Ochotona curzoniae (black-lipped pika): 121170732
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Entry
121170732 CDS
T11174
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
ocz Ochotona curzoniae (black-lipped pika)
Pathway
ocz00220
Arginine biosynthesis
ocz00330
Arginine and proline metabolism
ocz01100
Metabolic pathways
ocz04020
Calcium signaling pathway
ocz04022
cGMP-PKG signaling pathway
ocz04066
HIF-1 signaling pathway
ocz04071
Sphingolipid signaling pathway
ocz04151
PI3K-Akt signaling pathway
ocz04370
VEGF signaling pathway
ocz04371
Apelin signaling pathway
ocz04611
Platelet activation
ocz04915
Estrogen signaling pathway
ocz04921
Oxytocin signaling pathway
ocz04926
Relaxin signaling pathway
ocz04931
Insulin resistance
ocz04933
AGE-RAGE signaling pathway in diabetic complications
ocz05415
Diabetic cardiomyopathy
ocz05417
Lipid and atherosclerosis
ocz05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ocz00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
121170732 (NOS3)
00330 Arginine and proline metabolism
121170732 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
121170732 (NOS3)
04371 Apelin signaling pathway
121170732 (NOS3)
04066 HIF-1 signaling pathway
121170732 (NOS3)
04020 Calcium signaling pathway
121170732 (NOS3)
04071 Sphingolipid signaling pathway
121170732 (NOS3)
04022 cGMP-PKG signaling pathway
121170732 (NOS3)
04151 PI3K-Akt signaling pathway
121170732 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
121170732 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
121170732 (NOS3)
04921 Oxytocin signaling pathway
121170732 (NOS3)
04926 Relaxin signaling pathway
121170732 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
121170732 (NOS3)
05418 Fluid shear stress and atherosclerosis
121170732 (NOS3)
05415 Diabetic cardiomyopathy
121170732 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
121170732 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
121170732 (NOS3)
Enzymes [BR:
ocz01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
121170732 (NOS3)
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GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
121170732
NCBI-ProteinID:
XP_040857922
LinkDB
All DBs
Position
Unknown
AA seq
1211 aa
AA seq
DB search
MGNLKSVGQDPGPPCGLGLGLGLGLCGKQGPASPTSTSEPSRAPASPPPTPPAPDHSPTP
SSNSPPLTRPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTQRRCLGSLVFPRKLQSR
PCQGAPPAEQLLGQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVF
GAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYVCNHVKYATNRGNLRSAITVFP
QRSPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLL
LQAPDEPPELFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAP
FSGWYMSTEIGMRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQL
AKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPA
FRYQPDPWKGSGAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQ
SYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALME
MSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGL
GSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCV
GEDAKAAARDIFSPKRSWKRQRYRLSTQTEGLQLLPGLIHVHRRKMFQATILSVENLQSS
KSTRATILVRLDTRGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPPTEPVAVEQL
EKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPRLLQLLSTLAEEPSEQQELEA
LSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSIYPGE
IHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILV
GPGTGIAPFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGR
VLTAFSREHDSPKTYVQDILRTELASEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILA
SEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWA
FDLPGSDTPGS
NT seq
3636 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtaggccaggaccccgggccgccctgtggcctggggctggga
ctgggcctcgggctgtgtggtaagcagggtccagcctctccgacatccacgtcggagccc
agtcgggcaccagcatcgcccccaccgaccccaccggcaccagatcacagtcccactcct
agctccaacagccctccactcacccggcccccggaggggcccaagttcccccgagtgaag
aactgggaggtgggcagcatcacctacgacaccctcagtgcccaggcacagcaggatgga
ccttgcacccaaagacgctgcctgggttcccttgtatttccccggaaactgcaaagccgg
ccctgccagggtgctccacccgctgaacaactgctgggtcaggcccgggacttcatcaac
cagtactacagctccatcaagaggagcggctcccaggcccatgagcagcggcttcaggag
gttgaggccgaggtggcagccacaggcacctaccaacttcgggaaagcgaactggtgttt
ggagccaagcaggcctggcgcaacgctccccgctgcgtgggccggatccagtgggggaag
ctgcaggtgttcgatgcccgggactgcaggtccgcacaagaaatgttcacctacgtctgc
aatcacgtcaagtacgccaccaaccggggcaacctacgctcggccatcacagtgttcccc
cagcgctccccgggccgcggagacttccggatctggaacagccagctggtgcgctatgca
ggctaccgacagcaggacggctccgtgcggggagacccagccaacgtagagatcaccgag
ctctgcatccagcatggctggaccccaggaaacggccgcttcgatgtgctgcccctgctg
cttcaggcaccagatgagcccccagaactcttcactctgcccccagagctggtcctggag
gtgcccctggagcacccaacgctggagtggttcgcagctctgggcctgcgctggtacgcc
ctcccggccgtgtccaacatgctgctggaaattgggggcctggagttccccgcagccccg
ttcagcggctggtacatgagcacagagatcggcatgcgcaacttgtgcgacccccaccgc
tacaacatcctggaggatgtggccgtctgcatggacttggatacccggacaacatcatcc
ctgtggaaagacaaggcagccgtggaaatcaacctggctgtactgcacagttaccagctg
gccaaagtgaccattgtggaccaccatgctgccacagcctccttcatgaagcaccttgag
aatgagcagaaggccagaggaggctgccctgccgactgggcctggatcgtgccccccatc
tcaggaagcctcactcctgtcttccatcaggagatggtcaactacttcctgtcccctgcc
ttccgctaccagccagacccctggaaggggagtggagccaagggcactggcatcaccagg
aagaagacctttaaggaagtggccaatgccgtgaagatttctgcttcactcatgggcaca
gtgatggccaagagagtgaaggccacgatcctgtatggttctgagactggccgggcccag
agctatgcacagcagcttgggaggctcttccggaaggcctttgatccccgggttctgtgc
atggatgaatacgacgtcgtatcccttgaacacgagacactggtgttggtggtgaccagc
acatttgggaatggggatccaccagaaaatggagagagttttgctgcagccctgatggag
atgtccggcccctacaacagctctcctcggcctgagcagcacaagagttacaaaatccgc
ttcaacagcgtctcctgctcagacccgctggtgtcctcttggcgacggaagaggaaggag
tccagtaacacagacagtgcgggggctctgggcaccctcaggttctgtgtgtttgggctc
ggctcccgggcatacccccacttctgtgcctttgctcgtgcggtggacacgcggctggaa
gagctgggcggggaaaggctcctacagctgggccagggggatgagctctgcggccaggag
gaggccttccgtggctgggcccaggctgccttccaggcctcctgtgagactttctgtgtg
ggagaagatgccaaggccgctgcccgggacatatttagccccaaacggagctggaagcgt
cagaggtaccgcctgagtacccaaacagagggtctacagctgctgccaggtctgatccat
gtacacaggcggaagatgttccaggccaccatcctctcagtggaaaacttacaaagcagc
aaatccacccgggccacaatcctggtgcgtctggacactagaggccaggaagggctacag
taccagccaggggaccacataggagtctgcccacccaaccggcctggccttgtggaggca
ctgctgagtcgcgtggaggacccgccaccacccaccgagcctgtggcagtggagcagctg
gagaagggcagccctggtggccctccgccgggctgggtgcgggacccccggctgcccccg
tgcacgttgcgccaggctctcaccttcttcctggacatcacttccccacccagccctcgg
ctcctacaactgctcagcactctggccgaagagcccagtgaacagcaggagctggaagcc
ctcagccaggatccccggcgctatgaggaatggaaatggttccgctgtccgacactactg
gaggtgctggaacagttcccatctgtggcgctgcctgcacccctgctcctcacacagctg
cccctgctgcagccccggtactactcagtcagctcagcacccagcatctacccaggggag
atccatctcactgttgctgtgctggcctacaggacgcaggatgggctgggccccctgcac
tatggtgtctgctccacgtggctgagccaactcaaggctggagaccctgtgccctgcttc
atcaggggggccccctccttccggctgccacctgatcccagcttgccctgcatcctggtg
ggcccgggtaccggcattgccccattccggggtttctggcaggagcgtctgcatgacatt
gaaagcaaaggcctgcagcctgcccctatgactttggtgttcggctgccgctgctcccag
ctagaccatctctaccgcgacgaggtgcaggacgcccagcagcgcggggtgtttggccgc
gtcctcacagccttctcccgggaacacgacagccccaagacctacgtgcaggacatcctg
aggaccgagctggcgtctgaggtgcaccgcgtgctgtgcctcgaacgtggccacatgttc
gtctgcggcgatgtcaccatggcaaccagcgtcctgcagactgtgcagcgaatcctggcg
tccgagggcgacatggagctggacgaggccggtgacgtcatcggcgtgctgcgggatcag
caacgctaccacgaggacattttcggcctcacgctgcgcacccaggaggtgaccagccgc
atccgcacccagagcttctctttgcaggagcggcagctgcggggcgccgtgccctgggcg
ttcgacctgccgggctcagacacgcccggctcctga
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