Onychostoma macrolepis: 131527780 Help Entry 131527780         CDS       T09350                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism omc  Onychostoma macrolepis Pathway omc04020   Calcium signaling pathway omc04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     131527780 (ryr3)    04020 Calcium signaling pathway     131527780 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:omc04040]     131527780 (ryr3) Ion channels [BR:omc04040]  Voltage-gated cation channels   Ryanodine receptor    131527780 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Ago_Mid EF-hand_1 EF-hand_6 DUF2207_C Motif Other DBs NCBI-GeneID:  131527780 NCBI-ProteinID:  XP_058613082 LinkDB All DBs Position 20:complement(18593510..18684390) Genome browser AA seq 4865 aa AA seqDB search MAEGGEGEDEVQFLRTDDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYFPP DLCICNFVLEQSLSVRALQEMLAGQSGEGNPDHEQWAAQGGGHRTLLYGHAILLRHSFSG MYLTCLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSISNASIQVDASFMQTLWNVQPTCSRSNMEVGFLLGGHVMRLFHGHDESLTIP GSEQSQEQQRVVNYETGKGGSKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYLGQ TEDNGLILLDREKSDTTATAFCFRSSKEKIDSGPKRDIDGMGVAEIKYGDSVCFIMHVST GLWLSYQAPDAKSSRLGPLKRRAVLSLEGHMDDGLTLQLCQHEESRAARIIRNTTRLFTQ FIRGLDGLNGEKTTEVTLPVCEVLQTLNDLIEYFQQPDSELEHEEKQRQLRSLIKRQDLF KEEGMLTLVSHCIDRLNVYNSAAEFEELAGEEAGEAWKDILNLLYELLAALIRGNRTNCT QFSRKLDWLVSKLERLESSSGILEVLHCILIESPESLNIIRKAHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRANQNFICDHLLPRRDLLLQTRLVNDVQSMRPNIFLGMSEGSAQ YKKWYFELIIDQVDHYVTNEPTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNVDGFFF PVVSFSAGVKVRFLLGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDLEGVRD LLGTTEFLSQASFIPVPVDTSQIVLPPHLENVRDKLAENIHELWGMNKIELGWMYGKIRD DNKRQHPCLVDFTKLPETEKNYNLQMSAETLKTLLALGCHVAQVNINAEDDLKKMKLPKN YMMANGYKPTPLDLSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRN PRLVPYALLDERTKKSNRDSLREAIRTLVGYGYFIDPPDQETAHIEKEGIESIRLFRVEK TYAVKTGKWYFEFEALTGGDMRVGWARPGCRPDMELGLDDQSFIFDGYRGRRVHMGSHFF GRTWTKGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQI GRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPEDHPHIEVTR IDGTVDTPPCLKVTHKTYGTQTSNDDMVCCRLSMPVEFHSGPRKITDINEVIAEDQRAKK DDGGKIDYGSITKYFYSVRVFAGQDPSSVWVGWVTPDYHYYSKQFSLSTVRTVTVTLGDE RGRVHESVRRGNCYMVCAGDVVSGSTGRSNTDLEIGCSIDLVSGLVSFTANGRELPTAYQ VEPNTKLFPAVFIQPTSPNLFQFEFPKIPDAMPLSSAIFKSLQRNPEPQCPPRLDVQTIV SVLWSRMPNTFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCIDIMELSEIEDLRQ FHYHTLKLICALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGQLREGFYDVLISIHLE TGKEAHLMMNNEFIIPVTDETRSIRLFPDDSKRHSLPGVGLSTSLTPRLNFTPPCFIIPK RDQPLFSPQIPLGILKEKAISMLTEAVQGGGAHIRDPVGGSVEYQFVPILKLIGTLLIMG ALTSEEVRTILLLIDPSVFGDGKEEEEQMAVAEQGAEKEEAASNEEKAVEAGEEESKEAK QSPKGLLEKSLPESVKRQMCELLHYFCDCELKQRIEAIVAFSDDFVSKLQFNQKFRYNEL MQALNMSAAVTAKKTREFRSPPQEQINMLLNFSAGDDCTCPEELQEELQSFHDDLRLHCG IPMEEEEEEQDTSLKGRLMSLVYMIKGRPQKTEEKPTEQEQAAPTNLKELISQTMVTWAQ ECKIQDSALVRSMFSLLRRQYDGIGELLRALRKSYTISAKSVGDAINLLASLGQIRSLLS VRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGGKDKEIAFPK MVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMDNN SLALALEEPDLEKVVTYLAGCGLQNCPMLIARGYPDIGWNPIEGERYLSFLRFAVFVNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPNLPEGAAPI VGEDEEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTKD LVGIISIPLKMPVVNKDGTVTEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLMHLLEVG FLPDLRASASLDSEVLRTTETALAMNRYIGSAVLPLLTRCAYLFAHTEHYATLVDSTLHT IYRLSKGRSLTKAQRDAIDECLLAICMNLRPSMLQQLVRRLVFDVPQLTEYCKMPIKLLT NHYEQNWKYYCLPTGLGSYGMASEEELHLTKKLFWGLFDALSQKKFDAELFKMAMPCLSA IAGAIPPDYVDSSSGSALVKQVSVDAQGNFDPQPINTANISLPEKLDYVASKFAEHSHEK WFSEKIALGWTAGDKVHDKAKTHPLLKPYKALSEKERETYRYPVKETLKSMLAMGWNIER TKEGEAMFQQKETEKQRKISESSQSEFTPAPQDLENVILSRELQTMVETVAENYHNIWAK KKKKELDSKGGGSHPLLVPYDTLTAKEKYRDREKAQELFKFLQVNGYAISRGLKDMEQDS SSMEKRIAYKFLKRLLNYVDSAQEFIAHLEAMATSGKTEKSPHDQEIKFFAKVLLPLIDQ YFKNHCLYFLSSPNISLSSSGYASNKEKEMITSLFCKLAALVRHRISLFGSDSTTMVSCL HILSRSLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTLENLKLGKLGQSRTQMKGVTQI INYTSVALLPILTVLFQHITQYQFGAELLLDDIQLSCYRILTSLYSLGTGKNIYVEKQLP VLGECLSTLVGAMPVAFLESHLNMHNPQSVFNTKTPRERAILSMPDTVDEMCPEMPNLDG LMKDIGDISESGARYTEMPQVIEVIFPMLCNYLSYWWSKGPENSPADANCCTTVTSEHLS LILGNILKILNNNLGIDNAPWMKRLAVYTQPIISKASPDLLRMHFLPTLEKLKKKTVKVV AEEELLRAESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKQPDSDSAE LFKMVSEIFILWCKSHNFKREEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGKKR RGELYSIQTSLIVAAHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNLH LQEKSADPAVQWQLNLYKDIVVKNEGPPDPEQNVERVQAISAAVYHLDQVELPLRNKKMV FQKLLSKQRKRAVVACFRMAPLYNLPRYKNNNYFLNGYRYVWLEKVYHTSSFDRLFSMLT KTPMTVVEEEEEEEAEVQPDPLHQLILHFSHNALTERSFLEDDPLYIAYADMMAKSCAEN EEEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLK LGISILNGGNVLVQQKMLDYLKEKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMV TEEGSFNVRERGSKVLQNDDFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIIST VDYLLRLQESISDFYWYYSGKDVMDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQQS LAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGT IGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPDCKGVISKKEFHKSMDS QKQYTQSEIEFLLSCVEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSR LSTFLDLAESVLSYFEPYLGRIEIMGGGKRIERVYFEISESSRTQWEKPQVKESKRQFIF DVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDAAEPHEEDEEEELHSLLEGLSEEE DAPLESASAFTAACSSVKKSMSDFRKMLTFKSMKKQFKKFRKLTIREMITGFFSFFWMLF TGFFKGIFGIIFGFFHIIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVMEAEK TESSELVVSADMVQMTSAGAEKLEADTVMDLLNPAVKKEGKHGAEPGLGDVCEVLTESSA PVEKKKSQKVAAEKPESEPEKADTENQEKEDKAKEETPEEPAAAKPAPKAKRGSAKEEAP AFMASFFAGLEVFKAKMLNCLARNFYNLRLLALFMAFAINFILLFYKVTGEFDDEEEEEG SWGGEEEEDDEDDEGMEYFILQESTGYMAPTLMSLAVLHTIISLLCVVGYYCLKVPLVVF KREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKSALDFDPTEEAVVKEASLLSWLSSIDTKYHIWKMGVVLTDNSYLYL IWYTIMSVLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDEDAPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIVDPAGDPYELY RILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTP HGFETHTLQEHNLANYLFFLMYLINKDETEYTGQESYVWKMYQERCWDFFPAGDCFRKQN EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggtggtgaaggggaagatgaggttcagttcttacgaactgatgatgaggtg gtgctgcagtgtgtcgctgccattcagaaggagaatcgcaaattctgcctttcagcagag ggactcggcaaccgcctgtgttatctagagcccacatcagaggcgaagtattttcctcct gacctatgcatctgtaactttgtgctggagcagtcgctctcagtgcgggctctgcaggag atgctcgccgggcagagcggtgaaggaaatcctgatcatgagcaatgggcagcacaggga ggtggacatcggacactgctctacggtcacgccatcctccttaggcattccttcagtgga atgtatctcacatgtctaaagacttccaggtctctgacagacaaactgtcttttgatgtt ggccttcaagaggattcaactggggaagcttgttggtggacaattcacccggcatccaag cagaggtcagagggtgaaaaggtacgcattggagatgacctcatcttggtcagcgtgtcc tctgagaggtacctgcacctctccatctccaatgcaagtattcaagtggatgcttcattt atgcaaacactgtggaacgttcagcctacctgctccagaagcaacatggaagtgggattt cttctgggtgggcatgtgatgcgcttgttccatgggcacgacgagagcctcaccatacca ggatccgagcaaagccaagagcaacagagagtggtgaactatgagaccggcaaaggaggg tccaaggccaggtctttatggagactggagcctcttcggataagctggagcgggagtcac atcagatggggtcagcccttccgcctccgccatctctccaccggtcactatctgggccag acagaggacaatggcctgatactgctggacagagagaagtctgacaccactgcaacagcc ttctgtttccggtcaagcaaggaaaagattgactccggcccaaagcgtgatattgatggt atgggcgtcgcagagatcaaatacggcgattcagtctgcttcatcatgcatgtgtccacg ggcctgtggttgtcctaccaggcgcctgatgccaaatcttctcgcctgggaccactgaag agaagggctgtcctgtctcttgagggccatatggatgacgggctgactctgcagctttgc cagcatgaggagtcccgggcggctcgcatcattcgtaataccactcgcctcttcactcag ttcatcaggggtctggatggtttgaatggggagaagactacagaggtgacactgcctgtg tgtgaagtgctgcagacactaaacgacctcatcgagtacttccagcagcctgactctgag ctcgaacatgaggagaaacagaggcagctccgatctctcatcaagcgccaagatctcttc aaagaagagggaatgctaaccctggtctcacactgcatcgatcgtctaaatgtgtacaac agtgccgctgagttcgaggagttagcaggcgaggaggccggtgaggcctggaaggacatt ctcaacctcctctatgagcttctggccgctctgattcgaggcaacaggaccaactgcaca cagttctctcgcaagctggattggctggtcagcaagctagagagattggagtcctcatca ggcattttagaggtgcttcactgtatcctaatcgagagtccagaatctctgaacatcatt cggaaggcccacatcaaatccattatttctctgctgtacaagcatggacgcaaccacaag attttagatgttctctgttccctgtgtgtctgcaatggtgtggctgtgagagccaatcag aacttcatctgtgaccacctgcttcccaggagagacctgctgctccagacacgattggtc aatgatgtccaaagtatgagacccaatatcttcctgggcatgagtgagggctcggcacag tataagaaatggtactttgagctgatcatcgatcaagtagaccactatgtgaccaatgag cccacccaccttcgtgtcggctgggccaccaccaaaggctacgccccctatcctgggggt ggagagggctggggaggaaatggtgtgggtgatgatctttactcctatggttttgatggg cttcatctgtggtcagggcgaatcccacgggccgtggcctctattaaccagcacttgctg aattcagatgatgttgtgagctgctgtctggatctcggagcccctagcatgtctttccga attaacggtcagcccgttcaaggcatgtttgaagacttcaacgtagatggcttcttcttt cccgtcgtcagtttctctgcaggggtcaaggtccgtttcttgttgggtggacgccatgga gactttaagttcctccctccagcaggctatgcaccatgttatgaagccctgctccctaaa gaaaagatgcgtgtggagcctgtgaaggagtataaaagagacctggagggagtgagagat ctgctgggcaccacagagttcctgtcccaggcttccttcattcctgttcctgttgatacc agccagattgtcctgcctccacatcttgaaaatgtgcgggacaagttagctgagaacatc catgaactctggggcatgaacaaaatagagcttggctggatgtatggcaagatccgagat gacaacaagagacagcacccttgtcttgttgacttcactaaactgccagaaacagaaaag aattataacctgcaaatgtcagctgaaactttgaagaccctacttgctttgggatgccat gttgcacaagtcaatataaatgctgaagacgacctgaaaaaaatgaaactccccaagaac tacatgatggcaaatggttataaacctacaccactggacctttctgatgtgaaactgaca cctggtcaagaggttctagttgataaactggctgaaaatgctcataatgtttgggccaaa gatcgcattaaacaaggatggacctatggtattcagcaggatttgaaaaaccgtcgtaat ccacggctggtgccatatgctttattggacgaacgcacaaagaaatcaaacagagacagt cttcgagaggccatccgtactctggttggatatggatatttcatagacccacctgatcag gagactgctcacatagagaaggagggcattgaatccatccgtctcttccgtgtggagaag acctacgcggtgaagacagggaagtggtattttgagtttgaggcactcactggaggtgac atgcgggtgggctgggcacggcccggatgcagacctgatatggaactgggactagatgac cagtccttcatctttgatggctataggggccgccgggttcatatgggcagtcatttcttt gggaggacgtggactaaaggagatgtggtgggctgcatgatcaatatggaggacaaatcc atgatattcaccctgaatggagagatcttaatcaccaacaagggatctgagctctgcttt gctgactttgaaactgaagatggattcatcccagtgtgcagcctgggtctttcccaaatt ggccgcatgaatttaggaaaagatgctagtacttttaagtactacactatgtgtggcctt caggagggctttgaaccctttgctgtgaacatgaatcgagaggtcaccatgtggttcagc aaacgcctgcctacatttgttaatgtaccagaggaccacccccatattgaggttactaga attgatgggactgtggacacacctccatgtctaaaggtgacacacaagacatatgggacc cagaccagcaatgacgacatggtctgttgtcgtctgagcatgcctgttgagttccactct ggtcctcggaagatcactgatatcaatgaggtgatcgctgaggaccaaagagccaagaag gatgatggaggcaagattgattatggcagcattacaaagtacttctactctgtgagagtg tttgctggacaagatccatcatccgtttgggtgggctgggttacaccagactaccactac tacagcaagcaattcagcctcagcacagttcgcaccgtcactgtaacgctgggagatgag cgaggacgtgttcacgagagtgtgaggagaggtaattgttacatggtctgcgctggggat gttgtcagcggctccacaggccgtagtaacactgatctggagattggctgttccatagat ctggtctcaggcctggtctcattcactgccaatggtagagaactgcctactgcataccag gttgagcctaacactaagctcttccctgctgtttttattcaacccacaagtcccaacctc ttccagtttgagtttccaaaaatcccagatgcaatgcccctgtcttcagccatctttaag agtttacaaagaaacccagagccccagtgtcctcctcggctggatgtgcagacaatcgtg tctgtgttgtggagcagaatgcccaacaccttcctgtcggtggagacggcccgtgtgagt gagaggcatggctgggtggtgcagtgtctggagcccctgcagatgatggctgttcatatc ccagaggagaacaggtgtattgacatcatggaactatcagaaattgaagatctacggcag ttccactatcacactttaaagctcatctgtgccctttgtgcattgggaaacacccgcgtt gctcacgcgctctgtagccatcttgaccaatcgcagctcctgtacactattgataaccag tacctgtctggtcaactgcgtgaaggcttttacgatgtcctcatcagcattcacctggag actggcaaagaggcccatctcatgatgaacaatgagtttataatcccagtaacggatgag acaaggagcatccgcctcttccctgacgactctaagcgtcactctcttcctggcgtaggc ttgagcacttcacttacccctcgcctcaacttcacccctccatgtttcattatccccaag cgcgatcagcctctcttcagccctcaaatccctctgggtatcctgaaggagaaagccatc agtatgcttacggaagccgtgcagggcggaggcgcccacattcgagatcctgtgggcgga agcgttgagtatcagtttgtgccaattctcaagctgattggcaccctgctgataatgggg gcgttgaccagcgaggaggtgaggaccatcctgcttctcattgaccccagtgtgtttggg gacggtaaggaggaggaggagcaaatggcagtggcggaacagggagcggagaaagaggag gccgccagtaatgaagagaaggctgtggaggcaggggaggaggagagtaaagaggccaag cagtcccccaaaggtcttctagagaaaagcttgcctgaatcagtcaaacggcagatgtgt gagctgctgcactatttctgtgactgtgagctgaagcagcgcattgaggctatagtggcc ttctcagatgattttgtgtccaagctgcagttcaatcagaagttccgctacaatgagttg atgcaagccctcaacatgtcagctgctgtcactgccaagaagacaagagagttccgctca cctccccaagagcagataaacatgttgttgaacttcagtgctggtgatgattgcacctgc cctgaggagctgcaagaggagcttcaaagcttccatgatgacctgcgactacattgcggc atccctatggaagaggaagaggaggaacaggacacatctcttaaaggccgcctaatgtcc ctggtatatatgattaaaggtcgtccccaaaagactgaggaaaaaccaacagagcaagaa caggctgctccaaccaacctgaaggagctgatatctcagactatggtcacctgggctcag gagtgcaagatccaagactcggcactggtccgcagcatgttcagccttttgagaaggcag tatgatggcatcggtgagctgctcagggccttgaggaagagctacaccatcagtgccaag tctgtaggagacgcgatcaacctgctggcctccttgggccagatccgttcactacttagt gtccgcatgggggaagaggagggccagctcatgatcgacggcctgggggacatcatgaac aacaaagtgttttaccagcatccaaatcttatgcgtgttcttggcatgcatgagacagta atggaggtcatggtcaatgtgctgggaggaggcaaggataaggagattgccttccccaag atggtggccagctgttgtcgcttcctgtgctacttctgtcgcatcagccgtcagaaccag aaggctatgtttgaccacctgagctacctcctggagaacagcagtgtgggactggcatgc ccagccatgagaggctccacacctttagatgtggctgcttcttctgtgatggacaacaac agtttagctctggcactcgaggaacctgatcttgagaaggtggtgacatatctggcaggc tgtggcttacagaactgcccgatgctcattgccaggggatacccagacattggctggaac ccaatagaaggagaacgctatttatccttcctacggtttgctgtctttgtcaatggtgaa agtgttgaagagaacgctaatgtagtggtgaagcttttgatcaggcgtccggagtgcttt ggacctgctctcagaggagagggagggcaaggtttactcgctgctatgaaggaagccatc aagatctcagaagatcctgctttagacctgcctaacttacccgagggggctgcacccatt gttggagaggatgaagaggaggaggaggtcgcccacatgggcaactctattatgtctttc tactcagcccttattgatcttctgggccgctgtgcacctgagatgcatcttataaacaaa ggcaaaggtgaagcactgcgtatccgtgctatcctccgttccttagttcccactaaagat ttggtgggaattatcagtattccactcaaaatgccggtcgtcaataaagatggcactgtg acggagccagatatgaatgccagcttctgtccggagcacaaggcacccatggtgcttttc ctggaccgtgtctatggtattgacgaccagagcttcttgatgcacctactggaggtgggc ttcctgccagacctgcgagcatcagcctccctggactcggaggtgctcaggaccacagag acagccctggccatgaaccgctacattggatccgcagtgcttcctctgttgacccgctgt gcttacctgttcgctcacactgagcactatgcaacgctcgttgactctacgctgcatacc atctatcgcctctcaaagggccgatcactcaccaaggcccagagagatgctattgatgaa tgtctactggccatctgcatgaatctgaggccatcaatgctacagcaacttgtacgtcgt ctcgtgtttgatgttccacagcttacagagtactgtaagatgcccattaagctgttgacc aatcactatgagcagaactggaagtactactgtctgccaacaggcctgggcagctatgga atggcatcagaggaggaactccacctcaccaagaaactcttctggggactttttgatgct ctttctcaaaagaaatttgacgcagagcttttcaaaatggccatgccatgtctgagtgcc atagctggtgccataccacctgattatgttgactccagctcaggttccgcattagttaag caggtctctgtggatgcacaaggcaactttgacccccagcctattaacactgcaaacatc tcgctgcctgaaaaactagattacgttgcaagcaagtttgctgagcattcccatgagaaa tggttctctgagaagatcgctctcggctggactgcgggagataaagtacatgacaaagct aaaactcatccacttctgaaaccgtacaaagcactgagtgaaaaggaaagggagacttac cgctatcctgtgaaagagactctaaagagcatgctggcaatgggatggaacattgagagg accaaagaaggagaggccatgttccagcaaaaggaaacagaaaagcagcgcaagatatca gagtcctctcagagtgagtttactccagccccacaagatttggaaaatgttattctatca agagaactacagacaatggttgaaacagttgcagaaaattaccacaacatttgggcaaag aagaagaaaaaggaacttgacagtaaaggaggaggaagtcatccattgttggtaccgtac gacacgctgacggcaaaggaaaagtacagagatcgagagaaggcccaggaactctttaaa ttcctgcaggtcaatggatacgccatcagcagaggtctgaaggacatggagcaggattcc tcatctatggaaaagaggattgcctataagttcctcaagaggctcttgaattatgtagat tctgcacaggagtttatcgcccatcttgaggctatggctaccagtgggaagacagaaaaa tctccccatgatcaagagatcaagttttttgctaaggttctgctgcccctcatagaccag tacttcaaaaatcactgcttgtactttctgtcatcacccaacatcagcctgagcagcagt ggctacgcatccaacaaagagaaggagatgatcaccagtctattctgtaagctggcagcc cttgtcagacatagaatatcactctttggaagcgactccaccaccatggtcagctgcttg cacatcctgtcacgctcactggacttcaggactgtgatgaagtctggctcagagctggtg aaggctggtgtcaggacgttcttcgagaatgcagcagaagacctggagaagactctggag aacttaaagctggggaagttgggtcagtcacgcacccagatgaagggcgttacccagatc atcaattacacctcagtggccctgctgcccatcctgacggttctctttcagcatatcacc caataccagttcggagcagagctgctgttggatgacattcagctgtcctgctaccgcatc ctgaccagcctctattctttgggcactggcaagaatatctatgtggaaaaacagcttccc gtgctgggtgaatgtttatctactctggttggagccatgcctgttgcctttctggaatcc cacctaaatatgcacaacccccaatctgtcttcaacaccaagacaccaagagaacgtgct attttgagcatgccagacactgtggatgagatgtgtcctgagatgcccaatctggacggc ctgatgaaggacataggtgacatttctgaatccggcgcacgctacacagagatgccacag gtcatcgaggtcatctttcccatgttgtgtaactacctgtcttactggtggtcaaaaggc ccagaaaactccccagctgatgccaattgctgcacaactgtcacatctgagcatcttagc cttatcctgggcaatatcctcaagattctcaataacaaccttggcattgataacgcccct tggatgaaaagacttgcagtgtacacccagcctatcattagcaaggctagcccagatctt cttagaatgcacttcctgccgacgctggagaaactgaagaagaagacagtgaaggtagtg gctgaggaagagctgctgagggctgaaagcagggcagacactcaggaagctgaactacag attctggatgagtttgctgttctctgcagggatctgtatgccttctatccaatgctcatt cgttatgtggacaacaacagatccaaatggctgaagcaaccagattcagattcagcagaa cttttcaaaatggtgtcagagattttcatcctttggtgtaaatctcacaactttaaaagg gaagagcaaaattttgtggtgcaaaatgaaattaacaacctggcgttcctcactggagac agcaagacgaagatgtcaaaatctggaggtcaggaccaagagagaagaggaaaaaagaga aggggagagttgtactccatccagacttcccttatcgtagcagctcacaagaagatgttg cccattggtctgaacatgtgcactcctggagaccaggagctcatttcccttgccaagatc cgttatagtctgaaagacaccgatgatgaggttaaggattacctgaggaagaacctccat cttcaggagaagtcagcagatccagcagtgcagtggcagctgaacctctacaaagatatt gtggtgaagaatgagggacctccagacccagagcaaaacgtggagagagttcaggccatc tccgctgctgtctaccaccttgatcaggttgagctgccgctgaggaacaagaagatggtg tttcaaaagctgctgtcaaagcaaagaaagcgtgccgtggtggcctgtttccgcatggcg ccactctacaacttaccaagatacaaaaataataattacttcctgaatggctatcggtac gtttggctggaaaaggtgtaccatacctccagctttgaccgtctgttctccatgctaacg aaaactcccatgactgtggtagaggaagaagaggaagaagaagctgaagttcagccagac cctcttcatcagctcatccttcacttcagtcacaatgctctgacagagagaagtttccta gaagatgatcctctctacattgcatatgctgacatgatggcaaagagctgtgccgagaat gaggaagaagaagaagaagaggagggaaaagaaaaaacgtttgaggaaaaagaaatggag aagcagaagattctgtaccagcaggccagacttcacgcccgtggagctgctgagatggtg ctgcagatgatcagtgccagtaaaggccgacttgggcctatggtgactggcacccttaaa ctgggcatttctatcctaaatggaggcaacgttcttgtccagcagaaaatgctggattat ttgaaggaaaaacgagatgcgggcttctttaaaagtttatctggacttatgatgtcttgc agtgtgctggatttaaatgcatttgaaaggcaaaataaggcagagagtcttggaatggtg actgaagaggggtcattcaacgtgagagagcggggttcaaaagtactacaaaatgatgac tttacaaaggatctattcaggtttttgcaacttctatgtgaggggcacaataacgatttc caaaacttcttgcggacccagactggaaacactactacagtcaacatcatcattagcact gtggactacctattacgcctacaggaatctataagtgatttctactggtattactctggg aaagatgtcatggatgaggctgggcaacttaacttctccaaagctttggcagtagccaaa caaatctttaactcactcactgagtacattcagggcccttgtattgggaatcagcaaagt ttggcacacagcaggttgtgggacgcagtggtcgggttcctgcatgttttcgcaaacatg caaatgaaactgtcacaggattctagtcaaatcgagttattgaaagagctgatggatttg cagaaagatatggtggtcatgatgttatcccttctggagggtaatgtggtgaatggaact attggtaagcagatggttgacacattagttgagtcctccagcaatgtggaaatgatcctc aagttcttcgacatgttcctcaaactgaaggacctcactacatctgataacttcaaggag tacgacccagactgcaaaggcgttatatccaagaaggagttccataagtctatggatagc caaaagcaatacacacagtctgagattgagtttcttctctcctgtgtggaggcagatgaa aatgacatgttcaactacaaggagtttgtggaacgcttccacgaaccagcaaaggacatc ggcttcaacgtagctgtgctccttactaacctatcagaacacatgcctcatgactcacgc ctgtccacattcttagacctggctgaaagcgttctcagttactttgagccgtacctgggc cgtattgagatcatggggggtggcaaaaggattgagagggtttactttgagatcagcgag tctagcagaacccagtgggaaaaacctcaggtcaaagagtccaaacggcagttcattttc gatgtggtcaacgaaggtggtgagagtgaaaagatggagttatttgtgaacttctgtgag gacaccatctttgagatgcaattggcctctcagatctccgagccagacgctgcagaacca catgaggaggatgaagaagaggagttgcacagtctgcttgaaggattgtctgaggaggaa gacgcacctcttgagtccgcctcggccttcacagcagcctgctcctctgtgaagaagagc atgtctgatttccgtaaaatgctgacatttaagagtatgaaaaaacagtttaagaaattc aggaaattgaccatcagggaaatgatcacggggttcttctccttcttctggatgctcttc accgggttcttcaaaggcattttcggcatcatttttgggttcttccatattatttggtcc tccatgtttggtgggggtcttgtggagggtgctaaaaacatgaaagtgacagatatcttg ggtaacatgcctgatccaacacagtttgggatccatggtgatgtaatggaagcagaaaaa acagagagcagtgagttggtggtgtcggcagatatggtgcagatgaccagtgctggtgct gaaaagctggaggcggatacggtcatggatctacttaatccagctgtgaagaaggagggg aagcatggggcagaacctggtctgggtgatgtctgtgaagtcctgacagagtctagcgcc cctgttgagaaaaagaagagccagaaagtagcagcagagaagccagaatccgagccagag aaagctgacactgagaatcaggagaaagaagacaaggctaaagaggaaacgcctgaggaa ccagcagcagcaaaaccagctccaaaagccaaacgtggctcagcaaaggaagaagctcca gcattcatggccagcttctttgcagggcttgaagtcttcaaagccaaaatgctgaactgc ctggctcgcaatttctacaaccttcgtcttctggctttgtttatggccttcgccatcaac ttcatcctgctcttctacaaggtgactggagaatttgatgatgaggaagaggaggaggga tcctggggtggtgaagaggaggaagatgacgaagatgatgaaggaatggagtacttcatt cttcaggagagcactggctacatggcacccacattgatgtccttggctgtactgcacacg atcatctccttactctgtgtcgttggatattactgccttaaggttcctttagtcgtgttc aagcgggagaaggagatcgctaggaagcttgagtttgatggtttgtatattaccgagcag ccgtcagatgatgacatcaaaggacagtgggatcgtttggtcattgcaactccgtccttc cctaataattactgggacaaatttgttaagaggaaggtcatcaataaatatggtgacttg tacggggccgagcgcatagctgaactcctgggtctggataagagtgctctggactttgat cccactgaagaggccgtggtgaaggaggcctccctgctgtcctggttgagctcaatcgat acaaagtaccacatctggaaaatgggtgtggtgctgacagacaactcttacctctacctg atctggtacaccatcatgtctgttctgggacattacaataacttcttctttgccgctcat ttgctggacattgccatgggcgtcaagaccttgaggaccatcctctcttctgtgactcac aatggcaaacagctggtgttgaccgtgggcctcctggcggtcgtggtctacctgtacacc gtggtggcttttaacttcttccgcaagttctacaacaagagcgaggatgaggacgcacct gacatgaagtgtgatgatatgatgacttgctacctgttccacatgtacgtgggtgtgaga gctggcggtggcatcggtgatgaaatcgtggacccggccggcgacccgtacgagctctac cgcattctgtttgacatcaccttcttcttcttcgtcatcgtcattctgctggccatcatt cagggtttgatcattgatgccttcggtgagctgagagaccagcaggagcaggtgaaagag gacatggagacaaaatgcttcatctgtggaatcgggaatgattattttgacacaactccc catggctttgagacccataccttacaagagcacaatctggccaactatttattcttcctg atgtatcttatcaacaaagatgagactgaatacactggtcaggagtcgtatgtttggaag atgtatcaggagagatgctgggatttcttccctgctggagactgtttccggaagcaaaac gaggaccagctgggctag

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