Oncorhynchus keta (chum salmon): 118362454 Help Entry 118362454         CDS       T09424                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism oke  Oncorhynchus keta (chum salmon) Pathway oke04020   Calcium signaling pathway oke04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oke00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118362454    04020 Calcium signaling pathway     118362454  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oke04040]     118362454 Ion channels [BR:oke04040]  Voltage-gated cation channels   Ryanodine receptor    118362454 SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  118362454 NCBI-ProteinID:  XP_052342146 LinkDB All DBs Position 29:20956409..21110872 Genome browser AA seq 4896 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEHSLSVRALQEMLAKTGQNSEGAAQGGGHRTLLYGHAILLRHSFSAMYLTC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLTIPGSDQS DEQQRIVNYETGNAGAKARSLWRLEPLRISWSGSHIPWGQPFRLRHLTTGHYLSLTEERG VVLQDREKSDTSSTAFCFRASKEKLESSPKRDIEGMGMAEIKYGDSICFVMHVATGLWLS YQAPDVKSSRLGPLKRRAFLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSHFIRDL DCLGGKNHASVALPIEEVHQTLYDLITYFQLPDAELEHEEKQIMLRSLKNRQNLFKQEGM LTLVSCCIDRLNVYNSAAHFGECAGAEAGASWKEILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILTESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVSEGSAQYKKWY YELTIDQVDHFLTSDPSHLRVGWATNKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWS GRISRTVASNNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFFPVVSF SAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKVKVEPVKEYKRDMEGVRDLLGTT QFMSQASFIPTPVETSQIVMLPYLEKVRDRLAENIHELWAMNKIELGWSYGKIRDDNKRH HPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQVNANAEEDLKKIKLPKNYMMSN GYKPTPLELSDVKVTPGQELLVEKLAENAHNVWAKDRIKQGWTYGIQQDVKSKRNPRLVP YSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQDGAGHVVERLSIDKIRFFRVERTYA VLTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYKGHRLNMGSRFFGRC WQAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQVGRM NLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFFNVPKNNNHIMVTRIDG TIDSPPCLKVSHRTFGTQNSNGDMVYCRLSMPVEFHTFFKTIPVMDMNGVHEEHESLKLK HRHPLKSMRHSHDGIRGTDYSNITTYYYSVRVFAGQDPSCVWVGWVTPDYHYYSNHFNLS KNRTVTVTLGDERGRVHESVRRSNCYMVWGGDATSSGHSSSRSNVDLEIGCLIDLATGLV TFTVNGKELATSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNTMPLSAAIFKSEHKNP VPQCPPRLDVQTINSVLWSRMPNTFLKVETSRVSERHGWVVQCLEPLQMLAVHIPEENRC VDIMELSEQEDLRTFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGML REGFYNVLISVHLETAKEARLMMNNEFIIPVTAETRSIRLFSDATKHHSPPGVGLSTSLK PRLNFYPPCFISTKREQQLYSPQIPLDALKEKAITMLTEAVQGGGHYIRDPVGGSVEYQF VPILRLIGTLLTMGVLGSQDVHKILLLIDPKVFAEHHEEAATAVTEAAEKEGLTGAEEKA VEAGEEEAAKEAKQPIKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVS KLQYNQKFRYNELMLALNMSAAITAKKTKEFRSPPQEQINMLLNFSTGEDCPCPEDIQEE LYAFHNELRLHCGIPMEEEEDDQDTSIKGRLLALVYKVKGQPLKTEEEPTEQEQQAPSNL KELISQTMVSWAQECHVQDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAASIQDTIN LLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKIFYQHPNLMRVLGMHETVMEVMVNV LGGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGST PLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWNPIEGERY LSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISDNPA VDLPSSAQGVSSDASAEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEAL RIRAILRSLVPTEDLVGIISIPLKMPVVHKDGTVTEPDMAASFCPDHKAPMVLFLDRVYG IEDQSFLLQLLDVGFLPDLQASASLDTEVLSTTETALAMNRYIGSAMLPLLTRCAPHFAG TEHYAVLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKYLRPSMLQHLLRRLVFDVP LLTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLDSLSQRKY DADLFKMAMPCLSAISGALPPDYIDATISTTLEKPVSVDAQGNFDPKPISTANISLPEKL EHVANKYAEHSHDKWSAEKVMLGWRYGDCIDEKAKTHPLLRTYKGLTEKEKDIYRWPVRE TLKSMLAMGWNIDRTKDGETMSLRESEKMRKISQSSSHANGFNPNPIDTINVVLSRELQG MVEVVAENYHNIWAKKKKNDLGIRGGATHPLLVPYDTLTAKEKARDKEKARDLFRFLQIN GYAITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVNSAQEFIAHLETMATSGKTDKSPHEQ EIKFFAKVLLPLIDQYFKNHCLYFLSSPSKNLSSSGYASNKEKEMATSLFCKLAALVRHR ISLFGSDSTTMVSVLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTLENLKLG KFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLY ALGTGKNIYVERQLPALGECLATLAGAMPVAFLEPLLNKHNPCSVFNTKTARERAILGMP DAVEEMCPEMPRLEVLMKDINDMSESGARYTEMPHIIEVVLPMLCNYLSYWWEKGPENQA SPHSGGSVGGSVFSTTVTSEHLSLVLGNILKILNSNLGIDEASWMKRIAVYAQPIITKAR AVLLKSHFLPTLEKLKKKTVKVVSEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYP MLIRYVDNNRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFL TGDSKIKMSKSGGQDQERKHKRKRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISL AKTRYILKDTDDEVKEHLRQNLHLQEKSEDPAVRWQLNLYKDVMVKNEGPPDPERTVFRV QSISAAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLG YQRIWIETETYSFEEKLVQDLAKTQLKVEEEEEEEAEMQPDPLHQLILHFSHNALTERSS LEEDPLYIAYADMMAKSCAEDEEEEDEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVL QMISASKGSLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKRDAGFFKSLSGLMQSCS VLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQ NFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFSKALAVAKQ IFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIDLLKELLDLQ KDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSDNFKEY DPDSKGVISKKEFQKSMENQKQYSQSEIEFLLSCVEADENDMFNYEDFVERFHEPAKDIG FNVAVLLTNLSEHMPHDARLATFLDLAESVINYFEPFLGRIEIMGGAKRIERVYFEISES SRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDSVERL EEDEEDSQSVEEEGEEEEEESMMESHSAFTNSCVSMRKNLSSFRQLLTFKSMRRQYRNFR KMSVREMVRGLFSFFWKIITGLFRFLYNLVWGFFHILWSSMFGGGLVEGAKNMKVTDILG NMPDPTQFGIHGDVLEAEKMEASEASSVAEMVQMAQVDKAEADLMAELLNIQTKSQGGKH AAEPGLGDMGEVVGVDAPSLATAVKQKKAKEASTMEPANGDHKAKPEKADPEDEEKKDKD EAKEETPPESPPEEEKKAPKKRPGLKKEPPEAFMARFFSGLEIYQTKMLNYLARNFYNLR FLALFVAFAINFILLFYKVTGDDGDDDDPDPWNGGGGTDEEEDEGGMEYFVLQESTGYMA PTLRFLAILHTVISFLCVVGYYYLKVPLTVFKREKEIARKLEFDGLYITEQPSDDDIKGQ WDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETVMKE ASLVSWLSSVDTKYQCWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFK TLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDENQPDMKCDDMMT CYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDET EHTGQESYVWKMYQERQWDFFPAGDCFRKQYEDQLG NT seq 14691 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaagatgaaattcagttcttgagaactgatgatgaagtg gtgctccagtgtgtcgcctgcatccacaaggagaatcgcaagttctgcctgactgcagag gggctcggaaatcgactgtgctacctggaacccacatcagaggcaaagtatgtccctcca gacctgtgcatctgtaactttgtgctggagcattctctctctgtgcgagccctgcaggag atgctggctaagacgggccagaacagtgagggggcggcccaggggggcggacacaggaca cttctgtatggacacgctatcctcctgaggcactccttcagcgctatgtatctgacctgt ttaaagacatcaaggtcacagacagataagctgtcctttgatgtggggctgcaggaggac tcaacaggtgaagcctgttggtggaccatccatcctgcctccaaacagagatcagagggc gagaaagtgcgcatcggtgatgacctcatcctcgtcagcgtgtcatcagaacgatacctt cacctgtccatctccaatggcaacatccaggtggacgcgtccttcatgcagactctgtgg aacgtccaccccacctgctccggcagcaacgtggaggagggttatctgctgggtggccat gtgttgcgtctgttccacggtcatgatgaagttctgaccatcccaggttccgaccagagt gatgagcaacagaggatagtgaactatgagacggggaatgcaggagcgaaggccaggtct ctgtggaggctggagcctctgagaatcagctggagcgggagtcacattccctggggccag cccttccgtctccgccacctcaccacggggcactacctgtccctgacggaggaaaggggg gtggtgctgcaggaccgggagaagtctgacacatcctccactgccttctgctttagagcc tccaaggaaaagctggagtcgagtccaaagcgggacatcgagggcatggggatggcagag attaagtatggggactcaatctgcttcgtcatgcatgtggctacaggactctggctgtcc taccaggcgcctgatgtaaaatcatctcgcctgggccctctgaagagacgggccttcctc cactctgagggtcatatggatgatgggctgaccttgcagcggtgtcagcacgaagagtcc cgtgctgctcgcatcatccgtaacaccacccgcctcttcagtcacttcatcagagaccta gactgtctggggggtaagaaccatgcgtcagtagccctgcccatcgaggaggtccaccag actctctacgacctcatcacctacttccagctgcctgatgctgagctggagcacgaggag aaacagatcatgctgcgctctctcaagaaccgacagaacctcttcaaacaggaaggcatg ctgactctggtgtcctgctgcatcgaccgtctcaacgtgtacaacagtgcagcccacttt ggggagtgtgccggggcagaggctggggcttcctggaaggaaatcctcaacctgctctat gagctgctggcggcgctgatccgaggcaacaggaacaactgcacccagttctccaacaac cttgactggctggtcagcaagctggagagactcgagtcctcctcaggcatactggaggtt ctccactgcattctaactgagagcccggaggctctaaatatcatccagagaggacacatc aagtccatcatctccctgctctacaaacatggacgcaaccacaaaattctggatgtgctc tgctccctctgtgtgtgtaacggggtggctgtaagagccaatcagaatcttatctgcgat cacctgctccctaaaagagatctgcttctccagacccgattggtcaatgacgtccaaagc atgaggcccaacatcttcctgggagtgagtgagggctcggcccagtataagaagtggtac tacgagctgacgattgaccaggtggaccacttcttgaccagcgacccctctcacctgcgt gtgggctgggccaccaacaagggttacgccccttaccctggtggaggggagggctggggg ggcaacggggtgggggacgacctctactcttacggctttgacggacttcatctctggtca ggtcgtatctcccggacggtggcttctaataaccaacacatcctgacctctgaggatgtg gtgagctgttgtctggacctgggagctcccagcatctccttcaggatcaatggacagccc gtacagggcatgttcgagaacttcaacatcgatggactcttcttccctgttgtcagcttc tctgctggcgtcaaggtgcgtttcctgttgggcggtcgtcatggcgacttcaagttcctg cctccgtcaggctacgctccgtgttacgaggccctgctccctaaggagaaggtgaaggtg gagccagtgaaggagtacaagagggacatggagggggtccgagacctgctggggaccaca cagttcatgtcccaggcctccttcatacccacccctgtggagactagccagatcgtcatg ctgccatacctggagaaggtccgggacagactggctgagaatatccacgagctgtgggcc atgaacaagatagaactgggctggtcttatgggaagataagggacgataataagcggcat cacccctgccttgtggatttttccaaactgcctgaaacagaaaagaattacaacctgcag atgtcaactgaaaccttgaagaccctgctggcattaggctgccatgttgtccaggtcaac gccaacgctgaagaggacctgaagaagatcaaactccccaaaaactacatgatgtcgaat ggttacaagcccacaccgctggagctgtctgacgtgaaagtgaccccaggtcaggagctc ctggtggagaaactggcggagaacgcccacaacgtgtgggccaaggacaggatcaaacag ggttggacctacggcattcagcaggatgtgaagagtaagaggaaccctcgcctggtgcca tattctttattagacgagcgcactaagaagtccaacagggacagcctccgtgaggccatc cgcactctgattggatacggatacaacatcgaacctcccgaccaggatggcgcaggccac gtggtggagagactgagcattgacaaaatacgcttcttccgtgtggagagaacgtatgcg gtgctgacagggaagtggtactttgagtttgaggcggtgacgggaggtgacatgcgtgtg ggttgggccagacctggatgtaagccggatgtagagctgggtactgatgagctggctttc gtctttgatggatacaagggtcaccgtctgaacatgggcagccgtttctttgggcgttgt tggcaggcaggggatgtggtgggctgcatgatcaacatggaggacaagtctatgattttc accctcaatggagagatcctcatcaccaacaagggctctgagctctgcttcgccgacttc gagacggaggacggttttatcccagtatgtagtctgggcctgtcccaggtgggtcgtatg aacctggggaaggatgccagtacctttaagtactacaccatgtgtggtctccaggagggc tttgaacccttcgccgtcaacatgaaccgtgaggtcaccatgtggttcagcaaacgcctc cccacctttttcaatgtgccaaagaacaacaaccacataatggtgaccagaatagatggc accatcgacagccctccctgtctgaaggtgagtcacaggacatttgggacccagaacagt aatggtgacatggtatactgtcgtctgagcatgcccgtggagttccacaccttcttcaag accatccctgtcatggacatgaacggagtgcacgaagagcacgagtccctcaaactcaaa cacagacatccactgaagtccatgagacacagtcatgacggaataagaggaacagattac agcaacatcaccacgtactactactctgtcagggtattcgctggtcaggatccatcctgc gtgtgggtgggctgggtcaccccagactaccattactatagcaaccacttcaacctcagt aagaaccggacggtgacagttacccttggagacgagcgtgggcgggtccacgagagtgtg aggaggagtaactgctacatggtgtggggaggggatgccaccagctcaggccactcgtcc agtcgcagtaatgtggacctggagataggctgcctcattgacctggccactggcctggtg accttcactgtcaacggcaaggagctggccacctcctaccaggtggaacccaacacaaag ctgtttcctgctgtgtttgtgcgaccgaccagccccaatctcttccagtttgagctggcc aagataaagaacaccatgcctctgtcggcggccatctttaagagtgagcataagaaccca gtgcctcagtgccctccgaggctggacgtccagaccatcaactcagtgctgtggagccgc atgcccaacaccttcctaaaggtggagacatccagggtcagtgagagacacggctgggtg gtgcagtgtctggagcccctccagatgctggctgtgcacatacctgaggagaacaggtgt gttgacatcatggagctgtctgagcaggaggacctgaggacgttccactaccacaccctg aagctctactgtgccctgtgtgcactgggtaatacccgtgtagcacacgccctctgcagc cacctagaccaatcccagctgctctataccatcgacaaccagtacctgtcgggcatgctg cgtgagggcttctacaacgtcctgatcagtgttcatctggagacggccaaggaggcccgc ctcatgatgaacaacgagttcatcatccctgtcactgccgagactcgcagcatccgcctg ttctccgatgccaccaagcaccactctcctcccggcgtgggcctcagcacctccctgaag ccccggctcaacttctaccctccctgtttcatcagcaccaaaagggagcagcagctgtac agcccccaaatccccctggatgccctgaaggagaaggcaatcaccatgctgaccgaggcc gtacagggcggtgggcattacatcagagaccctgtagggggcagcgtggagtaccagttt gtgcccatcctgaggctgattggcacgctgctcaccatgggcgtgctgggcagtcaggac gttcataagatcctgctgcttatcgaccccaaagtgttcgcggagcatcacgaggaggcg gccaccgcggtgacggaggccgcggagaaggagggactgacaggtgccgaggagaaggcg gtggaggccggggaggaggaggctgccaaagaggccaagcaaccaatcaaaggcctgctg gagaagaggctgcctgagccagtcaaacgacagatgtgtgagctgcttcactacttttgt gactgtgagctgaagcatcgcatcgaggccatcgtgtccttctcagacagctttgtctcc aagctgcagtacaaccagaagttcaggtacaacgagctgatgctggccctcaacatgtct gctgccatcaccgccaagaagaccaaggagttccgctcccctccccaagaacagattaac atgctgttgaacttcagtacgggggaggactgcccgtgtccagaggacattcaggaggag ctctatgccttccacaacgagctgcggctgcactgtggaatccctatggaggaagaggaa gatgaccaggacacgtctattaaaggtcgtctgctggccctggtctacaaggtcaaaggt caacctctgaagactgaagaggagcccacagagcaggaacaacaagccccctccaacctg aaggagttgatctcccagaccatggtgagctgggctcaggagtgtcacgtccaggacccc gagcttgtcagagtgatgttcagcctgctgaggagacagtacgacagcattggagagctg ctccgggccatgaggaagagctacactatcagtgctgcctctatacaggacaccatcaac ctgctggcctctctgggtcagatcagatcactgctatccgtacgcatgggcaaggaggag gagaaactcatgatcgacggtctgggtgacatcatgaacaacaagatattctaccagcac cccaacctgatgcgtgttctaggcatgcatgagacggtgatggaggtgatggtcaacgtg ctgggaggaggcaagtcccaggagatagcgttccccaagatggtggccagctgctgtcgc ttcctgtgttacttctgcaggatcagtcgtcagaaccaaaaggccatgtttgaccacctc agctaccttctggagaacagcagcgtaggccttgcatccccagccatgagaggctcgact cctctagacgtggctgcctcctctgtgatggacaacaacggcctggccttggccctggaa gagcccgacctggacaaggtggtgacgtacctagcaggctgtgggctccagagctgtccc atgctgctggacaaaggttaccctgacatcggctggaaccccattgagggtgaacgctac ctctccttcctgcgcttcgctgtatttgtcaatggtgaaagtgtggaggagaactccagt gtggtggtgaagctactgatcaggcgtccagagtgttttggcccggctctgagaggagag gggggtaacgggctgctggcagccatgaaggaggccatcaaaatctcagataaccctgct gtggacttgccctcatccgcccagggggtcagctctgacgcgtctgctgaggacgatgag gaggaagaggtggtgcatatgggcaatgccatcatgtccttctactctgccctcatcgac ctactgggacgctgtgccccagagatgcacttgatcaacaagggtaaaggggaggccctg cgaatccgtgccatcctgcgctcccttgtgcccactgaagacctggtgggcatcatcagc atacccctcaaaatgcctgtcgtccacaaagacggcactgtgacagagcctgatatggca gccagtttctgcccggaccacaaggcccccatggtgctgttcctggaccgggtctatggt attgaggaccaaagcttcctacttcagctgctggacgtgggcttcctgcccgacctgcaa gcctctgcttctctggacacggaggtactcagcaccacagagacagctctggccatgaac aggtacatcggctctgccatgctgcccctgctcacccgctgtgccccccacttcgctggc acagagcactatgccgtgctcatcgactccacgctgcacaccatctacaggctgtccaag ggccgctcgctcaccaaggcccagagagacgctatcgaggagtgtctgctggccgtctgc aagtacctccgtccctccatgctgcagcatctcctgcgacgcctcgtctttgacgtgccc ttgctgacggagtactgcaagatgcctctcaggctcctgaccaatcactacgagcagagc tggaagtactactgtctgccatcaggctggggcagctacggcatggcctcagacgaggag ctgctcctcacaaagaagatcttctggggcgtcttggattcgctctcacagaggaagtac gatgcagatctcttcaagatggccatgccctgtctgagtgccatatctggggccttaccg cctgactacatagacgccaccatcagcaccaccctggagaagcctgtgtctgtggacgct cagggcaacttcgaccccaaacccatcagcacagccaacatatctcttccagagaaactg gaacacgttgccaacaaatatgctgagcattcccatgacaaatggtcagcagagaaggtg atgttgggatggaggtatggggactgtatagatgagaaggccaagactcaccctctactc aggacctacaaaggtctgacagagaaggagaaggatatctacaggtggcctgtgagggag actctgaagagcatgctggctatgggctggaacatcgacaggaccaaggacggagagacc atgtccctacgggagagtgagaagatgcgcaagatctcccagtcctcctctcatgctaac ggtttcaacccgaacccaatagacaccatcaatgtggttctgtctagagagttacagggc atggtggaggttgtggctgagaattatcacaacatctgggctaagaagaaaaagaatgac cttggaattagaggtggggcaactcaccctctgctggtgccctatgacaccctgaccgcc aaagagaaggcccgggacaaagagaaggcccgggacctgttccgcttcctgcagatcaac ggctacgccatcaccagaggtctgaaggacatggagcaggactcttcctccatggagaag aggtttgcctacaagttcctcaagaagctgctgaagtatgtgaactcagcccaggagttc attgcccaccttgagaccatggctaccagtgggaagaccgacaagtcgcctcatgagcaa gaaatcaagttttttgccaaagtcctcctccctctgatagaccagtacttcaagaaccac tgtctctacttcctgtcttctcccagtaagaacctgagcagcagcggctacgcctctaat aaggagaaggagatggccaccagcctgttctgtaaactggcagctcttgtcagacacagg atttccctatttgggagtgactccaccaccatggtgagcgttctccacatcctggcccac acactggacaccaggacggtgatgaagtctggctcagagctggtgaaggcggggttaagg acgttcttcgagaacgcagcggaggacttggagaagacacttgagaacctgaagttgggg aagttcacccactcccgctcacagatgaaaggcgtgtcccagaacatcaactacaccacg gtggcactgctgcccatcctcactgccctgtttgaacacatcacccagcaccactttgga gtggacctgctcttggatgatgtccaagtgtcctgctatcgtatcctgaccagcctctat gcgctcgggactgggaaaaacatctatgtggaaaggcagctgccggccctgggggagtgt ctggccaccctggcaggggccatgcctgtggccttcctagagcccctgctcaacaaacac aacccctgctctgtgttcaacaccaagaccgccagagaacgcgccatcctgggcatgcca gacgcggtggaggagatgtgtccggagatgcctcgtctagaagtcctgatgaaggacatc aacgacatgtctgagtctggggcgcgctacacagagatgccccacatcatcgaggtggtg ctacccatgctgtgtaactacctgtcctactggtgggagaagggcccagagaaccaggcg tctccgcacagcgggggaagtgttgggggcagtgtcttctccaccaccgtcacctcagaa cacctcagcctcgtcctgggaaacatcctgaagatcctcaacagcaacctgggcatcgac gaggcctcctggatgaagaggatcgcagtgtacgcccagcccatcatcactaaggccagg gctgttctgttgaagagtcacttcctgcctacactggagaagctgaagaagaagacagtg aaggtggtgtcggaagaggagctactgaaggctgacagtaagggagatacccaggaggct gagctcctcatcctggatgagttcgctgtgctctgcagagacctctacgccttctaccca atgctcatccgctatgtagacaacaacaggtccaggtggctgaaagaaccagacgctgac tccaatgaactcttcagaatggtggctgagatcttcatcctctggtgcaaatcacataac ttcaaaagggaagagcagaactttgtggttcagaatgaaatcaacaacctgtcattcctg actggtgatagcaagatcaagatgtcaaagtcagggggtcaggaccaggagaggaagcat aagaggaaacgaggagagttctactccatccagacctccctgatcgtggctgccctgaag aagatgctgcccattggactcaacatgtgcacccccggggaccaggagctcatctccctg gccaagacacgctatatcctgaaagacacagatgatgaagtgaaggagcatttgcggcag aatctgcaccttcaagagaagtcagaggaccctgcagtgcggtggcagctgaacctgtat aaggatgtgatggtgaagaacgaggggcctccagaccctgagagaacagtgttccgggtc cagagcatctcagctgcagtctttcatctggagcaggttgagcagccgttgaggtctaag aagtgtgtgtggcagaagctgctgtccaagcagagaaagcgtgcggtggtggcctgcttc cgcatggctcctctctacaacctgcccaggcatcgctctattaacctcttcctcctgggc tatcagagaatatggatagagacagagacgtactcttttgaagagaagctagtgcaggac ctggcaaagacccaactgaaggtggaggaggaggaagaggaggaggcagagatgcagcca gaccctcttcatcagctcatcctgcatttcagtcacaatgcgctcactgagcggagttct ttggaagaggatcctttgtatattgcatatgcagacatgatggcaaagagttgtgcagaa gatgaagaagaggaagatgaaggaaaagagaaaacgtttgaggaaaaagagatggagaaa cagaagactctgtaccagcaggccagactgcatgacagaggagctgctgagatggtgtta cagatgatcagtgccagcaaaggttcacttgggcccatggtgacctttaccttgaagctg ggcatctctatactcaacgggggcaacatactggttcagcagaaaatgcttgactatctg aaggaaaaaagagatgctggctttttcaagagtttatcaggactcatgcagtcttgcagt gtcctggatttgaatgcattcgaaaggcaaaacaaagcagaaggtcttgggatggtgact gaggaaggatcaatcaacgtgagtgagcggggttccaaggtactgcagaacgatgagttc actaaggatctgtttaggtttctgcaactgctctgtgagggacacaacaacgacttccaa aacttcctgcggactcagacagggaacacaaccacagtaaatatcatcatcagcactgtg gactacctgctccgtctgcaggaatccatcagtgatttctactggtactactctgggaaa gacatcatggatgaggctggccagcggaacttctccaaagccctggctgtggctaagcag atcttcaactctctcactgagtacatacagggcccgtgtattgggaaccagcagagtttg gcccacagcaggctatgggatgcagtggtgggcttcttgcatgtgtttgccaatatgcag atgaagctctcacaggactcaagtcagattgacttattgaaggagctgctggacctgcag aaggacatgattgtgatgatgctctcccttctggaaggtaatgttgtcaacggaaccatt ggcaaacagatggtggacaccctggtggagtcctccagcaatgtagagatgatcctcaag ttcttcgacatgttcctcaaactcaaagacctgacctcctcggacaacttcaaggagtac gacccggacagcaagggagtgatctccaagaaggagttccagaagtccatggagaaccag aagcagtactcccagtcagagatcgagttcctgctctcctgcgtcgaggctgacgaaaac gacatgttcaactacgaggactttgttgaacgttttcatgaaccggccaaggacattggt tttaacgtggcggtcctgctcaccaacctatcagaacacatgcctcacgacgcccgtcta gccaccttcctggacctggctgagagcgtaatcaactacttcgagcccttcctgggccgc atcgagatcatgggaggggccaagcgcatcgagagggtctactttgagatcagtgagtcc agtcgtacgcagtgggagaaaccccaggtcaaagagtccaagagacagttcatctttgac gtggtcaacgagggcggggaaagcgagaagatggagctgtttgtcaacttctgtgaggac accatctttgagatgcaactggcctcccagatctctgagcctgactcagtggagcgtctc gaggaggatgaggaagacagccagagtgtggaggaggaaggggaggaggaagaggaggag agcatgatggagtctcactcagccttcacaaactcctgtgtctccatgaggaagaacctg tccagcttccgccagctgctcaccttcaagagcatgcggcggcagtacaggaatttcagg aagatgagtgtgagggagatggttcgagggttattctccttcttctggaagataatcaca ggcctcttccgcttcctctacaacctggtgtggggcttcttccacatcttgtggtcctcc atgtttggtgggggcctggtggaaggggcaaagaacatgaaggttacagacatcctgggg aacatgcctgaccccacacagtttggtatccatggcgacgtgctggaggcagagaagatg gaggcgagcgaggcatcgtcggttgcagagatggtccagatggcccaagtggacaaggca gaggccgacctgatggctgagctgctcaacattcaaaccaagagccaggggggcaagcac gcagccgagccaggtctgggggacatgggggaagtggtgggggttgacgccccctcttta gccactgccgtcaaacagaagaaggccaaggaggcttctactatggagcctgccaatgga gatcacaaagccaagccagagaaggcagacccagaagatgaggagaagaaagacaaggac gaagccaaagaggagactccacctgagtccccaccagaagaggagaagaaggcccccaag aagagaccgggactaaagaaagagcccccagaggccttcatggccagattcttctctggc ctggagatctaccagaccaagatgttgaactatctggccagaaacttctacaacctgcgt ttcttagcgttgttcgttgctttcgccatcaactttattctgctcttctacaaagtgact ggcgatgatggggatgacgatgatccagacccctggaacggtggtggaggtactgatgaa gaggaggatgaaggtgggatggagtattttgtcctgcaggagagcaccggctacatggca cctacactgcgcttcctggccatactacacacagtcatctctttcctgtgtgtggtggga tactactacctgaaggtgcctctgacggtgttcaagagagagaaggagatcgccaggaag ctggagtttgacggcctctacatcacagagcagccgtcagacgatgacatcaaaggacag tgggaccgcctcgtcatcaacaccccttccttccctaataactactgggacaagtttgtg aaacgcaaggtgatcaataagtatggagatctgtatggagcagagaggatagcagagctg ctggggctggataagagtgctctggacttcaaccccacagaggagacagtgatgaaggag gcatcgctggtgtcctggttgagctctgtcgacaccaagtatcaatgctggaaaatgggt gtggtgtttacagacaattcgttcctgtacctggtgtggtacaccaccatgtccatcctg ggtcactacaacaacttcttcttcgctgcccatctgctagacatcgccatgggcttcaag accctccggaccatcctgtcctcagtcacccacaatggcaaacagctggttctgactgta ggtctactggcggtggtggtgtatctgtacactgtggtggccttcaacttcttccgcaag ttttacaacaagagtgaggatgagaaccagccggatatgaagtgtgacgacatgatgact tgctacctgttccacatgtatgttggtgtgagggcagggggtggcatcggagacgagata gaagaccctgcgggcgacccctacgagctataccgcatcctcttcgacatcaccttcttc ttcttcgtcattgtcatcctgctggctatcatccagggtctgatcattgatgcttttgga gagctgagagaccaacaggagcaagtgaaagaggatatggagaccaaatgtttcatctgt ggcatcggcaatgactactttgacacgacgcctcacggctttgaaacacacaccttacaa gagcacaacttggccaactacctgtttttcctgatgtacctcatcaacaaagacgagaca gaacacactggccaggagtcatacgtgtggaagatgtaccaggagaggcaatgggacttt ttccccgctggagactgtttcagaaagcagtatgaggatcagcttggatag

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