANNSICLGGFGIGKIEPSWLGPLFPDKTSNLRKQTNIGSI
LARMVLRHQMKSAVEEGAAPGSEENFPEGVLDKLDEWTFIPDSSMDSVFGQSDDLDSEGS
EGSFLVRKKSSSIGVGEFYRDPVLQRCSPNLPRHSNSLGPVFDQEDLRRQKRKILSSDDS
LRSTKLQSHGRQSDSVSSLASEREYITSLDLSANELREVDALSRRGCLSGHLEHLERLEL
QQNALVSFPQPLCEVLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDIGPSVILDP
AVRCLTLRQLNLSYNQLSAVPESLAEVAEKLEQLLLEGNKISGTCSPLSLKELKILNLSK
NHISCLPENFLEACPKVESFSARMNLLADMPFLPSSMTSLKLSQNKFTSVPEAILNLPHL
RSLDMSSNDIQCLPGPARWTSLNLRELLFSYNQISVLDLSEKAHAWCRVEKLHLAHNKLK
EIPPEIGYLENLTSLDVSYNSELRSFPNEMGKLSKIWDLPLDELRLNFDFKHVGCKAKDI
IRFLQQRLRKAVPYNRMKLMIVGNTGSGKTTLLQQLMRAKKADVGMQGATVGIDVRDWPV
QIRSKGKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNI
KARASSSPVILVGTHLDVSDEKQRKACIGKITRELLNKRGFPAIRDYHFVNATEESDALA
KLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPTEFPVIDRKRLLQLVR
DNQLQLDENELPHAIHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGY
PKHPKGIISRRDVEKFLSKKRRFPKNYMTQYVKLLEKFQIALPIGEEYLLVPSSLSDHRP
VIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGI
YLNWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEI
DICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLINPDQPRLTIPISQIAPD
LVLADLPRNIMLNNDELEFQQAPEFLLGDGSFGSVYRAVYEGEEVAVKIFNKHTSLRLLR
QELVVLCHLHHPSLISLLAAGIRPRMLVMELAPKGSLDRLLQQDKASLTRTLQHRIALHV
ADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGISQYCCRMGIKTSEGTPGF
RAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKE
YGCTPWPLVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKSVTVECMVAS
SPGGKSTSIWLGCSHTDKGQLSFLNLNTEGHTTEEVSESRVLCLALVSLPVEKESWIVCG
TQSGALLAISTEDGKRRHSLEKMTDSVTCLYCNSFPKQSKQKNFLLVGTADGKLAIFEDK
TVKCEGAAPVKTLNIGNVSTPLMCLSESVNSTEKNTMWGGCGTKIFSLSHDFTVQKLIET
RTNQLFSYAAFSDSNIIAVAVDTALYVAKKNSPVVEVWDKKTEKLCELIDCVHFLKEAMA
VGKQESKHSLFYSVRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRIIYNFCDSVRVM
ATAQSGNLKNVMLVLGYNRKSAEEIQSCLSIWDTNLPHEVQNLEKHIEVRKELAEKMRRT
SVE
NT seq
7572 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcggtggcagcaaccagggcagcgacgaggacgaggaaagtctgaagaag
ttgctggtcaagctgaacaacgtccaggagggcaagcaggtcgagacgctggtgcagacc
ctggaggacctgctcgtgttcacgtactcggagcgcgcctcaaggctgtttcggggcaaa
agcttccacgtgcctctgctgatcgtgttggactcgtatatgagggtcgcgagtgtgcag
caggtgggctggtcgcttctgtgcaaactgatagaagtctgtccagacactatgcaaagc
ttgatggggccccaagacgttggcagtgattgggaggtccttggagtccaccagctgatt
cttcgaatgctctcagtccacagtgccagtgtgaacctgttgacggtgggactgaaggcc
ttggacctcctcctgacttcaggtaaaatcactttgctgatactggaggaagaaagcgat
attttcctgttgatttttgatgccatgcgcaccttcccagccaatgatgagatccagaag
cttgggtgcaaagctctgcatgtgctgtttgagagagtctctgaggaacaactgactgaa
tttgttgagaacaaagattatatgatattgctgagtgcattaaaaaattttaaagatgaa
gaggagatagtcctccatgtcctacactgtttgcattccttggcaattccgtgcaacaac
gtggaagtgctcatgagcggcaatgtcaggtgctacaatattgtggtggaagccatgaaa
gccttccctgttagtgagaagattcaagaagtgagttgctgcttgctgcacaggctgacc
ctgggcaattttttcaacatcctggtgctgaacgaggtgcacgcgtttgtggtgagagct
gtgcggcggtatcccgagaacgcagcgctgcagatctcggcgctgggctgcctggcgctc
ctcactgagaccatttttttaaatcaagacttagaggaaaagagtgaggctcagagtggc
gaggaggaggaggaggaggacaagctgttctggctggaagcctgctacaaggcgctcacg
gggcaccggaagaacaggcatgtgcaggaggcggcgtgctggtccctgaacaacctgctc
atgtaccacagcagcctgcacgagaggatcggcgacgaggacggccagctccctgcgcac
agggaggtgatgctgtccatgctgatgcactcctcgtcgaaggaagtcttccaggcatcg
gcaaacgcgctgtcgaccctcctggagcaaaatgttaatttcagaaagatcctgttgtct
aaagggatatacctgaatgttctggagttaatgcagcggcacgcacattcccctgaagtg
gccgagagtggctgtaagatgctgaaccacctgtttgaaggcagtcacatttccctggat
acagtggcggcagtggtccccaaaataataacagttatgagaagtcacgaggcgtcactg
tcagtgcagctggaggcactccgagctattctacattttatgatgccaggcatgccggaa
gagtccagagaggaaacagaatctcagcggaacctaaacgtggttagaaagcagtgtttc
aggagtgacatccacaaactggtcctcgccgctttgaacaggttcattggaaatcctggg
attcagaaatgtggattgaaagtcatggcttcgataacgcaggtgccggatgcgctagag
gtgctatcgctggagggtgctgttgactcggtgctgcacacgctgcacatgtacccggat
gaccaagaaattcagtgtctgggtttaagtcttgtaggacgcttgattgcaaagaaaaat
ttatgcacaggaaccgggcatctgctggcgaaaattctcgtgtccagcttgcagcggttc
aaggacgctgctgaagtgcagttggaaggttttcggaccgtcttagcaatacttgaattg
tcagtgtctttttccaagctgcttgtccaccattcatttgattcagtaatattccatcag
atgtcttccagtattacggaacagaaggatcagcagtttctaagcctctgttgcaagtgc
tttgcaaagttggccatggaggatgagcttaagaatgcgatgctgcagcgggcctgtgac
cagaacaacagcatcatggtggagtgcttgctgctcttgggagctgacgccaaccagacc
aaggaggccacttctttaatttgtcaggtctgtgagaaggagagcagccccaagctggtg
gagctgctgctggacagcgggtcccgggagcaggacgtgcgcaaggcgctggccgtcagc
atcgggaagggcgacagccaggtcatcagcctgctcttgaagaggctggccctggatctg
gccaacaacagcatctgcctcggaggatttggtattggaaaaattgagccttcctggctc
ggtcctttatttccagataagacatccaatttaaggaaacaaacaaatattggctctata
ctagccagaatggtgctgaggcatcagatgaaaagcgccgtggaggagggggccgcccca
ggcagcgaggagaacttccccgagggcgtgctggacaagttggatgagtggaccttcatt
cccgactcttcgatggacagtgtgtttggtcagagcgatgatctggacagtgaaggaagt
gaaggctcatttcttgtgagaaagaaatcaagttcaattggtgtaggagagttttaccgg
gatcctgtattgcagcgctgctccccaaatttgccaaggcattccaattcactgggaccc
gtttttgatcaggaagatttacggaggcaaaaaaggaaaatcctgtcatcagatgactca
ctgaggtcgaccaagctgcagtcccacgggaggcagtcagacagcgtgtcctccctggct
tcggagagggagtacatcacctccttagacctttcagcgaatgaactcagggaggtcgat
gccctgagccgcaggggctgcctgagtggccacttggagcacctggagaggctagagctg
cagcagaatgcactggtcagcttcccacagccactctgcgaggtcctgaagtgcttgaca
catttggacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaac
tgcatcgccaacctcgatgtctcccgcaatgacattgggccctctgtcatcctggatccc
gcggtgaggtgtctgaccctgcggcagctgaatctgtcctataaccagctgtctgctgtc
cctgagagcctcgcagaggtggctgagaaactggagcagctgcttctagaaggaaataaa
atatcaggcacatgctcccccttgagcctgaaggaactgaagatcttaaaccttagtaaa
aaccacatttcatgcctaccagagaactttctggaagcttgtcctaaagtggagagtttc
agcgccaggatgaatttgcttgccgacatgcctttcttgccttcctccatgacaagctta
aaactatctcaaaacaaatttacaagtgttccagaagcaattttaaatcttccacacctg
cggtccctggacatgagcagcaatgacatccagtgtctgccaggccccgcacgctggacg
tccttgaacttacgggaactactgttcagctacaatcagatcagcgtgttggacttgagc
gaaaaggcgcatgcgtggtgtcgagtggagaaactgcaccttgctcacaataaactgaag
gagattcctcctgagatcggctatctggagaatctgacatctcttgatgtgagttacaac
tccgaactgaggtcctttcccaacgaaatggggaaactaagcaaaatctgggatctgcct
ctggatgaactgcgtcttaactttgattttaaacacgtaggatgcaaagccaaagacatc
ataaggtttcttcagcagcggctcagaaaggccgtgccgtacaaccgaatgaaactcatg
atcgtgggcaataccgggagtggcaagaccaccttgctgcagcagttaatgagagccaag
aaggccgacgtcggcatgcagggcgccacggtcggcatcgacgtgagggactggcccgtg
cagatcagaagcaaagggaagagagacctcgtgctgaacgtgtgggacttcgcagggcgc
gaggagttctacagcacacacccccatttcatgacccagcgtgctctgtacctggccgtg
tatgatctcagcaagggacaggctgaagttgatgccatgaagccctggctcttcaacata
aaggcacgggcgtcatcctcccccgtgatcctcgtgggcacgcacctggacgtttctgac
gagaagcagcgcaaggcctgcatcggcaagatcacacgggagctcctgaacaagcgtggc
ttccccgccatccgggactaccacttcgtcaacgccaccgaggagtccgatgccttggcc
aagctccggaagaccatcatcaacgagagcctgaatttcaagatccgagatcagcctgtt
gtcgggcagctgattccagactgctatgtagaacttgagaaaatcattttgtccgaacgt
aaaaatgtgccaactgaatttcccgtaattgaccggaaacgattattacaactggtgaga
gacaatcagctgcagctggatgagaatgagcttcctcacgccattcatttcctaaacgaa
tcaggggttcttcttcattttcaagacccagcgctgcagctgagtgacttgtactttgtg
gaacccaagtggctctgcaaagtcatggcccagattttgacagtgaaagtggaaggctat
ccgaaacatcctaagggaattatttcacgtagagatgtggaaaaattcctgtcgaagaaa
aggagatttccaaagaattacatgacacagtacgttaaactcctggaaaaattccagatc
gccttgccaataggagaagagtacttactggttccaagcagtctctctgaccaccggccc
gtaatagagcttccacactgtgagaactcggaaatcatcatccggctctatgaaatgcct
tatttccccatggggttttggtcaagattaattaaccggttacttgagatctcaccttac
atgctttcgggaagagaacgagcgcttcgccccaacagaatgtactggcgccagggcatc
tacctgaactggtctcctgaagcttactgcctggtgggatctgaagtcttagaccatcac
ccagagagtttcttaaagattacagttccttcttgtagaaaaggctgcattctactgggc
caagtcgtggaccacattgactctctcatggaggagtggtttcctgggctgctggagatt
gacatctgcggcgaaggagaaacccttttaaagaagtgggcattgtatagttttaatgac
ggtgaagaacatcaaaaaatcttactggatgacttgatgaagaaagcagaagaaggagac
ctcctgataaatcccgatcaaccgagactcaccatccccatatctcagattgctccggac
ctggttttggctgacctgcctagaaacattatgctgaacaacgatgagctggagtttcag
caggctccggagtttctcttaggggacggcagttttggatccgtgtaccgggccgtgtac
gaaggagaagaggtggcggtgaagattttcaacaagcacacgtctcttcggctgctgaga
caggagctggtggtgctctgccacctgcaccaccccagcctgatctcgctgctggcggct
gggatccgcccgcggatgctcgtgatggagctggcccccaagggctccttggaccggctg
ctgcagcaagacaaagccagcctcaccaggaccctgcagcacaggatcgcgctgcacgtg
gccgacggcttgagatacctgcactcagccatgatcatctaccgggacctgaagccccac
aacgtgctgctgttcaccctgtaccccaacgccgccatcatcgcgaagatcgccgactac
gggatttctcagtactgctgcaggatgggcatcaaaacctcagagggcacgccagggttt
cgtgcgcctgaagttgccagaggaaatgtcatttataaccagcaggccgatgtgtattcg
tttggcttgctgctctatgacattttgacaacgggaggtaggatcgtagagggtttgaag
ttccccaatgaatttgatgaattagcaatacaaggaaaattacctgatccagttaaagaa
tatggctgtactccctggccattggtggagaagttaattaaaaagtgtttgaaagaaaat
cctcaagaaaggcctacttctgcgcaggtgtttgacattttgaattccgctgagctgatc
tgtctgatgagacacattctaatccctaagagtgtcaccgtcgagtgcatggtggcttcg
agccccggaggcaagagcacgagcatttggctgggctgcagccacaccgacaaggggcag
ctgtcgtttcttaacctcaacacggaaggacacactactgaggaagttagtgagagcaga
gtcctgtgcctggccttggtgtcccttcctgttgagaaggaaagctggattgtgtgtggg
actcagtctggtgccctcctggccatcagcacggaggatgggaagaggagacacagcctg
gaaaagatgaccgattctgtcacttgcttatactgcaattcctttcctaagcaaagcaag
caaaaaaattttcttttggtgggaactgctgatggcaagttagcgatttttgaagataag
actgtgaagtgtgaaggagccgctcctgtgaagaccctcaacatcggaaacgtgagcacc
ccactgatgtgcctgagtgaatccgtgaattcaacagagaaaaacacgatgtggggaggg
tgtggaaccaagattttctcattgtctcatgatttcactgttcagaaactcattgaaaca
aggacaaatcagctgttttcttacgcagctttcagtgattccaacatcatcgcggtggca
gtggacacggctctctacgttgctaagaaaaatagccctgtggtggaagtgtgggataag
aagacagaaaaactctgcgagctcatagactgcgtgcactttctaaaggaagcgatggca
gtaggaaagcaggagtcaaagcacagcctgttctactccgtgcgcgtgaaggcgctttgc
cttcagaagaacacggcgctctggatcgggaccggaggaggccacatcctgctcctggac
ctctccacgcggcgcgtgatccgcatcatctacaacttctgtgattccgtgcgcgtcatg
gcgacagcacagtcaggcaaccttaaaaatgtcatgctggtcctgggctacaaccggaag
agtgccgaagagatacaatcttgcttgtctatttgggacacaaatcttccgcatgaagta
caaaatttagaaaaacacattgaagtgagaaaagaattagctgagaaaatgagaagaacg
tctgttgagtaa
DBGET
integrated database retrieval system
