KEGG   Ochotona curzoniae (black-lipped pika): 121163917
Entry
121163917         CDS       T11174                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
ocz  Ochotona curzoniae (black-lipped pika)
Pathway
ocz01522  Endocrine resistance
ocz04010  MAPK signaling pathway
ocz04015  Rap1 signaling pathway
ocz04068  FoxO signaling pathway
ocz04071  Sphingolipid signaling pathway
ocz04114  Oocyte meiosis
ocz04148  Efferocytosis
ocz04218  Cellular senescence
ocz04261  Adrenergic signaling in cardiomyocytes
ocz04370  VEGF signaling pathway
ocz04380  Osteoclast differentiation
ocz04517  IgSF CAM signaling
ocz04550  Signaling pathways regulating pluripotency of stem cells
ocz04611  Platelet activation
ocz04613  Neutrophil extracellular trap formation
ocz04620  Toll-like receptor signaling pathway
ocz04621  NOD-like receptor signaling pathway
ocz04622  RIG-I-like receptor signaling pathway
ocz04625  C-type lectin receptor signaling pathway
ocz04657  IL-17 signaling pathway
ocz04658  Th1 and Th2 cell differentiation
ocz04659  Th17 cell differentiation
ocz04660  T cell receptor signaling pathway
ocz04664  Fc epsilon RI signaling pathway
ocz04668  TNF signaling pathway
ocz04670  Leukocyte transendothelial migration
ocz04714  Thermogenesis
ocz04722  Neurotrophin signaling pathway
ocz04723  Retrograde endocannabinoid signaling
ocz04728  Dopaminergic synapse
ocz04750  Inflammatory mediator regulation of TRP channels
ocz04912  GnRH signaling pathway
ocz04914  Progesterone-mediated oocyte maturation
ocz04917  Prolactin signaling pathway
ocz04926  Relaxin signaling pathway
ocz04932  Non-alcoholic fatty liver disease
ocz04933  AGE-RAGE signaling pathway in diabetic complications
ocz04935  Growth hormone synthesis, secretion and action
ocz04936  Alcoholic liver disease
ocz05014  Amyotrophic lateral sclerosis
ocz05020  Prion disease
ocz05022  Pathways of neurodegeneration - multiple diseases
ocz05132  Salmonella infection
ocz05133  Pertussis
ocz05135  Yersinia infection
ocz05140  Leishmaniasis
ocz05142  Chagas disease
ocz05145  Toxoplasmosis
ocz05152  Tuberculosis
ocz05161  Hepatitis B
ocz05163  Human cytomegalovirus infection
ocz05167  Kaposi sarcoma-associated herpesvirus infection
ocz05169  Epstein-Barr virus infection
ocz05170  Human immunodeficiency virus 1 infection
ocz05171  Coronavirus disease - COVID-19
ocz05205  Proteoglycans in cancer
ocz05208  Chemical carcinogenesis - reactive oxygen species
ocz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocz05415  Diabetic cardiomyopathy
ocz05417  Lipid and atherosclerosis
ocz05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121163917 (MAPK12)
   04015 Rap1 signaling pathway
    121163917 (MAPK12)
   04370 VEGF signaling pathway
    121163917 (MAPK12)
   04668 TNF signaling pathway
    121163917 (MAPK12)
   04068 FoxO signaling pathway
    121163917 (MAPK12)
   04071 Sphingolipid signaling pathway
    121163917 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    121163917 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    121163917 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    121163917 (MAPK12)
   04218 Cellular senescence
    121163917 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    121163917 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121163917 (MAPK12)
   04613 Neutrophil extracellular trap formation
    121163917 (MAPK12)
   04620 Toll-like receptor signaling pathway
    121163917 (MAPK12)
   04621 NOD-like receptor signaling pathway
    121163917 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    121163917 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    121163917 (MAPK12)
   04660 T cell receptor signaling pathway
    121163917 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    121163917 (MAPK12)
   04659 Th17 cell differentiation
    121163917 (MAPK12)
   04657 IL-17 signaling pathway
    121163917 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    121163917 (MAPK12)
   04670 Leukocyte transendothelial migration
    121163917 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    121163917 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    121163917 (MAPK12)
   04917 Prolactin signaling pathway
    121163917 (MAPK12)
   04926 Relaxin signaling pathway
    121163917 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    121163917 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    121163917 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    121163917 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    121163917 (MAPK12)
   04722 Neurotrophin signaling pathway
    121163917 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121163917 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    121163917 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    121163917 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    121163917 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    121163917 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121163917 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    121163917 (MAPK12)
   05161 Hepatitis B
    121163917 (MAPK12)
   05171 Coronavirus disease - COVID-19
    121163917 (MAPK12)
   05163 Human cytomegalovirus infection
    121163917 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121163917 (MAPK12)
   05169 Epstein-Barr virus infection
    121163917 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121163917 (MAPK12)
   05135 Yersinia infection
    121163917 (MAPK12)
   05133 Pertussis
    121163917 (MAPK12)
   05152 Tuberculosis
    121163917 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    121163917 (MAPK12)
   05140 Leishmaniasis
    121163917 (MAPK12)
   05142 Chagas disease
    121163917 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    121163917 (MAPK12)
   05020 Prion disease
    121163917 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    121163917 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121163917 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    121163917 (MAPK12)
   05415 Diabetic cardiomyopathy
    121163917 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    121163917 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    121163917 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121163917 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    121163917 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocz01001]
    121163917 (MAPK12)
Enzymes [BR:ocz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     121163917 (MAPK12)
Protein kinases [BR:ocz01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   121163917 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 121163917
NCBI-ProteinID: XP_040847614
LinkDB
Position
Unknown
AA seq 367 aa
MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLQHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSAGCIMAEMITGKTLFKGNDHLDQLKEIMK
VTGTPPAEFVQKLQSADAKQYVQGLPVCERKDLSSVVTNASPLAVALLEKMLLLDGDQRV
TAAEALAHPYFESLHDTEDEPQPQKYDESFDDVDRTLDEWKSVTYREVLRFKPPRQLGAK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctcgccgccgcccgcccgcaagggcttctaccgccaggaggtaaccaagaccgcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctcgggcgcctatggcgcc
gtgtgctcggccgtggacagccgcaccggcgccaaggtggccatcaagaagctttaccgg
cccttccagtcggagctgttcgccaagcgcgcctatcgcgaactgcgcctgctccagcac
atgcgccacgagaacgtgatcggcctactagatgtgttcacaccggacgagagcctggat
gacttcacagacttctatctggtgatgccgttcatgggcaccgacctgggcaagctcatg
aaacatgagaagctgagcgaggaccgcatccagttcctggtctaccagatgctgaagggg
ctgaagtatatccacgccgctggcatcatccacagggacctgaagcctggtaacctggcc
gtgaatgaggactgcgagctgaagatcctggacttcggcctggccaggcaggctgacagt
gagatgaccggttatgtggtgacacggtggtacagggctcctgaggtcatcttgaattgg
atgcactacacacagacagtggacatctggtcagcgggctgcatcatggctgagatgatc
acgggcaagacgctattcaaaggcaatgaccacctggaccagctgaaggagatcatgaag
gtgactgggacaccgccggctgagtttgtgcagaagctgcaaagtgctgatgcgaagcag
tatgtgcagggcctccctgtgtgtgagaggaaggacttgtcctctgtggtgaccaacgca
agccccctggctgtggcgcttctggagaagatgctgctgttggatggggaccagcgggtg
acggcagccgaggccctggcccacccctacttcgagtcactacatgacacggaggacgag
ccccagcctcagaagtatgatgagtcgtttgatgacgtggaccgcaccctggatgagtgg
aagagtgtcacttacagggaggttctgcgcttcaagcctccgaggcagctgggagccaag
gtctccaaggagacggccctgtga

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