Oncorhynchus keta (chum salmon): 118387118 Help Entry 118387118         CDS       T09424                                  Name (RefSeq) obscurin isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism oke  Oncorhynchus keta (chum salmon) Pathway oke04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:oke00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     118387118  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oke01001]     118387118   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:oke04131]     118387118 Enzymes [BR:oke01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      118387118 Protein kinases [BR:oke01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    118387118 Membrane trafficking [BR:oke04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     118387118 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 PK_Tyr_Ser-Thr Ig_4 Izumo-Ig SOS1_NGEF_PH V-set_CD47 RhoGEF PH C2-set_2 Kdo fn3 IQ_SEC7_PH ABC1 IQ RIO1 Pox_ser-thr_kin RHG20_PH Motif Other DBs NCBI-GeneID:  118387118 NCBI-ProteinID:  XP_052382925 LinkDB All DBs Position 1:51211255..51303243 Genome browser AA seq 6767 aa AA seqDB search MGDKSGSKVAAAKNQIHLRVVKGLEDVDVHEREGCTFEVTLNLSYIAGTWTKDGVRLQAK PTCHIAAHKNKHTLTFTRVTVGDTGLFSFQTDGSQNWIQTSGQLTVIARDIQIVKELEDE EVTERQSVTFLCEVNCEDVDGRWYTDNTRIKHGDNVKIRHEGKTHTMCFKSVRPANAGEI KFTADRVSCYATLTVKELPVQIVKPLRVKIAMYKHKGLLECQVSRANALVRWFKNRSEIQ PSKKHQIVSDDVYRQLHIDDVASSDEDTYTCDAGDDKTSCQLLVEEQAISIVQGLRSVEV TEPREAMFQVETSLRVGRPPKWTLDGEVLMDGPELSIDRQGTVHTLCFISTDSSMTGSVQ FNAGKSRSTAQLTVKERPLKVVQPMPDVEAKENSSVTLRCQFAPSPRVVRWYRGRTALQT SSKYSMRTEKSQAELTILGLKETDTGQYSCVAGGSKSTAKVDVRRLKIVRHLEHVKVEED SNATFTCELNYVVANVQWLLNDNHLNTNTVTRIQNMGTIHSLTIKNLHPQESRVTFKAGL LTESTSLKVKEKPAVFLRSLEDMSGEEEGKVCLQCETSKEMATPVWRKDGSVLDSSDKYE LLMFGKSLTLIIHSLSKDDAGHYSCDLGTSQTKAKVTVHDIHITIAQRMKTVSVLEGESC SFECILSHDVIDEPSWTLNGQLVISNSRIQIVNKGRKYKMTIRDATVTEAGEVIFFVKDL SCRTMLFVKEKPVHVFRDMMSVKATPGENAELSCEITKPEAFIRWLKNGHQIRHSPPKYE ISVEDHLVRLVITNTCIRDSGEYCCEADGIATRAKLEVRELQHTFARELRDTRAEEKSKV MLECETRLPAKRVTWLKGMAELRAGRKYVMKQKGVVLYLTISCLEKVDTDVYTCDVGTMQ SRALLTVHGQKVLIMDELEDVECLENDTVMFRCRICPSDYVGVKWYLDETLLYTNELNEI QVIPGGYHSLTFKQLARKDSGTISFEAGDKRSYASLLVRERRPTITKALEDCEAIEGGGL VLVCITSKPCHILWYKDGCLMWISSRYHVSRSGNEARLTIREVSNSDAGVYECSAGSVST KAVVTVKAIPAEFTQPLQSMEVKEGEDVTLSCEFSLPGVAFHWRRGLETLRAGERYLMKQ KRSFISLTITGPKPQDSGDYTCQCRDHRTTASLTVHAIPISFTQQLKNVQAEEGNSLTLR CELSKPGVPVEWRKGEELLKNGVKFQIRKRETISEVQIWKTVPEDSGVYSCECADQKTTA TVKISALPVTFKQKLRNVHVEEGNNLVLHCELSKPGVPVEWMRGGEELLNNGERFQIRQR ELVNELKIIDAKPEDSNIYTCVCGNVETTAGVTVTAIPITFKQKLKNLQTEEGNTISLHC ELSKAGVPVEWRLGGERILQNGDKYQIKQTDSALELLIREALPEDSGVYSCVCRDKKTKA TVKVIAVPATFKVGLKNQEAPEEGSITLHCELSKAGVSVEWWRGETELSQDLSGGKYQMK LEGKIAEMTITNVQPEDIGKYSCVTGDQKTTAEVKVQALPVMFTQEVQNVVIKEGDSGEF WCELSKPGDPVDWRRGRVILKSGDKYEMRQEGRITKLLIHNVEERDAGKYTCKSRDAKST AELTVTGPPPTFKEQLRNVEVEEGKTVTLHCELSKAAASVEWKRGAKLLTNVAKYQMRKK DLLVELKIIDANLEDSGVYACICGEQKTTATVTIKARPVTFIEELRNVQVEEGNTVTLRC ELSKPGLSVEWRRGTALLQNGEKYQMKQKDATLELVIRKTLPEDSGVYSCVLEDQQTFAT IIITAIPATFKQTLKNQEAPEEGSVTLRCELSKSGVPVVWLKGEELLREGERHQMKQEGR TVEMVIRNAVLQDAGEYSCVTACNVKTTADIKVRALPVMFTREAQNVVIKEGDSGEFWCE LSKPGDPVDWRRGRVILKSGDKYEMRQEGRITKLLIHNVEERDAGKYTCKSRDAQSTAEL TVTAPPVTFKVKLKNQEVEEENSVTLFCELSKPGLTAEWRKGEELLKNGIKYQIKKREAA MELTIRNAVLEDTGFYSCVYAEAKTTATVNITPIPVTFKMGLKNQEASEGGIVTLRCELS KAGVPVEWWKGEEEVSPGGRYQIKLEGKIAELHIKNIQPEDVGEYSCIFGDQKTTAEVNV RAAASVFFEKELESNVVMEGKSVVLSCEVSSATVPVTWKKDARLVTDGERFIVKKKGPVH TLEIEKLSLEDAGEYSCITRGKKTTAMLVVKERVKILSGLKDMKVSAGQDAVFVCELSHA EVSEGEWWLGSSPLQKNEMNQMSFEGHQHCLVLTMTTPEETGTVAFVVGEERTSAQLLVV PKPKVHIVKKPQDIDIMEGETATLSCTTSDLITPVTWRRNNMPLLNGDKYETHKKGKLNL LLIHETEPEDSGIYSCDTGDMQSDANLTVNELPPYFEEELQAVEAEEGGTAFLFCELSKL GVPVQWRKGRLPLRPNRKYQMKQDGCVFQLHILELKSEDSGNYSCQAGCVETTASVSVKV KVLIEKKPRDTVIMEGETATLSCTTSDLTTPVTWRRNNMPLLNGDKYENRKEGKLNLLLI HNVDPDDSGIYSCDTGDMQSSANLTVTELAPCFEEELQAVEAEEGGTAFLSCELSKPGVP VQWSKGRLPLRPNRKYQMKQDGCVFQLHILELKSEDSGSYSCQAGCVETTASVSVKVKVL IEKKPRDTVVMEGETATLSCTTSDLTTPVTWRRNNMPLLNGDKYENRKEGKLNLLLIHNV DPDDSGIYSCDTGDMQSSANLTVTELAPCFEEELQAVEAEEGGTALLSCELSKPGVPVQW SKGRLPLRPNRKYQMKQDGCVFQLHILELKSEDSGSYSCQAGCVETTASVSVKVKVLIEK KPRDTVVMEWDTATLSCTTSDLTTPVTWRRNNMPLLNGDKYENRKEGKLNLLLIHNVDPD DSGIYSCDTGDMQSSANLTVTVKVLIEKKPRDTVVMEGETATLSCTTSDLTTPVTWRRNN MPLLNGDKYENRKEGKLNLLLIHNVDPDDSGIYSCDTGDMQSSANLTVTELAPCFEEELQ AVEAEEGGTAFLSCELSKPGVPVQWSKGRLPLRPNRKYQMKQDGCVFQLHILELKSEDSG SYSCQAGCVETTASVSVKVKVLIEKKPHDTVIMEGETATLSCTTSDLTSPVTWRRNNVPL LNGDKYENRKEGKLNLLLIHNVDPDDSGIYSCDTGDMQSSANLTVTELPPYFEEELQAVE AEEGETAFLSCELSKPGVPVQWRKGRLPLRPNRKYQMKQDGCVFQLYILELKSDDSGSYT CQAGCVETTASVSVKVKVLIEKKPRDTVIMEGETATLSCTTSDFTTPVTWRRNNMHLLNG DKYENRKEGKLNLLLIHNVDPDDSGIYSCDTGDMQSSANLTVTELPPYFEEELQAVEVEE GGTACLSCELSKPGVPVQWRKGRLPLRPNRKYQLKQDGCVFQLHILELKPEDSGSYTCQA GGVKTTASVAVKPLPAKTEPPKTKAPTKAASPTPPPGPKKQGMIWASIVGSEKDLEPEAE TVVDLHEKQSVRSIGKETMVDQQEKQQVKQTVRALVRDTEEKKPLESMVKEIEVDHMVKQ PVPPARRASIMSDTGIDQVVKQPVPLVRQASIMSDTGVDEMRKQPVPPVRRASIVSDVGV DEVRKQPVPPVRRASIVSDVGVDEVRKQPVPPVRRASVVSVSDTGVDEVRKQPVPPVRRA SVVSVSDTGVDEVRKQPVPPARRASVVSDAGLDEVRKQPVPPARRASVVSDAGLDEVRKP PVPPARRASVVSVSDTGVDEVRKQPVPPVRRASVVSVSDTGVDEVRKQPIPPVRQVSVVS DAGVDEVRKQPVSSVRRASVVSDAGIEQVVRKQPVPPVRRASVVSDAGLDEVRKQPVPPV RRVSVVSVSDTGVDEVRKQPVPPVRRASVVSVSDTGVDEVRKQPIPPVRRVSVVSDAGVD EVRKQPVSSVRRASVVSDAGIEQVVRKQPVPPVRRASVVSDAGLDEVRKQPVPPARRMSV VSVLDTGVDEVRKQPVPPVRRVSVVSVSDTGVDEVRKQPVPPVRRVSVVSVSDTGVDEVR KQPVPPVRRVSVVSDAGIEQVVKQPVPPLRQASVVSVLDTGVDEVRKRPVPPVRQASVVS VSDTGVDEVRKRPVPPVRQASVVSVSDTGVDEVRKQPVPPARRSSIVSDAGVDQIVRSKK KMDIEIDQDKQPVKSMVKETEIEQRDQQPVRSTVQETEKPKMVEDDNQLHISEDESFTEG HTQVTVNQKTSKPVVAVAGVPKGLQMTQQVDEIALDSVEDEHEMLEAVIKIQAAFKGYKT RKDMRPIFKQVFKNQSAETNGTLELECKVEGKLNAVRWLKNSQEVIGDQRHRMNTSEDGV CTLVIINMSAIDTGVYTCEVVNTFGVSSYNGNITVGESQMPPSSTQRPAAPSQPSTPSVH PVLASIGPLQPVQTSTPGKETVDSVDSVECEGISLWQTYNLTKEDPRMTLQERRRASLIA ASSMSSPSDYDTAPDFIEPADIIPKDHPREKEAIKSQDQLSNKEDEEQKVTSQPPRHFKA KVPDAMLRTPSPKHYHAHTPAALTGSGSESDCDEDRIETFDIYVARANCSPQQGGNKESF VLKEGQYVEVLDSVHPEKWLVRTKPSKTTSSRQGWVSPAYLEKKRKETFPQMRTPHQELD VPGSTGENYRRTLSQLIQGLIDGEQEFVKEMKEFMSHHLHHLDTSPRVPINIINQKETIF RNIKDIMALHERSILPSLSECSTDDDVAMHLVKHAVDFEKYLQYMVGQSQAEACVTDKTI QQYFKQNTETHPEPPETAVLDVITFLQRPVERIQTYQALLKELIKNKAKCAKSCLLLEDA FSMVSCLPWRSDNLHQVSLIENYPAPLTALGEPVRQGPFTVWEESPEIKTSSRGHQRQVF LFKDCVLLCKLKRDPGMNSDTYAFKNKMKLNDVEVKERVGGEEKSWGLWHEHRGSVRRYT LQGRSAVLKLSWLKDLRELQQRSSLTASSPPEFEVLLADCTTKIGQTIKLACKVTGTPKP VVSWFQDGLALEDGPHHIITADRAGTCCLIMDGVTPEDSGQYLCYASSSVGHASTLAKIV VDAPPRFLTRLQSVCLLEGEDIKFSCSTHSTPLPRVSWFKDGRELTDQRKYHMESDARSG ILTLTIMNPGETDLGQYKCELWNKLGSAKSKAEMCSAFAQVMDSEPDQPQAILIQDSDSE GWSTAMVKQWLQTDFHPTSVVKMLFQPGYPQPAEGSQEERDPTARGHVEAPQFPTELEER PEVEEELYVPEAIEEMPTAPPSIQVPVEDLCVEPGQSATFTIIITGRPTPEIQWYKDGEE LLATENVEVVQNGARCSLTVLCPESEDGGIYTCWAYNDLGHTSCQARLTVEEGPLESQER EVELGKRRKLLSVYDVHEEIGRGTYGVVKRVTHRRTGEGFAAKFLPLRSSTRTRAFQERD LLSRLAHPRVACLLDFFSTRRTLVLVTEACSSRGLLDHLLSKGSVSEREVQMYIQQILEG VGHIHSMNILHLDIKPDNILMVFPPREEIKICDFGFCQEMDTSRHQYSQFGTPEFVAPEI IHQDPVTIASDIWSIGVVAYLCLMCRCPFMGETDRATLMRVGEGTLNWDAPDLTYRSTGA QGFLRTVLQPDPVKRPTAFECLGHKWFQGEHEDETDDINTRALKVFISRRKWQRSLTCLG SVLILKPIPELLDAPLRETSITAPRDPHEPSSTSMSSGSSSEYDEADAWDFFHHCTTADE DEDEEEEEFDPLMERARIPEPFDKLKLEEEEEGTMEEEEEEEEMGGQMRVLERSLSRQSI GSSDASQQPTPQRERRVSRESSPSLYLSEGDDGSASGSEGGCIARSSLIRSTFYNSSAQL SPMSARHMTLRDKFQAKKQERGRKPLRRSLSSRLNEPLIEYVEDEGETNHGQRRGSLQSS MLKSCSFDSGVSLSHNAPPQRRSKSLDEYSRRSPGSAKCREEESALNLKEDFTDKEEEKS LDVSPLQVRGRRGSVAVAPKQLTARLQELCAKSPHAGPEKSLRPEEEVGNLAGSQYSLAE SLILEHGSEGSSRLDSCEELSHGYPAATQRGRAGDEYDDQEEHLITTSPCSLLQGSEAVE ANKEPQCRSGQLQIPPRRTTHPNQNSTARNNGKVEKTILPVKPSPSLSFKAPERPSRASD TEARLQRHVSTPALQAKPPSGKSPRMSPKVGLMNLLRRQSWAGHSYSQLEGTEQGPTLGE LEPKTPTMSLRKKMRASASSLTKLFTKSSSKEDLTKGGPIVKGSSPAPPEQKASAGLESA KKKSTLFSFKIPKIPAFKKNKEMLIHLTRPDVHQLEAGGFLLVWRPVQSRDQVVYCVQYS TDGGEWKPLCEEVTDSCYVVKDLLRGAGYVFRVGCITKKGAGPFSDPSPPVVMATHPKET HIPLIQTEYPGSKGSGSRGQPSHKTYSFLAEINRGRFSVVTQCQDSQSQQLFAAKITPYR PENRALVLREYQLLKKLNHPHLVQLHTAYITPHCLVLIQELCAGRELLYNLTERDLYAEL HVAELLAQILGAVDYLHSRRVVHLDLKSDNMLVTDRNVLKIVDLGSAQSFTPGQTLNIED IPGQEKETPSSASPQTTGRNRMADGVYIVLPKAPEILDGQGVGPETDIWAIGVLAFIMLS ADSPFHSDLNWERDRNIRKGKIQFGRCYPGLSEGAINFIKNTLSIKAWERPSAAECLQNP WVRGERAPSKHRDSILCFSTDKLQAFLTEREVKRDQVRTKLQGPFFQ NT seq 20304 nt NT seq  +upstreamnt  +downstreamnt atgggagacaagtctgggagcaaagtagctgctgcaaagaaccagatccatctccgggta gtgaaggggctggaggatgtggatgtgcatgagagggagggctgcacgttcgaggtgacc ctcaacctgtcctacatagcgggcacgtggaccaaggacggggtcaggctccaagccaag cccacctgtcacatcgctgcccataagaataaacacactctcaccttcacccgggtcacc gtaggagacactggcctgttttccttccagactgacgggagccaaaactggatccaaacc tcaggccaactcactgtcatagccagagacatacagattgtgaaggagttggaagacgag gaagtgactgagaggcagagcgtgaccttcctgtgcgaggtcaactgtgaggacgtggac gggcgttggtacaccgacaacaccaggatcaaacacggagacaacgtcaagatcaggcac gagggtaaaactcacaccatgtgcttcaagtctgtaaggccagcaaatgctggggagatc aaattcactgcagacagggtctcctgctatgcaactctcacggtaaaagagctgcctgtg cagatagtgaagcctctgagagtgaagattgctatgtacaaacacaaaggactgctggag tgccaggtgtccagggccaacgccctggtcaggtggttcaagaacaggagtgagatccaa cccagcaagaagcaccagattgttagcgacgatgtctacaggcagctgcacattgatgac gtggcctcgtcagacgaggacacctacacctgtgatgctggcgatgacaagacctcatgc caactacttgtggaggagcaggcgatcagcatagtgcaggggctgaggtctgtggaggtg accgagcccagggaggccatgttccaggtggagaccagcctgagggtagggaggccccca aagtggaccctggacggagaggtcctgatggacgggcctgaactgagcatagaccggcag ggcaccgtgcacaccctctgcttcatcagcacggacagctctatgactggctctgtgcag ttcaacgccgggaagagccgctccaccgcacagctcaccgtgaaggaacgccctctgaaa gtggtccagcccatgccagacgtggaggctaaagagaacagctcagtcacactgaggtgt cagtttgccccctcccccagggtggtgcgctggtacaggggccgcactgccctgcagaca tccagcaagtacagcatgaggacggagaagagccaggcagagctgaccatcttgggcctc aaggagaccgacactggccagtacagctgcgtggctggagggtcaaagagcacagccaag gtcgatgtgcgaaggctgaagatcgtaaggcacctggagcacgtgaaggtggaagaggat agcaacgccacattcacatgtgaactcaactacgtagtagccaatgtgcagtggcttctg aacgacaaccacctcaacaccaacactgttaccaggattcagaacatgggcaccattcac agcctcaccatcaaaaatctccacccacaggagagcagggtgaccttcaaggctggcctt ctcacagagtccacctccctcaaggtcaaagaaaagccagcagtgttcctcaggtctcta gaagacatgtcaggggaggaggaggggaaggtgtgtctgcagtgtgagacctctaaggaa atggccacccccgtctggaggaaggatggttcggtcctggacagcagtgacaaatatgag ctgctcatgtttgggaagtccttaacgctcatcatccatagtctgagtaaggatgatgca ggccactacagctgtgacttgggcaccagccagaccaaggccaaggtcactgtacatgac attcacatcaccatcgcccagcgtatgaagaccgtctctgttctggagggcgagagctgc agtttcgagtgcatcctctctcacgatgtcatcgacgagccctcctggaccctgaacggt caacttgtgatcagcaacagccgcatccagatcgtaaacaagggtcgcaaatacaagatg accatcagagacgcaactgttactgaagccggggaagtaatcttcttcgtcaaagacctc agctgcaggaccatgctgtttgtcaaagagaagccagtgcatgtgttcagggacatgatg agcgttaaagccaccccaggggagaacgctgagctgagctgtgagatcaccaagcctgag gccttcatccgctggctgaagaatggccatcagatcaggcacagcccccccaagtacgag atcagtgtggaggaccacctggtacggctggttatcacgaacacctgcatcagagactct ggggagtactgctgcgaggctgacggcattgccacccgggccaagctggaggtcagagag ctgcagcacacatttgctcgggagctgcgggacacacgggccgaggagaagagcaaggtg atgctggagtgcgagacgagactgccggccaagcgggtgacctggctgaagggcatggca gagctccgggcgggcaggaagtatgtgatgaagcagaagggcgtggtcctctacctcacc atcagctgcctggagaaggttgacaccgacgtgtacacctgcgatgttggcaccatgcag agccgggcgctactgaccgtgcatggtcagaaggtgttgatcatggacgagctggaggat gttgagtgtctggagaatgacacggtgatgttcaggtgtcgtatctgtcccagcgattat gttggggtcaagtggtacctggatgagaccttactgtacaccaatgagctgaatgagatc caagtgatcccggggggctaccacagcctcacgttcaaacaactggctcgtaaagactcg ggcaccatctcctttgaggcaggcgacaagaggtcctacgcctcgctgcttgttagagag agacgtcccaccatcaccaaagcattggaggactgtgaggccattgagggaggcggtttg gtgctggtgtgtatcacctctaagccatgccacatcctatggtacaaagatggctgccta atgtggatttcctcgaggtaccacgtcagtcgctcaggtaacgaggccaggctgaccatc agggaggtcagtaacagcgatgctggggtgtacgagtgcagcgctgggtcggtcagcacc aaggccgtcgtcactgtaaaagccattccagctgagttcacccagccgctgcagagcatg gaggtaaaggagggggaggatgtgaccctttcctgtgagttctccctgccgggggttgcg ttccactggaggaggggcttggagaccctcagagctggagagaggtacctgatgaagcag aagaggtccttcatctctttgaccatcactggcccgaagcctcaggactcaggagattac acctgtcagtgccgagaccacagaaccacagccagcctcacagtccacgccatccccatc tccttcacacaacagttgaaaaatgttcaggccgaggagggcaacagtttaacgttgcgc tgtgagctttctaaaccaggagtccctgtggagtggaggaaaggggaggagctgttaaag aatggggtgaagtttcagataaggaagagagagaccatatcggaggttcagatatggaaa actgtgcctgaagacagtggagtctacagctgtgagtgtgcagaccaaaagaccacagcc accgtcaaaatcagcgccctgcctgttaccttcaaacaaaagctgaggaatgtgcatgtt gaagaggggaacaatttggtgttacactgtgagctctctaaaccaggagtccctgtagaa tggatgaggggaggagaggagctgctgaacaacggagagcggtttcagataagacagaga gagttggtgaatgaactgaagataatagatgccaaacctgaagacagcaatatctacacc tgtgtttgtggcaatgtggaaaccacagccggtgttacagtcacagcaattcccatcact ttcaagcaaaagctgaagaacctgcagactgaggaagggaacaccatctcgctgcactgt gagctgtctaaagcaggggtgccagtggagtggagattgggaggagagaggatactgcag aatggagacaaataccagatcaagcagacagactcagcactggaactcctcatcagggag gctctgccagaggacagtggagtctacagctgtgtgtgtcgggacaagaagaccaaggcc actgtcaaagtcattgctgtacctgccaccttcaaagtgggtctgaagaaccaggaggcc ccagaggagggcagcataaccctgcactgtgagctgtctaaggctggggtctcagtggag tggtggaggggggagacagaactgtcccaagacctgtctggaggaaagtaccagatgaaa ctggaggggaaaatagctgagatgaccattaccaacgtgcaaccggaggacatagggaag tacagctgtgtcactggagaccagaagaccaccgctgaagttaaagtgcaggctctccct gtaatgttcacacaagaggtccagaacgtggtgatcaaagagggggacagtggggagttc tggtgtgagctctccaaacctggtgacccagtggactggaggaggggcagagtcatcctg aagtctggagacaaatatgagatgaggcaggagggacgcatcactaaactgctcatccat aacgtggaggagagggatgctgggaaatacacctgtaagagtcgagatgccaagtcaact gctgaactgaccgtaacgggcccaccccccactttcaaagaacagctgaggaacgtggaa gttgaggagggtaagactgtgacgctacactgtgaactgtctaaagcagcagcctcagtt gagtggaagaggggagcaaagctgttgacgaatgtagccaagtaccagatgaggaagaaa gatttactggtggaattgaagattatcgacgcaaatctggaggacagcggggtttacgcc tgtatttgtggcgaacaaaagaccacagcaactgttacaataaaggctcgcccggtcaca tttatagaagagttgaggaacgttcaggttgaggagggcaacactgtgacgttgcgctgc gagctctccaaaccagggttgtcggttgaatggaggagaggaacagctcttctgcagaac ggagagaagtaccagatgaagcagaaagatgcaacgttggagctggtcatcaggaaaacc ttgcccgaggacagtggtgtctacagctgcgtgttggaagaccagcaaaccttcgccacc atcattatcactgccatcccagccactttcaaacagacgttgaaaaaccaagaggctcca gaagagggcagcgtgacgttgcgctgtgagctgtctaaatcgggggtccctgtggtgtgg ctgaagggagaggagctgctgagggaaggtgagcggcaccagatgaagcaggagggcagg accgtggagatggtcatcaggaatgcggtccttcaggatgctggggagtacagctgtgtc acagcctgcaacgtcaagacgacagctgatatcaaagttagggctctccctgtaatgttc acacgagaggcccagaacgtggtgatcaaagagggggacagtggggagttctggtgtgag ctctccaagcctggtgacccagtggactggaggaggggcagagtcatcctgaagtctgga gacaaatatgagatgaggcaggagggacgcatcactaaactgctcatccataacgtggag gagagggatgctgggaaatacacctgtaagagtcgagatgcccagtcaactgctgaactg accgtgacggctcctcccgtcacgttcaaggtgaagttgaagaaccaggaagtcgaggag gagaacagtgtgacgttattctgcgagctctctaaaccaggactgacggcagagtggaga aaaggagaggagctgctgaagaacggaataaagtaccagataaagaagagagaggcagcg atggaactgacaataaggaatgcagtgctcgaggacaccggattctacagctgtgtttac gcagaagccaaaaccaccgccactgtcaacatcacccccattcctgtcaccttcaagatg ggtcttaaaaaccaggaggcctcagaggggggcatcgtgaccttgcgctgtgagctgtct aaagctggggtcccggtggagtggtggaaaggggaggaggaggtgagccctggaggaagg taccagattaagctggagggaaagatagcagagttgcacattaaaaacatccagccagag gacgtgggggagtacagctgtatattcggagatcagaaaaccactgctgaagtcaacgtg agagctgctgcctcagtgttctttgagaaggagctggagagcaatgtggtgatggagggg aagtccgtggtcctctcctgtgaggtatccagtgccactgtccccgtcacctggaagaag gacgcccgcctggtcacagatggggagaggttcattgtaaaaaagaaaggtcccgttcac accctggagatcgagaagctgagtctggaggacgccggcgagtacagctgcatcactagg ggaaagaagaccacagccatgctggttgtgaaagagcgtgtgaaaatattgtccggactg aaggacatgaaagtctcagccgggcaggacgcagtgtttgtgtgtgagctgtcccacgcc gaggtgagtgaaggagagtggtggctgggctccagcccactgcagaagaacgaaatgaac cagatgagctttgagggccaccaacactgcctggtcttgaccatgaccaccccggaggag accgggaccgtagccttcgtggttggggaggagagaacctctgcccaactgctagttgtc cccaaacccaaagtacacattgtgaagaagccccaggacattgacatcatggaaggggag acagccaccttatcctgtacgacctctgacctcattacccctgttacatggagaaggaac aacatgcccctcctgaacggagacaagtatgagacgcataagaagggcaagctcaacctc ctgctcatccatgagacggaaccagaggactctgggatatactcttgtgacactggagac atgcagagcgatgccaatctgacggtcaatgagctaccaccgtacttcgaggaggagctg caggctgtggaggctgaggaagggggcacagcctttctgttttgtgagctgtctaagctc ggagtcccagtccagtggaggaaaggccggctgcctctcaggcccaacaggaagtaccag atgaagcaggacggctgcgtgtttcagctacacatcctggagctgaagtccgaggacagt ggcaactactcgtgccaggcaggctgtgtggagaccaccgcctctgtgtctgtgaaagtt aaagtactcattgagaagaagccccgggacaccgtcatcatggaaggggagacggcgacc ttatcctgtacgacgtctgacctaactacccctgtcacatggagacgcaacaacatgccc ctacttaacggagacaagtatgagaaccgtaaggagggcaagctcaacctgcttctcatc cacaatgtggacccagatgactctggcatatactcctgtgatactggagacatgcagagc agcgccaatctgactgtcacagagctggctccatgctttgaagaagagctgcaggctgtg gaggctgaggaaggaggcacggccttcctttcatgtgagctgtctaagcccggagtccca gtccagtggagtaagggccggctgcctctcaggcccaacaggaagtaccagatgaagcag gatggctgtgtgtttcagctacacatcctggagctgaagtccgaggacagtggcagctac tcgtgccaggcaggctgtgtggagaccaccgcctctgtgtctgtgaaagttaaagtactc attgagaagaagccccgggacaccgtcgtcatggaaggggagactgcgaccttatcctgt acgacgtctgacctaactacccctgtcacatggagacgcaacaacatgcccctacttaac ggagacaagtatgagaaccgtaaggagggcaagctcaacctgcttctcatccacaatgtg gacccagatgactctggcatatactcctgtgatactggagacatgcagagcagcgccaat ctgactgtcacagagctggctccatgctttgaagaagagctgcaggctgtggaggctgag gaaggaggcacggccttactttcctgtgagctgtctaagcctggagtcccagtccagtgg agtaagggccgactgcctctcaggcccaacaggaagtaccagatgaagcaggatggctgt gtgtttcagctacacatcctggagctgaagtccgaggacagtggcagctactcgtgccag gcaggctgtgtggagaccaccgcctctgtgtctgtgaaagttaaagtactcattgagaag aagccccgggacaccgtcgtcatggaatgggacacggcgaccttatcctgtacgacgtct gacctaactacccctgtcacatggagacgcaacaacatgcccctacttaacggagacaag tatgagaaccgtaaggagggcaagctcaacctgcttctcatccacaatgtggacccagat gactctggcatatactcctgtgatactggagacatgcagagcagcgccaatctgactgtc acagttaaagtactcattgagaagaagccccgggacaccgtcgtcatggaaggggagact gcgaccttatcctgtacgacgtctgacctaactacccctgtcacatggagacgcaacaac atgcccctacttaacggagacaagtatgagaaccgtaaggagggcaagctcaacctgctt ctcatccacaatgtggacccagatgactctggcatatactcctgtgatactggagacatg cagagcagcgccaatctgactgtcacagagctggctccatgctttgaagaagagctgcag gctgtggaggctgaggaaggaggcacggccttcctttcatgtgagctgtctaagcccgga gtcccagtccagtggagtaagggccggctgcctctcaggcccaacaggaagtaccagatg aagcaggatggctgtgtgtttcagctacacatcctggagctgaagtccgaggacagtggc agctactcgtgccaggcaggctgtgtggagaccaccgcctctgtgtctgtgaaagttaaa gtactcattgagaagaagccccatgataccgtcatcatggaaggagagacggcgacctta tcctgtacgacctctgacctcacttcccctgtcacatggagacgcaataacgttccccta ctgaacggagacaagtatgagaaccgtaaggagggcaagctcaacctccttctcatccac aatgtggacccagatgactctggcatatactcctgtgatactggagacatgcagagcagt gccaatctgactgtcacagagctgcctccatactttgaggaggagctccaggctgtggag gctgaggaaggggaaacggccttcctgtcctgtgagctgtctaagcctggagtcccagtc cagtggaggaagggccggctgcctctccggcccaacaggaagtaccagatgaagcaggac ggctgtgtgtttcagctatacatcctggagctgaagtccgacgacagtggcagctacacg tgccaggcaggctgtgtggagaccaccgcctctgtgtctgtgaaagttaaagtactcatt gagaagaagcctcgggacaccgtcatcatggaaggagagacggccaccttatcctgtaca acctctgacttcactacccctgtcacatggagacgcaacaacatgcacctactgaacgga gacaagtatgagaaccgtaaggagggcaagctcaacctgcttctcatccacaatgtggac ccagatgactctgggatatactcctgtgatactggagacatgcagagcagcgccaatctg actgtcacagagctgcctccatactttgaagaagagctgcaggctgtggaggtagaggaa gggggcacagcctgcctgtcctgtgaactgtctaagcctggagtcccagtccagtggagg aagggccggctgcctctcaggcccaacaggaagtaccagttgaagcaggacggctgtgtg tttcagctacacatcctggagctgaagcccgaggacagtggcagctacacgtgccaggca ggtggtgtgaagaccactgcctctgtggcagtaaagcctctcccagccaagacagaacct cccaagacaaaggctcccacgaaggctgcctctcccacacctccaccagggccaaagaaa cagggcatgatctgggcatccattgtggggtcagagaaagacctggagcctgaggcagag acagtggtggacctacatgagaaacagtcagtaaggtctataggtaaggagactatggta gaccagcaggagaaacagcaagtcaaacagacagtaagagctctggtgagggacacagag gaaaaaaagccattggagtctatggttaaagagattgaagtagaccacatggtgaaacag ccagtgcccccagcgagacgagcatctataatgtcagatactggaatagaccaagtggtg aaacaaccagttccactagtgagacaagcatctataatgtcagatacgggggtagacgag atgaggaaacaaccagttccaccagtgagacgagcatctatagtgtcggatgttggggta gatgaggtgaggaaacagccagttccaccagtgagacgagcatctatagtgtcggatgtt ggggtagatgaggtgaggaaacagccagttccaccagtgagacgagcatctgtagtttca gtttcggatactggggtagatgaggtgaggaaacagccagttccaccagtgagacgagca tctgtagtttcagtttcggatactggggtagacgaggtgaggaaacagccagttccacca gcgagacgagcatctgtagtgtcagatgctgggttagacgaggtgaggaaacagccagtt ccaccagcgagacgagcatctgtagtgtcagatgctgggttagacgaggtgaggaaaccg ccagttccaccagcgagacgagcatctgtagtttcagtttcggatactggggtagacgag gtaagaaaacagccagttccaccagtcagacgagcgtctgtagtttcagtttcggatact ggggtagatgaggtgaggaaacagccaattccaccagtgagacaagtgtctgtagtgtca gatgctggggtagacgaggtgaggaaacagccagtttcatcagtgagacgagcatctgta gtgtcggatgctgggatagagcaagtggtgaggaaacagccagttccaccagtgagacga gcatctgtagtgtcagatgctgggttagacgaggtgaggaaacagccagttccaccagtg agacgagtgtctgtagtttcagtttcggatactggggtagatgaggtgaggaaacagcca gttccaccagtcagacgagcgtctgtagtttcagtttcggatactggggtagatgaggtg aggaaacagccaattccaccagtgagacgagtgtctgtagtgtcagatgctggggtagac gaggtgaggaaacagccagtttcatcagtgagacgagcatctgtagtgtcggatgctggg atagagcaagtggtgaggaaacagccagttccaccagtgagacgagcatctgtagtgtca gatgctgggttagacgaggtgaggaaacagccagttccaccagcgagacgaatgtctgta gtttcagttttggatactggggtagatgaggtgagaaaacagccagttccaccagtgaga cgagtgtctgtagtttcagtttcggatactggggtagacgaggtgaggaaacagccagtt ccaccagtgagacgagtgtctgtagtttcagtttcggatactggggtagacgaggtaaga aaacagccagttccaccagtgagacgagtgtctgtagtgtcagatgctggaatagagcaa gtggtgaaacaaccagttccaccactgagacaagcatctgtagtttcagttttggatact ggggtagatgaggtgaggaaacggccagttccaccagtgagacaagcatctgtagtttca gtttcagatactggggtagatgaggtgaggaaacggccagttccaccagtgagacaagca tctgtagtttcagtttcggatactggggtagatgaggtgaggaaacagccagtgccacca gcaagacgatcatctatagtgtccgatgctggggtagatcagatagttagatctaaaaag aagatggatatagaaatagaccaagataaacagccagtgaagtctatggtgaaggagaca gagatagaacagagggatcaacagccagtaaggtctacagtgcaggagactgaaaaaccc aagatggtggaggatgataaccaactccatatctcagaggatgagtccttcacagagggc cacacccaggtaacagtcaaccagaagaccagcaagcctgtagtcgctgttgctggagtt cccaaggggctacagatgactcagcaagttgacgagattgcacttgacagtgtcgaggac gaacatgagatgttggaagctgtcatcaagatccaggcagctttcaagggatacaagacc cgcaaagacatgcggcccatcttcaagcaggtgtttaagaaccagagtgctgagaccaat ggtaccctcgagctggagtgtaaggtggaagggaagctcaacgcagtacgctggctgaag aacagccaggaggtcataggagaccaacgccaccgcatgaacacctcagaggatggcgtc tgtacactggtgatcatcaacatgtctgccatagacactggggtctatacctgtgaggtg gtgaacacgtttggtgtgtcctcatataatggtaacattactgtgggtgaatctcaaatg cctccatcttctacccagaggcccgcagccccatcccagccgtccaccccttctgtgcat ccagtcctggcctccattggccctctccagccagtccagacctccactcctgggaaggag actgtggattctgtggattctgtggagtgcgaggggatctccctgtggcagacctacaat ctaaccaaggaggatccccgcatgaccctgcaggagaggaggagggcctcccttattgcc gccagctctatgtctagtccctctgactacgatacagctccagatttcatagagcctgct gacataatccccaaagatcaccccagggaaaaggaagccattaagtcacaggaccagtta tccaataaggaggatgaagaacagaaagtcacgtctcaaccacccaggcattttaaagcc aaagtacctgatgccatgttgaggactccatcccccaaacactatcatgcccacacacct gctgctcttacaggctctggctcggagtcagattgtgacgaggatagaatagagacattt gatatatacgtggccagagctaactgcagtcctcaacaaggtggcaacaaggagagcttt gtgttgaaggagggtcagtacgtggaggtcttggactctgtccacccggagaagtggctg gtccgcaccaagccctccaagaccacctcctcacgccaaggatgggtctctcctgcatac ctggagaaaaagagaaaggagacattcccacaaatgaggacaccacaccaggagctggat gtaccagggtctacaggggagaactacaggagaaccctaagccaattaatccaggggctg attgatggggagcaagagtttgtgaaggagatgaaggaattcatgtcccaccacctgcac cacttagacaccagccctcgtgtccctatcaacatcatcaaccagaaagaaaccatcttc cgcaatataaaggacatcatggctttacatgagagatctattctgcccagtctgagtgag tgttctactgacgatgacgtggccatgcatctggtcaaacatgcagtagactttgagaag tatctgcagtacatggtgggccaatcacaggcagaggcctgtgtcactgacaagaccatc cagcagtacttcaagcaaaacacggaaacacaccctgagccccccgaaactgcagtcctg gatgtcatcaccttcttacagagaccagtggagaggattcagacctaccaggccttgctc aaggaactgatcaagaacaaggctaagtgtgcaaaaagctgtcttctactggaagatgcc ttctccatggtgtcctgtctgccctggcgctctgacaacctacaccaggtgtctctaatt gagaactaccctgccccactcactgcactaggagaacctgtccgccagggtcctttcact gtgtgggaggagtctcccgagatcaagacgtcctccaggggccaccagaggcaggtgttc ctcttcaaggactgtgtcttgctgtgtaagctcaagagagaccctggcatgaactctgac acctacgccttcaagaacaagatgaagctgaatgatgtcgaggtgaaggagagggtgggg ggagaggagaagtcctgggggctgtggcacgagcaccggggctcagtgaggaggtacaca ctgcagggccgctccgccgtgctcaagctgtcctggctcaaagacctgagagagctgcag caacgctccagcctgactgccagcagtccaccagagtttgaagttctcctggctgactgc accacaaagatcgggcagacaatcaagctggcctgcaaagtcacaggaacacccaaacca gtggtcagctggttccaagatggcctggccctagaggatggcccccaccacatcatcact gcagaccgggcaggcacctgctgtctcatcatggatggcgtcactcctgaggactctgga cagtacttgtgctacgcttccagctctgtgggccatgctagcacactggccaagatagtg gtggatgcaccccccagattccttaccaggctgcagagtgtatgtctgctggagggagag gacatcaagtttagctgttccacacacagtactcctttaccccgagtcagttggtttaag gatggcagagagctgacagaccagaggaagtaccacatggagagtgatgcccgcagtggg atcctcacgctcaccatcatgaaccctggagagacagacctgggacagtataagtgtgag ctgtggaacaagttgggcagtgccaagagtaaagcagagatgtgctccgcctttgcacaa gtgatggacagtgagcctgaccaaccacaggccatcttgatccaagactctgactcagag ggctggtccactgccatggtgaagcaatggctgcagacagacttccaccccacctctgtt gtcaaaatgctcttccagcctggataccctcagccagccgagggtagccaagaggaaagg gaccctaccgccagaggacacgtggaggctccacagttccccactgagcttgaggagaga ccggaggttgaggaggaactttatgttcctgaggccatagaggaaatgccaacagctcct ccctccatccaggtgccggtggaggacctgtgtgtggagcctggtcaatcagctaccttc accatcatcatcacaggaaggcccacccccgagattcagtggtacaaggatggagaggag ctgttggccactgagaacgtggaggtggtccagaatggtgcccgctgctctctgacggtg ctgtgcccggagagtgaggacggtggcatctacacctgctgggcctataacgacttagga cacacctcctgtcaggctcggctgacagtggaggagggtccactggagtcgcaggagaga gaggtggagcttgggaagaggaggaagctgctgtctgtgtatgacgtccatgaggagatt gggagaggcacgtatggggtggtaaagcgggttacccacaggaggacgggtgagggcttt gccgccaagttcctgcccctgaggagcagtacgaggaccagggcgttccaagagagggac ctgctctcccggctggcccaccccagggtggcctgtctgctggacttcttctctacacgg aggaccctggtcctggtcaccgaagcctgctcttctcgcggtctccttgatcatttgctg tcgaagggatcagtcagcgagagagaggtgcagatgtacattcagcaaatcctggaggga gttggtcatatccacagcatgaacatcctacatctggacatcaaaccggacaatatcctg atggtgtttccacccagagaggagatcaagatctgtgactttggcttctgtcaggagatg gacacttccagacaccagtacagccagtttggcactcctgagtttgtggcccctgagatc atacatcaagaccccgtcactatagcaagtgacatctggtccattggtgttgtggcctat ttatgtctgatgtgccgctgtccgttcatgggggagacggaccgggccactctgatgagg gtgggggaggggacactgaactgggacgcacccgacctcacctacaggagcaccggtgcc cagggcttcctccgcacggtcctgcagccagacccagtaaagcggccaactgcatttgag tgtctggggcacaaatggttccagggtgaacatgaggatgagactgatgatatcaataca agggctctgaaagtcttcatctcaaggagaaaatggcagcgttctctgacctgcctgggc tcggtgctaatcctgaagcccatcccagagctgctggatgcccctcttcgggagacctcc atcacagccccccgggacccccatgagcccagcagcacctccatgagcagcggctcctcc tctgagtacgacgaggccgatgcctgggactttttccaccattgcaccacagctgacgag gatgaagacgaggaggaggaagaatttgaccccctcatggagagagccaggatccctgag ccctttgacaaactgaaattggaggaagaggaggaggggaccatggaggaggaggaggag gaggaggagatgggaggacagatgagagtgctggagaggagcctaagcaggcagtctata gggtcctcggatgcgtcacagcagccgaccccccagagggagaggagggtcagccgagaa agcagcccgtccctatacctctccgagggggatgatggctccgcgtccgggagtgaagga ggctgcatcgccaggagcagcctgatccgcagcactttctacaacagctccgcgcagctc tcgcccatgtccgctcgccacatgaccctcagggacaagttccaggccaagaagcaggag aggggccgcaagccactccgcagaagcctctctagccgcctcaacgagcctctcattgag tatgtggaggacgaaggcgagaccaatcacgggcaaaggcgagggtctttgcagtcgtcc atgctcaagtcctgctcctttgacagcggggtcagcctctcgcacaatgcaccaccacag aggaggagcaagtcgttggacgagtactcccgacgctcaccaggatccgccaaatgtaga gaagaggagagtgctttgaatcttaaggaggatttcactgacaaggaggaagagaagagc ttggacgtttcccctctccaagtgagaggtcgaagaggttcagtggcagtggctcccaaa cagcttacggccaggcttcaggaactatgtgcaaaatcgccccatgctggtccagagaag agcctcaggccagaggaggaggtggggaacctggctggctctcagtactccctggctgag tccctcatcctggagcatggctctgagggctccagcaggctggactcttgtgaggagctg tcccacggctaccctgcagccacacaaagagggagagcaggggatgagtatgatgaccag gaggagcacctgatcacaacgtccccctgctcactgctccaggggtctgaggctgtggaa gctaataaggagccccagtgccggagcggccaacttcagatcccaccgagaaggacaacc caccccaaccagaactcaacggccagaaataatggtaaggtagagaagacgatcctgccg gtgaaacccagccccagcctgtccttcaaggccccagagagaccctcgagggccagcgac acagaggcacgtctccagaggcacgtgtccaccccggccctccaggccaaaccgccctcg gggaagtctcccaggatgtcacccaaggttgggttgatgaatctgttacgtaggcagtcc tgggcggggcattcctactcacaactggagggcacggagcagggacccacgctaggggaa ttggagcccaaaacccccaccatgtcactcaggaaaaagatgagggcatcagcctctagc ctcaccaagctgttcaccaaatcgtccagcaaggaggacttaacgaagggagggccgatt gtaaagggttcctctcctgctccacctgagcaaaaggcgagcgctggcttggagagtgct aaaaagaagtccacattattttcatttaaaatacctaaaatacctgcattcaagaagaac aaagagatgctcatccacctgaccaggcctgatgtgcaccagttggaggcaggtggattt ctgcttgtatggagaccagtgcagtccagggaccaagtggtttactgtgttcagtacagc acagacggtggagagtggaagccactgtgcgaggaggtgacagacagttgctacgtagtg aaagacttactcagaggagcaggatacgtattcagggtgggctgcatcaccaagaagggg gcaggacctttcagcgacccttcgccccctgttgttatggcaacccatcctaaagagacc cacattcccctcatccagaccgagtacccaggatcaaagggcagtgggtcaagaggtcaa cctagccacaagacctacagcttcctcgcagagatcaacaggggtcgtttcagcgtggtg acccagtgtcaggacagccagagccagcagctgtttgctgccaagatcactccttacagg ccagaaaatagagctctggtgctcagggagtaccagctgcttaagaagctcaaccacccc cacctggtgcagctgcacacggcctacattaccccccactgcctggtgctcatccaggag ctgtgtgctggcagagagctgctctacaacctgacagagagagatctttatgctgaactc catgtggcagagctgctggctcagatcctgggtgctgtggactacctgcacagccgccgc gtcgtccacctggacctcaagtcggacaacatgctggtgacggaccgcaacgtgctgaag atcgtagacctgggctctgctcagtctttcacacccggacagacactcaacatagaggac attccgggacaagagaaagagactccatcgagcgcctctccacagacaacgggcagaaac agaatggcagatggggtttacattgtccttcctaaagccccagaaatcctcgacggacaa ggagtcggacctgagaccgacatctgggctattggggttttggcttttataatgttgagt gcagatagcccgttccattcagacctcaactgggagagggacagaaacatccggaagggg aagatccagtttggccgctgctaccctggtttgtcagagggagcaatcaacttcataaag aacacactgagcatcaaggcctgggagagaccctcggcggctgagtgcctccagaacccg tgggtacgaggcgagcgggccccctccaaacacagagactccatcttgtgtttctccact gacaagctgcaggctttcctcacggagagagaggtgaaacgagaccaggtccgcaccaag ctgcaaggaccgttcttccaataa

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