Oryzias latipes (Japanese medaka): 101172231 Help Entry 101172231         CDS       T02443                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism ola  Oryzias latipes (Japanese medaka) Pathway ola04020   Calcium signaling pathway ola04260   Cardiac muscle contraction ola04261   Adrenergic signaling in cardiomyocytes ola04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ola00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101172231    04020 Calcium signaling pathway     101172231  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     101172231    04261 Adrenergic signaling in cardiomyocytes     101172231  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ola04040]     101172231    04990 Domain-containing proteins not elsewhere classified [BR:ola04990]     101172231 Ion channels [BR:ola04040]  Voltage-gated cation channels   Ryanodine receptor    101172231 Domain-containing proteins not elsewhere classified [BR:ola04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101172231 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  101172231 NCBI-ProteinID:  XP_023805328 LinkDB All DBs Position 19:complement(17020296..17330803) Genome browser AA seq 4986 aa AA seqDB search MTECARTRGHSPSQHLSGAAAPASPTDLTMADGGDGEDEIQFLRTDDEVVLQCSATVHKE QQKLCLAAEGFGNRLCFLESISNSKNVPPDLSICTFVLEQSLSVRALQEMLANIKEKSDG GGGHRTLLYGHAVLLRHSYSGMFLCCLSTSRSSTDKLAFDVGLQENTTGEACWWTIHPAS KQRSEGEKVRVGDDLILVSVSSERYLHLSYGNCSLHVDAAFQQTLWSAAPICSGSEVAQG FLIGGDVLRLLLGHMDECLTVPSGEQGDEQRRTVHYEGGAICTHARSLWRLETLRVMWSG SHIRWGQPFRLRHVTTGKYLSLTEEKSLLLIDKEKADVKSTAFCFRSSKEKSDPGVKKEV DGMGTPDIKYGDSVCYIQHVETCLWLTYQTVDAKSVRMGGVQRKAIMHHEGHMDDGLTLS RSQHEESRTARVIRSTVFLFNLFIRGLDMLRKQGRSSAFNLPIDSVSLSLQDLIGYFQPP GEHMDHEERQNRLRALKNRQNLFQEEGMISLVLDCIDRLHVYNSTAHFADVVGHVAAEAW SSILNSLYQLLAALIRRNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEAL NIIKEGHVKSIISLLDKYGRNHKVLDVLCSLCVCNGVAVRSNQHLICDNLLPGRDLLLQT RLVNHVSSMRPNIFLGVSDGSAQYRKWYYEVIVDQALPFVTAEPTHLRVGWANTSGYAPY PSGGEGWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRSEDVVSCCLDLNVPSI SFRINGQPVQGMFENFNSDGLFFPAASFSAGVRVRFLLGGRHGEFKFLPPAGYAPCCEAV LPREKLKLEASQDQTAARELLGPTVTLSQAAFTPTPVDTSQIVLPLHLERIREKLAENIH ELWVMNKIDLGWTYGMVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHV GLADEKAVGRVKSLELSPTYELSSGYKPAPLDLNHIKLTPSQEAMVDKLAENAHNVWARD RIRQGWTYGIQQDLKNRRNPRLVPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQD HATQSDSSSLSAERFRIFRAEKTYCVHSGKWYFELEVLTFGEMRVGWARPGCLPDQELGS DDQAFVFDGFKVQRWHQGNEHFGRAWQAGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSEL AFKDFEVEDGFIPVCSLGVCQVGRMNFGKDVSTLRYFTICGLQEGYEPFAVNVNRDVTMW LSKRLPQFVPVPPNHQHIEVSRIDGTVECCPCLKVTQRSFGSQNSHTDITFYRLSMPIEC AEWRSGASGNLFSSKKELDDFETVSDFEVLIKSSHGHSVSNIPSVPGGPEKDEFNNHKDY NQEKSSKVKQRFLLKRNKTDSSSHQSAHLSEEAGSDDREGYELLLHTSVYYYSVRIFPGQ EPSSVWVGWVTSDFHQYDPGFELHKVRTVTVTLGDEKGKVHESIKRSNCFMVWAGESSST GGQGRNNTGLEIGCLVDTTTGLLSFTANGKELSTYFQVEPSTKLFPAVFAKATSPNVFQF ELGCVKNTMPLSAGLFRSERRNPVPQCPPRLHVQFLTPVLWSRVPNHFLRVSASRVNDRH GWLLQCDQPLQFMSLHIPEENRSVDILELSEQKDLLRFHYHTLRLYSAICALGNNRVAHA LCSHVDEAQLLQAIQNKYMPGLLRAGYYDLLIDIHLRSYATARLMMNNEYIVPMTEETKS ITLFPDKGKKHGLPGIGLSTSLRPRMHFSSPSFIRVAGSMLSSTTGSGSFFQFSPEFPLD TLKVKTIEMLTEAVQEGSMHVRDPIGGSTEFLFVPLVKLVYTMLIMGVFQDGDLKKILQL IEPSVFSEYREEAGEKSGSMNLEKLSRGEDGGKSVPKEGLLQMKLPEPVKLQMCHVLQYL CDCQVRHRIEAVVAFSDDFVACLQDNQRYRYNEVMLALNMSAALTAKKTKEFRSPPQEQI NMLLNFKGEKQDGPCPEFIREQLLDFHEDLMRHCGIELDDDIAIDGDNDFTFRGRLMLLV EKVSALKKKIGNPPKEKDRQPSTLQQLISNTMVSWAQESVIEDPDLVRAMFVLLHRQYDG IGGQVHALPKTYTINSVSVEDTINLLAALGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKV FYQHPNLMRALGMHETVMEVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAM FDHLTYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGL QSCIMLVHEGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPA LRGEGGDGLLAAMKEAIRISEDPSRDGPSPTSESSKSLSDLLGEEEDDTIHMGNAIMTFY SALIDLLGRCAPEMHLIHASKGEAIRIRAILRSLIPLEDLVGVISIPFSMPNEAKDGVVV EPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLMHLLEVGFLPDLRAAASLDTVALSATDM ALALNRYLCTAVLPLLTKCASLFAGTEPFASLIDSLLHTVYRLSKGGCLTKAQRDSIEEC LLAVCGKLRPSMMQHLLRRLVFDVPLLNDHTKMPLKLLTNHYERCWKYYCLAGGWGSYGA ASEEELHLSRKLFWGIFDALSCKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQ SSMDAEGNFTPQPADTSNVTIPEKLDYFISRYAEHNHEKWCTEKISSGWSHGETMCESSK SHPLLKPYKSLIEKDRDMYCCSVRESLKTMLSWGWCIDRSREGDPSSLHNKSRRISQSSQ FSFEGAPAFTPRPIDMSNVTLSTEMQSMAELLAENYHNIWARKKKMELEAKGGGSHPLLV PYDTLTAKEKSKDKEKAQDILKFLQINGYTVSRGPKSHELDTPAIEKRFAYTFLQKLIAY VEHAYQHMMDFDVATRRKGEKIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTVIHPISS GGHASNKEKEMVTSLFCKLGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVMKTGLEL VKAALRSFFTSVAEDLEKTQENLKLGQFTHNREQPRGVTQIINYTIFALLPVLSSLFEHI GQNMFGEDLMLDDIQVSCYRILNSLYFLGTNKSIFVERQRPALGKCLAAFSAAFPVAFLE PHINKFNSFSVYNSKGSSDRAALGLVGPVGDICPLVPNLHKSLEEIMELAESGVKYTQMP HVMEVVLPMLCSYMSHWWEHGPENNPGKADTCCSCVTSEHMNTLLGNILKIIYNNLGIDE GAWMKRLAVFSQPIISKAKPQLLRTHFLPLMEKLKKKAAVVLMDEEHSRAEGRGEMSERE LLIMDQFTVLVRDLYAFYPLLIRFVDYNRARWLKESNPDAEELFGMVAEVFIFWAKSHNF KREEQNFVVQNEINNMSFLISDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKR LLPVGLNTCAPGEQDLISLAKSRFSQKDTEEEVRETLRNNLHLQGKLEDPAIRWQMALYR DLPHHQEHTSDPEKTVERVLVIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFR MAPLYNLPRHRAVNLFLQGYEKSWIEAEEHYFEDQLIEDLAKAGEQEPAEEEEGMKHMDP LHQLIQLFSRTALTEKCKLDEDNLYIAYADIMAKSCHDEEEEDGEVKSFEEKEMEKQKLL YQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSKVQQKMLDYLKDKK DVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVISHERGEKVMQDDEFTCDL FRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWFYSGKDVID EQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLS QDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDM FLKLKDLTSSDAFKEHDPDGKGVISKRDFHKAMESHKHYTQTETEFLLSCTETDENELLD YEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIM GSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFE MQLAAQMSDAGERLAMKEDGEREKSEEDSADAGFFSMSTVYMALLALRYNLLLLIKVLSM KSLKKQIKKIKNMTMKDMVTTLVSFYWSLLLALLHVVFSVTRGFCRIFYNTFMGGNLVEG AKTIKVSELLANMPDPTQDEVRGEGEDREKRPTDRSTPSKDLADLALNTGESELLSDIFG LDLRKEGGQYRITPHNPDTSLTELLNSPAPPPSLPAAAEPELRQRHQSRSCFDENDTTTQ AAAETEKSSEGMETSETLQKNEKMKAKVRRHHSYRCDEPDLQESAFLKKIIAYQRKLLNY FARNFYNMRMLALFVAFAINFILLFYKVSTSSSLVEGKEAVYSSSSVQWEHQPEEWLEAK ERGMEGNGKPAKPITVRFVLEESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFK REKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFY GHDRISELLGLDKAALDFSDTQKKRKHRRDSSLATVLNSIDVKYQIWKLGVVFTDNSFLY LAWYMTVSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEI YRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTV PHGFETHTLHEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQ YEDQLN NT seq 14961 nt NT seq  +upstreamnt  +downstreamnt atgaccgaatgtgcgcgcacgcgcgggcactcgccgtctcagcatttgtcaggcgcagca gctccagcctctcccacagacctcaccatggctgacggaggagacggcgaggacgagatc cagttcttgagaacggacgatgaggtggtgctgcagtgctcagccacggtccataaagaa caacagaaactctgcctcgctgctgaaggttttggaaacagactctgctttcttgagtcc atctccaactctaagaatgttcctccagatctttccatttgcacttttgtcttggagcag tcgttgtctgttagagccctccaggagatgctggccaacatcaaggaaaagtccgacggg ggaggggggcatcgtactctgctgtatggtcatgctgtcttactgcggcactcctacagt ggaatgttcctgtgctgcctgtccacatcccgctcttccacagacaaactagccttcgat gttggattgcaagaaaacactacaggagaggcatgctggtggaccattcatcctgcatca aaacaacggtcggaaggagagaaggtcagagtgggagatgatctcattctggtcagcgtc tcctctgagagatatctgcatctgtcctacggcaactgcagcctccatgtggacgcagcc ttccagcagacgctttggagcgcggccccaatctgctctgggagtgaggtagcacaaggt ttcctaattggtggggacgttctacgcctgctccttggtcatatggacgagtgtctgact gttccatctggagagcaaggggacgagcagaggaggacagtgcactatgaggggggagca atctgcactcacgctcggtccttgtggaggctggagactctgcgggtcatgtggagtggc agccatatccgttggggtcagcctttcagactcagacatgtgaccactgggaagtatctg agtctcacagaagagaagtctctgctactgatagacaaagagaaggcggacgttaaatcc actgccttctgcttcaggtcctcaaaggaaaaatccgaccctggtgtgaagaaggaggtg gatggtatgggcactcctgacataaaatatggcgactctgtgtgttatatccaacacgtg gaaacctgcctttggctcacctaccagactgttgatgcaaagtccgttcgcatgggcggg gtgcagaggaaggctatcatgcatcatgaaggtcatatggatgacgggctcaccctgtcc aggtcacagcacgaggagagtcgtactgccagggtcatccgcagcaccgtatttctcttc aaccttttcatcagaggtctggacatgctgaggaagcaagggaggagttctgcctttaat ctaccaatagattcagtgagcttaagtctgcaggatcttattggttactttcagccacct ggagagcacatggaccatgaggagaggcagaaccgtctgagagctttgaagaacaggcag aacctcttccaagaggagggcatgatcagcctggtcctggactgcatcgatcgtctgcat gtgtacaacagcaccgctcactttgcagatgtggttggacacgtggctgcagaggcctgg agctctatcctgaactccctctatcagctgctggctgcacttataagacgaaaccgaaaa aactgtgcccagttttccggctcacttgactggctgataagcagactggagcggctggag gcctcctcaggtatactggaggttcttcactgtgtgctggtggaaagtcctgaagctcta aatatcatcaaagaaggacatgtaaaatctatcatctccctcctggacaagtatggacga aaccacaaggttctggatgtgttgtgctctctgtgtgtgtgtaacggcgtggccgtgcgc tccaatcagcacctgatctgcgacaacctgctgccaggaagagacctgctgctgcagacg cgcctcgtcaaccacgtcagcagtatgcgacccaacatcttcctgggtgtcagtgatggt tccgcccaatacaggaagtggtactatgaggtaatcgtggaccaggctttgccatttgtc acggcagaacccactcaccttagagtgggctgggccaacaccagtggctatgcaccgtac cccagtgggggagagggctggggaggcaatggggtgggggatgacctcttctcctacggc tttgatggacttcatctgtggtcaggttgcattgctcggactgttagttcacccaaccag catctgctgcgctctgaagatgtggtcagctgctgcctggatctgaatgttcccagcatt tccttcaggatcaatggccagccagttcagggcatgtttgagaacttcaactcggatggc ctgttcttcccagcagccagcttcagtgcaggtgtcagggtgcgtttcctccttgggggg cgtcatggggagttcaaattcctcccccctgcaggctatgccccatgctgtgaggctgtg cttcccagggagaagctaaagttggaggccagtcaggaccagactgcagccagagagttg ctgggacccaccgtcactttgagccaggcagcattcacccctacgccagtggacaccagc cagatagttctgccacttcacctggaaagaatccgagagaaactggcagaaaatatccac gagctgtgggtgatgaacaagatcgatctgggctggacatatggaatggttcgagatgat aacaagcggcagcacccttgtctggtggagttttctaagcttcctgaacaagagcgaagc tacaacctgcagatgtccttggagaccctgaagactttgctggcgttgggctgccacgtt ggactggctgatgaaaaggctgtgggaagagtgaagagcctggagctgtcaccaacatac gagttgtcaagtggttataaacctgcacctcttgacctgaaccacatcaagttgactccc agccaggaggccatggtagacaagctggcagaaaatgctcacaatgtctgggcaagagat cgcattcggcaaggctggacttacggcatccagcaggatttgaagaaccgcaggaaccct cgtttggtcccctataccctgttggatgaaagaaccaaaaagtccaacaaagacagctta agagaggctgttagaacgctactagggtatggatacaacctggaagctccggaccaggac catgcaactcagtctgattccagcagtttgtctgctgagagattccggatcttccgagca gagaaaacttactgcgttcattctgggaagtggtactttgaactggaggttctgactttc ggagagatgagggtgggctgggccagacccggctgtctgccagatcaggagctgggatcc gatgaccaggcctttgtttttgatggttttaaggtccaacgctggcaccaggggaacgag cactttgggcgagcttggcaggctggtgacgtagtgggctgcatggtggatctgaacgag cacaccatgatgttcacgctcaatggggaggtgctccttgatgactctgggtctgaactg gccttcaaagactttgaagttgaagacggtttcatccctgtgtgcagtctgggtgtgtgc caggtggggaggatgaactttgggaaggacgtcagcactctcagatactttaccatatgc ggcctgcaggagggctacgagccttttgctgtcaatgtgaaccgcgacgtgaccatgtgg ctcagcaagaggctgcctcagttcgtgccggttccccccaaccatcagcacatcgaggta tccagaatcgatgggacagtggaatgttgtccctgcttgaaggtcacccagaggtcattt ggctcccaaaacagccacacggatatcaccttctacagactcagcatgcctatcgagtgt gctgagtggagatctggagccagtggcaacctcttctcatccaagaaggagctggatgat tttgaaaccgtctcagactttgaagtcctgataaagtcgtcccatggccacagtgtttcc aacattcctagtgttcctggtggaccagagaaagatgaatttaacaaccacaaagattac aaccaagagaagtcgtccaaggtcaaacagaggttccttctaaagaggaacaagacagac agcagcagccatcaatcagctcatctgtctgaggaggcggggtctgatgacagggagggc tatgagcttctcctgcatacgtctgtgtactactattcggtgcggatctttccgggtcag gagcccagcagcgtgtgggtaggatgggtgacctctgattttcatcagtacgatcctggt tttgagctccacaaggtccgaactgtcacagttacccttggagacgagaagggaaaagtt catgaaagtataaagcgcagcaactgcttcatggtgtgggctggagagagcagcagcact ggtggtcaagggaggaacaataccggcttagagatcggatgtctggtggacactacaact ggtctgctaagctttacagccaacgggaaggagctcagcacctacttccaggtggagccc agcacaaagcttttcccagcagtctttgcaaaggctaccagtcccaatgtcttccagttt gaacttggctgtgtaaagaacaccatgccgctgtctgctggtttgtttaggagcgaaaga aggaaccctgtcccccagtgtcctcctcggctccatgtccagttcctcactcctgtgctt tggagtcgtgttcctaaccacttcctcagggtttcagcctccagagtgaacgatcgacac ggctggctgctccagtgtgatcagcctcttcagtttatgtctctgcacatacctgaggag aacaggtctgttgacatcctggagctttcagaacagaaggacttgctgagatttcattac cacaccctcagactttactccgccatctgtgctcttgggaataaccgagtggctcacgct ctttgctcccatgtggatgaggcgcagctgttgcaggctatacagaacaagtacatgcca ggtttacttcgagcaggctactatgacctcctgatcgacatccacctcagaagctacgcc accgctcggctcatgatgaacaacgagtacatcgttcccatgactgaggaaaccaaaagc ataaccctgttcccagataaagggaagaagcatggcctgccgggaatcggacttagcacc tctctgcgacccagaatgcatttctcctctccaagttttatccgagtggcaggatccatg ctgagtagcaccactggatcagggtctttctttcagttcagcccagagttccccctggac actttgaaggtcaaaactatcgagatgctgacagaagcagtgcaggagggcagcatgcat gtgagggatcccatcggtgggagcacagagtttctgtttgtgcccctagttaagctggtc tacaccatgctcatcatgggagtcttccaggacggagacctgaagaagattcttcagctc attgaaccatccgtgttctcagagtacagagaagaggctggtgagaagtccggatcgatg aacctggagaagctcagcaggggagaagatggagggaagagcgttcccaaagaaggactt ttgcagatgaagctgccagaaccagtaaagctccagatgtgccatgtgcttcagtacctg tgcgactgccaggtgcggcaccgtatcgaggcggtggttgctttctcagatgacttcgtg gcttgtcttcaggataaccagcggtaccgctacaacgaggtgatgctagcactcaacatg tcagcagccctcaccgccaagaaaaccaaagagttcagatcccccccacaggaacagatc aacatgttgctgaactttaagggcgaaaagcaggatggtccttgtccggaatttatccgg gaacaactgctggatttccatgaagacctgatgcgacactgcggcattgagctggacgat gatatagccattgatggcgacaacgacttcaccttcagagggcgccttatgttgttggtg gagaaagtatcagctcttaagaaaaagatcggcaacccaccaaaggagaaggacagacag cccagtactttacagcagctcatttcaaacacgatggtcagctgggctcaagaatctgtg attgaagatccagatctggtcagggcaatgtttgtcctgctgcaccgccagtatgacggt ataggcggccaggtgcatgctcttccgaagacctacaccataaactctgtatcagttgag gacaccattaacctactggctgccctgggtcagatcagatctctgctgagtgtccgtatg ggcaaagaggaggagaaattgatgatccgggggttgggtgacatcatgaataacaaggtg ttctaccagcatcccaacctgatgagagctctgggcatgcatgagactgtcatggaggtc atggtcaacgttcttagcggtggagactccaaggaaatcaccttccccaaaatggtggcc aactgttgtcgcttcctgtgctacttctgtcgaatcagccggcagaatcagaaggccatg tttgaccatctcacctatctgctggagaacagcagtgttggtcttgcatctccatcaatg agagggtccactcccctggatgtagctgcagcgtctgtcatggacaacaacgagctagcc ttggctttaagagagccagacctggagaaggtagtacagtacctggctggctgtgggctg cagagctgcattatgctggtccatgaaggatatccagacatcggctggaatcctgtggaa ggcgagcgttacctggacttcctgcgctttgctgtcttctgtaacggggagagtgtggag gagaacgctaacgttgtggtgaggcttctcattcgccggccagaatgttttggccccgcc cttcgtggtgagggtggtgatgggttactggcagcaatgaaggaagcaattaggatttct gaagatccctccagagacggtccttctccaacatctgagagcagcaaaagcctcagtgac ttgttaggggaggaggaagatgacaccatccacatggggaacgccatcatgacgttctac tctgctcttattgacctattgggtcgctgtgctccagagatgcatctaatccatgccagc aaaggtgaggcaatccgcattcgagccattttaaggtctctgattccacttgaggacctg gtgggtgttatcagcattcccttctccatgcccaatgaggccaaagatggggtggttgtg gagccagacatgtcggcaggtttctgtccagaccacaaagctgccatggtcctgtttcta gatcgtgtttatggcatagaagaccagaattttctcatgcacctccttgaagttgggttc ttgcctgatttaagagctgctgcctcactggacactgttgctctcagcgccactgacatg gcacttgccctcaaccggtacctgtgcactgcagtgctgcctcttctaaccaagtgtgct tctctgtttgctggcaccgagccctttgcctcccttattgactccctcctccatacggtg tatcgtctgtccaaaggtggctgcttgaccaaagctcagagagactccatcgaggagtgt ctgctggcggtgtgtggcaaactgaggccttccatgatgcagcacctgctgaggaggctg gtgtttgacgttccactgctcaatgaccacaccaagatgcctctgaagctgctgaccaat cactacgagcgatgctggaagtattactgcctggctggaggctgggggagttatggagca gcgtctgaggaagaacttcacctctccaggaagcttttctggggaatttttgatgccctg tcctgcaagcgctatgaccaggaacttttcaagctggctctgccatgcctcagcgccgtg gctggagctcttcctccggactacatggagtccaactacatggccatgatggagaagcag tcatccatggatgcagaaggaaacttcacaccgcagcctgcagatacctccaatgtgacc atccctgaaaaactggactatttcatcagtagatatgcagaacacaaccatgaaaagtgg tgcacagagaagatttccagtggatggtcacacggagaaaccatgtgtgaaagcagcaaa agccatcctcttctgaagccttacaagagcctcattgaaaaggacagagacatgtactgc tgttcagtcagagagtctctaaagaccatgttgtcgtggggctggtgcatcgatcggagt cgggaaggagacccttccagtctccataacaaatcaaggcgtatatctcaaagcagccag ttttctttcgaaggagctccagctttcactccaagacccatcgatatgagcaacgttacc ctgtccacagagatgcagtccatggcagagctgctggcagagaattaccacaacatttgg gccaggaagaagaaaatggagctggaagccaaaggtggaggaagccatcccctgctggtc ccatatgacactttgactgccaaagaaaaatcaaaagacaaagagaaggctcaggatatc cttaagttcctccagatcaatggatacactgtttccagaggcccaaagtcgcatgaacta gacactccagctatagaaaaaagatttgcctacacattcctgcagaagctcatcgcatat gtggagcacgcttaccaacatatgatggactttgatgttgctacgagaagaaagggagag aagattcctcatgaacagcagatcaagttctttggaaaagtggtcttacccttggtagac cagtactttaaaaaccacaggttgtatttcctatctacggtcattcatccaatcagcagt gggggccatgcctccaataaggaaaaagagatggtgacgagtctcttctgcaaactggga gttcttgtcagacacaggatatccttatttgggaacaatgcaacatccattgtcaactgc ctgcagatcctgggacaaagccttgatgccaggacggtgatgaagactggtcttgagttg gtgaaagcggctttgcggtcgttcttcaccagtgtggctgaggacttggagaagacccag gagaacctgaaactgggtcagttcactcacaatagagagcagccacggggcgtcacccag atcatcaactacaccatttttgccttgttgcctgtgctctcctcactttttgagcacatt ggacagaacatgttcggagaagacctcatgttggatgatatccaggtctcctgctacaga atcctgaacagcctctacttcctgggaaccaacaaaagcatctttgtggagaggcagcga ccagcattagggaagtgcctggctgccttctcagcagctttccccgtcgctttcttggag cctcacattaacaagttcaacagcttttccgtctacaacagcaaaggcagcagtgacaga gcagctttaggcctcgtggggccagtgggagacatctgtcctttagtcccgaacctgcat aagtctttggaagagattatggaacttgcagagtctggtgtgaaatacacacagatgcct catgtcatggaggtggtgctgccgatgctgtgcagctatatgtctcattggtgggagcac ggaccagaaaacaacccggggaaggcagacacttgctgttcctgtgttacttctgaacac atgaacactctgctgggaaacattctaaagataatctacaacaatttgggaattgacgaa ggcgcctggatgaagaggctggcagtcttctcacagcccatcattagcaaagccaaacct cagctgctccggacccacttcctacctctgatggaaaaactcaagaaaaaagcagcagtt gtgttgatggatgaggagcacagcagggctgaagggaggggcgagatgtccgaaagagag ctgctcatcatggaccagtttaccgttttggtcagagacctgtatgccttctacccactt ctcatccggtttgtggattataacagggcccggtggttgaaggagtccaacccggatgca gaagagctgtttggaatggtggcagaggtcttcatcttttgggccaagtctcataacttc aaaagagaagaacagaactttgtggtccagaatgaaatcaacaacatgtccttcctgata tctgacacaaagtgcaagatgtcaaaggggatagtttcagaccaggagaggaagaagatg aagaggaagggagacagatactcaatgcagacgagtctgattgttgccaccttgaagcgt ctgctacctgtgggcctgaacacctgtgctcctggagagcaggacctcatctcgctagct aagagccgcttctctcagaaagacacagaggaagaagtcagagaaaccttgaggaacaat ctgcacctgcaggggaagctggaggatccagctatccgctggcaaatggcattgtacagg gacctcccccaccaccaagaacacacctctgacccagaaaagactgtggagagagtcctg gtcatcgctcatgttctcttccacctggatcaggtggagcatccccaacgcagcaagaag gcagtgtggcataagcttctgtctaagcagaggaaaagagccgtggtggcctgcttcaga atggcgccactctacaacttgcccagacaccgcgctgtgaacctgttcctgcagggctat gagaagtcatggattgaagcagaggagcattactttgaagaccaactcattgaggactta gctaaagcaggggagcaggagccagctgaagaggaggaggggatgaagcacatggatcct ctgcatcagctaatccagctcttcagccggacagcactcacagagaaatgtaaactagac gaggacaatctctacatcgcctacgctgacatcatggctaagagttgccatgacgaggag gaagaagatggggaagtcaagagttttgaagaaaaggagatggagaagcagaagctgttg taccagcaggcacgactgcatgaccgcggagcagcagagatggtgcttcagaccatcagc gctagtaaaggtgaaatgggacctatggtggcatctactctcaaactgggcattgctatt ctcaatggaggaaactccaaagtgcagcagaaaatgttggattatttgaaagacaagaag gacgtgggcttctttcaaagtctggcgggtttaatgcagtcgtgcagtgttctggacctg aatgcgtttgagcggcagaacaaagcagagggtttggggatggtgacagaggaaggttca gtcatcagtcatgagcgtggtgagaaggtcatgcaggatgatgagtttacctgtgacctt ttccgcttcctgcagctgctttgtgaaggacacaactcagacttccagaactatttgagg acacaaacagggaacaatacaactgtcaacatcatcatctccactgtggattatttactc agagttcaggagtctatcagtgacttttactggttttattctgggaaagatgtcattgat gagcagggtcagagaaacttctccaaggccataaacgttgccaagcaggtgttcaacacc ctgacagaatacatccagggtccatgcacaggaaaccagcagagtctggcacacagccga ttgtgggatgccgttgttggttttctgcatgtttttgctcacatgcagatgaaattatct caggactctagtcagattgagttactaaaggaactgatggatctgcagaaagacatggtg gtcatgctgctgtcgatgctggaaggtaatgtcgtaaatggcacaattggaaagcagatg gtggacatgttggtggagtcttccaacaatgtggagatgatcctcaagttcttcgatatg tttctcaaattgaaagacctcacatcatcagatgccttcaaggagcatgaccctgatgga aaaggcgttatctccaagcgggacttccataaggctatggagagtcacaaacactacaca cagactgagacagagttcctgctatcctgcactgagactgatgagaacgaactcctggac tatgaggagtttgtggagcgttttcatgaaccagccaaggacattggctttaatgtagct gttctgcttaccaacctgtctgagcacatgccccatgacacccggctgcaaacctttctg gagctggcagaaagtgtcctaaactacttccagccatacttgggccgcatcgagataatg ggcagtgccaagcggatcgagagggtctactttgagatcagtgagtccagccggactcag tgggagaaacctcaggtcaaagagtccaaacgtcagttcatctttgatgtagtgaatgaa ggaggggagaaggagaagatggagctgtttgtgaatttctgtgaggacaccatttttgaa atgcagctagcggctcagatgtctgatgccggcgagcggctagctatgaaggaggatggc gagcgtgagaagtcggaggaggacagtgctgatgcaggcttcttctccatgagcacagtg tacatggctctgcttgctctgcgctacaacctccttctgctgattaaggtgctgtccatg aagagcttgaagaagcagattaagaagataaagaacatgacgatgaaggatatggtgacc accctggtctccttctactggtccctcctgctggcccttctccatgtggtgttcagcgtg actcgaggattttgcagaatcttctataataccttcatgggaggaaatctggtggagggg gccaaaaccataaaggtgtcagagctgctggccaatatgcctgaccccacccaggatgag gtgcgaggggaaggggaggacagggaaaagaggccaactgaccgtagcacccccagcaag gacttggctgacctggccttaaacaccggcgagagcgagctgctgtcagacatttttggt ttggacctgaggaaggagggggggcagtacaggatcacacctcataaccctgacaccagc ctcactgagctcctcaactccccggcgccccctccatcactgcctgctgcagccgagcct gaactccggcaaaggcatcagtccaggagttgtttcgatgaaaatgacacaacaacacaa gctgcagctgaaacagagaagtcctctgaaggcatggagacatctgagacactgcagaag aatgagaagatgaaagcaaaagtgcgacgacaccacagctacaggtgtgatgagcctgat ctgcaggagtctgccttcctaaagaagattatcgcctaccagaggaagctcctgaactac tttgccagaaacttttacaacatgaggatgctggcgctgtttgttgcctttgccatcaat ttcattctcctcttctataaggtttccacctcttcatctctggttgagggaaaggaggca gtttatagcagcagcagtgtccagtgggagcatcagcctgaagaatggttggaggctaaa gagagagggatggaggggaacggcaagccagcgaagccaatcacagtccggtttgtcctg gaagaaagcagtggatacatggagcccatgctacggatcctagctgttctgcacacagtc atctccttcttctgcatcattggatattactgcctaaaggtccccctagtgatcttcaag cgggaaaaggaagtagcccgaaagctggagtttgatggtctctacatcacagaacagcct tcagaggatgatatcaaaggacagtgggacagactcgtgatcaacactcaatctttcccc aacaactactgggataagtttgtgaaaaggaaagtgatggacaagtatggagaattttat ggtcatgaccgcatcagtgagttgctaggattggacaaggcagctctggatttcagtgac actcaaaagaagcgaaaacacagaagagacagctccctggcaactgttctcaactccatt gatgttaagtaccagatctggaagcttggggttgtatttacagacaactcctttctgtac ctggcttggtacatgaccgtgtccattcttggtcactacaacaacttcttctttgctgct catctgctggacatcgccatgggattcaaaacgttgcgcaccatcctatcgtcagtcaca cacaacggaaaacagctggtgctgacagtcggcctattggctgtggttgtgtacctctac acggttgtagcctttaacttcttcaggaagttttacaacaagagtgaggacggcgagctg ccagacatgaaatgtgatgacatgctaacatgctacatgtttcacatgtacgtgggtgta cgggccggcgggggcattggagaccaaatcgaagacccagcaggcgatgaatatgagatc taccgcatcatctttgacatcaccttcttcttctttgttattgtcatcctgctggccatt attcagggactgattattgatgcctttggggagctgagggaccagcaggagcaagtaaag gaagacatggagaccaaatgcttcatctgtggaattggtaacgattattttgacaccgtt ccacatggctttgaaacgcacacactgcatgagcataacctggcaaactacctattcttc ttgatgtatcttatcaacaaggatgaaacggagcacacaggccaggagtcttacgtatgg aagatgtaccaggagcgctgttgggagttcttccctgccggcgactgtttccgaaagcag tatgaggatcaactcaactga

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