KEGG   Otolemur garnettii (small-eared galago): 100941062
Entry
100941062         CDS       T07855                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
oga  Otolemur garnettii (small-eared galago)
Pathway
oga01521  EGFR tyrosine kinase inhibitor resistance
oga01522  Endocrine resistance
oga04010  MAPK signaling pathway
oga04012  ErbB signaling pathway
oga04014  Ras signaling pathway
oga04015  Rap1 signaling pathway
oga04022  cGMP-PKG signaling pathway
oga04024  cAMP signaling pathway
oga04062  Chemokine signaling pathway
oga04068  FoxO signaling pathway
oga04071  Sphingolipid signaling pathway
oga04072  Phospholipase D signaling pathway
oga04140  Autophagy - animal
oga04150  mTOR signaling pathway
oga04151  PI3K-Akt signaling pathway
oga04210  Apoptosis
oga04218  Cellular senescence
oga04270  Vascular smooth muscle contraction
oga04360  Axon guidance
oga04370  VEGF signaling pathway
oga04371  Apelin signaling pathway
oga04510  Focal adhesion
oga04540  Gap junction
oga04550  Signaling pathways regulating pluripotency of stem cells
oga04613  Neutrophil extracellular trap formation
oga04625  C-type lectin receptor signaling pathway
oga04630  JAK-STAT signaling pathway
oga04650  Natural killer cell mediated cytotoxicity
oga04660  T cell receptor signaling pathway
oga04662  B cell receptor signaling pathway
oga04664  Fc epsilon RI signaling pathway
oga04666  Fc gamma R-mediated phagocytosis
oga04720  Long-term potentiation
oga04722  Neurotrophin signaling pathway
oga04726  Serotonergic synapse
oga04730  Long-term depression
oga04810  Regulation of actin cytoskeleton
oga04910  Insulin signaling pathway
oga04912  GnRH signaling pathway
oga04914  Progesterone-mediated oocyte maturation
oga04915  Estrogen signaling pathway
oga04916  Melanogenesis
oga04917  Prolactin signaling pathway
oga04919  Thyroid hormone signaling pathway
oga04921  Oxytocin signaling pathway
oga04926  Relaxin signaling pathway
oga04928  Parathyroid hormone synthesis, secretion and action
oga04929  GnRH secretion
oga04935  Growth hormone synthesis, secretion and action
oga05010  Alzheimer disease
oga05022  Pathways of neurodegeneration - multiple diseases
oga05034  Alcoholism
oga05132  Salmonella infection
oga05152  Tuberculosis
oga05160  Hepatitis C
oga05161  Hepatitis B
oga05163  Human cytomegalovirus infection
oga05164  Influenza A
oga05165  Human papillomavirus infection
oga05167  Kaposi sarcoma-associated herpesvirus infection
oga05170  Human immunodeficiency virus 1 infection
oga05200  Pathways in cancer
oga05205  Proteoglycans in cancer
oga05206  MicroRNAs in cancer
oga05207  Chemical carcinogenesis - receptor activation
oga05208  Chemical carcinogenesis - reactive oxygen species
oga05210  Colorectal cancer
oga05211  Renal cell carcinoma
oga05212  Pancreatic cancer
oga05213  Endometrial cancer
oga05214  Glioma
oga05215  Prostate cancer
oga05218  Melanoma
oga05219  Bladder cancer
oga05220  Chronic myeloid leukemia
oga05221  Acute myeloid leukemia
oga05223  Non-small cell lung cancer
oga05224  Breast cancer
oga05225  Hepatocellular carcinoma
oga05226  Gastric cancer
oga05230  Central carbon metabolism in cancer
oga05231  Choline metabolism in cancer
oga05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oga00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100941062 (RAF1)
   04012 ErbB signaling pathway
    100941062 (RAF1)
   04014 Ras signaling pathway
    100941062 (RAF1)
   04015 Rap1 signaling pathway
    100941062 (RAF1)
   04370 VEGF signaling pathway
    100941062 (RAF1)
   04371 Apelin signaling pathway
    100941062 (RAF1)
   04630 JAK-STAT signaling pathway
    100941062 (RAF1)
   04068 FoxO signaling pathway
    100941062 (RAF1)
   04072 Phospholipase D signaling pathway
    100941062 (RAF1)
   04071 Sphingolipid signaling pathway
    100941062 (RAF1)
   04024 cAMP signaling pathway
    100941062 (RAF1)
   04022 cGMP-PKG signaling pathway
    100941062 (RAF1)
   04151 PI3K-Akt signaling pathway
    100941062 (RAF1)
   04150 mTOR signaling pathway
    100941062 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100941062 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    100941062 (RAF1)
   04218 Cellular senescence
    100941062 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100941062 (RAF1)
   04540 Gap junction
    100941062 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100941062 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100941062 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100941062 (RAF1)
   04625 C-type lectin receptor signaling pathway
    100941062 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    100941062 (RAF1)
   04660 T cell receptor signaling pathway
    100941062 (RAF1)
   04662 B cell receptor signaling pathway
    100941062 (RAF1)
   04664 Fc epsilon RI signaling pathway
    100941062 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    100941062 (RAF1)
   04062 Chemokine signaling pathway
    100941062 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100941062 (RAF1)
   04929 GnRH secretion
    100941062 (RAF1)
   04912 GnRH signaling pathway
    100941062 (RAF1)
   04915 Estrogen signaling pathway
    100941062 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    100941062 (RAF1)
   04917 Prolactin signaling pathway
    100941062 (RAF1)
   04921 Oxytocin signaling pathway
    100941062 (RAF1)
   04926 Relaxin signaling pathway
    100941062 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    100941062 (RAF1)
   04919 Thyroid hormone signaling pathway
    100941062 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    100941062 (RAF1)
   04916 Melanogenesis
    100941062 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100941062 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    100941062 (RAF1)
   04720 Long-term potentiation
    100941062 (RAF1)
   04730 Long-term depression
    100941062 (RAF1)
   04722 Neurotrophin signaling pathway
    100941062 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    100941062 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100941062 (RAF1)
   05206 MicroRNAs in cancer
    100941062 (RAF1)
   05205 Proteoglycans in cancer
    100941062 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    100941062 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100941062 (RAF1)
   05230 Central carbon metabolism in cancer
    100941062 (RAF1)
   05231 Choline metabolism in cancer
    100941062 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100941062 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100941062 (RAF1)
   05212 Pancreatic cancer
    100941062 (RAF1)
   05225 Hepatocellular carcinoma
    100941062 (RAF1)
   05226 Gastric cancer
    100941062 (RAF1)
   05214 Glioma
    100941062 (RAF1)
   05221 Acute myeloid leukemia
    100941062 (RAF1)
   05220 Chronic myeloid leukemia
    100941062 (RAF1)
   05218 Melanoma
    100941062 (RAF1)
   05211 Renal cell carcinoma
    100941062 (RAF1)
   05219 Bladder cancer
    100941062 (RAF1)
   05215 Prostate cancer
    100941062 (RAF1)
   05213 Endometrial cancer
    100941062 (RAF1)
   05224 Breast cancer
    100941062 (RAF1)
   05223 Non-small cell lung cancer
    100941062 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100941062 (RAF1)
   05161 Hepatitis B
    100941062 (RAF1)
   05160 Hepatitis C
    100941062 (RAF1)
   05164 Influenza A
    100941062 (RAF1)
   05163 Human cytomegalovirus infection
    100941062 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100941062 (RAF1)
   05165 Human papillomavirus infection
    100941062 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100941062 (RAF1)
   05152 Tuberculosis
    100941062 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100941062 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    100941062 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    100941062 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100941062 (RAF1)
   01522 Endocrine resistance
    100941062 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oga01001]
    100941062 (RAF1)
Enzymes [BR:oga01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100941062 (RAF1)
Protein kinases [BR:oga01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100941062 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 100941062
NCBI-ProteinID: XP_012664687
Ensembl: ENSOGAG00000003256
UniProt: H0WME6
LinkDB
Position
Unknown
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRIPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIEIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPIF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcttggaagacgatcagcaatggttttggatttaaagatgcg
gtgtttgatggctccagctgcatctcccctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagattcttctaagacaagcaacactatacgagtt
ttcttgccgaacaagcaaagaacagtggtaaatgtacgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccatgaacacaaaggtaaaaaagcccgtttagattggaatactgatgctgcctct
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctaaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgaacactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgtttccaaattccacc
attggtgatagcggggtcccagcactgccttctttgacgatgcgtcgtatgcgagagtct
gtttcccggatacctgttagttcccagcaccgatattccacacctcatgccttcacgttc
aacacctccagcccctcctctgaaggttccctctcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccactcttcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcttcaccttcagccctgtccagcagccccaacaatctg
agcccaacaggctggtcacagcctaaaacacctgtgccagcacaaagagagcgggcacca
ggatctgggacccaggagaagaacaaaattaggcctcgtggacagagagattcaagctat
tactgggagatagaagccagtgaagtgatgctttccactcggattggatcaggctccttt
ggaactgtttataagggcaaatggcatggagacgtcgcagtaaagatcctaaaggttgtt
gacccaaccccagagcagttccaggccttcaggaatgaggtggctgtcttgcgcaaaaca
cggcatgtgaacattctgctcttcatggggtacatgacaaaggacaacctggcgattgtg
actcagtggtgtgagggcagcagcctctacaaacacctgcacgtccaggagaccaagttt
cagatgttccagttaattgaaattgcccggcagacggctcagggaatggactatttgcat
gcgaagaacattatccacagagacatgaaatccaacaatatatttctccatgaaggccta
acggtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggctctcag
caggttgaacaacccactggctctatcctgtggatggccccagaggtgatccgaatgcaa
gataacaacccattcagcttccagtctgacgtctactcctatggtattgtgctgtatgag
ctgatgacaggggagcttccttactcccacatcaacaatcgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatctcagtaagttatacaagaattgcccgaaagca
atgaagaggctggtagctgactgtgtgaagaaagttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctacccaagattaaccggagtgct
tctgagccatccctgcaccgggcagcccacactgaggatatcaatgcttgcacgctgacc
acatccccaagactgcccattttctag

DBGET integrated database retrieval system