KEGG   Ochotona curzoniae (black-lipped pika): 121148559
Entry
121148559         CDS       T11174                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ocz  Ochotona curzoniae (black-lipped pika)
Pathway
ocz00562  Inositol phosphate metabolism
ocz01100  Metabolic pathways
ocz04015  Rap1 signaling pathway
ocz04020  Calcium signaling pathway
ocz04022  cGMP-PKG signaling pathway
ocz04062  Chemokine signaling pathway
ocz04070  Phosphatidylinositol signaling system
ocz04071  Sphingolipid signaling pathway
ocz04072  Phospholipase D signaling pathway
ocz04081  Hormone signaling
ocz04082  Neuroactive ligand signaling
ocz04261  Adrenergic signaling in cardiomyocytes
ocz04270  Vascular smooth muscle contraction
ocz04310  Wnt signaling pathway
ocz04371  Apelin signaling pathway
ocz04540  Gap junction
ocz04611  Platelet activation
ocz04613  Neutrophil extracellular trap formation
ocz04621  NOD-like receptor signaling pathway
ocz04713  Circadian entrainment
ocz04720  Long-term potentiation
ocz04723  Retrograde endocannabinoid signaling
ocz04724  Glutamatergic synapse
ocz04725  Cholinergic synapse
ocz04726  Serotonergic synapse
ocz04728  Dopaminergic synapse
ocz04730  Long-term depression
ocz04742  Taste transduction
ocz04750  Inflammatory mediator regulation of TRP channels
ocz04911  Insulin secretion
ocz04912  GnRH signaling pathway
ocz04915  Estrogen signaling pathway
ocz04916  Melanogenesis
ocz04918  Thyroid hormone synthesis
ocz04919  Thyroid hormone signaling pathway
ocz04921  Oxytocin signaling pathway
ocz04922  Glucagon signaling pathway
ocz04924  Renin secretion
ocz04925  Aldosterone synthesis and secretion
ocz04926  Relaxin signaling pathway
ocz04927  Cortisol synthesis and secretion
ocz04928  Parathyroid hormone synthesis, secretion and action
ocz04929  GnRH secretion
ocz04933  AGE-RAGE signaling pathway in diabetic complications
ocz04934  Cushing syndrome
ocz04935  Growth hormone synthesis, secretion and action
ocz04961  Endocrine and other factor-regulated calcium reabsorption
ocz04970  Salivary secretion
ocz04971  Gastric acid secretion
ocz04972  Pancreatic secretion
ocz04973  Carbohydrate digestion and absorption
ocz05010  Alzheimer disease
ocz05016  Huntington disease
ocz05017  Spinocerebellar ataxia
ocz05022  Pathways of neurodegeneration - multiple diseases
ocz05142  Chagas disease
ocz05143  African trypanosomiasis
ocz05146  Amoebiasis
ocz05163  Human cytomegalovirus infection
ocz05200  Pathways in cancer
ocz05415  Diabetic cardiomyopathy
ocz05417  Lipid and atherosclerosis
Module
ocz_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ocz00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121148559 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    121148559 (PLCB2)
   04310 Wnt signaling pathway
    121148559 (PLCB2)
   04371 Apelin signaling pathway
    121148559 (PLCB2)
   04020 Calcium signaling pathway
    121148559 (PLCB2)
   04070 Phosphatidylinositol signaling system
    121148559 (PLCB2)
   04072 Phospholipase D signaling pathway
    121148559 (PLCB2)
   04071 Sphingolipid signaling pathway
    121148559 (PLCB2)
   04022 cGMP-PKG signaling pathway
    121148559 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    121148559 (PLCB2)
   04081 Hormone signaling
    121148559 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    121148559 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121148559 (PLCB2)
   04613 Neutrophil extracellular trap formation
    121148559 (PLCB2)
   04621 NOD-like receptor signaling pathway
    121148559 (PLCB2)
   04062 Chemokine signaling pathway
    121148559 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    121148559 (PLCB2)
   04922 Glucagon signaling pathway
    121148559 (PLCB2)
   04929 GnRH secretion
    121148559 (PLCB2)
   04912 GnRH signaling pathway
    121148559 (PLCB2)
   04915 Estrogen signaling pathway
    121148559 (PLCB2)
   04921 Oxytocin signaling pathway
    121148559 (PLCB2)
   04926 Relaxin signaling pathway
    121148559 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    121148559 (PLCB2)
   04918 Thyroid hormone synthesis
    121148559 (PLCB2)
   04919 Thyroid hormone signaling pathway
    121148559 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    121148559 (PLCB2)
   04916 Melanogenesis
    121148559 (PLCB2)
   04924 Renin secretion
    121148559 (PLCB2)
   04925 Aldosterone synthesis and secretion
    121148559 (PLCB2)
   04927 Cortisol synthesis and secretion
    121148559 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    121148559 (PLCB2)
   04270 Vascular smooth muscle contraction
    121148559 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    121148559 (PLCB2)
   04971 Gastric acid secretion
    121148559 (PLCB2)
   04972 Pancreatic secretion
    121148559 (PLCB2)
   04973 Carbohydrate digestion and absorption
    121148559 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    121148559 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    121148559 (PLCB2)
   04725 Cholinergic synapse
    121148559 (PLCB2)
   04728 Dopaminergic synapse
    121148559 (PLCB2)
   04726 Serotonergic synapse
    121148559 (PLCB2)
   04720 Long-term potentiation
    121148559 (PLCB2)
   04730 Long-term depression
    121148559 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    121148559 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    121148559 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    121148559 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    121148559 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121148559 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    121148559 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121148559 (PLCB2)
   05142 Chagas disease
    121148559 (PLCB2)
   05143 African trypanosomiasis
    121148559 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121148559 (PLCB2)
   05016 Huntington disease
    121148559 (PLCB2)
   05017 Spinocerebellar ataxia
    121148559 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    121148559 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121148559 (PLCB2)
   05415 Diabetic cardiomyopathy
    121148559 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    121148559 (PLCB2)
   04934 Cushing syndrome
    121148559 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocz04131]
    121148559 (PLCB2)
Enzymes [BR:ocz01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     121148559 (PLCB2)
Membrane trafficking [BR:ocz04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    121148559 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    121148559 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 121148559
NCBI-ProteinID: XP_040824595
LinkDB
Position
Unknown
AA seq 1152 aa
MSQLSPVLRPPQVKAYLSQGERFIKWDDETAVASPVILRVDPKGYYLYWTYQSKEMEFLD
VTSIRDTRFGKFAKMPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLTLAKHPLTANAPRITFLDKILVKLRMQLNAEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVFKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPEQVQGLIEKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRAMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFAAPAAPSKEHAGE
AGPPSTPTSEDAGVWVGEEVAELEEEEEVEEEEESLGNLDEEEIKKMQSDEGTAGLEVTA
YEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKASDLLSKSSVQFVEYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RPDKQFNPFSVDRIDVVVATTLAITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPNANSINPVWKEEPFVFEKILMPELASLRVAVMEEGGKFLGHRIIPINALNSGYHHLCL
HSESNMPLTMPALFIFLEMKDYVPDTWADLTVALANPIKFFNAHDKKSVKLKEAMPGVPE
KPFSSGSSVAGPVKAPSTPSGNGSAEPRTASLEELRELKGVVKLQKRHEKELRELQRRGA
RRWEELLQQGAAQLAEMGSLGPGGCGARKLAPSKGSRKKRSLPGEETPGALPVEGPDCVD
SLVRELKDRLQLELRRQGEEQCQCVRTRREQQAAEQVAKMMELAKEKHAAELKTLKETSE
IDTKEMKKKLEAKRLERIQAMTKITTDKMAQERLKREINNSHIQEVVQVIQQMTKNLERY
QEKLEEKQAACLEQIRDMEKQFQQEALVEYEAKMKGLETEVKELVRTWILLEPGEPNEQE
SHPAQDAEESRL
NT seq 3459 nt   +upstreamnt  +downstreamnt
atgtctcagctcagccctgtcctacggcctccgcaggtgaaggcctatctgagccaaggc
gaacgctttatcaaatgggatgacgaaacagcagtggcctccccggttattctccgtgtg
gatcccaagggctactatttatactggacatatcagagtaaggagatggagtttctcgat
gtcaccagcatccgggatacccgctttggaaagtttgccaagatgcccaagagccagaaa
ctccgtgaagtcttcaacatggacttccctgacaaccacttcctgctgaagacgctcact
gtggtgtccggccccgacatggtggacctcaccttccacaactttgtctcctataaggag
aacgtgggcaaggactgggccgaggatgtccttaccttggccaagcacccgctgacggcc
aatgcccctcgcatcacattcctggacaagatcctggtgaagctcaggatgcagctcaac
gctgaggggaagattcctgtgaagaattttttccagatgttccctgctgaccgaaagcgg
gtggaagctgctctcagtgcctgccaccttccaaaaggcaagaacgatgccatcaatcca
gaggacttcccggaatctgtattcaagagtttcctcatgagcctgtgtcctcggccagaa
atagacgagatcttcacttcctaccatgctaaggccaaaccttacatgaccaaggaacac
ctgaccaaattcatcaaccagaaacagcgagattcgcggctcaactctctgctgttccca
cccgcgcggcctgaacaggtgcaaggcctcattgaaaagtacgagcccagtgggatcaat
gtgcagagaggccagctttcacccgaggggatggtgtggtttctgtgcgggccggagaac
agcgtgctggctcaggacaagctgttgctgcaccacgatatgacacagcccctgaatcat
tacttcattaactcctcacataacacctacctgacagctggccagttctcgggcctgtcc
tcggctgagatgtaccgccaggtgctgctggctggctgccgctgtgtggagctggactgc
tggaaggggaagccacccgatgaagagcccatcatcacccatggcttcaccatgaccacg
gatatcttcttcaaggaagcaattgaagctattgcagagagtgcctttaagacctccccc
tatcctgttatcctgtcttttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtactgccgggccatgtttggggacatgctgctcacggagccgctggagaagttc
ccactgaagccaggcatccccctgcccagccctgaggatctacggggcaagatccttatc
aagaacaagaaaaatcagtttgctgctccagcagcgcccagcaaggagcatgctggggag
gctggtccacccagcacccccactagcgaggatgctggagtgtgggttggagaggaggtg
gctgagctggaggaggaggaagaagtggaggaggaggaggagtcattgggaaacctggat
gaagaggagatcaaaaagatgcagtcggatgagggcacagcaggcctggaggtgacagcc
tacgaggagatgtccagcctggtcaattacatccaacctaccaagttcgtctctttcgag
ttctctgcccagaagaaccgcagttatgtcatctcctccttcaccgagctcaaggcttct
gacctgctctccaagtcctcggtgcagtttgtggagtacaacaagcgccagatgagccgc
atttaccctaagggcacccgcatggactcttccaactacatgccacagatgttctggaat
gctgggtgccagatggttgccctcaacttccagactatggacctgcccatgcagcagaac
atggcactgtttgagttcaacgggcagagtggctacctcctcaagcatgagttcatgcgc
cggccggacaagcagttcaatcccttctcagtggaccgcatcgacgtggtggtggctacc
accctcgctataacggtgatctccgggcagttcctgtcagaacgcagcgtgcgcacctat
gtggaagtagagttattcggtctccctggggatcccaagaggcgctaccgcaccaagctg
tcccctaatgccaactccatcaatcctgtctggaaggaagagccctttgtgtttgagaag
atcctgatgcctgagctggcctccctcagggtggctgtgatggaggaaggaggcaaattt
cttggacatcgcatcatacccatcaatgccctaaattctggataccaccacctgtgcctg
cacagcgagagcaacatgcccctcaccatgcctgctctctttatcttcttggagatgaaa
gactacgtacctgacacctgggcagatctcacagtggcccttgccaatcccatcaaattc
ttcaatgcccatgacaagaagtctgtgaagctcaaggaggccatgccaggtgtacctgag
aagcccttctcatctgggagttcagttgctgggccagtcaaggcgccatcaacccctagc
ggcaatgggtcagcagagccgcgcaccgccagcctggaggagctgcgggagctgaagggc
gtcgtgaagctgcagaagaggcacgagaaggagctgagggagctgcagcgccgaggcgcc
cggcgctgggaggagctgctacaacagggagcagcacagctggcagagatgggctcgctg
gggccggggggctgcggagcacgcaagctcgcccccagcaagggttcccgcaaaaagagg
tctttgcctggcgaggagacccccggcgccctgccggtagagggccccgattgcgtggac
tcgcttgtgcgggagctgaaagaccggctgcagctggagctgcgccgacaaggcgaggag
cagtgccagtgcgtccggacgcgcagggagcagcaggcggctgagcaagtagccaagatg
atggagctggccaaagagaaacatgcggcggagctgaagaccctcaaagagacctcagag
attgacaccaaagagatgaagaaaaagctggaggccaagaggctggagaggatccaggcc
atgaccaagatcaccacagacaagatggcccaagaaaggttgaagagagagatcaacaac
tcccacatccaggaagtggtgcaggtcatccagcagatgaccaagaacctggaacggtac
caggaaaagctggaggagaagcaggccgcctgcctagaacagatccgggacatggaaaag
cagttccaacaggaggcactggtggagtacgaggccaagatgaagggcctggagactgag
gtgaaggagctggtgaggacgtggatcctcctggagccgggggagcccaacgagcaagag
tcacacccagcccaggatgccgaggagagccgcctctga

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