KEGG   Oryctolagus cuniculus (rabbit): 100351964
Entry
100351964         CDS       T03373                                 
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X6
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu04010  MAPK signaling pathway
ocu04012  ErbB signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04068  FoxO signaling pathway
ocu04150  mTOR signaling pathway
ocu04270  Vascular smooth muscle contraction
ocu04510  Focal adhesion
ocu04650  Natural killer cell mediated cytotoxicity
ocu04720  Long-term potentiation
ocu04722  Neurotrophin signaling pathway
ocu04726  Serotonergic synapse
ocu04730  Long-term depression
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04928  Parathyroid hormone synthesis, secretion and action
ocu04934  Cushing syndrome
ocu05010  Alzheimer disease
ocu05022  Pathways of neurodegeneration - multiple diseases
ocu05034  Alcoholism
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05200  Pathways in cancer
ocu05205  Proteoglycans in cancer
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05216  Thyroid cancer
ocu05218  Melanoma
ocu05219  Bladder cancer
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100351964
   04068 FoxO signaling pathway
    100351964
   04024 cAMP signaling pathway
    100351964
   04150 mTOR signaling pathway
    100351964
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100351964
   04062 Chemokine signaling pathway
    100351964
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    100351964
  09156 Nervous system
   04726 Serotonergic synapse
    100351964
   04720 Long-term potentiation
    100351964
   04730 Long-term depression
    100351964
   04722 Neurotrophin signaling pathway
    100351964
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100351964
   05205 Proteoglycans in cancer
    100351964
   05208 Chemical carcinogenesis - reactive oxygen species
    100351964
  09162 Cancer: specific types
   05210 Colorectal cancer
    100351964
   05212 Pancreatic cancer
    100351964
   05225 Hepatocellular carcinoma
    100351964
   05226 Gastric cancer
    100351964
   05214 Glioma
    100351964
   05216 Thyroid cancer
    100351964
   05221 Acute myeloid leukemia
    100351964
   05220 Chronic myeloid leukemia
    100351964
   05218 Melanoma
    100351964
   05211 Renal cell carcinoma
    100351964
   05219 Bladder cancer
    100351964
   05215 Prostate cancer
    100351964
   05213 Endometrial cancer
    100351964
   05224 Breast cancer
    100351964
   05223 Non-small cell lung cancer
    100351964
  09172 Infectious disease: viral
   05161 Hepatitis B
    100351964
   05160 Hepatitis C
    100351964
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100351964
   05022 Pathways of neurodegeneration - multiple diseases
    100351964
  09165 Substance dependence
   05034 Alcoholism
    100351964
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100351964
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100351964
   01522 Endocrine resistance
    100351964
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocu01001]
    100351964
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100351964
Protein kinases [BR:ocu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100351964
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 100351964
NCBI-ProteinID: XP_017194278
Ensembl: ENSOCUG00000005487
UniProt: A0A5F9CFV9
LinkDB
Position
Unknown
AA seq 755 aa
MIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVS
SSASTDTVTSSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPAR
CGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPL
TTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVS
KFFEHHPVPQEEASLAETALTSGSSPSAPPSDSIGHQILTSPSPSKSIPIPQSFRPADED
HRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSP
LLPSVPSDIVFDFEPGPVFRGSTTGLSATPPASLPGSLTSVKAVQRSPGPQRERKSSSSS
EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK
LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQ
LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRG
YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPS
LNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2268 nt   +upstreamnt  +downstreamnt
atgattaagttgacacaggagcatatagaggccctattggacaaatttggtggggagcat
aatccaccatcaatatatctggaggcctacgaagaatacaccagcaagctagatgccctc
caacaaagagaacagcagttattggaatccctggggaatggaactgatttttctgtttct
agctctgcgtcaacggacaccgttacgtcttcttcctcttctagcctttcagtgctacct
tcatctctttcagtttttcaaaatcccacagatgtgtcacggagcaaccccaagtcacca
caaaaacctattgttagagtcttcctgcccaacaaacagaggacagtggtacctgcaaga
tgtggagttacggttcgagacagtctaaagaaagcgctgatgatgagaggtctgatccca
gaatgctgtgctgtttacagaattcaggatggagagaagaagccaattggctgggacact
gatatttcctggctcactggagaagagctgcatgtggaagtgttagagaatgtcccactc
accacacataactttgtacggaaaacttttttcaccttagcattttgtgacttctgtaga
aagctgcttttccagggtttccgctgtcaaacatgtggctacaaatttcaccagcgttgt
agtacggaagttccactgatgtgtgttaattatgaccaacttgatttgctgtttgtctcc
aagttctttgaacaccacccagtaccacaggaggaggcctccttagcagagactgccctc
acatctgggtcatcgccttccgcacctccctcagactctattgggcaccaaattctcacc
agtccgtccccttcaaaatccattccgattccacagtccttccgaccagcagatgaagat
catcgaaatcagtttgggcaacgagaccggtcttcatcagcgcctaatgttcacattaac
acaatagaacctgtcaatattgatgacttgattagagaccaagggtttcgtggtgatgga
gcccctttgaaccagctgatgcgctgtcttcggaaataccaatcccggactcccagtccc
ctcctaccttctgtccccagtgacatagtgtttgattttgagcctggcccagtgttcaga
ggatcgaccacgggtttgtctgccactccccctgcctcattacctggctcactcactagt
gtgaaagctgtacagagatccccaggacctcagcgagagaggaagtcgtcttcctcctca
gaagacaggaatcgaatgaaaactcttggtagacgggattcaagtgatgattgggagatt
cctgatgggcagatcaccgtgggacagagaattggatctggatcatttggaaccgtctac
aagggaaaatggcacggtgatgtggcagtaaaaatgttgaatgtgacagcacctacacct
cagcagttacaggccttcaaaaatgaagtaggagtactcaggaaaacacgacatgtgaat
atcctacttttcatgggctattccacaaagccacagctggctattgttacccagtggtgt
gagggctccagtttatatcaccatctccacatcattgagaccaaattcgagatgatcaaa
cttatagatattgcacggcagactgcacagggcatggattacttacacgccaagtcaatc
atccacagagacctcaagagtaataatatatttcttcatgaagacctcacagtaaaaata
ggtgattttggtctagccacagtgaaatctcgatggagtgggtcccatcagtttgaacaa
ttgtctggatccattttgtggatggcaccagaagtaatcagaatgcaagacaaaaaccca
tatagctttcagtcagatgtatatgcatttgggattgttctgtatgaattgatgactggg
cagttaccttactcaaacatcaacaacagggaccagatcatttttatggtgggacgtggc
tacctgtctccagacctcagtaaggtacggagtaactgtccgaaagccatgaagagatta
atggcagagtgcctcaaaaagaaaagagatgagagaccactctttccccaaattctcgcc
tccattgagctgctggcccgctcattgccaaaaatccaccgcagtgcatcagaaccctcc
ttgaatcgggctggtttccagacagaggattttagtctatatgcttgtgcttctccaaaa
acacccatccaggcagggggatatggagaatttgcagccttcaagtag

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