KEGG   Oryctolagus cuniculus (rabbit): 100358134
Entry
100358134         CDS       T03373                                 
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu04062  Chemokine signaling pathway
ocu04081  Hormone signaling
ocu04148  Efferocytosis
ocu04151  PI3K-Akt signaling pathway
ocu04217  Necroptosis
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04630  JAK-STAT signaling pathway
ocu04658  Th1 and Th2 cell differentiation
ocu04659  Th17 cell differentiation
ocu04725  Cholinergic synapse
ocu04917  Prolactin signaling pathway
ocu04920  Adipocytokine signaling pathway
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu05140  Leishmaniasis
ocu05145  Toxoplasmosis
ocu05152  Tuberculosis
ocu05161  Hepatitis B
ocu05164  Influenza A
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05200  Pathways in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100358134
   04151 PI3K-Akt signaling pathway
    100358134
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100358134
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    100358134
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100358134
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    100358134
   04659 Th17 cell differentiation
    100358134
   04062 Chemokine signaling pathway
    100358134
  09152 Endocrine system
   04917 Prolactin signaling pathway
    100358134
   04935 Growth hormone synthesis, secretion and action
    100358134
  09156 Nervous system
   04725 Cholinergic synapse
    100358134
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100358134
   05207 Chemical carcinogenesis - receptor activation
    100358134
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100358134
  09172 Infectious disease: viral
   05161 Hepatitis B
    100358134
   05164 Influenza A
    100358134
   05167 Kaposi sarcoma-associated herpesvirus infection
    100358134
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100358134
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100358134
   05140 Leishmaniasis
    100358134
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100358134
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100358134
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100358134
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocu01001]
    100358134
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100358134
Protein kinases [BR:ocu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100358134
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 Kdo FERM_C_FAK1 RIO1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 100358134
NCBI-ProteinID: XP_051701988
Ensembl: ENSOCUG00000016853
LinkDB
Position
1:complement(63155097..63288435)
AA seq 1132 aa
MGMACLTMTEMEETSTTPMHQNGDIPGNPNSVKQIDPVLQVYLYHSLGKAEGDYLIFPTG
EYVAEEICVAASKACGITPVYHNMFALMSETERNWYPPNHVFHIDESTSHNVLYRIRFYF
PHWYCNGSNRTYRHGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKDQTPLAIYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVSIKQANQEGANESRVVTIHKQDGKNLEIELSSLK
EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPLSPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKTLIHGNVCAKNILLIREEDRKTRNSPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLTTDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTFQI
CKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNHRPSFRDLALRVDQIRDNMTE
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgtctcacaatgacagaaatggaagaaacatctacaactcctatgcat
cagaatggtgatattcctggaaatcctaattctgtgaaacagatagatccagtccttcag
gtgtatctttaccattcactcgggaaagctgagggagattatctcatcttcccaacgggg
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcttgtggtattacacctgta
tatcataatatgtttgctttaatgagtgaaacagaaagaaactggtatccacccaaccat
gtcttccatatagatgagtcaaccagtcataatgtcctctacagaataagattttacttt
cctcactggtattgtaatggtagcaacagaacttatcgacacggagtatctcgaggtgct
gaagcacctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttgtgcatggttggatcaaagtacctgtgactcacgaaactcaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaaggatcaaactccactggccatc
tataactctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagat
tatcatattttgacaaggaagcgaataaggtatagatttcgcagatttatccagcagttc
agccagtgtaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgatttt
cctgatattattgatgtcagtattaagcaagcaaaccaagaaggtgcaaatgaaagcaga
gttgtaactattcataagcaagatggtaaaaatttggaaattgaacttagctcattaaag
gaagctttgtcttttgtgtcgttaattgatggatattatagattaactgcagatgcacat
cattacctctgtaaagaagtagctcctccaacagtgcttgaaaatatacaaagcaactgt
catggcccgatttcaatggattttgccatcagtaagctgaagaaagcaggtaatcagact
ggactatatgtacttcgatgcagtcctaaggactttaataaatattttctgaccttcgct
gttgagagagaaaatgtcattgaatataaacactgtttgattaccaaaaatgagaatgga
gagtataacctcagtgggactaagaagaacttcagtaatcttaaagatcttctgaattgc
taccagatggaaactgttcgctcagacagtataattttccagtttactaagtgctgcccc
ccaaagccaaaggataagtcaaatcttctagtcttcagaaccaatggtgtttctgatgta
ccgctctcaccaactttacagaggcataataatgtcaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatattcaatgaaagtcttggccaaggtacttttacaaaaattttt
aaaggtataagaagagaagtaggagactatggtcaactacatgaaacagaagttctttta
aaagtcctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcataaacatttggttttaaattatggagtatgtgtgtgtggagag
gagaatattctggttcaggagtttgtaaaatttggatcactagatacatatttaaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaaacccttattcatgggaatgtgtgtgccaaaaatattcta
cttatcagagaagaagacaggaagacgagaaactcccctttcatcaaacttagtgatcct
ggcattagtattactgttttgccgaaggatattctgcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaatttaacaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctttgagtgctctggattctcaa
cgaaaactacaattttatgaagatagacaccagcttcctgcaccaaagtggacagaatta
gcaaaccttataaataattgtatggattacgaaccagattttaggccttctttcagagcc
atcatacgagatcttaacagtttgtttactccagattatgaactattaacggaaaatgac
atgttaccaaatatgaggataggtgccctagggttttctggtgcttttgaagatagggac
cctacacagtttgaagaaagacatttgaaatttctgcaacaacttggcaagggtaatttt
ggaagtgtggagatgtgccggtatgaccctctgcaggacaacactggagaggtggtggct
gtgaaaaagctccagcacagtactgaagagcacctcagagactttgaaagggaaattgaa
atcctaaaatccttacaacatgacaacattgtaaagtacaaaggagtgtgctacagtgct
ggccggcgtaatctaagattgattatggaatatttaccatatggaagtttacgggactat
ctccagaaacataaagaaaggatagatcacaaaaaacttctgcagtacacatttcaaata
tgcaagggtatggaatatcttggtacaaaaaggtatgtccacagggatctggcaacaaga
aatatattggtagagaatgagaacagagttaaaataggagattttgggttaaccaaagta
ttaccacaagacaaagaatattacaaagtgaaagaacctggtgaaagtcccatcttctgg
tatgctccagaatcactgacagagagtaagttttctgttgcttcagatgtttggagcttt
ggagtggttctgtacgaacttttcacgtatattgaaaagagtaaaagtccaccagcggaa
tttatgcgcatgattggcaatgacaaacaaggacagatgattgtgttccatttaatagaa
ctcttgaagaataatgggagattaccaagaccagatggatgtccagatgagatttatatg
attatgacagaatgctggaacaataacgtaaatcatcgtccatcttttagggacctagct
cttcgagtggatcaaataagggacaacatgactgaatga

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