Otolemur garnettii (small-eared galago): 100948829
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Entry
100948829 CDS
T07855
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
oga
Otolemur garnettii (small-eared galago)
Pathway
oga00562
Inositol phosphate metabolism
oga01100
Metabolic pathways
oga01521
EGFR tyrosine kinase inhibitor resistance
oga04012
ErbB signaling pathway
oga04014
Ras signaling pathway
oga04020
Calcium signaling pathway
oga04062
Chemokine signaling pathway
oga04064
NF-kappa B signaling pathway
oga04066
HIF-1 signaling pathway
oga04070
Phosphatidylinositol signaling system
oga04072
Phospholipase D signaling pathway
oga04360
Axon guidance
oga04370
VEGF signaling pathway
oga04380
Osteoclast differentiation
oga04611
Platelet activation
oga04613
Neutrophil extracellular trap formation
oga04625
C-type lectin receptor signaling pathway
oga04650
Natural killer cell mediated cytotoxicity
oga04662
B cell receptor signaling pathway
oga04664
Fc epsilon RI signaling pathway
oga04666
Fc gamma R-mediated phagocytosis
oga04670
Leukocyte transendothelial migration
oga04722
Neurotrophin signaling pathway
oga04750
Inflammatory mediator regulation of TRP channels
oga04919
Thyroid hormone signaling pathway
oga04933
AGE-RAGE signaling pathway in diabetic complications
oga04935
Growth hormone synthesis, secretion and action
oga05167
Kaposi sarcoma-associated herpesvirus infection
oga05169
Epstein-Barr virus infection
oga05170
Human immunodeficiency virus 1 infection
oga05171
Coronavirus disease - COVID-19
oga05200
Pathways in cancer
oga05205
Proteoglycans in cancer
oga05206
MicroRNAs in cancer
oga05214
Glioma
oga05223
Non-small cell lung cancer
oga05225
Hepatocellular carcinoma
Module
oga_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
oga00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100948829 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
100948829 (PLCG2)
04064 NF-kappa B signaling pathway
100948829 (PLCG2)
04066 HIF-1 signaling pathway
100948829 (PLCG2)
04070 Phosphatidylinositol signaling system
100948829 (PLCG2)
04072 Phospholipase D signaling pathway
100948829 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100948829 (PLCG2)
04613 Neutrophil extracellular trap formation
100948829 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
100948829 (PLCG2)
04662 B cell receptor signaling pathway
100948829 (PLCG2)
04664 Fc epsilon RI signaling pathway
100948829 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
100948829 (PLCG2)
04670 Leukocyte transendothelial migration
100948829 (PLCG2)
04062 Chemokine signaling pathway
100948829 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
100948829 (PLCG2)
04919 Thyroid hormone signaling pathway
100948829 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
100948829 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
100948829 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
100948829 (PLCG2)
04380 Osteoclast differentiation
100948829 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100948829 (PLCG2)
05206 MicroRNAs in cancer
100948829 (PLCG2)
05205 Proteoglycans in cancer
100948829 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100948829 (PLCG2)
05214 Glioma
100948829 (PLCG2)
05223 Non-small cell lung cancer
100948829 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100948829 (PLCG2)
05171 Coronavirus disease - COVID-19
100948829 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
100948829 (PLCG2)
05169 Epstein-Barr virus infection
100948829 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100948829 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100948829 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
oga04131
]
100948829 (PLCG2)
Enzymes [BR:
oga01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100948829 (PLCG2)
Membrane trafficking [BR:
oga04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100948829 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
100948829 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
SH3_9
PH
PH_12
EF-hand_PLCG1
SH2_1
SH3_2
PH_14
Adhesin_E
Motif
Other DBs
NCBI-GeneID:
100948829
NCBI-ProteinID:
XP_003791350
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MTTMVNVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAARQKEDCCLTILYGSQFVLSTLSLAADSKEDAV
KWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSA
KSLKDRFVEIGAHKDELSFEQFHLFYKNLMFEQQKLILDEFKKDSSVFMLGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYVRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKT
FKEVFGDLLLMKPTEASADQLPSPSQLREKILIKHKKLGPRGDVDVNVDDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEELPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCTETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDML
MRIPRDGAFLIRRREGSDSFAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVNYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSITRQKPLDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWVCGSQMVALNFQSADKY
MQMNHALFSLNGRTGYVLQPESMRTETYHPMPPESQRKIQMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNMAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVLCEMRPVLECEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNQNQLQLYQEKCSRRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccaccatggtcaacgtggatgcccttccagagtatgagaagagtcagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacacggcaggtggcctggagtaagaccgctgacaag
atagagggcttcttggatatcatggaaattaaggaaatccgcccagggaagaattccaag
gactttgagcgcgcaaaagcggcccgtcagaaggaggactgctgcctgaccatcctgtac
ggctcccagttcgtcctcagcacgcttagcctggcagctgactctaaagaggatgccgtt
aagtggctgtctggcttgaaaatcttacaccaagaagcaatgaacgcatccacaccgacc
atgatcgagagttggctgagaaagcagatttattctgtggatcaaaccagaaggaacagc
atcagcctccgagagttgaagaccatcttgcccctggtcaacttcaaagtgagcagcgcc
aagtccctcaaagataggttcgtggaaataggtgcgcacaaagacgagctcagctttgaa
cagttccatctcttctataaaaaccttatgtttgagcagcagaaattgattcttgatgaa
ttcaaaaaggattcctccgtgttcatgctggggaacacggaccggccggatgcctctgct
gtctacctgcatgacttccagaggtttctcctacatgaacagcaggaactttgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcatcgatgacaccatgcgggaaact
gccgagcctttcctgttcgtggatgagttcctcacctacctgttctcacgagaaaacagc
atctgggatgagaagtatgatgtggtggacatgcaggacatgaacaaccccttgtcccat
tactggatttcctcatcacacaacacgtacctgacgggggaccagctgcggagcgagtcg
tccacagaggcgtacgtccgctgtctgcgcatgggctgccgctgcatcgagttggactgc
tgggacgggcccgacgggaagcccatcatctaccatggctggacgaggaccaccaagatc
aagtttgatgatgttgtgcaggccatcaaagaccacgcctttgtaacctcaagcttcccg
gtgatcctgtccatcgaggaacactgcagtgtggagcagcagcgccacatggccaagacc
ttcaaggaggtgtttggggacctgcttctgatgaagcccacggaggccagtgccgaccag
ctgccctcacccagccagctgcgggagaagatcctcatcaagcataagaagctgggtccc
cgaggtgacgtggatgtcaacgtggatgacaagaaggatgaacacaagcaacagggtgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccatcgctgat
gccaagctgtcttttagtgacgatattgaacagactgtagaggaagaactgccccaggat
ataccccccacagagctgcattttggggagaagtggttccacaagaaggttgagaagagg
acgagtgccgagaagctgctccaggaatactgcacggagacggggggcaaggacggtacc
tttttggtgcgggagagtgagaccttccccaacgactacaccctgtccttctggcgctca
ggccgtgtccagcactgccggatccgctccaccatggagggcgggaccctgaagtactac
ctgactgacaacctgaccttcaccagcatctacgccctcatccagcactaccgcgagacg
cacttgcgctgcgccgagttcgagctgcggctcaccgaccccgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacaggctgagccgtggagaagcagaggacatgctg
atgagaattccccgggatggagccttcctcatccggaggcgggaaggaagcgactccttc
gccatcacctttagggctagaggcaaggtgaagcactgccggatcaaccgagacggcaga
cacttcgtgctggggacctctgcctactttgagagcctggtggagctcgtcaattactat
gagaagcatgccctctaccggaagatgcgtctgcgctaccctgtgacccccgagctcctg
gagcgctataacatggaaagagatataaactccctctatgacgtcagcaggatgtatgtg
gatccgagtgaaatcaacccgtccatgcctcagagaacggtgaaagctttgtatgactac
aaagccaagcaaagtgacgagctgagcttctgccgtggggccctcatccacaatgtctcc
aaggagcctgggggctggtggaaaggagattatgggaccagaatccagcagtacttcccg
tctaactatgtcgaggacatttcaaccgccgatgttgaggagctggagaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtt
gtgaaagccccgcaggggaaaaaccagaagccgtttgtctttatcctggagcccaagaag
caaggtgatcctccggtggagtttgccacagacaaggtggaagagctcttcgagtggttc
cagagcatccgtgagatcacctggaagatcgataccaaggagaacaacatgaagtactgg
gagaagaaccagtccattgccatcgagctctctgacctcgttgtttactgcaaacccacc
agcaaaaccaaggataatttagaaaatcctgacttccgagaaatccgttccttcgtggag
acaaaggcagacagcatcacccgacagaagcccctagatctcttgaagtacaatcaaaag
ggcctgacccgcgtctaccccaagggacaaagggttgactcctccaactacgatcccttc
cgcctctgggtgtgcggctcccagatggtggcgcttaatttccagtctgcagataagtac
atgcagatgaatcacgcgttgttttctctcaacgggcggacgggctacgtcctacagcct
gagagcatgaggacagagacgtaccacccgatgccacctgagtcccagaggaagatccag
atgacgctgactgtcaaggttctcggcgcccgccatctccccaaacttgggcgaagtatt
gcctgtccttttgtagaggtggagatatgtggagccgagtatgacaacaacaagtttaag
acgacagttgtgaatgataacggcctcagccctgtctgggctccaacacaggagaaggtg
acgtttgagatttacgacccaaacatggcgtttctacgctttgtggtttacgaggaagac
atgttcagtgatcccaactttcttgctcacgccacttaccccattaaaggaatcaagtca
ggattcagatctgttcctctgaagaatgggtacagtgaggacatcgagcttgcttccctc
ctggttctctgtgagatgcggccagtcctggagtgcgaggaagagctttactcctcctgt
cgccagctgcggaggcgtcaagaagagctcaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgagatgccctcattaaggaattcaatgtcaaccagaac
cagctccagttataccaggagaagtgcagccggaggttaagagagaagagggtcagcaac
agcaagttttactcgtag
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integrated database retrieval system
