KEGG   Otolemur garnettii (small-eared galago): 100955336
Entry
100955336         CDS       T07855                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
oga  Otolemur garnettii (small-eared galago)
Pathway
oga01521  EGFR tyrosine kinase inhibitor resistance
oga01522  Endocrine resistance
oga04010  MAPK signaling pathway
oga04012  ErbB signaling pathway
oga04015  Rap1 signaling pathway
oga04024  cAMP signaling pathway
oga04062  Chemokine signaling pathway
oga04068  FoxO signaling pathway
oga04150  mTOR signaling pathway
oga04270  Vascular smooth muscle contraction
oga04510  Focal adhesion
oga04650  Natural killer cell mediated cytotoxicity
oga04720  Long-term potentiation
oga04722  Neurotrophin signaling pathway
oga04726  Serotonergic synapse
oga04730  Long-term depression
oga04810  Regulation of actin cytoskeleton
oga04910  Insulin signaling pathway
oga04914  Progesterone-mediated oocyte maturation
oga04928  Parathyroid hormone synthesis, secretion and action
oga04934  Cushing syndrome
oga05010  Alzheimer disease
oga05022  Pathways of neurodegeneration - multiple diseases
oga05034  Alcoholism
oga05160  Hepatitis C
oga05161  Hepatitis B
oga05200  Pathways in cancer
oga05205  Proteoglycans in cancer
oga05208  Chemical carcinogenesis - reactive oxygen species
oga05210  Colorectal cancer
oga05211  Renal cell carcinoma
oga05212  Pancreatic cancer
oga05213  Endometrial cancer
oga05214  Glioma
oga05215  Prostate cancer
oga05216  Thyroid cancer
oga05218  Melanoma
oga05219  Bladder cancer
oga05220  Chronic myeloid leukemia
oga05221  Acute myeloid leukemia
oga05223  Non-small cell lung cancer
oga05224  Breast cancer
oga05225  Hepatocellular carcinoma
oga05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:oga00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100955336 (BRAF)
   04012 ErbB signaling pathway
    100955336 (BRAF)
   04015 Rap1 signaling pathway
    100955336 (BRAF)
   04068 FoxO signaling pathway
    100955336 (BRAF)
   04024 cAMP signaling pathway
    100955336 (BRAF)
   04150 mTOR signaling pathway
    100955336 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100955336 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100955336 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100955336 (BRAF)
   04062 Chemokine signaling pathway
    100955336 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100955336 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    100955336 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100955336 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100955336 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100955336 (BRAF)
   04720 Long-term potentiation
    100955336 (BRAF)
   04730 Long-term depression
    100955336 (BRAF)
   04722 Neurotrophin signaling pathway
    100955336 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100955336 (BRAF)
   05205 Proteoglycans in cancer
    100955336 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100955336 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100955336 (BRAF)
   05212 Pancreatic cancer
    100955336 (BRAF)
   05225 Hepatocellular carcinoma
    100955336 (BRAF)
   05226 Gastric cancer
    100955336 (BRAF)
   05214 Glioma
    100955336 (BRAF)
   05216 Thyroid cancer
    100955336 (BRAF)
   05221 Acute myeloid leukemia
    100955336 (BRAF)
   05220 Chronic myeloid leukemia
    100955336 (BRAF)
   05218 Melanoma
    100955336 (BRAF)
   05211 Renal cell carcinoma
    100955336 (BRAF)
   05219 Bladder cancer
    100955336 (BRAF)
   05215 Prostate cancer
    100955336 (BRAF)
   05213 Endometrial cancer
    100955336 (BRAF)
   05224 Breast cancer
    100955336 (BRAF)
   05223 Non-small cell lung cancer
    100955336 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100955336 (BRAF)
   05160 Hepatitis C
    100955336 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100955336 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100955336 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    100955336 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100955336 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100955336 (BRAF)
   01522 Endocrine resistance
    100955336 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oga01001]
    100955336 (BRAF)
Enzymes [BR:oga01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100955336 (BRAF)
Protein kinases [BR:oga01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100955336 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 100955336
NCBI-ProteinID: XP_023369958
Ensembl: ENSOGAG00000009646
LinkDB
Position
Unknown
AA seq 784 aa
MEPEAGAAAPSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYT
SKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVSR
SNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKK
PIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGY
KFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPISQEEASLAETALTSGSSPSAPPSDST
GPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQ
GFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDS
SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLR
KTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDY
LHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIR
MQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCP
KAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLY
ACASPKTPIQAGGYDAFKHGCVPFTKIGLKSASVKSAGLEPQACVRSRSCCVAGRGASTV
REEA
NT seq 2355 nt   +upstreamnt  +downstreamnt
atggagcccgaggccggcgctgcggccccttcagctgcggaccctgccattccggaggag
gtgtggaacatcaaacaaatgattaagttgacacaggaacatatagaggccctgttggac
aaatttggtggggagcataatccaccatctatatatctggaggcctatgaagaatacacc
agcaagctagatgccctacaacaaagagaacaacaattattggaatccctggggaatgga
actgatttttctgtttctagctctgcatcaatggacaccgttacatcttcttcctcttct
agcctttcagtgctaccttcatctctttcagtttttcaaaatcccacagatgtgtcacgg
agcaaccccaagtcaccacaaaaacctattgttagagtcttcctgcccaacaaacagagg
acagtggtacctgcaaggtgtggagttacagtccgagacagtctaaagaaagcactgatg
atgagaggtctaataccagagtgctgtgctgtttacagaattcaggatggagagaagaaa
ccaattggctgggacactgatatttcctggcttaccggagaagaattgcatgtggaagtg
ttggagaatgttccactaacaacgcacaactttgtacggaaaacttttttcaccttagca
ttttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaaacgtgtggttat
aaattccaccagcgttgtagtacagaggttccactgatgtgtgttaattatgaccaactt
gatttgctgtttgtctccaagttctttgaacatcacccaatatcacaggaagaggcctcc
ctagcagagactgcccttacatctggatcatccccttctgcacccccctcagattctact
gggccccaaatcctcaccagtccatctccttcaaaatccattccaattccacagcccttc
cgaccagcagatgaagatcatcgaaatcaattcgggcaaagagaccggtcttcatcagct
cccaatgtgcatataaacacaatagaacctgttaatattgatgacttgattagagaccaa
gggtttcgtggtgatggaggatcaaccacaggtttgtctgccacccctcctgcctcatta
cctggctcactcactaatgtgaaagccttacagaaatctccaggacctcagcgggaaagg
aagtcatcttcatcctcagaagatagaaatcgaatgaaaacacttggtaggcgggattca
agtgatgactgggagattcctgatgggcagattacagtgggacaaagaattggatctgga
tcatttggaactgtctacaaggggaagtggcatggtgatgtggcagtaaaaatgttgaat
gtgacagcacctacacctcagcagttacaagccttcaaaaatgaagtaggagtactcagg
aaaacacgacatgtgaatatcctactcttcatgggctattccacaaagccacaactggct
attgttacccagtggtgtgagggctccagtttatatcaccatctccacatcattgagacc
aaatttgagatgatcaaacttatagatattgcacggcagactgcacagggcatggattac
ttacacgccaagtcaatcatccacagagacctcaagagtaataatatatttcttcatgaa
gacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcgatggagtggg
tcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagtaatcaga
atgcaagacaaaaacccatacagctttcagtcagatgtgtatgcatttgggattgttctg
tatgaattgatgactggacagttaccttattcaaatatcaacaatagggaccagataatt
tttatggtgggacgaggatacctatccccagatctcagtaaggtacggagtaactgtcca
aaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagatgagagaccgctc
tttccccaaattctcgcctctattgagctgctggcccgctcattgccaaaaattcaccgc
agtgcatcagaaccctccttgaatcgggctggtttccaaacagaggattttagtctatat
gcttgtgcttctccaaaaacacccatccaggcagggggatatgatgcttttaaacatggc
tgtgttccctttaccaagattggcttaaagtctgcctcggtgaagagtgctgggcttgaa
ccacaggcatgtgtccgttccaggtcctgctgcgtggcgggcaggggagccagtacggtg
agggaggaagcttag

DBGET integrated database retrieval system