Otolemur garnettii (small-eared galago): 100956289 Help Entry 100956289         CDS       T07855                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism oga  Otolemur garnettii (small-eared galago) Pathway oga04020   Calcium signaling pathway oga04371   Apelin signaling pathway oga04713   Circadian entrainment oga04921   Oxytocin signaling pathway oga04970   Salivary secretion oga05010   Alzheimer disease oga05012   Parkinson disease oga05020   Prion disease oga05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:oga00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100956289 (RYR3)    04020 Calcium signaling pathway     100956289 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100956289 (RYR3)   09154 Digestive system    04970 Salivary secretion     100956289 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     100956289 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100956289 (RYR3)    05012 Parkinson disease     100956289 (RYR3)    05020 Prion disease     100956289 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     100956289 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oga04040]     100956289 (RYR3) Ion channels [BR:oga04040]  Voltage-gated cation channels   Ryanodine receptor    100956289 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  100956289 NCBI-ProteinID:  XP_012661754 Ensembl:  ENSOGAG00000011146 LinkDB All DBs Position Unknown AA seq 4884 aa AA seqDB search MNREHGLTDWRSKNGRLGKENVFLSASGRAVPEEDEVVLQCITTVHKEQRKFCLAAEGLG NRLCFLEPTSEAKYIPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLL YGHAILLRHSFSGMYLTCLTTSRSHTDKLAFDVGLREHGTGEACWWTIHPASKQRSEGEK VRIGDDLILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVV RLFHGHDECLTIPSTDQNDAQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAF RLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSFRPSKEIKEKLDSSHKRDIEGMGVP EIKYGDSICFVQHIASGLWVTYKAQDAKTPRLGPLKRKVILHQEGHMDDGLTLQRCQREE SQAARIIRNTTALFSQFVSGNNRTAAPVALPIQEVLQTLQDLIAYFQPPEEEMQHEDKQN KLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLL AALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSI ISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRP NIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNG VGDDLYSYGFDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQG MFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPV KEYKRDAEGIRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNK IELGWTFGKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAQVNPAA EEELKKVKLPKNYMMSNGYKPAPLDLSDMKLLPPQEILVDKLAENAHNVWAKDRIKQGWT YGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPGVE KVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFE GSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIE NGFVPICSLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTF VNVPKDHPHIEVIRIDGTMDSPPCLKVTHRTFGTQNSNADMIYCRLSMPVECHSSFSHSP CLDSEAFQKRKQMQEILSHTTTQCYYAVRVFAGQDPSCVWVGWVTPDYHLYSEKFDLNKN CTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLVDLAMGMLSF SANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVP QCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVD ILELCEQQELMQFHYHTLRLYSALCALGNNRVAYALCSHVDLSQLFYAIDNKYLPGLLRS GFFDLLISIHLANAKERKLMMKNEYIIPITRATRNICLYPDQSKRHGLPGVGLRTCLKPE FQFSTPCFVTTSEEHQKQSPEIPLETLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVP VLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHGGEMLEEGAEKEEVTQVEEKAVEAGE KASKEAPVRGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIFVSKLQANQKF RYDELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDL LLHCGIPLEEEEEEEADTSWTGKLRALMYKIKGPPKPEREQPTEEEERCPATLKELISQT MILWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQVSVSDTINLLAALGQ IRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQ IAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASS VMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAV FVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPTLDLPSQGY KREATEDEEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIRTGKGEAIRIRSILRSLV PTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYSIKDQSFLLHL LEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDS TLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPLLNEYCKMPL KLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSRKKYDPDLFRMALP CLSAIAGALPPDYLDTRITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYVVTKYAEH SHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGW TVERTKEGEALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYH NIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVIVSRGMKD MELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVGSGKTEKSPHDQEIKFFAKVLL PLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTT MVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLQKTSENLKLGKFTHSRTQMK GVSQNINYTTVALLPILTSTFEHVAQHQFGVDLLLNDVQISCYHILCSLYSLGTGKNIYV ERQRPALGECLASLAAAIPVAFLEPTLDRYNPLSVFNTKTPRERSILGMPDMVEEMCPDI PQLEDLMKEINDLAESGARYMEMPHVIEVVLPMICNYLSYWWERGPENLPPSSGPCCTKV TSEHLSLILGDILKIINNNLGIEEASWMKRIAVYAQPIISKARPDLLRSHFLPTLEKLKK KAVKTVQEEEQLKADSRGDTQEAELLILDEFAVLCRDLYAFYPILIRYVDNSRSNWLKSP DADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSG GQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYGYRDTDE EVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQV EQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSF EEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMM AKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGTAEMVLQMISASKGEMSPM VVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKA EGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTV NIIISTVDYLLRLQESISDFYWYYSGKDVIDESGQHNFSKALAVTKQIFNSLTEYIQGPC VGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEG NVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDQDGKGIISKKEF QKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEH MPNDSRLKCLLGPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEEDPSYTLE IEGEEEEDKCFEPISAFAMACASVKRNISSFLRKASLKNLRKQYRNVKKMTAKELVKVFF SFFWTLFMGIFQLFFAILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHE DAMEVERAEVTEPGITAELVHFVKGEKGDADMSDLFGLHPKKEGSLKHGPEVGLGDLSEI IGKDEPPTLESTVRKKRKAQAAEMKAVREAEGKADSEKADMEDGEKEDKEEEEEPAEHLW AEVAKRRKRRHGQKAEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINF ILLFYKVTEEPLEEDTEDVTNLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAVIHTI ISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFP NNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDM KYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHN GKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRA GGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVRED METKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKM YQERCWDFFPAGDCFRKQYEDQLG NT seq 14655 nt NT seq  +upstreamnt  +downstreamnt atgaatagagaacatggactgacagactggagaagcaagaatggaaggcttgggaaggaa aatgttttcctctcagcctcaggaagggctgtaccagaagaagatgaagtggtactccag tgcatcaccacggttcacaaggaacagaggaagttctgcttggctgctgagggacttggt aaccgcctgtgcttcctggaacccacgtcagaagccaagtatattcctccagatctttgc gtctgcaatttcgtgctggaacagtccctgtctgtcagagccctgcaggaaatgcttgcc aacacaggtgaaaatggcggtgaaggggctgcacaagggggaggccacaggaccctgcta tatggacatgcaattctcctgaggcactccttcagcggaatgtatctaacatgtttgact acatcaagatcccacactgataaacttgcctttgacgtaggtctacgggaacatggcaca ggggaagcctgttggtggactatacatcctgcctccaaacagcggtctgagggggagaaa gtgcgaattggcgatgacctcatcctcgtcagcgtgtcctcagaaagatacctccacctc tcaatatcaaatggtaacatacaagtggacgcctcctttatgcaaacgctctggaatgta catccgacctgctcgggaagtagcatcgaagaaggatacctacttggtgggcatgtagta cgtctcttccacggtcatgatgagtgtttgacaataccgtctacagaccagaacgatgcc cagcacaggagaatattctatgaagctgggggagctgggacacgagccaggtctctgtgg agagtggagccccttcggatcagctggagtggcagtaatattagatggggccaggccttc cgactccggcatctgaccacaggccattatctggccttgacagaagaccaaggccttcta ctgcaagaccggggaaagtcagacacgaagtccacagccttctctttccggccgtcgaag gaaatcaaggagaaattggattccagtcacaagcgagacatagaaggcatgggagttcca gaaatcaagtatggagattccatctgctttgtccagcacattgccagtggtctgtgggtg acctacaaagcacaagatgccaaaacaccccgcctgggacctctgaaaagaaaggtcatc ctccatcaggaaggccacatggatgatgggttaaccctgcagaggtgccagcgcgaggag tcccaggctgctcggatcatccggaacaccacggccttgttcagccagtttgtcagtggg aacaaccgcacagctgcccctgtcgccctgcccatacaggaggtcctgcagaccctgcag gacttgattgcctacttccagcccccagaggaggagatgcagcacgaggacaagcagaac aagctccgctcgctcaaaaacaggcagaatctctttaaggaagagggaatgctggccctt gtcttaaattgcatcgatcgcttaaatatctacaatagcgtcgcacactttgcagggatt gcaagggaagagagcggcatggcctggaaagaaatcctgaacctcctctacaaattgctg gctgctctcattcgtggaaacaggaacaactgtgctcagttctccaataatcttgactgg cttatcagtaaattggacagactagaatcttcctcaggtattttggaagttttgcactgc atcttgattgaaagcccagaagccttaaacctgatagccgagggccacatcaaatccatc atctccctgttggataagcacgggcggaatcacaaggttctggatgtcctgtgctcccta tgcctctgcaacggggtcgcagtgagagccaaccagaatctgatctgcgacaacttgctg ccccggagaaacctgctcctgcagacacgactgattaatgacgtaaccagtatccggccg aacattttcctgggagttgctgagggctcagcccagtataagaagtggtactttgagctg attatcgaccaggtggaccccttcctaacagcagagcctacacatctgcgggtgggctgg gcctcttcctcaggctatgcaccgtacccaggaggtggagaaggatggggaggcaatggt gtcggcgatgacctgtactcctatggcttcgatggccttcatctctggtcaggccggata cccagagctgtggcctccatcaaccaacacctcctgaaatcggacgatgtggtcagctgc tgccttgacctcggagtgcccagcatctctttccgcatcaacgggcaacccgtgcagggg atgtttgagaacttcaacacagatgggctcttcttccctgtgatgagcttttcagcaggt gtcaaagtacgtttcctgatgggtggacgacatggggaatttaagttcctgccgccctct ggctatgccccttgctacgaagccttacttccaaaagagaagatgagattggagcctgtc aaagaatataaacgcgatgctgaaggcattagagatctcctgggcaccacccagttcctc tcccaagcctccttcatcccctgccccatagacaccagtcaggttgttttgccacctcat ctagagaagatccgagacagactggctgaaaacatccacgagctctgggggatgaataaa atagagctcggctggactttcggcaagatacgagatgacaacaaaagacaacacccttgc cttgtggagttttcaaaactccccgaaacggagaagaattataacttgcaaatgtcaacg gaaaccttaaaaaccctcctggccctggggtgccacatcgctcaggttaatccagccgcc gaggaggagctcaagaaagtcaaactgcccaaaaactacatgatgtccaatggctataag ccagcccctttggatttgtctgacatgaagctgttacctcctcaagaaattctagtggat aagcttgcagaaaacgcacacaatgtctgggcaaaggacagaattaaacaaggatggacc tatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtgccatatgcatta ctggacgagcgtaccaagaaatcaaatagggacagcctgcgggaagctgttcgcacgttt gttggttacgggtataacattgagccatcagaccaagaactagctgaccctggtgtagag aaggtcagcatagacaagatccgattcttccgggtagagaggtcttatgcggtgagatct ggcaagtggtattttgagtttgaagtggtgactggaggagacatgcgggtcggctgggcc aggccaggctgtcgacctgacatcgagctgggtgctgatgaccaagccttcgtgtttgaa ggcagcaggggccagcgttggcatcaaggaagtgggtattttgggcgtacctggcagcct ggagatgtggtcgggtgcatgattaacctggatgatgcctcgatgatcttcacactgaat ggggagctgctgatcaccaacaagggctctgaacttgcatttgctgactacgagattgag aatggctttgtgcccatctgctctctggggctgtctcagatcggtcgcatgaacctcggg acagatgccagtaccttcaagttttataccatgtgcggcctccaagagggctttgagccc tttgctgttaacatgaaccgagatgttgcaatgtggttcagcaagcgtctcccgacgttt gtcaacgtgccaaaggatcacccacacatcgaggtcataaggattgatggcactatggac agcccaccttgcctcaaggtgacccacaggacattcggcacacagaacagcaatgccgac atgatctactgccgtctcagcatgcctgtcgagtgccactcttccttcagccacagcccc tgcctggacagtgaagctttccagaagaggaaacagatgcaagaaatactctctcataca acaacacagtgctactacgcagtccgcgtctttgctggccaggacccctcctgcgtctgg gtcggatgggtaactccggactatcacttgtacagcgaaaagtttgacctgaataaaaac tgcacggtgactgtcaccctaggggatgaaagaggccgggtccacgaaagtgtgaaacgc agcaactgctacatggtctggggtggggacattgtggccagttcccaaagatccagtcgg agcaacgtggacctggagatcggttgtcttgtggatctggcgatgggcatgttgtccttc tcagccaatgggaaagaactcggcacctgctaccaggtggagcctaataccaaggtattc ccagcagtcttcctgcaacccacgagtacttctttgtttcagtttgaacttgggaagctg aagaatgccatgcccctgtcggcggccatattcaagagtgaagagaagaaccctgtcccg cagtgtccacctcggctggacgtgcagaccatccagcccgtgctctggagccgcatgccc agcagcttcctgaaggtggagacggagcgggtgagcgagcgccatggctgggtggtgcag tgcctggagcccctgcagatgatggcgctccacatccccgaggagaacaggtgtgtggac atcctggagctctgtgagcagcaggagctgatgcagttccattaccacacgctgagactc tacagtgccttgtgcgccctgggaaacaaccgagtggcctatgccctgtgtagccacgtg gacctctcccagctcttctacgccattgacaacaagtaccttcctggcctccttcgatct ggtttctttgacctgctcatcagcatccacctggccaatgccaaggagaggaagctgatg atgaagaacgagtacatcatccccattaccagggccacccggaacatctgcctgtaccca gaccagtccaagaggcatgggctgccgggggtgggcctgagaacatgcctcaaaccggag ttccagttctccaccccttgctttgtcacaaccagtgaggagcaccaaaagcagagccct gagatccccttggagaccctcaggacaaaggcgctgagcatgctgacagaggcagtgcag tgcagcggggcccacatcagggaccccgtcggggggtctgtggagttccagtttgtgcct gtgctgaagctcatcggcaccttgctggtcatgggggtgtttgatgacgacgatgtccgg cagatcctcctcctcatagacccctctgtgtttggggagcacggcggggagatgttggag gagggagcagaaaaggaggaagtgacccaggtggaggagaaggcggtggaggccggggag aaggccagcaaggaggctcccgtcagaggcttgttgcaaacccgcttaccagagtccgtc aaactgcagatgtgtgagctcctcagctatctttgcgactgtgagctacagcaccgagta gaggccatcgtggcgtttggtgacatttttgtctccaagctgcaggcaaatcaaaagttc cgctatgatgagctcatgcaggccctgaatatgtctgcagccctgactgctcggaagacc agggagttccgctcacccccgcaggagcagatcaacatgctccttaactttcagctggga gagaactgcccctgcccagaggagatccgggaggagctgtatgacttccacgaggacctt ctccttcactgcgggattcccttggaggaagaggaagaagaggaggcagacacctcgtgg acaggaaaactccgtgccttgatgtataaaatcaaaggcccacccaagccagagagggaa cagcccacagaggaggaggagagatgtcctgcaacgctgaaggaactcatctcacagacg atgatcctctgggcccaggaggaccagatccaggatgcggagctggtccggatgatgttc aacctcctccggaggcagtatgacagcatcggggagctgctgcaggccctgcggaagacc tacaccatcagccaggtctccgtgagcgacaccatcaacctgctggctgcactgggccag atccgctccctgctcagtgtcaggatgggcaaagaggaggagctcctcatgatcaacggg ctgggagatataatgaacaacaaggtgttttaccagcatcccaacctcatgagagtcctt ggcatgcatgagacggtgatggaggtgatggtgaacgtgctgggtacagagaaatctcag attgcttttccaaaaatggttgctagttgctgccgcttcctttgctatttctgtcgaatt agccggcagaatcagaaggccatgtttgagcacctgagttacctgctggaaaatagcagt gttggcctagcctccccatcaatgagaggatccacccctctggacgtggccgcttcctct gtgatggacaacaacgagttagccctgggattagaggaaccagacctggaaaaggtggtg acctacttggcaggctgtggcctgcagagctgccccatgcttctggccaaaggataccct gatgtcggctggaaccccattgaaggggaacgctacctgtccttcctgaggtttgccgtc ttcgtgaacagtgagagcgtggaagaaaatgcaagcgtggtggtcaagctgctcatcaga cgcccagagtgcttcggcccagccctgcggggcgagggaggaaacggcctcttggcagcc atgcagggagccatcaagatctctgagaacccaacactcgacctcccctctcagggatac aagagggaagccacggaggatgaggaagaggaagaagaaatcgtgcacatgggcaatgcg attatgtccttttattcggcgctcatagacctactgggccgctgtgctcctgaaatgcac ctcatccggacaggaaaaggggaagccatccgcatcaggtccatcctgcgctccctggtc cccaccgaggacctggttgggattatcagcatccccttgaaacttccctccctaaacaaa gatgggtcagtcagtgagccagatatggcagccaacttctgccctgaccacaaggcaccg atggtgctgttcttggaccgagtgtacagcattaaggatcaaagttttctgctccactta ctagaggttggatttttacctgacttaagagcctctgcctctctagatacggtctccctc agcaccacagaggctgcgctcgcactaaacaggtacatatgctccgcggtgctcccgctc ctcacgagatgcgcccctctctttgccgggacagaacactgcacctctctgatcgactcc acactgcagacaatatacaggctttccaagggacggtccctcaccaaagcacagagggac actatagaagaatgtctgctcgccatttgcaatcacttgaggccttctatgttgcagcaa ctcctgagacgccttgtttttgatgtgccactactcaatgaatattgcaaaatgcctctc aagcttctgacaaatcactatgagcagtgctggaagtattactgtctgccctccgggtgg gggagctacggcctcgctgtggaggaagaactgcacctaacagagaagctcttctggggg attttcgactccctctcccgtaagaaatatgacccagatcttttccgaatggccctgcct tgtctcagcgctatagccggggccttgccaccagattatttagataccagaatcacagcc acgttggagaaacaggtctcagtggatgcagatggcaactttgaccccaaacccatcaac accatgaatttttccttgcctgaaaaactggaatacgtggtcaccaagtatgctgagcat tcacacgataaatgggcctgtgacaagagtcagagtggatggaagtatgggatttccctc gatgaaaatgtgaagacccacccactgataaggcctttcaagacattaacagagaaggag aaggaaatttatcgctggcctgccagagagtccctgaaaacgatgctggcagtgggctgg actgtggagaggaccaaagagggggaagctttggttcagcagagggaaaatgagaagctt cgaagtgtgtcccaggccagccagggcaacagctacagccctgctcccctcgacctctca aacgtcgtgctttccagagagctccagggaatggtggaggtcgtggctgagaactatcat aatatctgggccaagaagaaaaagctggaactggagagtaaaggtggtggcagtcaccct cttctggtgccatatgacaccttgactgccaaggaaaagttcagggaccgagagaaggca caggacctgtttaaattcctccaagtgaatggcgttatagtttccagaggtatgaaggat atggagctggacgcctcctccatggaaaagagatttgcctataagtttttgaagaagatc ctgaaatacgttgattctgctcaagagtttattgcccacttggaagccattgtcggcagt gggaaaacggaaaagtctccccatgaccaagagatcaaattctttgccaaagtcctcctc ccactggtcgatcaatacttcaccaatcaccgcctctacttcctgtcatcccctctgaag cccctcagcagcagcgggtacgcctctcacaaggagaaagaaatggtggccagcctgttc tgcaaacttgctgctcttgttagacacaggatttccctctttgggagtgactctactacc atggtgagctgtcttcacatcttagctcagacacttgacacaaggaccgtcatgaagtcg ggctcagagctggtgaaggctggcttacgagcattctttgaaaacgctgctgaagatttg cagaagacttcggaaaacctgaagctcgggaagttcacccattccaggacacagatgaaa ggcgtttcgcagaatattaactacaccacggtggctctgctccccatcctcacgtccacc ttcgagcacgtcgctcagcatcagtttggggtggacctgctcttgaacgacgtgcagatt tcatgctaccacatactgtgcagcctctactcccttgggacaggaaagaacatctatgtt gaaaggcaacgtcctgcccttggagaatgtctggcctcattggcagctgccataccagtg gcattcctggagcccacccttgaccgctataatccactctcagtcttcaacaccaaaacc cccagggagagatccattctaggaatgccagacatggtggaagagatgtgtcctgacatc ccccagctggaagacttgatgaaggaaatcaacgacctggctgagtcaggggcccggtac atggagatgccacacgtcattgaggtggtcttgcccatgatctgcaactacctgtcctac tggtgggagcgggggcccgagaacctgccccccagctcggggccctgctgcaccaaggtc acttctgaacacctcagtctcatcctgggcgacattctgaagatcatcaacaacaacctg ggcatcgaggaagcctcctggatgaagcgcatcgcagtgtacgcccagcctatcatcagc aaagccaggccagacctgctgagaagccacttcctcccgactctggagaagctgaagaaa aaggccgtcaagaccgtgcaggaagaggagcagctgaaagctgacagccggggggacacc caggaggcagagctgctcatcctggacgagtttgcagtcctctgcagagatctctacgcc ttctaccccatattgatccgctatgtggacaacagcagatctaactggctcaaaagccct gatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctgtggtgtaaa tcgcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaataatttg gcatttttgactggagacagcaaaagcaagatgtcaaaagccatgcaagtaaagtctgga ggacaggaccaggaacggaagaagaccaagagaaggggagatttatattccatccagacc tccctcatcgtggctgctctcaagaaaatgctgcccatcggtttgaatatgtgcaccccg ggtgatcaggagctgatctccctggccaagtcccgatatggctatagggacacagatgaa gaggtcaaggaacacctgcggaataacttgcacttgcaggaaaagtctgatgaccccgct gtaaaatggcaactgaatctctacaaagatgttctaaagagtgaagaaccttctaatcca gagaagacagtagaacgtgtacagagaatttcagcagccgtcttccacctggagcaggtg gaacagcctttgaggtccaagaaggctgtctggcacaaactgttgtcaaagcaacggaaa cgggcggtggtggcctgtttcaggatggcccctctctacaacctgccaaggcaccgctct attaacctcttcctccatggctatcagaggttttggatagaaacagaggagtattccttt gaagagaaactagttcaggatttggctaaatctcccaaggtggaagaggaagaggaagaa gagacggaaaagcagcctgacccgctccatcagattattctctatttcagccgcaacgct ctcacggagaggagcaaattggaagacgaccctttgtacacctcttattccagtatgatg gccaagagttgtcagagtggtgaggatgaagaagaggaggaagacaaggaaaaaactttt gaagagaaagagatggagaaacagaaaaccctctatcagcaagctcggctgcatgagcgc ggcacagccgagatggtcctgcagatgataagcgccagcaaaggtgagatgagccccatg gtggtagagactctgaagctggggatcgccattctgaatggaggcaacgctggtgtacag cagaaaatgctggattacctcaaggagaaaaaggacgctgggttctttcaaagcctctct ggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagct gaaggcctggggatggtgactgaagaaggaacactcattgtccgtgaacgtggtgaaaaa gtactccagaacgacgagttcacccgcgatctctttagattcctacagttactttgtgag ggacacaacagtgactttcagaacttcctgaggactcaaatgggcaacaccaccaccgtg aacatcatcatcagcaccgtggactaccttctgcgtctgcaggagtcaatcagtgatttc tactggtattattcagggaaggacgtcattgatgaatctggacagcacaatttttccaag gctctggcagtcaccaagcagattttcaattctcttacagaatatatccagggcccttgt gttgggaaccagcagagcctggctcacagcaggctgtgggacgcagtggtcggcttcctc cacgtgtttgctaacatgcagatgaagctctcccaggattccagtcagatcgagctgctg aaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaaggg aatgtggtaaatggaactattggcaagcagatggttgacacactggtagaatcatctacc aatgtagaaatgatcttgaaattctttgatatgttcttgaaacttaaagacttaaccagc tcagataccttcaaagaatatgaccaagacggtaaagggattatctccaaaaaagaattc cagaaggccatggaagggcaaaaacagtacacacagtcagagattgactttctcctttca tgcgcagaagctgatgagaatgacatgtttaattacattgattttgtagaccggttccat gagccggccaaggacatagggttcaatgtggcagtgttgttgacaaatctttctgagcac atgccaaatgactctcgcctgaagtgtctgctgggcccggcagaaagtgtgctgaattac tttgaaccatacctaggacggatcgagatcatgggtggggccaagaaaatcgagcgtgtt tattttgagatcagtgaatcgagtcggactcagtgggagaagcctcaggtgaaggaatca aagagacaattcatctttgatgttgtcaacgaaggtggagagcaggagaagatggagctg ttcgtgaacttctgcgaggacacgatctttgagatgcagttagcatctcagatctctgaa tctgactccgctgacaggccagaggaggaggaagaggaagacccttcttacacgttagaa attgaaggcgaagaggaggaagacaagtgttttgagcctatctcagcatttgccatggcc tgcgcctcagtgaagagaaacatctccagctttctgaggaaggcctccctgaagaacctc aggaagcaatacaggaacgtgaaaaagatgaccgcaaaggagctggtgaaggtgttcttc tctttcttctggacattgttcatggggatcttccagctgttcttcgccatattgggaggg atctttcagatcctgtggagcacagtgtttggagggggcctagtagaaggggcaaagaac atcagagtgaccaagatcctgggtgacatgcctgacccgacccaatttggtatccatgag gatgctatggaggtggagagggccgaagtgactgagccgggtatcacagctgaactggtg cactttgtaaagggtgagaagggagatgcagacatgtcagacctctttggactgcaccca aagaaggaaggtagcttaaagcatgggcccgaagtgggtttgggtgacctctctgaaatt attggcaaggacgagccccccacattagagagtactgtacggaagaaaaggaaagcacag gcagcagagatgaaggcagtgcgtgaagcagaaggaaaagcagactctgagaaggcagac atggaagacggagagaaggaggacaaagaggaagaggaggagccagccgagcacctgtgg gcagaggtggccaaacgaaggaagcggcggcatggtcagaaggctgagaagccagaagcc ttcatggccaatttctttaaagggctggaaatctatcagaccaagttactgcactacctg gccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaacttc atcctgcttttttataaggtgacagaagaacctttagaagaagacacggaggacgttacg aacctgtggaattcctttaatgatgaggaagaggaggaagcgatggtgttctttgtcctg caggagagcactggatacatggcgcccaccctgcgggccctggccgtcattcacacaatc atctctctagtctgcgtggtgggctactactgcttgaaggtccctttggtggtattcaaa agggaaaaagaaattgccaggaagctggagtttgatggcctgtatatcacggaacaacct tccgaagatgacatcaaggggcagtgggaccgcttggtcatcaacacaccgtcttttcct aataactattgggacaagtttgtaaagagaaaggtgatcaacaagtatggagatctctac ggagcagagcgcattgctgaactcctgggtttggacaaaaatgcccttgactttagcccc gtggaagagaccaaagcagaggcggcctcgctggtgtcatggctgagttccatcgacatg aagtaccatatctggaagctgggggttgtttttaccgacaactcctttctctaccttgcc tggtacacaaccatgtcgatcctgggccactacaacaacttcttctttgctgctcaccta ctggatatcgcaatgggcttcaagacgctgaggacgattctgtcatctgtaactcacaat ggcaaacagttggttctgaccgtcggtctcctggccgtggtggtttacctctacacggtg gtggctttcaacttcttccgcaagttctacaacaagagtgaagacgatgacgagccggac atgaagtgtgacgacatgatgacgtgttaccttttccacatgtatgtgggtgtgagagca ggagggggcattggcgatgaaattgaagaccctgctggggatccctatgaaatgtatcgc atcgtctttgacatcacctttttcttctttgtcattgtcatcctactggccatcattcaa ggtctcattattgatgctttcggagagctaagggatcaacaggagcaagtgagagaagat atggagactaaatgtttcatctgtgggattggcaatgactactttgacacgacccctcat ggttttgagacacatacgttacaagagcacaacttggccaattacttgttctttctgatg tatttgattaataaagatgaaacagagcacacaggtcaggaatcttatgtctggaagatg taccaagaaaggtgttgggatttcttccccgcgggagactgctttcgtaaacaatatgaa gatcagcttggataa

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