Otolemur garnettii (small-eared galago): 100943020 Help Entry 100943020         CDS       T07855                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism oga  Otolemur garnettii (small-eared galago) Pathway oga01521   EGFR tyrosine kinase inhibitor resistance oga01522   Endocrine resistance oga04010   MAPK signaling pathway oga04012   ErbB signaling pathway oga04014   Ras signaling pathway oga04062   Chemokine signaling pathway oga04068   FoxO signaling pathway oga04072   Phospholipase D signaling pathway oga04150   mTOR signaling pathway oga04151   PI3K-Akt signaling pathway oga04510   Focal adhesion oga04540   Gap junction oga04630   JAK-STAT signaling pathway oga04650   Natural killer cell mediated cytotoxicity oga04660   T cell receptor signaling pathway oga04662   B cell receptor signaling pathway oga04664   Fc epsilon RI signaling pathway oga04714   Thermogenesis oga04722   Neurotrophin signaling pathway oga04810   Regulation of actin cytoskeleton oga04910   Insulin signaling pathway oga04912   GnRH signaling pathway oga04915   Estrogen signaling pathway oga04917   Prolactin signaling pathway oga04926   Relaxin signaling pathway oga04935   Growth hormone synthesis, secretion and action oga05034   Alcoholism oga05160   Hepatitis C oga05161   Hepatitis B oga05163   Human cytomegalovirus infection oga05165   Human papillomavirus infection oga05200   Pathways in cancer oga05205   Proteoglycans in cancer oga05206   MicroRNAs in cancer oga05207   Chemical carcinogenesis - receptor activation oga05208   Chemical carcinogenesis - reactive oxygen species oga05210   Colorectal cancer oga05211   Renal cell carcinoma oga05213   Endometrial cancer oga05214   Glioma oga05215   Prostate cancer oga05220   Chronic myeloid leukemia oga05221   Acute myeloid leukemia oga05223   Non-small cell lung cancer oga05224   Breast cancer oga05225   Hepatocellular carcinoma oga05226   Gastric cancer oga05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:oga00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100943020 (SOS2)    04012 ErbB signaling pathway     100943020 (SOS2)    04014 Ras signaling pathway     100943020 (SOS2)    04630 JAK-STAT signaling pathway     100943020 (SOS2)    04068 FoxO signaling pathway     100943020 (SOS2)    04072 Phospholipase D signaling pathway     100943020 (SOS2)    04151 PI3K-Akt signaling pathway     100943020 (SOS2)    04150 mTOR signaling pathway     100943020 (SOS2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100943020 (SOS2)    04540 Gap junction     100943020 (SOS2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100943020 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     100943020 (SOS2)    04660 T cell receptor signaling pathway     100943020 (SOS2)    04662 B cell receptor signaling pathway     100943020 (SOS2)    04664 Fc epsilon RI signaling pathway     100943020 (SOS2)    04062 Chemokine signaling pathway     100943020 (SOS2)   09152 Endocrine system    04910 Insulin signaling pathway     100943020 (SOS2)    04912 GnRH signaling pathway     100943020 (SOS2)    04915 Estrogen signaling pathway     100943020 (SOS2)    04917 Prolactin signaling pathway     100943020 (SOS2)    04926 Relaxin signaling pathway     100943020 (SOS2)    04935 Growth hormone synthesis, secretion and action     100943020 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     100943020 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     100943020 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100943020 (SOS2)    05206 MicroRNAs in cancer     100943020 (SOS2)    05205 Proteoglycans in cancer     100943020 (SOS2)    05207 Chemical carcinogenesis - receptor activation     100943020 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     100943020 (SOS2)    05231 Choline metabolism in cancer     100943020 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     100943020 (SOS2)    05225 Hepatocellular carcinoma     100943020 (SOS2)    05226 Gastric cancer     100943020 (SOS2)    05214 Glioma     100943020 (SOS2)    05221 Acute myeloid leukemia     100943020 (SOS2)    05220 Chronic myeloid leukemia     100943020 (SOS2)    05211 Renal cell carcinoma     100943020 (SOS2)    05215 Prostate cancer     100943020 (SOS2)    05213 Endometrial cancer     100943020 (SOS2)    05224 Breast cancer     100943020 (SOS2)    05223 Non-small cell lung cancer     100943020 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     100943020 (SOS2)    05160 Hepatitis C     100943020 (SOS2)    05163 Human cytomegalovirus infection     100943020 (SOS2)    05165 Human papillomavirus infection     100943020 (SOS2)   09165 Substance dependence    05034 Alcoholism     100943020 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100943020 (SOS2)    01522 Endocrine resistance     100943020 (SOS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH IQ_SEC7_PH PH_19 RHG20_PH PH_13 Motif Other DBs NCBI-GeneID:  100943020 NCBI-ProteinID:  XP_003792205 Ensembl:  ENSOGAG00000014279 UniProt:  H0XAX0 LinkDB All DBs Position Unknown AA seq 1332 aa AA seqDB search MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD IGLISLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFRPSDI EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI LSPEFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA CSEEQEDRECLNQAITALLNLQGSMDRIYRQYAPRRRPGDPVCPFYNRQLRSKHLAIKKM NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG YSSAEYRLKEKFVMRKIQICDKEDTCEYKHAFELVSKDENSIIFAAKSAEEKNNWMAALI SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR KVAEITGEIQQYQNQPYCLRIEPEIRRFFENLNPMGNASEKEFTDYLFNKSQEIEPRNCK QPPRFPRKTTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESAA SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGNLHKLS EETLIPPPLPPRKKFDHDASNSKGNTISDDDPPAIPPRQPPPPKVKPRVPVPAGAFDGPL HSPPPPPPRDPLPDTPPPIPLRPPEHFINCPFNLQPPPLGHLHRDPDWFRDVSTCPNSPS TPPSTPSPRVPRRCHMLSSSHNNLAHPPAPPVPPRQSSSPHLPKLPPKTYKRELSHPPLY RLPLLENAETPQ NT seq 3999 nt NT seq  +upstreamnt  +downstreamnt atgcagcaggcgccgcagccgtacgagttcttcagcgaagagaacagcccgaaatggcgg ggactgttggtgtcggccctgcggaaggtgcaggaacaagtacatcccaatctttcagct aatgaagagtctctctattatattgaagagttgatttttcagctgcttaataaattatgc atggcccaaccaaggacagttcaagatgtggaggaacgagttcaaaagacctttcctcac ccaattgataaatgggctattgctgatgcacaatctgccatagagaaacgaaaacgaaga aatcctcttttactgcctgtggacaaaatccatccttcattgaaggaagttttagggtac aaagtggactaccatgtgtcactatatattgtggctgtactagagtatatctctgctgat attttgaagttggctggtaattatgtttttaatatccgacattatgaaatatctcagcag gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac ataggtttgatttctctctgtgaggacgaacctagttcttcaggtgaattaaactactat gaccttgtcagaactgaaattgcagaagaaagacagtatctgcgggaactgaatatgatc ataaaagtatttcgagaagccttcctttctgacaaaaaactgtttagaccttctgacatt gaaaagatttttagtaacatttcagatatacatgaattgactgtgaaacttttaggcttg attgaagacactgttgaaatgactgatgaaagcagtcctcatcccttagctggcagctgt tttgaagatctggcagaagaacaagcatttgatccttatgaaacgttatcacaggacatt ctttcaccagagtttaatgaacatttcagtaaactaatggccagacctgcagttgctcta cactttcagtccattgctgatggttttaaagaggcagttcgttacgttcttccacgcctt atgctggtgccagtatatcattgttggcactattttgaattattaaagcaattgaaagca tgtagtgaagagcaagaagacagagagtgtttgaatcaagctattactgccctcctgaat ctccagggtagcatggaccgaatttacaggcagtatgcacctagacgtcgacctggggat cctgtttgccctttttataatcgtcaattaagaagcaagcacctggctatcaaaaaaatg aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgcaat gaattcattatggaaggaccattgacaagaattggtgctaaacatgaacggcatattttt ctctttgatggcttaatgatcagttgtaaacctaatcatggccagacccgacttccaggt tacagtagtgctgaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatctgt gataaagaagatacctgtgagtacaaacatgcttttgaattagtatccaaagatgaaaac agcataatatttgctgctaagtctgctgaagagaaaaacaattggatggcagccctcatt tctcttcattatcggagtactctagatcgaatgctagattcagtattattgaaagaagaa aatgagcagccattgagattaccaagtccagaagtgtatcgttttgtagtaaaagactct gaggaaaatatcgtttttgaagacaacttgcaaagtcgaagtggaatccccattattaaa ggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat tttgtccgtacttttcttaccacgtatcgttcattttgtaaaccacaggaattgctaagc ttactgattgaacgatttgaaattccagagccagaacctactgaagcagacaaactggca atagagaaaggcgagcagccaatcagtgcagaccttaaaagatttcgcaaggaatatgtc caaccagtgcaacttaggatcttaaatgtgtttcggcactgggttgaacaccatttttat gactttgaaagagatttggaattacttgaaagactagaatccttcatttcaagtgtaaga gggaaagctatgaagaaatgggtggagtcaattgctaagatcatcaagaggaagaagcaa gctcaggcaaatggaataagccataatattacctttgaaagtccccctccaccaattgaa tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacacttcatccaata gaaattgcacgtcagctaacacttttggaatctgatctctacaggaaagttcaaccatct gaacttgtagggagtgtctggaccaaagaagataaggaaataaattctccaaatttatta aaaatgattcgccataccacaaatcttacactctggtttgaaaaatgcattgtggaagca gaaaattttgaagaacgagtagcagtactgagtagaattatagaaattctgcaagttttt caagatttgaataacttcaatggtgtattggagatcgtcagtgcagtaaattcagtgtca gtctacagactagaccatacctttgaggcattgcaggaaagaaaacggaaaattttggat gaagctgtggaactgagtcaagatcactttaaaaaatacttagtaaaacttaaatcaatt aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaa gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg aaagtagctgaaattactggagaaattcagcagtatcagaatcagccttactgtttacgg atagaaccagaaataaggagattctttgaaaaccttaaccccatgggaaatgcatctgaa aaagagtttacagattatttgttcaataaatcacaagaaatagaaccccgaaattgcaaa cagccacctcgatttccgaggaagacaactttctccctaaaatctcctggaataaggccc aacacaggccgacatggctctacctcaggcactttacgaggtcacccaacaccattagaa agagaaccatgtaaaataagctttagtcgaattgctgaaacggagctggagtcagcagcg tcagcacccacctctccaaacacaccatctactccaccagtatctgcttcttcagacctc agtgtgtttttagatgtggatctcaacagttcctgtggcagcaatagcatctttgctcca gtgctcctgccacattcaaagtctttcttcagttcctgtggtaatttacataaactaagt gaagagacactgattccacctccacttcctcctcgaaaaaagtttgatcatgatgcttca aattccaagggaaatacgatatctgatgatgaccctcctgctattccaccgagacagcct cctcctccaaaggtaaaacccagagttcctgttcctgctggcgcatttgatgggcccctg catagtccacctccaccaccgccaagagatcctcttccagatacccctcctccaattccc ctgcggcctccagaacacttcataaactgtccatttaatcttcagccgcctccactggga catcttcacagagatccagactggttcagagatgttagtacatgtccaaattcgccaagc actcctcctagcacaccctctccacgggtaccacgtcgatgccacatgctcagctctagt cataacaatcttgctcatcctccagcaccccctgttccaccaaggcagagttcaagccct cacctgccaaaactgccaccaaagacttacaaacgggagctttcgcatcccccattgtac agactgcctttgctagaaaatgcagaaactcctcaatga

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