Oryctolagus cuniculus (rabbit): 100352594 Help Entry 100352594         CDS       T03373                                  Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu01521   EGFR tyrosine kinase inhibitor resistance ocu04151   PI3K-Akt signaling pathway ocu04217   Necroptosis ocu04380   Osteoclast differentiation ocu04550   Signaling pathways regulating pluripotency of stem cells ocu04620   Toll-like receptor signaling pathway ocu04621   NOD-like receptor signaling pathway ocu04630   JAK-STAT signaling pathway ocu04658   Th1 and Th2 cell differentiation ocu04659   Th17 cell differentiation ocu05140   Leishmaniasis ocu05145   Toxoplasmosis ocu05152   Tuberculosis ocu05160   Hepatitis C ocu05161   Hepatitis B ocu05162   Measles ocu05163   Human cytomegalovirus infection ocu05164   Influenza A ocu05165   Human papillomavirus infection ocu05166   Human T-cell leukemia virus 1 infection ocu05167   Kaposi sarcoma-associated herpesvirus infection ocu05168   Herpes simplex virus 1 infection ocu05169   Epstein-Barr virus infection ocu05171   Coronavirus disease - COVID-19 ocu05200   Pathways in cancer ocu05203   Viral carcinogenesis ocu05212   Pancreatic cancer ocu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     100352594    04151 PI3K-Akt signaling pathway     100352594  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100352594  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     100352594    04658 Th1 and Th2 cell differentiation     100352594    04659 Th17 cell differentiation     100352594   09158 Development and regeneration    04380 Osteoclast differentiation     100352594  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100352594    05203 Viral carcinogenesis     100352594    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100352594   09162 Cancer: specific types    05212 Pancreatic cancer     100352594   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100352594    05161 Hepatitis B     100352594    05160 Hepatitis C     100352594    05171 Coronavirus disease - COVID-19     100352594    05164 Influenza A     100352594    05162 Measles     100352594    05163 Human cytomegalovirus infection     100352594    05167 Kaposi sarcoma-associated herpesvirus infection     100352594    05169 Epstein-Barr virus infection     100352594    05165 Human papillomavirus infection     100352594   09171 Infectious disease: bacterial    05152 Tuberculosis     100352594   09174 Infectious disease: parasitic    05145 Toxoplasmosis     100352594    05140 Leishmaniasis     100352594   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100352594  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ocu01001]     100352594 Enzymes [BR:ocu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      100352594 Protein kinases [BR:ocu01001]  Non-receptor tyrosine kinases   JAK family [OT]    100352594 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  100352594 NCBI-ProteinID:  XP_008263345 Ensembl:  ENSOCUG00000006227 UniProt:  G1SQL4 LinkDB All DBs Position 13:101582720..101723625 Genome browser AA seq 1151 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVDLEAPEPGVEVVFYLSDREPLRLGSGEYTAEEV CIRAAQECRISPLCHNLFALYDESTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DSEQSVWRHSPKKQKNGYEKKKVPDATPLLDANSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMRKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHSSDSGIVLYYEVMVTGNLGIQWRQKPNVVPVEKEKSKLKRKKLENKLRKDEERNKTR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGNEEGMYVLRWSCTDFDNILMTVT CFEKSERQFKNFQIEVRKGCYSLHGSDRSFPSLGELMSHLKKQILRTDNISFVLKRCCQP KPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHLGRGTRTHIYAGTLVDHK DDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMV EEFVEGGPLDLFMHRKSDLLTTPWKFKVAKQLASALSYLEDKDMVHGNVCTKNLLLAREG IDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI CYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDIN KLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVA VKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKE YLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTK AIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSEYSPMA LFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDQVYQLMRKCWEFQPSNRTTFQNLI EGFEAILKKHE NT seq 3456 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagaccgaggtggatctggaggcccctgagcctggggtggaagtggtcttc tatctgtcggacagggaacccctccggctgggcagtggagagtacacggcggaggaggtg tgcatcagggccgcacaggaatgccgtatctctcctctgtgtcacaacctctttgccttg tatgatgagagcaccaagctctggtatgctccgaatcgcaccatcactgttgatgacaag acgtccctccggctgcactaccggatgaggttctatttcaccaactggcatgggaccaat gacagcgagcagtctgtgtggcgacattctccaaagaagcagaaaaatggctatgagaaa aagaaggttccagatgcaacccctctccttgacgccaactccctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcctattcgagaccccaagacggaacag gatgggcatgacatcgagaatgagtgtctagggatggccgtcctggccatctcacactat gccatgatgaggaaaatgcaattgcctgaactccccaaggacatcagctataagcgatat atcccagaaacgttgaataagtccatcagacagaggaaccttctcaccaggatgcggatt aataatgttttcaaggatttcctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtcaacacatgacctgaaagtgaaataccttgctactttggagactttgacaaaacat tatggtgctgaaatatttgagacttccatgttactgatctcatcagaaaatgagatgaat tggtttcattccagtgacagtggaattgttctctactatgaagtgatggtgactggaaat cttggaatccagtggaggcagaaaccaaatgttgtgcctgttgaaaaagaaaaaagtaaa ctgaagcggaagaaactggaaaataaactcaggaaagatgaggagagaaacaaaacgcga gaagagtggaacaatttttcctacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcattaacaagcaggataacaaaaaaatggaactgaagctctcttcccatgag gaggccttgtccttcgtgtccctggtggatggctacttccggctcacagcagacgcccat cattacctctgcactgacgtggctccaccactgatcgtccacaacatacagaatggctgt catggtccaatctgcacagagtatgccatcaataaactgcggcaagaagggaatgaggag gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgactgtcacc tgctttgagaagtctgagagacagttcaagaactttcagatcgaggtgcggaagggctgc tacagcctgcacggctcagaccgcagcttccccagcctgggagaactcatgagccacctc aagaagcagatcctgcgcacagacaacatcagcttcgtgctgaaacgctgctgccagccc aagcccagagagatctctaacctgctggtggctactaagaaagcccaggagtggcagcct gtctatcccatgagccagctgagttttgaccggatcctcaagaaagatatcatgcagggc gagcacctggggagaggcaccagaacccacatctacgccgggaccctggtagatcacaag gatgacgaagggacttcagaagagaagagaataaaagtgatcctcaaagtcttagacccc agccacagggacatctctctggccttctttgaggcagccagcatgatgagacaggtctcc cacaagcacatcgtgtacctctatggtgtctgtgtccgcgacgtggagaatatcatggtg gaagagtttgtggaaggagggcccctcgatctcttcatgcaccggaaaagcgacctgctc acgacgccgtggaagttcaaagttgccaagcagctggccagcgccctgagttacctggag gacaaggacatggtccacgggaatgtgtgcaccaagaacctactgctagcgcgcgagggc atcgacagcgagtgcgggccgttcatcaagctcagcgaccccggcatccccatcaccgtg ctgtcccggcaggagtgcatagaacgcatcccgtggattgctcccgagtgtgtggaagac tccaagaacctgagcgtggctgctgacaagtggagcttcggaaccacgctctgggagatc tgctacaatggcgagatccccctcaaagacaagacactcatcgagaaagagagattctac gagagccgctgccggccagtgaccccgtcctgtaaggagctggcggaccttatgacccgc tgcatgaactacgaccccaaccagagacccttcttccgcgccatcatgagagacatcaac aagctggaagagcagaatccagacatcgtgtcggagaggaagccagccactgaggtggac cccacgcattttgaaaagcgcttcctcaagaggatccgggacttgggcgagggccacttt gggaaggttgagctctgcaggtatgaccccgagggggacaacacgggggagcaggtggct gtgaagtccctaaagccagagagcggcggtaaccacatagctgacctcaagaaggaaata gaaatcttgcggaacctctatcacgagaacatcgtgaagtacaaagggatctgcaccgag gacggaggaaacggtattaagctcatcatggaatttctgccttcgggaagccttaaggag tatcttccaaagaataaaaacaaaattaatctcaagcaacagctaaaatatgccgtgcag atttgtaaggggatggactatttgggttctcggcagtacgtccaccgggacttagcagca agaaatgtccttgttgagagtgaacaccaagtgaaaattggagacttcggcttaaccaaa gcgatcgagacagacaaggagtactacaccgtcaaggacgaccgggacagccctgtgttt tggtatgccccagaatgtttaattcagtgtaaattctatattgcctccgacgtctggtcc tttggagtgactctgcacgagctactcacttactgtgattcagaatatagtcccatggcc ttgttcctgaaaatgataggcccaactcatggccagatgacagtaacaagacttgtgaat acactgaaggaaggaaaacgtttgccgtgtccacccaactgtccagatcaggtttatcaa cttatgaggaaatgctgggaattccaaccttccaatcggacaacctttcagaaccttatt gaaggattcgaagcaattttaaaaaagcatgaataa

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