Oryzias latipes (Japanese medaka): 101159404 Help Entry 101159404         CDS       T02443                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism ola  Oryzias latipes (Japanese medaka) Pathway ola04020   Calcium signaling pathway ola04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ola00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101159404 (ryr3)    04020 Calcium signaling pathway     101159404 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ola04040]     101159404 (ryr3) Ion channels [BR:ola04040]  Voltage-gated cation channels   Ryanodine receptor    101159404 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  101159404 NCBI-ProteinID:  XP_020570400 LinkDB All DBs Position 24:complement(20029711..20174252) Genome browser AA seq 4850 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSAATIGKEHRKFCLAAEGLGNRLCYLEPTSEAKYVPP DMCICNFVLEQSLSVRALQEMLANTGQNSEGSADHEKWAAQGGGHRTLLYGHAILLRHSF SGMYLTCLKTSRSLTDKLSFDVGLQEDSIGEPCWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSISNGNIQVDASFMQTLWNVQPTCSSSSMAVGFLIGGNVMRLCHGHDESLT IPGADKSEEEQRIVNYEAGKGASRARSLWRLEPLRVSWSGSHIRWGQAFRLRHLSTGHYL ALTEDRGLVLEDREKSGTKSTAFCFRPSKEKVDTGPKRDIDGMGVPEIKYGDSVCFVMHV ATGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQLCQHEEARAARIIRNTTFLF STFIKALDSVKDGESSTVGGYIEEVLQTLNDLIEYFKQPDSELEHEEKQGLLRSLIRRQD LFKEEGMLALLSKCIDRMNLYDSAAHFAEVAGEEAGAAWKDILNLLYELLAALICGNRNN CTQFSRNLDWLVSKLERLESSSGILEVLHCILVESPEALNIIQKAHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGMAEGS AQYKKWYFELVIDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHQLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMRVEPVKEYKRDHDGV RDLLGTTPFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFPKLPETERNYNLQMSSETLKTLLALGCHVAQVNVNAEDDLKKIKLP KDYIMSNGYKPAPLELSDVKLNPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYALLDERTKKSNRDSLREAIRTIVGYGYDIDPPDQESVHVLDDHSVETIRFFR VEQTYAVKTGKWYFEFEVLSGGDMRVGWARPGCRPDVELGSDDQAYVFDGYRGRRMHTGS RYFGHPWKKGDVVGCMINMEDKSMIFTLNGELLITGKGSELCFTDFETQDGFIPVCSLGM AQIGRMNLGKDASTFKYYTMCGLQEGFEPFGVNMKREITMWFSKRLPTFFNVPQDHAHIE VTRIDGTVDSPPCLKVTHKTFGTQNSNSDMVYCKLSMPVEFYSADKMLDESVKLSQPPKE GADYSCITTYFHSVKVFAGQDPACVWVGWVTPDYHYYSKNFSLAKTQTVTVTLGDERGRV HESVQRSNCYMVCAADAVSPSSSSRSNSDLEIGCLIDLATGLVSFTANGNELPTVYQVEP NTKLFPAVFVLPTSPNLFQFEFVKIKDAMPLSSAMFKSEHNNPVPQCPPRLDVQTIVAVL WSRMPNTFLNVETARVSERHGWVIQCLEPLQMMAVHIPEENRCLDILELSEHEDLRKFHY HTLKLYCALCALGNTRVSHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAK EARLMMNNEFIIPVTDETRSIKLFPDESKQHSLPGVTLSTSLKPRVNFSPVGIINTKRPQ FLYSPQIPLGILKEKAITMLSEAVQGGGSHIRDPVGGSLEYQFVPILKLIGTLLIMGVLT SEEVRLILLLVEPNVFGENKEGEEAKGEVLAVAGEKEEVSKNEEKAVEAGEEETKESKSP SKGLLEKSLPEPVKHQMCELLHYFCDCELRHRIEAIVSFSDRFVSKLQFNQKFRYNELMQ AFNMSAAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIQDELNAFHEELRLHCGIP MEEEEEEQDTSIKGRLLALLYKIKGPPQKAAEEPTETEQAAPTNLKELISQTITSWAQES HIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVR MGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQKIAFPKMV ASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGL ALALEEPDLEKVVMYLAGCGLQSCAMLVAKGYPDIGWNPIEGERYLSFLRFAVFCNGESV EENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKTSAGDVTGSA EEEEEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLVGI ISIPLNMPVVHKDGTVTEPDMSASFCPDHKAPMVLFLDRVYGIEDQSFLLQLLEVGFLPD LKASASLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFANTEHYAQLVDSTLETIYRL SKGRSLTKAQRDAIEDCLLTICKHLRPSMMQQLLRRLVFDVPMLSEYCKIPLRLLTNHYE QNWKYYCLPSGMGSFGIASEEELLLTKKLFWGIFDSLSQKKYDAELFKMAKSCLCAIAGA LPPDFVDTSLAASLEKQGSVDAQGHFDPKPVSTANISLPEKLEYAANKYAEHCHDKWSSE KMSAGWKHGDSLDEQAKAHPLLKPFKALSEKERETYRWPVREALKSMLAMGWNIERTKEG EAMFQQRESEKQRRQSESQGDGFSPAPMDLHNITLSRELQGMVEVVAENYHNIWAKKKKT ELQSKGGVAHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDLELDSSSME KRFSFKFLKRLLKYVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLIDQTFKN HCLYFLSTPSKNLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLHILT NSLDTRTVMKSGSELVKASFKAFFENASEDLEKLVEMLKLGKFMQSRAQMKSVSQSINYV TVALLPILTALFEHIRTHEFAADLLLNDVQLSCYRILMCFYSLGIGKNIFVERLLPALGE SLATLVAAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCLDMPRLDKLLKD VNDISDSGARYSDMPQVIEVILPMLCNYLSYWWEKGPENSPPDTDCCTMVTSEHLSIILG NILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRSHFLPTLDKLRKKTVKVVAEEE LLKADSKGDNQEAELLILDEFAMLLRDLYAFYPMLIRYVDNNRSRWLKEPDADSTELFKM VAEIFILWCKSNNFKREEQNFVIQNEINNLAFLTEEGKAKMSKSGGDQERKHKRRRGEYY SIQTSLIVAALKKLLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEYLQQNLHLQEKS DDPAVQWQMNLYKDVVVRSGELTNPEHTVDRIQSISAAVFHLEQVEQPLRNKKCVVQKLL SKQRKRAVVACFRMAPLYNLPRHRAINFFIPAYQRLWIEAEEYSFEEKLVQDLAKTPMKI VEEEEEEVADIKPDPLHQLILHFSHNALTERSHLEVDPLYIAYADMMAKSCAEDEEEEEE EGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMIGASKGRLGLMVTCTLKLGISILN GGNVHVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTSH TGRGSKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRLQ ESISDFYWYYSGKDIIDETGRLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSNNVEMILKFFDMFLKLKDLTTSDNFREYDPEFKGIISTKEFQKSMESQKQYTQSE IEFLLSCAKADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLSTFLDLA ESVLSYFEPYLGRIEILGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGE SEKMEMFVNFCEDTIFEMQLASQISEPDVAEQPEEEEEEEHSLLEELAGDEDGALESPSA FTTACRSLKKKISDVRQIFAIKNLRKQFKKIRKLSVKEMITGFFSFFWMIFIGFFKGIYS LIFGFFHIIWSSMFGGGLVEGAKNMKVTDILGHMPEPTQFGIHGDTVEGDKAETTESSGS IDTATAPTGDIVEVDTMMEMLAPKKEGGKHVEPGLGDVSELSSDSSAADHKKKGSSKLAD TIESGKEKADSENQEKEDKPKEEEVKEPAAQEKPRTRSSQPKEASPAFMSTIFAVLDVYL TKMLNYLARNFYNLRFLALFVCFAINFILLFYKVTEEIVEEEEDENPWSEDEGDENTLFD MDEFVLQESTGYMQPALRFLAVFHTVISLLCLFGYYCLKVPLVVFKREKEIARKLEFDGL YITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDMYGAERIAELLGLDKS ALDFDPTVETVEKEASLVSWFSSIDTKYHMWKMGVVLTDNNFLYLIWYTTMSICGHFNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYSVVAFNFFRKFYNKSE DEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14553 nt NT seq  +upstreamnt  +downstreamnt atggccgagggcggagagggggaggacgagatccagttcctgagaactgatgatgaggtg gttcttcagagcgccgccaccatcgggaaggagcatcgcaagttctgtctggcagcagag ggcctcggaaaccgcctgtgttacctggaacccacatctgaagccaagtatgtccctccg gacatgtgcatctgtaactttgtgctggaacagtcgctgtcagttcgggccctgcaggag atgctggctaacacggggcagaacagtgaagggagtgctgaccatgaaaaatgggccgct caaggaggtgggcatcgaaccctgctttatggccatgccattcttctgcggcactccttc agtggcatgtatttaacctgtttgaagacatcaaggtctctgaccgacaagctgtcgttt gacgtcggactgcaagaagattcaatcggagagccctgctggtggaccattcaccccgca tccaagcagagatctgaaggagaaaaagtccgtatcggagacgatttgatacttgtcagc gtgtcaacagagagatacctgcatctctccatctccaatggcaacattcaggtcgatgca tccttcatgcagactctgtggaacgtgcagccgacctgttcttcaagcagcatggccgtg gggtttctgattggtggcaatgtgatgcgcctctgtcatggacacgatgagagcctgacc atccccggagccgacaagagtgaagaagaacagagaatcgtgaactacgaggcggggaaa ggagcatcgagggcacgctccctgtggaggctggagcctctccgagtcagctggagcggc agccacatccgatggggtcaggccttccgcctgcgccatctctccacgggtcattatctg gccttaacggaagaccgaggtctggttctggaggacagagagaagtctggcaccaagtcc acggctttctgcttcaggccctcaaaggaaaaggtggacaccggtccaaagagggacata gatggcatgggggttccggaaatcaagtacggagactccgtctgctttgtcatgcatgtg gcgactggactctggctgtcctacctggctcctgatgccaaatcctcccgccttggcccc ttgaaaagaagggcctgcctgcactctgagggccacatggacgacggcctcatcctgcag ctctgccagcacgaggaggctcgggctgctcgcatcatccgaaacaccacattcctcttc tcaaccttcatcaaggctttggacagcgtcaaggacggagagtcgtccacggtgggcggg tacatcgaggaggtcctgcagacgctgaacgacctgattgagtatttcaagcagccagac tctgagctggagcacgaggagaagcagggtcttctccgctcactaatcaggcgccaggac ctcttcaaggaggagggcatgttggccctcctgtccaaatgtatcgaccggatgaacctg tacgacagtgctgctcactttgcagaggtggccggcgaggaggctggggcagcgtggaag gacatcctcaacctgctgtatgagctattggctgcactcatttgtggaaacaggaacaac tgcacccagttctcccggaacttggattggttggtgagcaaactggagcgactggaatcc tcatcaggaatcctggaagtccttcattgcatcctggtggaaagtccagaagctctgaac atcattcagaaagctcacatcaaatccatcatttctctgctctacaaacacggacggaac cacaagattctggacgttctttgttctctctgtgtttgcaacggcgtggcagtgagagcc aatcagaatctgatctgtgacaacctgcttcccaaacgggatctgctgcttcagactcga ctggtcaatgatgtacaaagcatgcgtcccaacatcttcctgggcatggcggaaggttca gcccagtacaagaagtggtactttgagctggtcattgaccaggtggaccattttgttact ggagagccgacccacttgagggtgggatgggccaacacaaaaggttacgcaccttacccc ggtggaggagaaggatggggaggcaatggagtgggagacgacctttactcgtacagcttc gatggactccatctgtggtcaggtcgtatcccgagagccgttgcctccataaaccaacac cagctgaactctgacgatgtggtcagctgctgtctggatctgggtgctcccagcatgtcc ttcaggatcaatggccagcccgtccagggaatgtttgaggatttcaacacagacgggttc ttcttccctgttgtcagcttttctgccggggtcaaagtccgtttcctgttgggtggacgc catggagactttaagtttctgccccctgctggttactctccgtgctacgaagccctgctg cccaaagagaaaatgcgggtggagcctgtgaaggagtacaagagggatcacgatggagtc cgagacctgctgggaaccacaccgtttttgtctcaagcctccttcatccccacccctgtt gacaccagccagattgttctgccgcctcatctggaaaacattcgggacaaactggcagaa aacatccatgaactttgggggatgaacaaaatcgaactgggctggacgtacggcaaggtt cgggatgacaacaagcgtcagcatccgtgtcttgtggatttccccaaactgcctgaaact gaaaggaactacaacctgcaaatgtccagtgaaacactaaaaactctgttagctctggga tgccatgttgcccaggttaatgttaacgcagaggacgatctgaagaaaatcaaactgccc aaagactacattatgtcaaacgggtacaagcctgcaccactggaactctctgacgtcaag ctgaatccgggtcaagaggttctggtcgataaactggccgagaatgcacataatgtgtgg gccaaagaccgaataaaacaaggatggacctacggcatccaacaggatctgaaaagcaga cgaaatcctcgcctggtgccgtatgctttactggatgaacgcactaaaaagtctaaccga gacagtctaagggaggccatcaggaccatagtgggatatggatatgacatcgaccccccg gaccaggagtcggtgcatgtgttggatgatcacagtgtggagaccatccgcttcttccgt gtggagcagacgtacgccgtgaagacggggaagtggtactttgaatttgaagtgctgagt gggggtgatatgcgagttggctgggccagaccaggctgcagacctgatgtagagctggga tcagacgaccaggcctatgtctttgacggatacaggggccgacggatgcacactggcagc cgctactttggacatccatggaagaaaggggacgtggttgggtgtatgatcaacatggag gacaagtccatgattttcaccctgaatggagaacttctgatcacaggcaaaggctctgag ctctgcttcactgactttgagacccaggatggtttcatccccgtgtgtagccttggcatg gctcagatcggccgcatgaacctggggaaggacgccagcacctttaagtactacaccatg tgtggtctgcaggaaggctttgaacctttcggcgtcaacatgaaaagagaaatcaccatg tggttcagcaaacgcctgcccaccttcttcaatgtcccccaggaccacgcccacatcgag gtgaccaggatcgacgggacggtggacagtcccccctgccttaaagtcacccataagaca tttggtacgcagaacagcaacagtgacatggtgtactgcaaactgagcatgcctgtggag ttctactctgcagacaagatgctggatgaatccgtgaagctcagccaacctcctaaagaa ggtgctgattacagctgcatcacaacctacttccactcagtgaaagtgttcgcgggacag gaccccgcctgcgtgtgggtaggctgggtgacgcctgactatcactattacagcaagaac ttcagcctcgcaaaaacacaaactgttactgtcaccctgggagacgagagggggcgggtc catgagagtgttcagaggagtaactgttacatggtgtgtgcggcagacgccgtcagcccg tcctcctccagccgctccaactctgatctggagatcggctgtctgatagacctggccacc ggtctggtctccttcactgccaatgggaacgagctccccacagtttatcaggtggagcca aatacaaagctcttccccgctgtgtttgttcttcctaccagcccaaacctcttccagttt gagtttgttaaaattaaggatgccatgccactgtcgtcagccatgtttaagagtgaacac aacaacccagtgcctcagtgtccaccgcggctggatgtgcagaccattgtagccgttctt tggagccgcatgccaaacacattcttgaatgttgagacggctcgagtcagtgaaaggcac ggctgggtgatccagtgtttggagccgctgcagatgatggctgtgcacatacctgaggag aacagatgtttggacatcttggagctgtcagagcatgaggacctcaggaagttccactat cacactctaaagctctactgcgccctctgtgctctgggaaacacgcgcgtcagccatgcc ctctgcagccacttggatcaatctcagctcctttacaccatcgacaaccagtacctgtcc ggcatgttaagggagggattttacaacgtcctcatcagcattcatcttgagacagcaaag gaggctcgcctgatgatgaacaacgagttcatcatccctgtgacagacgagactcgttcc atcaagctgttcccggatgagtcaaagcagcactctctgccgggcgtgactctaagcacc tccctcaaacccagagtcaacttctcacctgttggcatcatcaacaccaagcgcccccag ttcctctacagcccccagatccctctgggaattctgaaggagaaggccatcaccatgcta agtgaggctgtgcagggcggggggtcccacatccgagatccagttggtggaagtttggag taccagtttgtccccatcctgaaactgattggaaccctgctgataatgggggtcctcacc agtgaggaggtgaggctgattctcctcctggttgagcccaacgtctttggagagaacaag gagggcgaggaggccaaaggagaagtgttggctgtggccggggagaaggaggaggtgagc aagaacgaggagaaggctgtggaggcaggagaggaggaaaccaaggagagcaagtccccc tccaaaggcctgttggagaagtcgctgcctgagccagtgaaacatcagatgtgtgagctt ctgcactacttctgtgactgtgagctgaggcaccgcattgaagccatcgtctccttctcc gaccgcttcgtctccaagcttcagttcaaccagaagtttcgttacaatgagctgatgcag gcattcaacatgtctgctgccgtcacggccaagaagaccaaggagttcaggtctcctcca caggagcagatcaacatcctgctaaacttcagcgcaggagaggactgcccgtgtcccgag gagatccaggacgagctcaatgctttccacgaggagctgcggctgcactgtggaatcccg atggaagaggaagaggaggagcaggacacttcaattaaaggcagacttctggctttgctc tacaagatcaaagggcctcctcagaaagcagcggaggagcccaccgagacagagcaggcc gccccgactaacttgaaggagctgatttctcagaccataacgagttgggcgcaagagtcc cacatccaggaccctgagctggtcagggtcatgttcagcctgctgaggaggcagtacgac ggcattggagagctgctccgcgccatgaagaagtcttacaccatcagcgccgcgtcggtg caggacgccatcaacctgctggcttctctgggtcagatccgttctctgctgtcggtgcgc atggggaaggaagaggagaagcttatgattgatgggcttggggacatcatgaacaataaa gttttctaccagcatcctaatctgatgcgggttctgggcatgcacgagaccgtgatggag gtcatggttaatgttctaggaggagacaaatcccagaaaattgccttcccaaagatggtg gccagctgctgtcgtttcctgtgttacttctgccgcatcagccggcagaaccagaaggcc atgtttgaccacctgagctacctgctggagaacagcagcgtgggtctggcctctgaagcc atgcggggctccactccgcttgacgttgcagcctcctcggtcatggacaacaacggcctg gctctggctctggaggagcctgacctggagaaggtggtgatgtacttggcgggatgcggc ctacagagctgcgccatgctggttgctaaaggttaccctgacattggatggaaccccata gaaggagaacgttacctgtccttcctgaggttcgccgtcttttgtaatggtgaaagcgtg gaggaaaacgccaacgtggtggtgaagctgctgatccgacgtcctgagtgttttgggccc gccctccggggggagggggggcagggtttgttggctgccatgaaggaagccatcaagatt tccgaggatcctgctctggacctgcccaagacctccgctggagacgttactgggtctgct gaagaggaagaagaagttattcacatgggaaacgccatcatgtccttctactctgccctc attgacctgctgggacgctgtgctccagagatgcatctcatcaacgccggtaaaggggag gcgctgcgtatccgggccatactgcgctctctggttcccacctctgacttggtcggcatc atcagcatccccctcaacatgccggtggttcataaagatggcaccgtgacagaaccggac atgtctgcttctttctgtccggaccacaaggcccctatggtgcttttcctagacagagtg tatggcatcgaggaccagagcttcctgctccagctgctggaggtcggcttcctccctgac ctgaaagcctctgcgtctctggacactgaggtgctgagcaccacagagacggctctggcc atgaacaggtacatcggctcggcactgctacctttgctgacgcgctgtgccgccctgttt gccaacactgagcattacgctcagctggtggactccacgctggagaccatctaccggctg tcgaaaggccgttcgctcaccaaagcccagagggacgccatcgaggactgtctgctcacc atctgcaaacatctgcgaccctctatgatgcagcagctgctcaggcggctggtgttcgac gttcccatgctgtcagaatactgcaagatacctctgcggctgttgaccaaccactacgag cagaactggaagtactactgtctgccgtcaggtatgggcagcttcggcatcgcttctgaa gaggagctgttgctcaccaagaaactcttctggggaatctttgactcgctgtctcagaag aagtacgacgctgaactcttcaaaatggccaaatcctgcctgtgtgccatcgccggagca ctgccgccagactttgtggacaccagcttagcggcgagtctggagaaacaaggatcggtg gatgcgcagggccatttcgaccccaaacccgtcagcacggccaacatctcccttcctgaa aaactggagtacgctgccaacaagtacgcagagcactgccatgataagtggagctcagag aaaatgtctgcaggctggaaacatggagacagtctggacgagcaggccaaagcccatcca ctgctgaagcctttcaaagctctgagtgagaaggaaagagagacgtaccgctggcctgtg agggaggcgctgaagagcatgctggctatgggctggaacatcgagaggaccaaggaggga gaagccatgttccagcaacgagagagtgaaaagcagagacgccagtcagagtcccagggt gacggatttagtcccgcccccatggacctccataacatcactttgtctcgagagttgcag ggcatggtggaggtggttgcagagaattatcacaacatctgggccaagaagaagaaaaca gagctgcagagcaaagggggggttgctcacccgctgctcgtgccatatgacactctgacg gctaaagagaagtacagagacagagagaaggcacaggagctcttcaagttcctgcagata agtggctatgccatcacaagagggttaaaggacctagagctcgactcgtcttccatggaa aagcgtttttccttcaagttcctcaagagactcctgaaatacgtggactctgctcaggag ttcatcgctcatctggaggccatggccaccagcggaaagacagacaagtcccctcatgac caggaaatcaagttcttcgctaaggtgctgctccccctgattgaccaaaccttcaagaac cattgcctttacttcctgtccacacctagcaagaacctgagcagctgcggctgcgcctcc aacaaggagaaagagatggtgaccagcctgttctgtaagctagctgctctggtcaggcac aggatttctctctttgggagtgactctgccatgatggtcagctgtttgcacattctcaca aactcgctggacaccaggacggtgatgaagtctggctctgagctggtcaaagccagtttc aaggcattctttgagaacgcttcagaggacctggaaaagctggtggagatgctgaagctg gggaagttcatgcagtcacgtgcgcagatgaagagtgtcagccagagcatcaactatgtg accgtggcgctgctgcccattctcactgcgctcttcgagcacatccggacgcacgagttt gctgcagatctgctcctgaacgacgtccagctgtcgtgctacagaatcctgatgtgcttc tactctctgggaatcggaaagaacatctttgtggagaggctactgccagcactcggtgag agtctggccactctggtggccgccatgccggttgctttcctggagccccatctcaacgcc cacaacccactttcggttttcaacaccaagaccccccgagaaagagccatcctgagcatg cccgacacggtggaggagatgtgtctggacatgcctcgcctggacaaactgcttaaggac gtcaacgacatctccgactccggagcgcgctacagcgacatgccgcaggtcatcgaggtc atcctccccatgctctgtaactacctgtcgtactggtgggaaaaaggtccagagaactcc cccccagatacagactgctgcaccatggtgacctctgaacatctgagcatcattctggga aacatcctgaaaatcctcaacaacaacctaggtatcgacgacgccccctggatgaagagg attgcggtctactcccagccaatcatctgcaaagctggggcggatctgttgagaagccac ttcctgcccacgctggacaaactgcggaagaagacggtgaaggtcgtggctgaagaggag ctactgaaagccgacagtaaaggagacaaccaggaggctgagcttctcatcttggatgag tttgcaatgctgttgagggacctgtatgccttctaccccatgctcatccgatatgtggac aacaaccgatccagatggctgaaggagccagatgcagactccaccgaactgttcaagatg gttgctgagatcttcatcctctggtgcaagtccaataactttaagcgtgaggagcagaac tttgtgatccagaatgagatcaacaatttggctttcttaaccgaagaaggaaaagcaaag atgtccaagtcgggaggggaccaggaaaggaagcacaagcgtcgtcgcggtgagtactac tccatccaaacgtcgctgatcgtcgctgcgctgaagaagctgctgcccatcggcctgaac atgtgcacacctggagatcaggagctcatctctttggctaagatccgctacagcttgaaa gacacagatgatgaggtgaaggagtatctgcagcagaacctccacctgcaggagaagtcg gacgacccggcggtgcagtggcagatgaacctttacaaagacgtggtggtgaggagcggc gagctgaccaacccagaacacacagtggacagaatccagagcatctcggctgccgtcttc cacctggagcaggtggaacagcctctgaggaataagaagtgcgtggtccagaagctgctg tctaagcagcggaagcgcgccgtggtggcttgtttccgcatggctcctctctacaacctc cccaggcatcgtgctatcaacttcttcatcccggcctatcagagactttggatagaagca gaggagtactcctttgaggagaagctagttcaggacctggcaaaaacccccatgaagatt gtggaggaagaggaggaggaggtggcggacatcaagcctgaccctcttcatcagctcatt ctccatttcagccacaatgccctgacagagagaagccacttggaagtagatcctttgtat attgcatatgcagacatgatggcaaagagctgtgcggaggacgaggaggaagaggaagaa gaagggaaagagaagacatttgaggagaaggagatggaaaagcagaagatcttgtatcag caggccaggctgcacgcgcgtggagccgccgagatggtgctgcagatgatcggtgccagc aaaggacgtttgggtctcatggtgacctgcaccctcaaactgggaatctccatcctcaac ggaggcaacgtgcacgttcagcagaaaatgctcgattatctaaaagaaaaaagggacgcg ggatttttcaagagtctctcaggactgatgcagtcgtgcagtgtcctggacttgaatgca tttgagaggcagaacaaagctgaaggacttggcatggtgacagaggaaggtacatcccac actggacggggctccaaggtgctgcagaatgacgagttcaccaaagatctcttccgcttc ttgcaacttctctgtgagggacacaacggagatttccagaacttcctgagaacccagaca ggaaacacaaccacagtgaacatcattattagcactgtggactatttgctccgtcttcag gaatccatcagtgatttctactggtactactctggcaaagatatcatcgatgagactgga aggctgaacttctccaaggccttggctgtagcaaaacagatcttcaactcactgactgag tacattcagggcccgtgcattgggaaccagcagagtttggctcacagcagactgtgggac gccgtcgtgggttttttgcacgtgtttgccaacatgcagatgaaactgtctcaggatgcc agtcagatagagctgctgaaggagttgatggacctacagaaggacatggttgtcatgttg ttgtctctccttgagggtaacgtggtgaacggaaccatcggaaagcagatggtcgacacc ctggtggagtcctccaacaatgtagagatgatcctcaagtttttcgacatgttcctgaag ctgaaggatctaacaacctctgacaactttagagagtacgaccccgagtttaaaggcatc atttccaccaaagagttccagaagtcaatggagagccagaagcagtacacccagtcagag atcgagttcctgctctcatgcgcaaaggcagacgagaacgacatgttcaactacaaggag tttgtggagcgcttccacgagccggccaaagacattggcttcaatgttgccgtgctgctg accaacctgtccgaacacatgccccacgactcccggctcagcaccttcttggacctggca gaaagcgtgctgagctactttgagccttacctgggtcgtattgaaattctgggcagcgca aagcgaattgaaagggtttactttgagatcagcgagtccagcagagagcagtgggagaag ccacaagtcaaggaatccaaacgccagttcatctttgacgtggttaatgagggtggagag agcgagaagatggagatgtttgtgaatttctgcgaggacaccatctttgagatgcagctg gcctcacaaatctctgaacctgatgtggctgagcagccggaagaggaggaggaagaagag cacagcctcctggaggagctggctggagatgaagatggagccctcgagtccccctcagcc tttaccactgcatgccgttcgctgaagaagaagatctcagatgtccgtcagatttttgcc attaaaaatctacgcaagcagtttaagaaaatccgaaaactaagtgtgaaggaaatgatc accggcttcttctccttcttctggatgatctttattggcttctttaagggaatctacagc ctcatatttggtttcttccacatcatctggtcctccatgtttggtggaggtctagttgaa ggagccaaaaacatgaaggtgacagacatcctgggacacatgcctgaaccaactcagttt ggtatccatggagacacggtggaaggagacaaagccgaaacaacagagtcatcaggaagc atagacacagccacggcgcccactggagatatcgtagaggtggacaccatgatggaaatg ctggcacctaaaaaagaaggagggaagcatgtggagcctggcctgggagatgtttctgag ctaagttcagattcttctgctgcagatcacaaaaagaaagggtcttccaagctggccgat accatcgagagtggaaaagagaaagcagactcagagaaccaagagaaggaggataagcca aaagaagaggaggtgaaggagccagcagctcaggagaaacctcgaacaagatccagccag cctaaagaagcctcccctgcctttatgtcgaccatctttgctgttcttgatgtctatttg accaagatgctgaactacttggctcgtaacttctacaacctccgtttcctggctctgttt gtgtgctttgccatcaacttcatcctgctcttctataaggtcactgaagagattgtggag gaggaagaggatgagaacccttggagtgaggatgaaggtgacgagaacacgctctttgac atggatgagtttgtgcttcaggagagcacaggttacatgcagccagcgctgcgcttcctg gcggttttccacacagtcatctcgctcctctgtctgttcggctactattgtctgaaggtt cctctggtggtcttcaaaagggaaaaggagatcgccaggaagcttgagtttgatggtttg tacatcactgaacaaccttctgatgatgacatcaagggtcagtgggatcggctcgtcatc aacactccgtctttcccgaacaattactgggacaagtttattaagcgcaaggtcatcaac aaatatggcgacatgtatggggctgaacgcatcgctgaactcctgggtctggataaatct gctctagactttgacccaacagtggagacggtggagaaggaggcctccttggtgtcctgg tttagctccattgataccaaataccacatgtggaagatgggcgtggttttgactgacaat aacttcctgtatctgatctggtacaccaccatgtccatttgtggacacttcaacaacttc ttctttgctgctcatctgctggacatcgccatgggcttcaagaccctccgcaccatcctg tcgtccgtcacccacaacggcaagcagctggtgctgacggtgggtctgctggccgtggtc gtttatctctactccgtggtggccttcaatttctttagaaagttctacaataagagcgag gatgaggacgagccggacatgaagtgtgacgatatgatgacgtgctacttgttccacatg tatgtgggcgtgagggctggaggaggcattggagacgagttggaggacccagctggagat ccctacgagctctaccgcatcctgtttgacatcaccttcttcttctttgtcatcgtcatc ctcctggccatcattcagggtttgatcattgatgcctttggggagctgagagaccagcag gagcaggtgaaggaggacatggagaccaaatgcttcatctgtggcattggaaacgactac tttgaccggacacctcacggctttgaaacccacaccttacaggagcacaacctcgccaac tacctgttcttcttgatgtacctgatcaacaaggacgagaccgagcacacgggtcaggag tcgtatgtgtggaagatgtaccaggagagatgctgggacttcttccccgccggagactgc ttccgcaaacaatacgaggaccagctgggttag

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