Oryctolagus cuniculus (rabbit): 100344622 Help Entry 100344622         CDS       T03373                                  Symbol TYK2 Name (RefSeq) tyrosine kinase 2   KO K11219   non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04217   Necroptosis ocu04380   Osteoclast differentiation ocu04621   NOD-like receptor signaling pathway ocu04630   JAK-STAT signaling pathway ocu04658   Th1 and Th2 cell differentiation ocu04659   Th17 cell differentiation ocu05145   Toxoplasmosis ocu05160   Hepatitis C ocu05161   Hepatitis B ocu05162   Measles ocu05164   Influenza A ocu05165   Human papillomavirus infection ocu05167   Kaposi sarcoma-associated herpesvirus infection ocu05168   Herpes simplex virus 1 infection ocu05169   Epstein-Barr virus infection ocu05171   Coronavirus disease - COVID-19 Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     100344622 (TYK2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     100344622 (TYK2)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     100344622 (TYK2)    04658 Th1 and Th2 cell differentiation     100344622 (TYK2)    04659 Th17 cell differentiation     100344622 (TYK2)   09158 Development and regeneration    04380 Osteoclast differentiation     100344622 (TYK2)  09160 Human Diseases   09172 Infectious disease: viral    05161 Hepatitis B     100344622 (TYK2)    05160 Hepatitis C     100344622 (TYK2)    05171 Coronavirus disease - COVID-19     100344622 (TYK2)    05164 Influenza A     100344622 (TYK2)    05162 Measles     100344622 (TYK2)    05168 Herpes simplex virus 1 infection     100344622 (TYK2)    05167 Kaposi sarcoma-associated herpesvirus infection     100344622 (TYK2)    05169 Epstein-Barr virus infection     100344622 (TYK2)    05165 Human papillomavirus infection     100344622 (TYK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     100344622 (TYK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ocu01001]     100344622 (TYK2) Enzymes [BR:ocu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      100344622 (TYK2) Protein kinases [BR:ocu01001]  Non-receptor tyrosine kinases   JAK family [OT]    100344622 (TYK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo ABC1 Motif Other DBs NCBI-GeneID:  100344622 NCBI-ProteinID:  XP_017194260 LinkDB All DBs Position Un Genome browser AA seq 1098 aa AA seqDB search MFLCQRRAGSRGSLPGAAAAQPLAAGGGLRVLLHWAGPGGGEPWVTFGEVSLTAEEVCVH IAHRIGITPPCFNLFALFDVQAQVWLPPNHVLEVSRDETLTLYFRMRFYFRNWHGMNPQE PAVYRCGPPGTEAPSERPEQGVQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEETHHF KNESLGMAFLHLCHLALCRGVPLEEVARKTSFKDCIPRSFRQQIHQHNALTRLRLRNVFR RFLRAFQPGRLSQQAVMVKYLATLERLAPRFGSERTPVCCLRLLAQADGEPCYIRDHRPA PADPGPEAAPGPPTHEVLVTGTGGIQWRPVLAEVRAGRLFLLGLDPAAAGASPGGRGPQA LAAPRCCPLVPSREPFVQAKLRPADGLYLVQWSTSHFHRLILTVAQRDPGPGLQTLRLRK FPIELRDGAFVLEGWARSFTSVRELRAALQGCSLRAGDDCFLLRRCCLPQPGEISNLIVT RGPRASSRPPNLSQLSFHRVRQDDLRQLSHLGQGTRTNVYEGLLQVGGPEEAQVDGGEPL APSGGQELRVVLKVLDASHHDVALAFYETASLMSQVSHVHLAFVHGVCVRGSENIMVTEY VEHGPLDVWLRRERGRVPMAWKVAAAQQLASALSYLEDKNLAHGNVCGRNILLARLGLAE GATPFIKLSDPGVGLAVLSREERVERIPWTAPECLPAGNSSLIPAADKWGFGATLLEICF DGEAPLQGHSPSEKERFYQRQHRLPEPSCPELAMLTSQCLNYEPAQRPSFRTVLRDLTRL QPQDLVDVVAVSPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPNNDGTGEMVAV KALKAGCGPQLRSGWRREIDILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDY LPRHSVGLAQLLLFAQQICEGMAYLHGQHYIHRDLAARNVLLDHDRLVKIGDFGLAKAVP EGREYYCVREDGDSPVFWYAPECLKDSKFYYASDVWSFGVTLYELLTHCDASQSPPSKFL ELIGLTQGQMAVLRLTELLDRGERLPRPDRCPGEIYLLMKNCWEAEASFRPSFQNLVPVL KALHEQYRGQAPSVFSVC NT seq 3297 nt NT seq  +upstreamnt  +downstreamnt atgtttctgtgccagagaagagccggctccaggggcagcctgccgggcgcggctgccgct cagcccctggctgcggggggaggcctgcgggtgctcctgcactgggccggccccggcggc ggcgagccctgggtcacgtttggggaggtttcgctgactgctgaggaggtctgtgtccac atcgcacacaggatcggcatcactccaccctgcttcaacctctttgccctcttcgatgtc caggcccaagtctggctgcccccaaaccatgtcctggaggtgtccagggacgagaccctg accctgtatttccgcatgaggttttacttccggaactggcacggcatgaatccccaggag ccggctgtgtaccgctgcgggcccccagggaccgaggctccctcagaacggccagaacag ggagtccaactcctggacccggcctcgtttgagtacctttttgagcagggcaaacacgag tttgtgaatgacgtggcctcgctgtgggagctgtccagtgaggaggagacccaccacttt aagaacgagagcctgggcatggccttcctgcacctctgccacctggctctgtgccgcggc gtcccgctggaggaggtggccaggaagaccagcttcaaggactgcatcccgcgctccttc cgccagcagatccaccagcacaacgcgctgacccggctgcgcttgcgcaacgtcttccgc aggttcctgcgcgccttccagcccggccgcctctcgcagcaggcggtcatggtgaagtac ctggccacgctggagcgcctggcgccccgcttcggctcggagcgcacgcccgtgtgctgc ctgcggctgctggcccaggccgacggggagccctgctacatccgggaccacaggccggcc cccgcagaccccggccccgaggccgcgccgggaccccccacccacgaggtgctggtgaca ggcaccggtggcatccagtggcggccggtcctggccgaggtgagggcggggcgccttttc ctccttggcctggaccctgctgcagcaggtgcctccccaggggggaggggcccgcaggcc ttggctgcgccacgatgctgcccccttgtcccctccagggagccattcgtgcaggccaag ctgcggcccgcggacggcctctacctcgtccagtggagcaccagccacttccaccgcctc atcctcaccgtggcccagcgcgacccgggccccggcctgcagaccctgcgtctgcgcaag tttcccatcgagctccgggacggggccttcgtgctggagggctgggctcgctccttcacc agtgtgcgcgagctgcgggccgccctgcagggctgctcgctgcgggcgggggacgactgc ttcctgctgcgccgctgctgcctgccgcagcctggagaaatctcgaacctcattgtgacg cgggggccccgggccagctccaggccgcccaacctcagccagctcagtttccaccgagtc cggcaggacgacctccggcagctgtcgcacttgggccagggcacaaggaccaatgtgtat gagggcctgctgcaagtggggggccctgaggaggctcaggtagacggtggggagcccctg gcccccagtgggggccaggagcttcgagtggtgcttaaggtactggacgccagtcaccac gacgtcgccctggccttctacgagaccgccagcctcatgagccaggtgtcccacgtgcac ctggcttttgtgcacggcgtgtgtgtgcgcggctcggagaacatcatggtgaccgagtac gtggagcacgggcccctggatgtgtggctgcggcgggagaggggccgggtgcccatggcc tggaaggtggcggcagcccagcagctggccagcgccctcagctatctggaggacaagaac ctggcccatggtaacgtgtgcggccggaacatcctgctggcccggctggggctggccgag ggcgccactcccttcatcaaactcagcgaccccggcgtgggcctggccgtcctgtccagg gaagagcgggtggagcggatcccctggacggcccccgagtgcctgcccgccgggaacagc agcctgatacctgcggccgacaagtggggcttcggcgccacactgctggagatctgcttt gacggcgaggccccgctgcagggccacagcccctccgagaaagagcgcttctaccagagg cagcacaggctgcccgagccctcgtgccccgagctggccatgctcaccagccagtgcctc aactatgagccagcccagcgcccctccttccgcaccgtcctgcgcgacctcacccggctg cagccccaggatctggtggacgtggtggctgtgagcccagactcgccagcgtctgacccc acggttttccacaagcgctacttgaaaaagatccgggatctgggcgagggtcacttcggc aaggtcagcttgtactgctacgacccgaacaacgacggcaccggcgagatggtggccgtg aaggccctcaaggccggctgcggccctcagctgcgctccggctggaggcgggagattgac atcctgcgcacgctctaccacgagcacatcgtcaagtacaagggctgctgcgaggaccaa ggtgagaagtcggtgcagctcgtcatggagtacgtgcccctgggcagccttcgggactac ctgccccggcacagcgtcgggctggcccagctgctgctcttcgcccagcagatctgcgag ggcatggcctacctgcacgggcagcactacatccaccgggacctggctgcacgcaacgtg ctcctggaccacgacaggctggtcaagatcggcgactttggccttgccaaggccgtgccc gagggccgcgagtactactgcgtgcgggaggatggggacagccccgtgttctggtacgcc cccgagtgcctcaaggactccaagttttactacgcgtccgacgtctggtccttcggcgtc acgctctatgaactgctgacgcactgtgacgccagccagagccccccctcgaaattcctt gagctcatcggcctcacccagggccagatggcggtgctgaggctgacggagctgctggac cgcggggagaggctgccgcggccggacaggtgccccggcgagatctaccttctcatgaag aactgctgggaggcggaggcctcgttccgccccagcttccagaacctcgtccccgtcctc aaggccctgcacgagcagtaccggggccaggcgccctcggtgttcagcgtgtgctga

Oryctolagus cuniculus (rabbit): 100352594 Help Entry 100352594         CDS       T03373                                  Symbol JAK1 Name (RefSeq) Janus kinase 1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu01521   EGFR tyrosine kinase inhibitor resistance ocu04151   PI3K-Akt signaling pathway ocu04217   Necroptosis ocu04380   Osteoclast differentiation ocu04550   Signaling pathways regulating pluripotency of stem cells ocu04621   NOD-like receptor signaling pathway ocu04630   JAK-STAT signaling pathway ocu04658   Th1 and Th2 cell differentiation ocu04659   Th17 cell differentiation ocu05140   Leishmaniasis ocu05145   Toxoplasmosis ocu05152   Tuberculosis ocu05160   Hepatitis C ocu05161   Hepatitis B ocu05162   Measles ocu05163   Human cytomegalovirus infection ocu05164   Influenza A ocu05165   Human papillomavirus infection ocu05166   Human T-cell leukemia virus 1 infection ocu05167   Kaposi sarcoma-associated herpesvirus infection ocu05168   Herpes simplex virus 1 infection ocu05169   Epstein-Barr virus infection ocu05171   Coronavirus disease - COVID-19 ocu05200   Pathways in cancer ocu05203   Viral carcinogenesis ocu05212   Pancreatic cancer ocu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     100352594 (JAK1)    04151 PI3K-Akt signaling pathway     100352594 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     100352594 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100352594 (JAK1)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     100352594 (JAK1)    04658 Th1 and Th2 cell differentiation     100352594 (JAK1)    04659 Th17 cell differentiation     100352594 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     100352594 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100352594 (JAK1)    05203 Viral carcinogenesis     100352594 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100352594 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     100352594 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100352594 (JAK1)    05161 Hepatitis B     100352594 (JAK1)    05160 Hepatitis C     100352594 (JAK1)    05171 Coronavirus disease - COVID-19     100352594 (JAK1)    05164 Influenza A     100352594 (JAK1)    05162 Measles     100352594 (JAK1)    05168 Herpes simplex virus 1 infection     100352594 (JAK1)    05163 Human cytomegalovirus infection     100352594 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     100352594 (JAK1)    05169 Epstein-Barr virus infection     100352594 (JAK1)    05165 Human papillomavirus infection     100352594 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     100352594 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     100352594 (JAK1)    05140 Leishmaniasis     100352594 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100352594 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ocu01001]     100352594 (JAK1) Enzymes [BR:ocu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      100352594 (JAK1) Protein kinases [BR:ocu01001]  Non-receptor tyrosine kinases   JAK family [OT]    100352594 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 ABC1 RIO1 Motif Other DBs NCBI-GeneID:  100352594 NCBI-ProteinID:  XP_008263345 Ensembl:  ENSOCUG00000006227 UniProt:  G1SQL4 LinkDB All DBs Position 13:101452691..101594526 Genome browser AA seq 1151 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVDLEAPEPGVEVVFYLSDREPLRLGSGEYTAEEV CIRAAQECRISPLCHNLFALYDESTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DSEQSVWRHSPKKQKNGYEKKKVPDATPLLDANSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMRKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHSSDSGIVLYYEVMVTGNLGIQWRQKPNVVPVEKEKSKLKRKKLENKLRKDEERNKTR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGNEEGMYVLRWSCTDFDNILMTVT CFEKSERQFKNFQIEVRKGCYSLHGSDRSFPSLGELMSHLKKQILRTDNISFVLKRCCQP KPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHLGRGTRTHIYAGTLVDHK DDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMV EEFVEGGPLDLFMHRKSDLLTTPWKFKVAKQLASALSYLEDKDMVHGNVCTKNLLLAREG IDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI CYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDIN KLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVA VKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKE YLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTK AIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSEYSPMA LFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDQVYQLMRKCWEFQPSNRTTFQNLI EGFEAILKKHE NT seq 3456 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagaccgaggtggatctggaggcccctgagcctggggtggaagtggtcttc tatctgtcggacagggaacccctccggctgggcagtggagagtacacggcggaggaggtg tgcatcagggccgcacaggaatgccgtatctctcctctgtgtcacaacctctttgccttg tatgatgagagcaccaagctctggtatgctccgaatcgcaccatcactgttgatgacaag acgtccctccggctgcactaccggatgaggttctatttcaccaactggcatgggaccaat gacagcgagcagtctgtgtggcgacattctccaaagaagcagaaaaatggctatgagaaa aagaaggttccagatgcaacccctctccttgacgccaactccctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcctattcgagaccccaagacggaacag gatgggcatgacatcgagaatgagtgtctagggatggccgtcctggccatctcacactat gccatgatgaggaaaatgcaattgcctgaactccccaaggacatcagctataagcgatat atcccagaaacgttgaataagtccatcagacagaggaaccttctcaccaggatgcggatt aataatgttttcaaggatttcctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtcaacacatgacctgaaagtgaaataccttgctactttggagactttgacaaaacat tatggtgctgaaatatttgagacttccatgttactgatctcatcagaaaatgagatgaat tggtttcattccagtgacagtggaattgttctctactatgaagtgatggtgactggaaat cttggaatccagtggaggcagaaaccaaatgttgtgcctgttgaaaaagaaaaaagtaaa ctgaagcggaagaaactggaaaataaactcaggaaagatgaggagagaaacaaaacgcga gaagagtggaacaatttttcctacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcattaacaagcaggataacaaaaaaatggaactgaagctctcttcccatgag gaggccttgtccttcgtgtccctggtggatggctacttccggctcacagcagatgcccat cattacctctgcactgacgtggctccaccactgatcgtccacaacatacagaatggctgt catggtccaatctgcacagagtatgccatcaataaactgcggcaagaagggaatgaggag gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgactgtcacc tgctttgagaagtctgagagacagttcaagaactttcagatcgaggtgcggaagggctgc tacagcctgcacggctcagaccgcagcttccccagcctgggagaactcatgagccacctc aagaagcagatcctgcgtacagacaacatcagcttcgtgctgaaacgctgctgccagccc aagcccagagagatctctaacctgctggtggctactaagaaagcccaggagtggcagcct gtctatcccatgagccagctgagttttgaccggatcctcaagaaagatatcatgcagggc gagcacctggggagaggcaccagaacccatatctacgccgggaccctggtggatcacaag gatgacgaagggacttcagaagagaagagaataaaagtgatcctcaaagtcttagacccc agccacagggacatctctctggccttctttgaggcagccagcatgatgagacaggtctcc cacaagcacatcgtgtacctctatggtgtctgtgtccgcgacgtggagaatatcatggtg gaagagtttgtggaaggagggcccctcgatctcttcatgcaccggaaaagcgacctgctc acgacgccgtggaagttcaaagttgccaagcagctggccagcgccctgagttacctggag gacaaggacatggtccacgggaacgtgtgcaccaagaacctactgctagcgcgcgagggc atcgacagcgagtgcgggccgttcatcaagctcagcgaccccggcatccccatcaccgtg ctgtcccggcaggagtgcatagaacgcatcccgtggattgctcccgagtgtgtggaagac tccaagaacctgagcgtggctgctgacaagtggagcttcggaaccacgctctgggagatc tgctacaatggcgagatccccctcaaagacaagacactcatcgagaaagagagattctac gagagccgctgccggccagtgaccccgtcctgtaaggagctggcggaccttatgacccgc tgcatgaactacgaccccaaccagagacccttcttccgcgccatcatgagagacatcaac aagctggaagagcagaatccagacatcgtgtcggagaggaagccagccactgaggtggac cccacgcattttgaaaagcgcttcctcaagaggatccgggacttgggcgagggccacttt gggaaggttgagctctgcaggtatgaccccgagggggacaacacgggggagcaggtggct gtgaagtccctaaagccagagagcggcggtaaccacatagctgacctcaagaaggaaata gaaatcttgcggaacctctatcacgagaacatcgtgaagtacaaagggatctgcaccgag gacggaggaaacggtattaagctcatcatggaatttctgccttcgggaagccttaaggag tatcttccaaagaataaaaacaaaattaatctcaagcaacagctaaaatatgccgtgcag atttgtaaggggatggactatttgggttctcggcagtacgtccaccgggacttagcagca agaaatgtccttgttgagagtgaacaccaagtgaaaattggagacttcggcttaaccaaa gcgatcgagacagacaaggagtactacaccgtcaaggacgaccgggacagccctgtgttt tggtatgccccagaatgtttaattcagtgtaaattctatattgcctccgacgtctggtcc tttggagtgactctgcacgagctactcacttactgtgattcagaatatagtcccatggcc ttgttcctgaaaatgataggcccaactcatggccagatgacagtaacaagacttgtgaat acactgaaggaaggaaaacgtttgccgtgtccacccaactgtccagatcaggtttatcaa cttatgaggaaatgctgggaattccaaccttccaatcggacaacctttcagaaccttatt gaaggattcgaagcaattttaaaaaagcatgaataa

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