KEGG   Otolemur garnettii (small-eared galago): 100959926
Entry
100959926         CDS       T07855                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
oga  Otolemur garnettii (small-eared galago)
Pathway
oga01521  EGFR tyrosine kinase inhibitor resistance
oga01522  Endocrine resistance
oga04010  MAPK signaling pathway
oga04012  ErbB signaling pathway
oga04014  Ras signaling pathway
oga04015  Rap1 signaling pathway
oga04022  cGMP-PKG signaling pathway
oga04024  cAMP signaling pathway
oga04062  Chemokine signaling pathway
oga04066  HIF-1 signaling pathway
oga04068  FoxO signaling pathway
oga04071  Sphingolipid signaling pathway
oga04072  Phospholipase D signaling pathway
oga04114  Oocyte meiosis
oga04140  Autophagy - animal
oga04148  Efferocytosis
oga04150  mTOR signaling pathway
oga04151  PI3K-Akt signaling pathway
oga04210  Apoptosis
oga04218  Cellular senescence
oga04270  Vascular smooth muscle contraction
oga04370  VEGF signaling pathway
oga04371  Apelin signaling pathway
oga04380  Osteoclast differentiation
oga04510  Focal adhesion
oga04540  Gap junction
oga04550  Signaling pathways regulating pluripotency of stem cells
oga04613  Neutrophil extracellular trap formation
oga04620  Toll-like receptor signaling pathway
oga04650  Natural killer cell mediated cytotoxicity
oga04660  T cell receptor signaling pathway
oga04662  B cell receptor signaling pathway
oga04664  Fc epsilon RI signaling pathway
oga04666  Fc gamma R-mediated phagocytosis
oga04668  TNF signaling pathway
oga04720  Long-term potentiation
oga04722  Neurotrophin signaling pathway
oga04725  Cholinergic synapse
oga04726  Serotonergic synapse
oga04730  Long-term depression
oga04810  Regulation of actin cytoskeleton
oga04910  Insulin signaling pathway
oga04912  GnRH signaling pathway
oga04914  Progesterone-mediated oocyte maturation
oga04915  Estrogen signaling pathway
oga04916  Melanogenesis
oga04917  Prolactin signaling pathway
oga04919  Thyroid hormone signaling pathway
oga04921  Oxytocin signaling pathway
oga04926  Relaxin signaling pathway
oga04928  Parathyroid hormone synthesis, secretion and action
oga04929  GnRH secretion
oga04934  Cushing syndrome
oga04935  Growth hormone synthesis, secretion and action
oga05010  Alzheimer disease
oga05022  Pathways of neurodegeneration - multiple diseases
oga05034  Alcoholism
oga05132  Salmonella infection
oga05135  Yersinia infection
oga05160  Hepatitis C
oga05161  Hepatitis B
oga05163  Human cytomegalovirus infection
oga05164  Influenza A
oga05165  Human papillomavirus infection
oga05166  Human T-cell leukemia virus 1 infection
oga05167  Kaposi sarcoma-associated herpesvirus infection
oga05170  Human immunodeficiency virus 1 infection
oga05200  Pathways in cancer
oga05205  Proteoglycans in cancer
oga05206  MicroRNAs in cancer
oga05207  Chemical carcinogenesis - receptor activation
oga05208  Chemical carcinogenesis - reactive oxygen species
oga05210  Colorectal cancer
oga05211  Renal cell carcinoma
oga05212  Pancreatic cancer
oga05213  Endometrial cancer
oga05214  Glioma
oga05215  Prostate cancer
oga05216  Thyroid cancer
oga05218  Melanoma
oga05219  Bladder cancer
oga05220  Chronic myeloid leukemia
oga05221  Acute myeloid leukemia
oga05223  Non-small cell lung cancer
oga05224  Breast cancer
oga05225  Hepatocellular carcinoma
oga05226  Gastric cancer
oga05230  Central carbon metabolism in cancer
oga05231  Choline metabolism in cancer
oga05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:oga00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100959926 (MAP2K1)
   04015 Rap1 signaling pathway
    100959926 (MAP2K1)
   04668 TNF signaling pathway
    100959926 (MAP2K1)
   04066 HIF-1 signaling pathway
    100959926 (MAP2K1)
   04068 FoxO signaling pathway
    100959926 (MAP2K1)
   04072 Phospholipase D signaling pathway
    100959926 (MAP2K1)
   04071 Sphingolipid signaling pathway
    100959926 (MAP2K1)
   04024 cAMP signaling pathway
    100959926 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    100959926 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100959926 (MAP2K1)
   04150 mTOR signaling pathway
    100959926 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100959926 (MAP2K1)
   04148 Efferocytosis
    100959926 (MAP2K1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100959926 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100959926 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    100959926 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100959926 (MAP2K1)
   04660 T cell receptor signaling pathway
    100959926 (MAP2K1)
   04662 B cell receptor signaling pathway
    100959926 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100959926 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100959926 (MAP2K1)
   04062 Chemokine signaling pathway
    100959926 (MAP2K1)
  09152 Endocrine system
   04929 GnRH secretion
    100959926 (MAP2K1)
   04915 Estrogen signaling pathway
    100959926 (MAP2K1)
   04917 Prolactin signaling pathway
    100959926 (MAP2K1)
   04921 Oxytocin signaling pathway
    100959926 (MAP2K1)
   04926 Relaxin signaling pathway
    100959926 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    100959926 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100959926 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    100959926 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    100959926 (MAP2K1)
   04726 Serotonergic synapse
    100959926 (MAP2K1)
   04720 Long-term potentiation
    100959926 (MAP2K1)
   04730 Long-term depression
    100959926 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100959926 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100959926 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100959926 (MAP2K1)
   05206 MicroRNAs in cancer
    100959926 (MAP2K1)
   05205 Proteoglycans in cancer
    100959926 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    100959926 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100959926 (MAP2K1)
   05230 Central carbon metabolism in cancer
    100959926 (MAP2K1)
   05231 Choline metabolism in cancer
    100959926 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100959926 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100959926 (MAP2K1)
   05212 Pancreatic cancer
    100959926 (MAP2K1)
   05225 Hepatocellular carcinoma
    100959926 (MAP2K1)
   05226 Gastric cancer
    100959926 (MAP2K1)
   05214 Glioma
    100959926 (MAP2K1)
   05216 Thyroid cancer
    100959926 (MAP2K1)
   05221 Acute myeloid leukemia
    100959926 (MAP2K1)
   05220 Chronic myeloid leukemia
    100959926 (MAP2K1)
   05218 Melanoma
    100959926 (MAP2K1)
   05211 Renal cell carcinoma
    100959926 (MAP2K1)
   05219 Bladder cancer
    100959926 (MAP2K1)
   05215 Prostate cancer
    100959926 (MAP2K1)
   05213 Endometrial cancer
    100959926 (MAP2K1)
   05224 Breast cancer
    100959926 (MAP2K1)
   05223 Non-small cell lung cancer
    100959926 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100959926 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    100959926 (MAP2K1)
   05161 Hepatitis B
    100959926 (MAP2K1)
   05160 Hepatitis C
    100959926 (MAP2K1)
   05164 Influenza A
    100959926 (MAP2K1)
   05163 Human cytomegalovirus infection
    100959926 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100959926 (MAP2K1)
   05165 Human papillomavirus infection
    100959926 (MAP2K1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100959926 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100959926 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    100959926 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    100959926 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100959926 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100959926 (MAP2K1)
   01522 Endocrine resistance
    100959926 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oga01001]
    100959926 (MAP2K1)
Enzymes [BR:oga01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100959926 (MAP2K1)
Protein kinases [BR:oga01001]
 Serine/threonine kinases: STE group
  STE7 family
   100959926 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 100959926
NCBI-ProteinID: XP_003784493
Ensembl: ENSOGAG00000015876
UniProt: H0XE68
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctccgcggtt
aacgggactagctctgcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgaacagcagcggaagcgccttgaggccttccttacccagaagcagaaagtg
ggagaactgaaggatgatgacttcgagaagatcagtgagctgggggctggcaatggcggt
gtggtattcaaggtctcccacaagccttctggtttggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttttgcatgag
tgtaactctccatacattgtgggcttctatggtgcattctacagtgatggcgagatcagt
atctgcatggagcatatggatggaggttccttggatcaagtcctgaagaaagctggaaga
attccagaacaaattttaggaaaagttagcattgctgtaataaaaggcctaacatatctg
agggagaagcacaagattatgcacagagatgtcaagccctccaacatcctagtcaactct
cgtggggagatcaagctctgtgactttggggtcagtgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcttacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgtcaagtggaa
ggagatgcggctgagaccccacccaggccaagaacccctgggaggcccctcagctcatat
ggaatggatagccgacctcccatggcaatttttgaattgttggattacatagtcaatgag
cctcctccaaaattgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcggagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtagattttgcaggctggctgtgttccaccattggc
cttaaccagcccagcacgccaacccacgcggcaggtgtctaa

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