Osmerus eperlanus (European smelt): 134022613 Help Entry 134022613         CDS       T10927                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism oep  Osmerus eperlanus (European smelt) Pathway oep04020   Calcium signaling pathway oep04260   Cardiac muscle contraction oep04261   Adrenergic signaling in cardiomyocytes oep04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oep00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     134022613 (ryr2b)    04020 Calcium signaling pathway     134022613 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     134022613 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     134022613 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oep04040]     134022613 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:oep04990]     134022613 (ryr2b) Ion channels [BR:oep04040]  Voltage-gated cation channels   Ryanodine receptor    134022613 (ryr2b) Domain-containing proteins not elsewhere classified [BR:oep04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    134022613 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 GRP Motif Other DBs NCBI-GeneID:  134022613 NCBI-ProteinID:  XP_062320274 LinkDB All DBs Position 6:complement(19770936..19817299) Genome browser AA seq 4996 aa AA seqDB search MARTIESEDEIHFLRTSDEVVLQSAYTSQQEHLKLCLAAEGYGCRLCSLQSTSHCKNVPP DLSVCAFVLAQCLSVRALQEMLANREEKANGIGLGGGNRTLLYGQAVLLRHSYNGMYLCC LSTSGSSTDKLAFDVGLQEDNTGEACWWTVHPASKQRSEGEKVRVGDDLIFVSVSSERYL HLSIGCVVDNKSESGNLIVDASFQQTLWSVAPICSGGRIVEGYLKGGDTLRFLHGHTDEC LTIPSTEQGEELRRVVHYEGGAVSSHARSLWRLEILRVAWSGSHTRWGQPFRLRHVTTGR YLSVTEDRGLLLVDREKAEVKVSAFCFHPSKEKLEPWMKKDVDGMGVPEIKYGDSLCYVQ HVDTGLWLTYQAVDAKCARMGALQRRAIVHSEGHMDDGLSLSRSQREESHTARLIRCTVL LFSRFIRRLDGVSLCENLPNANVQLDTVRLSLQDLIGYFQPPEAGLSHEVHQNSVRALKK RQNLFQEEGVIGLVLDCIDRLHLYSRASHSAETAGRDAGEDWEDILNSFYELLAALIRGN RKNCAQFSGSLDWLVGRLETLEASTGVLEVLHCVLVESPESLNAIKEGHIKSLISLLDKH GRNHKVLDVLSSLCVCHGMAVRSNQNLICDNLLSERDLLLQTHLINQVTSMRPNIFLAMT DDSAQYRRWYYELVVDHVEPFLSPEPTHLRVGWACVDGYLPCPAQGHGWGGNGVGDDLCS YGFDGLHLWSGGVGRKVSSPYHHLLRAEDVVSCCLDLCTPCISFRVNGQPVQGMLENFNM DGLLFPAVSFSAGIKVRFLLGGRHGEFRFLPPPGFAPCSEALLPKVKLRLEPCQSFTSDH QDGIKNLQGPSAPLSPATFNPTPVDISQTVLPSQLEHICERLAENLQELWVVDRVDLGWM YGPVRDDSKRQDPCLVEFSKLPEQERNHKLQMSQDTLRTLLAFGFHIGLADDHADEGVRY MRLPTKYEQPSGYRPAPVDVSQVTLTSGQEGVVDLLAENEHNVWAWDRIRHGWTYGVQDV KARRSPHLVPYALLEERSKREGRDSVRETVCTLLGYGYSLEPLDQDRAVMPDPNRVPSER FRVFRADRSYAVTRGKWYFEFEVVTTGTMRVGWARPGCSPNTEPGSDEQAFVFEGSKALW CHQGAEPLGRPWQGGDVIGCMVDMAERTMMVTLNGELLFNDRGSEVAARDFDVRDGLLPV CSLGVNQMGRLNLGRDVSTLRYFTVCGLQESYEPFAVIMARDPSLWMSRRQPQFVPVPPE QNILVTRLSGSLECPPCLRVTQRSFSPQSGGANMGFFRLSMPIECASFLSRPPGGAVPAS ASALTGRKELEEFEVDSDFEMLMKSARGYVGSRDELNYHKDHSHDKTSKLKQRFMLKKTK PGLVNSSSSARLLEEVHVDKDNFEHLIQSSTYYFSVRVLPGQEPSNVWVGWVTSGFHQHG LTFHPDKARTVTVTLGDESGKVQESVKRCSCYMVCAGEGTGLGQSRRSTGLEIGCLIDTA SGLLTFTSSGMDLTTFYQVESSTRLFPAVFIKPTSANMFQFELGRVKNVLPLSAGVFRSQ RRNATPQCPPRLGVQQLVPVLWTRVPDHALVVQAARPDDRHGWMVQCSDPQATLILHIPE ENRYVDILELSELDDLLTFHHHTLLLYSALCALGNTRVGHALCSHVDQSQLLYAIQSPGL PGPLRTGFYQLLIQVHLSAHATARLMMNQEYIVPMTDQTRAIKLFHRPGGPGGAKTPEII PSMDLSTSLQPRLYFSSPCFVREGGWGGDGAGSGGGETAHRGSPEIPLEVLRELTVQMLS EAVCAVGLGVRDPEGGSVELLLVPLIRLFYTLLVMGVFGDEDLGRALRLIEPGVFSRPTD TQEEEEEEEEEEEEYESEGGSLGEGQVEQKECTPKQGLLQMKLPEAVKLEICHLLQFLCD CQVRHRVEAVVAFSDSFVGLLQENQRSRYNEVMQAMNMSAGLTARRTKEFRSLPQEQINM LLSFGEEQQGACPCPEEIRDQLLDFHHLLIAHCGIDIDAGCEVEQMSEVSLKEQLLGVVG RALGLRRTTPEQEEGGGVHTLKSLQQLVLSTVVHWAQESVMENPSLVRVMFSLLHRQYQG LGGQMGGPLRRAYSISQASVEDTMDLLASLGQIRSLLSVRMGKEEEKLMIRGLGNIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGEGESKEITFPKMVAHCCRFLCYFCRISRQNQGS MFDHLSYLLENSSVGLASPSMRGATPLDVAAASVMDNNELALSLREPDLEKVVQYLAACG LQSCPMLVSKGYLDLGWNPVEGERYLDMLRFAVFCNGESVEENAYVVVRLLIRRPECFGP ALRGEDGDGLLAAIQEAIRISEDPSMDGPTLAYESNRTLDVVQDEEDDVIHMGHAIMTFY SALIDLLGRCAPEMHLIRSGKGEAIRIRAILRSLIPLGDLQGVISLPLQIPVLAKDGTVI EPDPSTVFCPDHKAAMVLFLDRVYGLEDQNFLFHLLDVGFLPDLQAAASLDTPDLGSTDM ALALNRYLCVAVLPLLTKTSALFSGAESQALLMDALLQAVYRLSRALSLTKAQRDAIEDC LLAVCSKLRPFMMQPLLQRLVFDVPLLSETTKMPLKLLTNHFEQSWKYYCLIGRSGSLCS ASEEELHLSRKLFWGVFKALAKKSYDADLFRLALLCLGAVGGALPPDHMDHACVSWLEKH ATMDPQQHFDPQPVDTTNVLVPDRLELVVNKYAEHTHEKWSLDKFARGWVHGEQLCENAK VHPLLKPYRALAEKDKETYRWAIRETVRSMLAFGWTIERTKDGDACGLHTCARRISQSGQ LSFEGASTFSPKPMDMSSITLTWDQCSMAELLAENYHNTWARKKMLELEAKGGGSHSLLV SYDTLSGKEKSRLRERAQDVLKFLQLNGLTVWRDRKSVEMESPAIANRFAYTFLQQLLFY TEEAQEHMLEMEVMQARGQMTKGERTPHQQEIYFFSKVILPLVEHYLKNHLSYFLSTSNS SHGNGGHASNKEKEMVASLFCKLGALVRHRTSLFGSDASSIVSCLHILAQSLDARTLMKT APEWLRSSLRSFFEAAAVDLEVTVENLSMTLGPQSRAQPRGVAQLLVYTTSTLLPCLTAL FQHLGSQQHGQDLLVDGIQVSCYKILNSLYSLGTSQSPYADGQRPAAGACLAALSGAFPV CFLEPDLNEDNPYSVYNSMSPTEREELGVFDLVEEVCPRLPSLQKALGEVEELVGAGSGA RLAQYAHVTEVTLPLLCSYVARWWAWGPQGQSDSDGPVFTCLTPQHASTLLGNILRVIHN HLGTRQGDWMKRLAVFSQPIVGQACPELLESHFLPLMEKLKTRAEAVLLEEEHAKAEGRS LESDSEAELRVQERFSVLVRDLYAFYPLLIPFVDCNRARWLREPSPEAEKLFSMVADIFI FWAKSHNFKWEEQNYVVQNEINNMAFLVNNDSNMSKVSHQERRKTKRKGDRYSTHTSLIV ASLKRLLPVGLSVCSHGDQGLIFQAKSRFSQKDTEEEIQESVFNGLLQIQTQNSPGVCWQ DALVQGSPGQAGGPSDPHRATQRVIDIARVLHHLDQVEHPERTKKAVWNKVLSKQRKRAV VACLRMAPLYILPRHRAVNLFLQGYDKFWISADDHSFEEKLVEDLARTGRACQREQEEEA EEGANQMDPLHQLITLFSHTALTERSRLEDDSLYLSFAAILAKSCHEEEEEYEEEEVKTF EEKELEKQKLLYQQARLHGRGAAEMVLQTISSSRGTMGSMVVCTLKLGIAILNGGNTTVQ QKMLDYLKEKKDVGFFQSVAGLMQCCSVLDLNAFERQNKAEGLGMVIEESSGDKVMSDSE LTSDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWFYSG KAVIDEHGRKNFSKAISVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHM QMKLSQDSSQIELLKDLMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSSNVEMIL KFFDMFLKLKDLTSSEAFKEYDPDGKGRVSKKDFLKAMEACKRFSQSETHFLLSCVETNE GELLDYVAFVDRFHEPAKDIGFNMAVLLTNLSEHMPHDSRLATFLQLAECVLSYFQPYLG RIEILGSGKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMEMFINFCE DTIFEMQLASQISGSDGGERAASDEGEEKKEKEQGHEGEGRPKPGLFSGSTVWFLVCALP YGLMMLVSVLSVKNLKKQLRRMTLKDMAVGVASFFRGIVMALVRWVCGLTRGLVYILYLV FVNGGLVEGAKRMTVVELLCGILDPTSDEVSGWSGGERQRRSSAMFASHQEDRDTAQTAD ASPRDANSLTDMFGLRLRKDGGQYTLLTHDLSSSLTDLFNAATGHRGMTDTIRKYQAQVS QRGDGEESETKLSDSEKSPEEASNKKSKWRSRRTSKPEVPEPQQSAFWDMISTQHKILLN YFARNFYNMRMLALFVAFAINFILLFFKVSSSSATAQAGEDVTVLHTSPLELGGGHGGGH GGGHGGGQGGGQDPVRNDHRQSDSVHFVLQESSGYMKPSLHFLAVAHTLISFCCIIGYYC LKVPLVIFKREKEVARKLEFDGLYVTAQPPDEDIKGQWDRLVIDTPSFPSNYWDKFVKRK VMGKYGELYGSARIGRLLGLDQAALDFSSQEQERRRPRRANTWSSLLNSIDVKYQIWKLG VVFTDNSFLYLTWYMIMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV GLLAVVVYLYTVVAFNFFRKFYNKTEDGDTLNMKCDDMLTCYMFHMYVGVRAGGGIGDEI EDPAGDEFEVVRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFIC GIGNDYLDTAPHGFETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEF FPVGDCFRKQYEDQLS NT seq 14991 nt NT seq  +upstreamnt  +downstreamnt atggcaagaaccatagagagcgaggatgaaattcattttctacgaacgagtgatgaggtg gtcctacagagtgcttacacgtcccagcaagagcatctgaagctgtgcctggctgcagaa ggctacggctgcagactctgcagcctgcagtccacctcccactgcaagaatgttccccca gacttgtcggtgtgtgcctttgtgctggcccagtgtctgtctgtcagagccttgcaggag atgctggccaacagggaggaaaaggctaatgggattgggctggggggagggaatcgtacc cttctctatggccaggctgttttgctacgacattcctacaatggaatgtatctctgctgc ttgtccacatccgggtcctccactgacaagcttgcttttgacgtgggtttgcaggaagat aacacaggggaggcctgctggtggaccgttcaccccgcctccaagcagaggtcggagggg gagaaggtgcgtgtcggtgacgacctcatctttgtcagcgtctcgtcagagagatacctg catttgtctatcggatgtgtggtggataacaagagcgagagcgggaatctcatcgtggac gcatctttccagcagacactctggagcgtcgctccaatctgttcaggaggcagaatagtt gaaggttatctaaagggcggggatacgttgaggtttctgcatggtcacacggacgagtgt ctgaccatcccctctacggaacagggggaggagctacgaagggtggtgcactatgaaggg ggagctgtctccagccacgcccgctctctctggaggctggagattctacgtgttgcgtgg agtggtagccacacacgctggggtcagccgttccgcctgcgtcatgtgaccacagggagg tacctaagtgtgacggaggatcgaggcctcttattggtcgaccgggagaaggcggaggtc aaagtctctgccttctgcttccatccctccaaggagaagctggagccgtggatgaagaag gatgtggatggcatgggcgtcccggagatcaagtatggagactccctgtgctacgtccag catgtggacactggcctctggctcacctaccaggctgtggacgccaagtgtgcccgcatg ggagcactgcagcgcagggccatcgtgcatagtgagggtcacatggatgatgggctgagt ctgtctcgctctcagagggaggagtctcacacagccagactcatccgctgcactgttctc ctcttctctcgcttcatcaggagactggatggagtcagtctgtgtgagaaccttccaaat gccaacgtgcaattggacaccgtgagacttagtctgcaggatctcattggctacttccag cctccagaggcgggtcttagccatgaagtccatcaaaacagtgtgagagcactgaagaaa agacagaacctattccaagaagagggggtcattggtcttgtcttggactgcattgaccgt ctacacctctacagcagagcctcccattcggctgaaactgctgggagagatgctggagaa gactgggaggacatccttaactccttctatgaactactggcggccctcatcaggggaaat cgtaagaactgtgcccagttttctgggtctctggactggctggtcggcaggctggagacc ctggaggcctccactggcgtcctggaagtacttcactgtgttctggtggagagtccagag agtctcaacgccatcaaggaaggacacatcaaatctctcatatctctcctcgacaaacac ggacgcaatcacaaggtattagacgtgctgtcttccttgtgtgtgtgccacgggatggca gtgcgatccaatcaaaatctgatctgtgataacctgttgtccgagagagacctgcttctc cagactcaccttatcaaccaggtcaccagcatgcgtcctaacatcttcctggccatgacg gacgactctgcccagtaccggcgctggtactacgagctggtggtggaccatgtggagcct ttcctgtcccccgagcccactcacctgcgtgtgggctgggcctgcgtggatggctacctc ccctgcccagctcagggtcacggctgggggggaaacggggtgggagacgacctctgctcc tacggctttgacgggctgcacctgtggtcaggtggtgttggtcggaaagtgagctctcct taccaccacctgttgagggcagaagatgtggtcagctgctgtctggacctctgcacaccc tgcatctccttccgtgtcaacggccaacccgtccagggcatgctggagaacttcaacatg gatgggctactgtttcctgcggtcagcttctcggcagggatcaaagtgcgtttccttctg ggcggtcgtcacggagagttccgcttcctgcccccccccggttttgccccgtgttcggag gctctcctcccgaaggtcaaactgaggctggagccgtgtcagagtttcacctcagaccac caggacggaataaaaaacctccaaggaccaagcgcccctctctcaccggccaccttcaac ccaactccagtagacatcagccagacggtgttgccctcccagctggagcacatctgcgag aggctggctgagaacctgcaggagctctgggtcgtggacagggtggacctgggctggatg tacggaccggtacgagatgacagtaagcggcaagatccctgtctggtcgagttttccaag cttccggaacaggagagaaaccacaaactccagatgtcccaggacacactaaggactctt cttgccttcggcttccatatcggtctggcagatgaccatgctgatgagggtgtgagatac atgaggctccctaccaagtacgagcagcccagcgggtacaggccggcccctgtagacgtg agccaagtgaccctgacctccggccaggagggcgtggtcgacctgctggctgagaacgag cacaacgtctgggcctgggaccgtatccgacatgggtggacctacggagtgcaggatgtc aaagccaggcggagcccccacctggtgccctacgccctccttgaggagaggagcaagagg gagggcagggacagcgtgagggagaccgtgtgcactctgctgggctacggctacagtctg gagcccttggaccaggaccgagctgtgatgccggacccaaaccgggtgccgtctgagaga ttccgtgtgttccgggcggacaggtcgtacgctgtgacccgtgggaagtggtactttgag tttgaggtggtgaccacggggaccatgagggttggctgggcccggcccggctgctccccg aacacagaacctggctcggacgagcaagcgttcgtgttcgaaggctccaaagccctgtgg tgtcaccagggagcggagccactgggacgcccatggcagggtggtgatgtgattggctgc atggtggacatggccgaacgcaccatgatggtcaccctgaacggagagctgctttttaac gaccgaggatccgaagtggctgccagagacttcgatgtcagagacggtctcctccctgtg tgcagtttgggggtcaaccagatgggcaggttgaacctgggtcgtgatgtcagcaccctg aggtacttcactgtgtgtgggctgcaggagagctacgaaccctttgctgtcatcatggcc agagacccctctctctggatgagccggagacagcctcagttcgtgcccgttcctccagaa cagaacatactggtgacacgactcagcgggagcttggaatgccccccgtgtctaagggtc actcagaggtccttctccccccagagcgggggtgccaacatgggcttcttccgtctcagc atgcccatcgagtgtgcctccttcctctccagaccaccaggtggcgccgtgcccgccagt gccagcgccctcacaggcaggaaggagctggaggagtttgaggtggactctgacttcgag atgctgatgaagtcggctcgtgggtacgtaggctccagagacgagcttaactaccacaag gaccacagccacgacaagacatccaaactcaaacagcggttcatgttgaagaaaaccaaa ccaggcctggtgaacagcagctcttctgctcggctgttagaagaggtccacgtcgacaag gacaacttcgagcatctcatccagagctcaacgtactacttctcagtaagggtccttcca ggtcaggagccctctaatgtctgggtaggctgggtgacctctggcttccaccagcatggc ctgacttttcaccctgacaaggctcgcacggtcaccgtcaccctgggcgatgagagtggc aaggtccaagagagtgtgaagcggtgtagctgttacatggtgtgtgctggcgagggcact ggcctgggtcagagcaggagaagcacaggcctggagataggctgtctgatcgacacagct tctggtctcctcaccttcacctccagtggcatggatctgaccaccttctaccaggtggag tccagcaccagactcttccctgctgtgttcatcaagcccactagcgccaacatgttccag tttgagctaggacgcgtcaagaacgtgctgcccttgtctgcgggggtgttccgtagccag aggaggaacgccacgccccagtgcccccccaggcttggggtgcagcagctggtgcccgtc ctgtggacccgagtacctgaccacgccctcgtggtgcaggccgcccggccagacgaccgc cacggctggatggtgcagtgctccgacccccaggcgaccctcatcctacacatacccgag gagaacagatatgtagacatcttagagctctctgagttagacgacctcctgaccttccac caccacaccctcctcctctactccgccctctgtgcccttggcaacacccgcgtcggccac gccctctgtagccacgtggaccaatcacagctcctgtatgccatccagagccctggcctt cccggccctctccgcaccggtttctaccagctactcatccaggttcacctcagtgcccac gccaccgcccgcctcatgatgaaccaggagtacattgtacccatgacggaccagaccagg gccatcaagctgttccaccgccctgggggacctggcggggccaagacgccggagatcatc cccagcatggacctcagtacctcccttcagccccggctgtacttctcctccccctgcttt gtgagggagggtggatggggaggagatggggctgggagcgggggaggtgagacagcccac aggggcagcccggagatccctctggaggttctgagagagctgactgtgcagatgttgagc gaggcggtgtgcgctgtgggtctgggtgtgagggatccagaagggggcagtgttgagcta ctgttggttcctctgatcaggctgttctacacgctgctggtaatgggagtgtttggagac gaggacctgggacgagccctcaggctcattgagcccggggtgttttccagaccgactgac acccaggaggaagaggaagaggaggaggaggaggaagaggagtatgaaagtgagggggga agtctgggagaggggcaggtagaacagaaggaatgtactccgaaacaagggcttctccag atgaaactaccggaagctgtcaaactagagatctgtcacctgctgcagttcctgtgtgac tgccaggtgcgtcaccgggtggaggcggtggttgccttctccgactcctttgtgggtctc ctgcaggagaaccagcgctcccgctacaacgaggtgatgcaggcgatgaacatgtcagct ggcctcaccgcccgcaggaccaaggagtttcgctctctgcctcaggagcagatcaacatg ctgctgtcctttggagaggagcagcagggagcctgtccctgcccagaggagatcagagac cagctcctagacttccaccacctcctcattgctcactgtgggattgatattgacgcaggt tgtgaggtggagcagatgtcagaggtgtccttgaaggagcagctcctgggtgtggtgggg agggccctgggcctccggaggacaacacctgaacaagaggaggggggcggagtccacact ctcaagagcctccagcagctggttctgtccacggtggtgcactgggctcaggagagcgtg atggagaacccttctctggtccgagtcatgttctccctgctgcatcgccagtaccagggc ctgggggggcagatgggaggcccgctccgcagggcctacagcatcagtcaggcgtcagtg gaggacaccatggaccttctggcctcgctgggccagatccgatcgctgctcagcgtacgc atgggcaaggaggaggagaagctgatgatcagaggactaggtaacataatgaacaataaa gttttctaccagcatcccaacctgatgagggctctgggaatgcacgagacagtcatggag gtgatggttaacgtcctgggagaaggagagtccaaggagataacgtttcccaagatggtg gcgcactgctgccggttcctgtgttacttctgtcgtatcagcagacagaatcagggctcc atgtttgaccacctcagctacctgctggagaacagcagtgttggactagcctctccctcc atgcgcggtgccactcccctggatgtggcggctgcctctgtcatggacaacaacgagctg gccctgtcgctgagggaaccagacctggaaaaggtggtgcagtacctggcagcctgtggt ctccagagctgtcccatgctggtgtctaaggggtacctggacctgggctggaaccctgtg gagggcgagcgctacctggacatgctgcgattcgctgttttctgcaacggtgagagcgtc gaggagaacgcttacgtggtggtgaggctgctgattcgtcgacccgagtgctttggcccc gccctgcgtggtgaagacggtgacggtctcctagcagccattcaggaagccataaggata tctgaggacccgtccatggatgggcctaccctggcctacgagtccaacaggaccctagac gtggttcaggatgaagaggatgacgtcattcacatgggacacgccatcatgacattctac tctgccctcatcgatctgctaggccgctgtgcccccgagatgcacctgatccgttcaggg aagggggaggccatccgtatccgagccatcctgaggtccctcatccccctgggggatctg cagggggtcatcagcctgcccctgcagatccctgtcctggccaaagacggtactgtgatt gagccggacccatccacggtgttctgcccggaccacaaggcagccatggttctgttcctg gaccgggtctacggcctagaagatcagaacttcctgttccacctgctggacgtgggcttc ctgccagaccttcaggctgcagcctccctggacactcctgacctgggctccacagacatg gccctggccctcaacaggtacctgtgtgtggccgtgctcccgctgctcaccaagacctct gctctgttctctggagcggagagccaggcgctgctgatggacgctctcctccaggccgtc taccgcctctccagggccctcagcctcaccaaggcccagagggacgctatcgaagactgc ctgctggccgtgtgcagcaagctcagacctttcatgatgcagcctctgctgcagagactt gtgtttgatgtccccctgctttctgagaccaccaagatgcctctcaagctgctgaccaat cactttgagcagagctggaaatactattgtctgattggacgatctggatctctgtgctcc gcctctgaggaggaactccatctttccaggaagctgttctggggagtgttcaaggccttg gccaagaaaagctacgatgcagatctgttccggctggctctgctgtgcctgggggccgtg ggaggggccctgcccccggaccacatggaccacgcctgtgtgtcctggctggagaaacac gccaccatggacccccagcagcacttcgacccccagcctgtagacacaaccaatgtgttg gtgccagacaggctggagctggtagtgaacaagtatgccgaacacactcatgagaagtgg tcactggacaagtttgccaggggatgggtccacggggagcagctgtgtgagaacgccaaa gtccaccctcttctgaagccttaccgagcattggccgagaaggataaggagacataccgc tgggccataagggagacagtgaggagcatgctggcttttggctggaccatcgagagaacc aaagatggggatgcttgcggcctgcacacctgtgcacgacggatctcccagtctggacag ctgtcgtttgaaggagcatcaaccttcagccccaagcccatggacatgagcagcatcacc cttacctgggaccagtgttcgatggctgaactgctggctgagaactaccacaacacttgg gctaggaagaagatgctggaactggaggctaaaggcggaggcagtcattccctgctggtt tcctacgataccctttctggcaaagagaaatccagactccgggagagagctcaggatgtc cttaagtttctgcagcttaatggcttaacagtttggagggacaggaagtccgtagagatg gagtctccagccatcgccaaccgcttcgcctacaccttcctccagcagctcctcttctac acagaggaggctcaggaacacatgctggagatggaggtcatgcaggccagaggacagatg accaaaggagagagaaccccacatcagcaagagatttatttcttcagcaaggtcattctg cccctggtggagcactacctgaagaaccacctcagctacttcctgtctacctcgaacagc tcccatggcaacggtggccacgcctccaacaaggagaaggagatggtagccagcctcttc tgcaagctgggggctctggtcagacacaggacctctctgtttggcagcgatgcctcatca atcgtcagctgccttcacatcctggcacagtctctagacgccagaaccctgatgaagacc gccccggagtggctcaggtcgtctctgcgatccttcttcgaggcggcggcggtggacctg gaagtgaccgtggagaacctgtcgatgacgttgggacctcagagccgagcccagcccaga ggagtggcccagctcctggtctacaccacctccacgctgctgccctgcctcactgccttg ttccagcacctgggctcacagcaacatggacaagacctactggtggacgggatccaggtg tcctgttataagatcctcaacagtctctactctctggggaccagccaaagcccttacgct gacggacagagaccagccgcaggggcttgtctcgctgccttgtctggagctttccctgtg tgcttcctggagcctgatctcaacgaggacaacccttactctgtctacaactccatgagc cccacagagagagaggaactaggagtgtttgacctggtggaggaagtgtgtcctcgcctc ccgtccctccagaaggctctgggggaggttgaggagctggtgggggccggctccggggcc cgcctggcccagtacgcccacgtcaccgaggtcaccctgcccctgctctgcagctacgtg gcccgctggtgggcctggggcccccagggccagtctgacagcgacggccccgtcttcacc tgtctcaccccccagcacgccagcaccctgctggggaacattctgcgcgtcatccacaat cacctggggacgagacagggggactggatgaaacgcctggcggtgttctctcagccaatc gtgggccaggcctgcccggagctcctggagagccacttcctgcctctgatggagaagctg aagacgagggcggaggcagtgctgctggaggaggagcacgccaaggcagagggccgcagc cttgagtctgactcggaggcagagctgagggtacaggagaggttctctgtgctggtcagg gatctctacgccttctaccctctcctcatcccctttgttgactgcaatagagccaggtgg ttacgtgagcccagcccagaggctgagaagttgttcagcatggtggcagacatcttcata ttctgggccaagtcacataatttcaaatgggaggaacaaaattacgtggtccagaatgag atcaacaacatggccttcttggtcaacaatgacagcaacatgtctaaggtgtcccaccag gagaggaggaagaccaagaggaagggagaccgctactccacacacacttccctgatcgtc gcttcactgaaacggctacttcctgtcggcctgagtgtttgttcccacggcgaccagggg ctcatcttccaagcgaagagccgattttctcagaaggacactgaggaggagattcaagag agtgtgtttaatggccttcttcaaattcagacccagaactccccaggtgtctgctggcag gatgccctggtccaggggtcacctggccaggcaggggggccctcagacccccacagggcc acacagagggtcatcgacatcgcccgtgttctccaccatctagaccaggtggaacaccct gagaggactaagaaagccgtgtggaacaaggtgttatccaagcagaggaagagggcagtg gtggcttgcctgaggatggctcctctctacatcctgcctagacatcgcgctgtcaacctc ttcctgcagggttatgataagttctggatctctgctgatgatcacagctttgaggagaag ctggtggaggatttagcaagaacaggaagggcctgtcagagggagcaggaagaggaggcg gaggaaggagccaatcagatggaccctcttcaccaactcatcactctgttcagccacact gccttgacggaaaggagcaggcttgaggacgacagtctctacctctcctttgctgccatc cttgcaaagagctgccacgaggaggaagaggagtacgaggaagaggaggtgaaaacattt gaagagaaggagctggagaagcagaagctgctgtaccagcaggcccggctgcacggccgc ggggctgcagagatggtgctgcagaccatcagctccagcagaggtaccatggggtccatg gtggtctgtactctgaaacttggtatcgcaatcctcaatggagggaacaccactgtccag cagaaaatgctcgactatttgaaggagaagaaggatgtgggcttcttccagagcgtggct ggcctcatgcagtgctgtagcgtgctcgacctgaatgcgtttgagaggcagaacaaggca gagggattaggcatggttattgaggagagctcaggggataaggtcatgagcgacagtgag ttgacctctgacctgttccgcttcctgcagcttctctgtgagggccacaactcagatttt cagaactacctcagaacacaaacgggaaacaataccactgtcaacatcatcatatccacc gttgactatctgctgagagtgcaggagtccatcagtgacttctactggttctactctggg aaggcagtgatagacgaacatggcaggaagaacttctccaaggccatcagtgtggccaag caggtcttcaactcactcacagagtacatacagggtccgtgcacggggaaccagcagagc ctggcccacagtcgtttgtgggatgcagtggttggcttcctccatgtttttgctcacatg cagatgaagctctcccaggattccagtcaaatcgagcttctcaaagacctgatggatttg caaaaggatatggttgttatgttgttatccatgttggaaggcaatgtggttaacggaact atcggtaaacagatggtagacatgctagtggaatcatcaagcaacgtagagatgatcctc aagttcttcgacatgttcctcaaactcaaagacctcacgtcctccgaagccttcaaagag tacgaccccgacggcaagggccgcgtttccaagaaggacttcctgaaggccatggaggct tgcaagcgtttctcccagtccgagacccacttcctgctctcctgcgtcgagaccaacgaa ggcgagctcctggactacgtggccttcgtggatcgtttccacgagccggccaaggacatc ggcttcaacatggccgtcctcctgaccaacctgtcggagcacatgccccacgactcccgc ctggccaccttcctgcagctggcagaatgtgtcctcagctacttccagccctacctgggc cgcatcgagatcctgggcagtgggaaacgcatcgagagggtctactttgagatcagcgag tccagccggacgcagtgggagaagccccaggtgaaggagtccaagcgccagttcatcttc gacgtggtgaacgagggcggggagaaggagaagatggagatgttcatcaacttctgcgag gacaccatctttgagatgcagctggcttctcagatctcgggctcggacggcggggagcga gcggcgagcgacgagggggaggagaagaaggagaaggaacaggggcatgaaggggaggga aggcccaaacctgggctcttctccggttccaccgtctggttcctcgtctgtgctctaccc tatggactgatgatgctggtctccgtgctctctgtgaagaacctgaagaaacagttgagg aggatgactctgaaggacatggctgtgggcgtggcctccttcttcaggggcatcgttatg gctctggtccgatgggtgtgtggcctgactcggggcctcgtctatatcctgtacctggtg ttcgtcaacgggggtctggtggagggagccaagaggatgacggtggtggagctgctgtgc gggatccttgacccgacctcggacgaggtgagcgggtggtcgggaggggagcgacagagg agatcctctgccatgtttgcgtctcaccaggaggacagggacacggcccagactgcagac gcctcccccagggacgccaactccctcaccgacatgtttggtctgcgcctgaggaaggat ggagggcagtacacgttattgacccatgacctgagttctagtctgactgacctcttcaat gctgccacgggtcatcgaggcatgacagataccatcagaaaatatcaggctcaagtttcc cagaggggagacggtgaggagtccgaaacgaaactgtctgattctgaaaaatctccagaa gaggcctcaaacaagaagtccaaatggaggtccaggagaacatctaaaccagaagtccct gagccccaacagtcagccttctgggatatgattagcactcagcacaaaatacttttgaac tactttgcgaggaatttctacaacatgcggatgcttgctttgtttgttgctttcgcaatc aacttcattctcctcttcttcaaggtctcttcctcctctgccacagcccaggcaggagag gacgtaactgtgttgcacaccagccccctggagctgggtggaggccatggtggaggccat ggtggaggccatggtggaggccagggtggaggccaggaccctgtgagaaatgaccacaga cagtcagacagcgtccattttgtcctgcaggagagctctggctacatgaagccctcgttg catttcctggccgtagctcacacgctcatctccttctgctgcatcattggctactactgc ctgaaggtcccgctggtcattttcaagcgtgagaaagaggtggcgaggaagctggagttt gacggcctctacgtcaccgcgcaaccccccgacgaagacatcaaagggcagtgggatcga ctggtcattgacacgccatcgtttcccagtaattactgggataaatttgtgaaaaggaag gtgatgggtaagtacggggagctgtatggcagcgcgcgcatcggcaggctgctggggttg gaccaggctgctctagacttcagctcccaggagcaggagagacggaggcccaggagggcc aacacttggagctccttgttgaactccatcgacgtcaagtatcagatctggaaattgggg gttgtgttcacagataattccttcctgtacctgacctggtacatgatcatgtctgtcctg ggacactacaacaacttcttctttgctgctcacctgctggacatcgccatgggcttcaag accctgcgcaccatcctgtcctctgtgacgcacaacggcaaacagctggtgctgacggtg ggcctgctggccgtggtggtctacctctacactgtggtggccttcaacttcttccgcaag ttctacaacaagactgaagatggagacacgctcaacatgaagtgtgatgatatgctcact tgctacatgttccacatgtatgtgggtgtgagagcgggtggagggatcggagacgagatt gaggatccagccggggacgagtttgaggtggtcaggatcatctttgatatcaccttcttt ttcttcgtcattgtcatcctcctggccattatacagggtttgatcatcgatgcttttggg gaacttcgggaccagcaggagcaggtgaaggaggacatggagaccaagtgtttcatttgt gggatcggaaacgactacctcgacaccgcccctcatgggtttgagacccacacactgcag gaacacaacctggctaactacctgttcttcgtgatgtacctcattaacaaggatgaaacg gaacacacaggccaggaatcctacgtgtggaagatgtaccaggaacgctgctgggagttc tttcccgtgggcgactgtttccggaagcagtatgaggatcagctgagctga

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