Oryctolagus cuniculus (rabbit): 100356164
Help
Entry
100356164 CDS
T03373
Name
(RefSeq) serine/threonine-protein kinase mTOR
KO
K07203
serine/threonine-protein kinase mTOR [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04012
ErbB signaling pathway
ocu04066
HIF-1 signaling pathway
ocu04072
Phospholipase D signaling pathway
ocu04136
Autophagy - other
ocu04140
Autophagy - animal
ocu04150
mTOR signaling pathway
ocu04151
PI3K-Akt signaling pathway
ocu04152
AMPK signaling pathway
ocu04211
Longevity regulating pathway
ocu04213
Longevity regulating pathway - multiple species
ocu04218
Cellular senescence
ocu04371
Apelin signaling pathway
ocu04613
Neutrophil extracellular trap formation
ocu04630
JAK-STAT signaling pathway
ocu04659
Th17 cell differentiation
ocu04714
Thermogenesis
ocu04910
Insulin signaling pathway
ocu04919
Thyroid hormone signaling pathway
ocu04920
Adipocytokine signaling pathway
ocu04930
Type II diabetes mellitus
ocu04931
Insulin resistance
ocu04935
Growth hormone synthesis, secretion and action
ocu05010
Alzheimer disease
ocu05014
Amyotrophic lateral sclerosis
ocu05016
Huntington disease
ocu05017
Spinocerebellar ataxia
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05163
Human cytomegalovirus infection
ocu05165
Human papillomavirus infection
ocu05167
Kaposi sarcoma-associated herpesvirus infection
ocu05168
Herpes simplex virus 1 infection
ocu05170
Human immunodeficiency virus 1 infection
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05206
MicroRNAs in cancer
ocu05207
Chemical carcinogenesis - receptor activation
ocu05210
Colorectal cancer
ocu05212
Pancreatic cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05221
Acute myeloid leukemia
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
ocu05230
Central carbon metabolism in cancer
ocu05231
Choline metabolism in cancer
ocu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
100356164
04066 HIF-1 signaling pathway
100356164
04072 Phospholipase D signaling pathway
100356164
04151 PI3K-Akt signaling pathway
100356164
04152 AMPK signaling pathway
100356164
04150 mTOR signaling pathway
100356164
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100356164
04136 Autophagy - other
100356164
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100356164
04659 Th17 cell differentiation
100356164
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
100356164
04919 Thyroid hormone signaling pathway
100356164
09149 Aging
04211 Longevity regulating pathway
100356164
04213 Longevity regulating pathway - multiple species
100356164
09159 Environmental adaptation
04714 Thermogenesis
100356164
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100356164
05206 MicroRNAs in cancer
100356164
05205 Proteoglycans in cancer
100356164
05207 Chemical carcinogenesis - receptor activation
100356164
05230 Central carbon metabolism in cancer
100356164
05231 Choline metabolism in cancer
100356164
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100356164
09162 Cancer: specific types
05210 Colorectal cancer
100356164
05212 Pancreatic cancer
100356164
05225 Hepatocellular carcinoma
100356164
05226 Gastric cancer
100356164
05214 Glioma
100356164
05221 Acute myeloid leukemia
100356164
05215 Prostate cancer
100356164
05224 Breast cancer
100356164
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100356164
05163 Human cytomegalovirus infection
100356164
05167 Kaposi sarcoma-associated herpesvirus infection
100356164
05165 Human papillomavirus infection
100356164
09164 Neurodegenerative disease
05010 Alzheimer disease
100356164
05014 Amyotrophic lateral sclerosis
100356164
05016 Huntington disease
100356164
05017 Spinocerebellar ataxia
100356164
05022 Pathways of neurodegeneration - multiple diseases
100356164
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
100356164
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
100356164
04931 Insulin resistance
100356164
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100356164
01522 Endocrine resistance
100356164
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100356164
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ocu04131
]
100356164
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100356164
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: Other
PIKK family [OT]
100356164
Membrane trafficking [BR:
ocu04131
]
Autophagy
Other autophagy associated proteins
mTORC1 complex
100356164
mTORC2 complex
100356164
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
FAT
PI3_PI4_kinase
mTOR_dom
FRB_dom
FATC
TOR1L1_N
HEAT_ATR
HEAT_EZ
HEAT_2
UME
HEAT_ECM29
EPSP_synthase
DUF7418
Motif
Other DBs
NCBI-GeneID:
100356164
NCBI-ProteinID:
XP_002723399
Ensembl:
ENSOCUG00000013053
UniProt:
G1T4N5
LinkDB
All DBs
Position
Unknown
AA seq
2547 aa
AA seq
DB search
MLGTGPAAAAAAAATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDASERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAVQVDA
TVFTCVSMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLNTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTPIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLASRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPDLRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLA
RHRISHQRYDVLICRILKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVNPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSSRKIDAFQHMQHFVQSMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYCSAATEHDRGWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHGSGANITTAATATAATATTTASTEGSNSESEAESAENSPTP
SPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEA
LVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKS
TTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGER
NVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWD
LYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQV
ITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSI
QRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQ
KVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPS
NLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHT
VMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVE
LGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVP
TQVELLIKQATSHENLCQCYIGWCPFW
NT seq
7644 nt
NT seq
+upstream
nt +downstream
nt
atgctggggaccgggcccgccgccgccgccgccgccgccgccacctcaagcaacgtgagc
gtcttgcagcagtttgccagtggcctgaagagccggaatgaggagaccagggccaaggct
gccaaggagctccagcactacgtcaccatggagctccgcgagatgagtcaggaagaatcg
acacgattctacgatcagctgaaccatcacatatttgaactggtttccagctccgatgcc
agtgagaggaaagggggcatcttggccatagccagcctcatcggcgtggaaggtgggaat
gccacccggatcggcaggtttgccaactatcttcggaatctcctcccctccaatgacccg
gttgtcatggagatggcatccaaggccattggccgccttgccatggcaggggacactttc
actgccgagtacgtggagttcgaggtgaagcgagccctggaatggctgggtgctgaccgc
aacgagggccggagacacgccgccgtcctggttctccgtgaactggccatcagcgtcccc
accttcttcttccagcaagtgcagcccttcttcgacaacatttttgtggccgtgtgggac
cccaaacaggccatccgtgagggagccgtggccgccctccgtgcctgtctcatcctcacc
actcagcgagagccgaaggagatgcagaagccgcagtggtaccggcacacgttcgaagag
gcagagaaggggtttgatgagaccttggccaaggagaaggggatgaatcgggatgaccgg
atccacggagccttgctgatcctcaacgagctggttcggatcagcagcatggagggcgag
cggctgagagaagagatggaagaaatcacccagcagcagctggtgcacgacaagtactgc
aaagatctcatgggcttcggaacaaaacctcggcacatcacgcccttcaccagtttccag
gctgtgcagccccagcagtcgaacgccttggtggggctgctgggctacagctctcaccaa
ggcctcatgggattcggggcctcccccagcccagctaagtccaccctggtcgagagccgg
tgttgccgagacttgatggaggaaaaattcgatcaggtgtgccagtgggtgctgaagtgc
aggaacagcaagaactcgctgatccaaatgacgatccttaatctgttgccccgcctggct
gcattcagaccttctgcctttacagacactcagtacctccaggacaccatgaaccacgtc
ctaagctgtgtcaagaaggagaaggaacggacagcagctttccaagctctggggctgctt
tctgtggctgtgaggtcagagttcaaggtctacttgcctcgtgtgctggacatcatccgg
gcggccctgccccctaaggactttgcccacaagaggcagaaggcagtgcaggtggacgcc
acggtgttcacgtgtgtcagcatgctggcgcgcgcaatggggccaggcatccagcaggac
atcaaggagctgctggagcccatgctggctgtgggactgagcccggcgctcactgctgtg
ctctacgacctgagccgccagatcccgcagctgaagaaggacatccaggacgggctcctg
aagatgctgtccctggtccttatgcacaaacctctccgacacccaggcatgcccaagggc
ctggcccaccagctggcctcccccgggctcaacaccctgcccgaggccagcgatgtgggc
agcatcactctcgccctccggacccttggtagcttcgaatttgaaggccactctctgacc
cagtttgttcgccactgtgcggatcatttcctgaacagtgagcacaaggagatccgcatg
gaagctgcccgcacctgctcgcgtctgctcaccccctccatccacctcatcagcggccac
gcacacgtggttagccagacggcagtgcaggtggtggcagacgtgctcagcaagctgctc
gtggtcgggataacagatcctgaccctgacatccgctactgtgtcttggcatccctggat
gagcgcttcgacgctcacctggcccaggcagagaatttgcaggcgctgtttgtggccctg
aatgaccaggtgttcgagatccgggagctggccatctgcactgtgggccggctcagcagc
atgaacccggcctttgtcatgcctttcctgcgcaagatgctcatccagatcctgacagag
ctggagcacagcggcattgggagaatcaaggagcagagtgcccgcatgctgggacacctg
gtttcgaacgccccccgactcatccgcccctacatggagcctattctgaaggctttaatt
ttgaaattgaaagacccagatcctgatccaaacccaggtgtgatcaataatgtcttggcc
acaataggagaactggctcaagttagtggcctggaaatgaggaagtgggttgacgagctt
ttcatcatcatcatggacatgctccaggactcctccctgttggccaagaggcaggtggct
ctgtggaccctgggacagttggtggccagcactggctatgtcgtggagccctataggaag
taccccactttgcttgaggtgctgctgaatttcctgaagactgagcagaatcagggtaca
cggagagaggccatccgtgtgttggggctgttgggggctctggacccctacaagcacaag
gtgaacatcggcatgattgaccagtcccgggacgcatctgccgtcagcctgtcagagtcc
aagtccagccaggattcctctgactacagcaccagtgaaatgctggtcaacatgggaaac
ctgcctctggacgagttctaccctgctgtgtccatggtggccctgatgcggatcttccga
gaccagtctctgtctcatcatcacaccatggttgtccaggccatcaccttcatcttcaag
tccctggggctcaagtgtgtgcagttcctgccccaggtcatgcccacattcctgaatgtc
attcgagtctgtgacggggccatccgggaatttctgttccagcagctgggaatgctggtg
tcctttgtgaagagccacatcagaccgtacatggatgaaatcgtcaccctcatgagagaa
ttctgggtcatgaacaccccgatccagagcaccatcattctgcttattgagcaaattgtg
gttgctcttgggggtgaattcaagctctacctgccccagctcatcccgcacatgctgcgt
gtcttcatgcatgacaacagccaaggccgcatcgtctccatcaagctgttggctgcgatc
cagttgttcggggccaatctagacgattacctgcatctgctgctgcctcctatagtgaag
ctgtttgatgctccggaagtcccactggcctctcggaaggcagccttggagacggtggac
cgcctgacagagtccctggacttcaccgactatgcctcccgcatcatccacccgattgtc
cgaacgctggaccagagccccgatctgcgttccacagccatggacacgttgtcctcactt
gtcttccagctggggaagaagtaccagattttcattccaatggtgaataaggtcctggcg
cggcaccggatcagccatcagcgctacgatgtgctcatctgcagaatcctcaaggggtac
acccttgctgatgaagaggaggaccccttgatttatcaacatcgaatgttgaggagtggc
caaggggatgcattggccagtggaccagtagaaacaggacccatgaagaagctgcatgtc
agcaccatcaacctgcaaaaggcctggggagccgccaggagggtctccaaagacgactgg
ctggagtggctgcggcggctgagcctggagctgctgaaggactcctcgtccccctccctg
cgctcgtgctgggccctggcgcaggcctacaacccgatggccagggacctcttcaatgct
gcttttgtgtcctgctggtcagaactgaatgaagaccagcaggacgaactcatcagaagc
atcgagctggcccttacctcacaggacatcgctgaagtcacacagacactcttgaacttg
gctgagttcatggagcatagtgataagggccccctgccactgagagatgacaatgggatt
gttctgctgggcgagagagctgccaagtgccgagcgtatgccaaagccctgcactacaag
gagctggagttccagaagggccccacccccgccattttggagtctctcatcagcatcaat
aataagcttcagcagccggaggcagctgccggggtgctggagtatgccatgaaacacttc
ggagagctggagatccaggccacgtggtatgagaagctgcacgagtgggaggacgccctc
gtggcctatgacaagaaaatggacaccaacaaggatgaccctgagctgatgctgggccgc
atgcgctgtctggaggccctgggggaatggggacagctccaccagcagtgctgtgaaaag
tggaccttggtgaatgatgaaacccaagccaagatggcccggatggctgctgcagctgca
tggggcctaggccagtgggacagcatggaagagtacacctgcatgatccctcgggacacg
cacgatggggcgttctacagagctgtgctggcgctgcatcaggacctcttctcgttggcc
caacagtgtatcgacaaggccagggacctgctggatgcagagctcaccgccatggcagga
gagagctacagccgggcgtacggggccatggtttcttgccacatgctctctgagctggag
gaggttatccagtacaaacttgttcctgagcggcgcgagatcatccgtcagatctggtgg
gagcgactgcagggctgccagcgtattgtagaggactggcagaaaatcctcatggtgcga
tcccttgtggtcaaccctcatgaggacatgagaacatggctcaagtacgcaagcctgtgt
ggcaagagcggccggctggcgcttgcccataaaaccttagtgttgcttctgggagtcgat
ccatctcgccaacttgaccaccctctgccaacagttcaccctcaggtgacctacgcctac
atgaagaacatgtggaagagctctcgtaagatcgatgccttccagcacatgcagcacttt
gtgcagagcatgcagcagcaggcccagcacgccatcgccaccgaggaccagcagcacaag
caggagctgcacaagctgatggcccgctgtttcctgaagcttggggagtggcagctgaac
ctgcagggcatcaacgagagcaccatccccaaggtgctgcagtactgcagcgccgccacc
gagcacgaccgcggctggtacaaggcctggcacgcgtgggcggtgatgaactttgaagct
gtgctgcactacaagcatcagaaccaagcccgtgacgagaagaagaagctgcgccacggc
agcggggccaacatcaccaccgccgccaccgccaccgccgccaccgccaccactaccgcc
agcaccgagggcagcaacagcgagagcgaggccgagagcgccgagaacagccccaccccc
tcccccctgcagaagaaggtcactgaggatttgtccaaaaccctcttgatgtatactgtc
cctgcggtccagggcttcttccgttccatctccttgtcacgaggcaacaacctgcaggac
acgctcagagtcctcaccctgtggtttgattatggccactggccagatgtcaatgaagcc
ctagtggaaggggtgaaagcgatccagattgacacctggttgcaggtgatacctcagctc
attgcaaggattgatacacccagacccctggtgggacggctcattcaccagcttctcaca
gacatcggtcggtaccacccccaggccctcatctacccgctgaccgtggcgtctaagtcc
accacgacggcccgtcacaatgcggccaacaagatcctcaagaacatgtgtgagcacagc
aacaccctggtccagcaagccatgatggtgagtgaggagctgatccgcgtggccatcctc
tggcatgagatgtggcacgagggcctggaagaggcttctcgtttgtactttggggagagg
aacgtgaagggcatgttcgaggtgctggagcccctgcacgccatgatggagcggggcccc
cagaccctgaaggagacgtccttcaatcaggcgtatggccgagacctgatggaggcccag
gagtggtgccgcaagtacatgaagtcggggaacgtcaaggacctcacccaggcctgggac
ctctactaccacgtgttcaggcggatctcgaagcagctgccccagctcacatccttagag
ctacagtatgtctccccaaaacttctgatgtgccgggaccttgaattggctgtgccagga
acgtatgaccccaaccagccaatcattcgcattcagtccatagccccgtctttgcaagtc
atcacgtctaagcagaggccccgaaagctgacactcatgggcagcaacgggcatgagttt
gttttcctcctcaaggggcacgaagacctgcggcaggacgagcgggtgatgcagctcttc
ggcctggttaacaccctcctggccaacgacccgacgtctcttcggaagaatctcagcatc
cagagatacgccgtcattcctctgtcgaccaactcgggcctcattggctgggtcccgcac
tgtgacacgctgcacgccctcatccgggactacagggagaaaaagaagatccttctcaac
attgagcatcgcatcatgttgcggatggctccagactacgaccacttgactctgatgcag
aaggtggaggtgtttgagcacgccgtcaataacacagccggagacgacctggccaagctg
ctgtggctgaagagccccagctcagaggtgtggtttgaccgaagaaccaattacacccgc
tcgttagctgtcatgtcaatggtggggtatattttgggcctgggagatagacacccgtcc
aatctgatgctagaccggctgagtgggaagatcctgcacattgactttggagactgcttt
gaggttgctatgaccagagagaagttcccagagaagattccatttagactaacgagaatg
ttgaccaatgctatggaggtgactggtctggatggcaactacagaatcacctgccacacc
gtgatggaggtgctgcgggaacacaaggacagtgtcatggccgtgctggaggccttcgtc
tacgaccccttgctgaactggaggctgatggacacaaataccaaaggcaacaagcgatcc
cggacgcgaacagattcctactctgcgggccagtcagtagaaattttggacggtgtagaa
cttggagaaccagcccataagaaaacggggaccacagtgccagaatccattcattctttc
attggagacgggttggtgaaaccagaagccctaaataagaaagccattcagatcattaac
agggtccgcgataagctcactggtcgggacttctcgcacgatgacactctggacgtccca
acacaagtggaactgctcatcaagcaagccacgtcccatgagaacctctgccagtgctac
atcggctggtgtcctttctggtaa
DBGET
integrated database retrieval system
