KEGG   Oryctolagus cuniculus (rabbit): 127486116
Entry
127486116         CDS       T03373                                 
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04010  MAPK signaling pathway
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04370  VEGF signaling pathway
ocu04371  Apelin signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04728  Dopaminergic synapse
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04920  Adipocytokine signaling pathway
ocu04922  Glucagon signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04936  Alcoholic liver disease
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05132  Salmonella infection
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05145  Toxoplasmosis
ocu05152  Tuberculosis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05200  Pathways in cancer
ocu05205  Proteoglycans in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    127486116
   04012 ErbB signaling pathway
    127486116
   04014 Ras signaling pathway
    127486116
   04015 Rap1 signaling pathway
    127486116
   04370 VEGF signaling pathway
    127486116
   04371 Apelin signaling pathway
    127486116
   04630 JAK-STAT signaling pathway
    127486116
   04668 TNF signaling pathway
    127486116
   04066 HIF-1 signaling pathway
    127486116
   04068 FoxO signaling pathway
    127486116
   04072 Phospholipase D signaling pathway
    127486116
   04071 Sphingolipid signaling pathway
    127486116
   04024 cAMP signaling pathway
    127486116
   04022 cGMP-PKG signaling pathway
    127486116
   04151 PI3K-Akt signaling pathway
    127486116
   04152 AMPK signaling pathway
    127486116
   04150 mTOR signaling pathway
    127486116
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127486116
  09143 Cell growth and death
   04210 Apoptosis
    127486116
   04218 Cellular senescence
    127486116
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127486116
   04550 Signaling pathways regulating pluripotency of stem cells
    127486116
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127486116
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    127486116
   04613 Neutrophil extracellular trap formation
    127486116
   04620 Toll-like receptor signaling pathway
    127486116
   04625 C-type lectin receptor signaling pathway
    127486116
   04660 T cell receptor signaling pathway
    127486116
   04662 B cell receptor signaling pathway
    127486116
   04664 Fc epsilon RI signaling pathway
    127486116
   04666 Fc gamma R-mediated phagocytosis
    127486116
   04062 Chemokine signaling pathway
    127486116
  09152 Endocrine system
   04910 Insulin signaling pathway
    127486116
   04922 Glucagon signaling pathway
    127486116
   04923 Regulation of lipolysis in adipocytes
    127486116
   04920 Adipocytokine signaling pathway
    127486116
   04929 GnRH secretion
    127486116
   04915 Estrogen signaling pathway
    127486116
   04914 Progesterone-mediated oocyte maturation
    127486116
   04917 Prolactin signaling pathway
    127486116
   04926 Relaxin signaling pathway
    127486116
   04935 Growth hormone synthesis, secretion and action
    127486116
   04919 Thyroid hormone signaling pathway
    127486116
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    127486116
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    127486116
  09156 Nervous system
   04725 Cholinergic synapse
    127486116
   04728 Dopaminergic synapse
    127486116
   04722 Neurotrophin signaling pathway
    127486116
  09158 Development and regeneration
   04380 Osteoclast differentiation
    127486116
  09149 Aging
   04211 Longevity regulating pathway
    127486116
   04213 Longevity regulating pathway - multiple species
    127486116
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127486116
   05205 Proteoglycans in cancer
    127486116
   05207 Chemical carcinogenesis - receptor activation
    127486116
   05208 Chemical carcinogenesis - reactive oxygen species
    127486116
   05230 Central carbon metabolism in cancer
    127486116
   05231 Choline metabolism in cancer
    127486116
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127486116
  09162 Cancer: specific types
   05210 Colorectal cancer
    127486116
   05212 Pancreatic cancer
    127486116
   05225 Hepatocellular carcinoma
    127486116
   05226 Gastric cancer
    127486116
   05214 Glioma
    127486116
   05221 Acute myeloid leukemia
    127486116
   05220 Chronic myeloid leukemia
    127486116
   05218 Melanoma
    127486116
   05211 Renal cell carcinoma
    127486116
   05215 Prostate cancer
    127486116
   05213 Endometrial cancer
    127486116
   05224 Breast cancer
    127486116
   05222 Small cell lung cancer
    127486116
   05223 Non-small cell lung cancer
    127486116
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127486116
   05170 Human immunodeficiency virus 1 infection
    127486116
   05161 Hepatitis B
    127486116
   05160 Hepatitis C
    127486116
   05164 Influenza A
    127486116
   05162 Measles
    127486116
   05168 Herpes simplex virus 1 infection
    127486116
   05163 Human cytomegalovirus infection
    127486116
   05167 Kaposi sarcoma-associated herpesvirus infection
    127486116
   05169 Epstein-Barr virus infection
    127486116
   05165 Human papillomavirus infection
    127486116
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127486116
   05135 Yersinia infection
    127486116
   05152 Tuberculosis
    127486116
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    127486116
   05142 Chagas disease
    127486116
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127486116
   05017 Spinocerebellar ataxia
    127486116
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127486116
   05418 Fluid shear stress and atherosclerosis
    127486116
   05415 Diabetic cardiomyopathy
    127486116
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    127486116
   04932 Non-alcoholic fatty liver disease
    127486116
   04931 Insulin resistance
    127486116
   04933 AGE-RAGE signaling pathway in diabetic complications
    127486116
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127486116
   01524 Platinum drug resistance
    127486116
   01522 Endocrine resistance
    127486116
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocu01001]
    127486116
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     127486116
Protein kinases [BR:ocu01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   127486116
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11
Other DBs
NCBI-GeneID: 127486116
NCBI-ProteinID: XP_051685791
LinkDB
Position
Unknown
AA seq 487 aa
MNAVSIVKEGWLHKRGEYIKTWRPRYFLLKTDGTFIGYKERPQDVEQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEDTMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEERARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIRITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKALLAGLLKKDPKQRLGGGSEDAKEIMRHRFFSGIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQVPCPCPADDSMECVDSERRPHFPQFS
YSASGTA
NT seq 1464 nt   +upstreamnt  +downstreamnt
atgaacgccgtgagcatcgtgaaggagggctggctgcacaagcgaggggagtacatcaag
acctggcggccacgctacttcctcctcaagactgatggcaccttcatcggctacaaggag
cggccacaggacgtggagcagcgcgagtccccactcaacaacttctctgtggcacaatgc
cagctgatgaagacggagcggccgcggcccaacaccttcatcatccgctgcctgcagtgg
accacggtcatcgagcgcaccttccacgtggagacccccgaggagcgggaggagtggacg
actgccatccagacggtggccgacgggctcaagaagcaggaggaggacacgatggacttc
cggtcagggtctcccagtgacaactcgggggccgaggagatggaggtgtccctggccaag
cccaagcatcgtgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcacc
tttgggaaggtgatcctggtgaaggagaaggccacgggccgctactacgccatgaagatc
ctgaagaaagaggtcatcgtggccaaggatgaggtggcgcacacgctcacggagaaccgc
gtgctgcagaactccaggcaccccttcctcacggccctcaagtactctttccagacgcat
gaccgcctctgctttgtcatggagtacgccaacgggggcgagctcttcttccacctgtcc
cgcgagcgcgtcttctccgaggagcgggcccgcttctacggcgccgagatcgtgtcggcg
ctggactacctgcactcggagaagaacgtggtgtaccgcgacctcaagctggagaacctc
atgctggacaaggacgggcacatcaggatcacggacttcgggctgtgcaaggagggcatc
aaggacggcgccaccatgaagaccttctgcgggacgcccgagtacctggcccctgaggtg
ctggaggacaacgactacggccgggcggtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggccgcctgcccttctacaaccaggaccacgagaagctgttcgagctc
atcctcatggaggagatccgcttcccgcgcacgctgggccccgaggccaaggccctgctc
gccgggctgctcaagaaggaccccaagcagcggctcggcgggggctccgaggacgccaag
gagatcatgcggcaccgcttcttctccggcatcgtgtggcaggacgtgtatgagaagaag
ctgagcccgcccttcaagcctcaagtcacctccgagacggacaccaggtattttgacgag
gagttcacggcccagatgatcaccatcacgccgcctgaccaagtgccctgtccctgcccc
gcagatgacagcatggagtgcgtggacagcgagcgcaggccgcacttcccccagttctcc
tactcggccagcggcacggcctga

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