Onychostoma macrolepis: 131545425 Help Entry 131545425         CDS       T09350                                  Symbol obscna Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism omc  Onychostoma macrolepis Pathway omc04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:omc00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     131545425 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:omc01001]     131545425 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:omc04131]     131545425 (obscna) Enzymes [BR:omc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      131545425 (obscna) Protein kinases [BR:omc01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    131545425 (obscna) Membrane trafficking [BR:omc04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     131545425 (obscna) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase PK_Tyr_Ser-Thr Ig_5 Ig_4 Izumo-Ig SOS1_NGEF_PH Ig_6 RhoGEF C2-set_2 PH Kdo IQ IQ_SEC7_PH RHG20_PH APH Motif Other DBs NCBI-GeneID:  131545425 NCBI-ProteinID:  XP_058640209 LinkDB All DBs Position 08:19214768..19263237 Genome browser AA seq 6771 aa AA seqDB search MALNRIQLVKGLEDVTLCEKEACTFEVLLSHAYVQGQWSRDGVPLKSRPVCRIATQGKKH TLTLTRVTVADMGVISFKAEGIESSAMLSVTARNIKIVKALQNVSVTERESVAFICEVNW EDVDGKWYKDDSRLRAGDNVKIRCEGKIHSLTYKSVKPEDAGEIRFTAERVSSIATLRVK ELPVHIVKPLRVKIAMYKHRALLECQVSRANAAVKWYRRNHEIVPNRKYQTISEGVYRQL IIDDVGSSDEDTFICDAVDDRTSCQLFVEEQAISILKGLSSVEVMEPKEARFKVETSIKL ERAPKWTLNGQILCPCPEIRIERQGTSNRLIFTQTDSSMCGTVQFASGKSKSEAQLTVTE RPLIVKQPISDVEVKENGSVTLSCEFCPSPRVVRWFKGRTPLFASKKHTMKQVKNQVEMT IVGVKAADSGEYRCLAGGLETRGRVTVEVKRLKIIKHLEQVEVEEDGTAVFSCELNHESP SVQWLLNDRVLYTNYINKVQNSGKVYSLILKRLAPQESRVTFKTFDISESAFLRVREKPA VFLRSLEDIAGEERGEILLQCDVSKPLVTPVWRKDGEILTANEKYEILHVGKSLTLIIHK LRKDDGGEYSCDIGCSQTKAKVIVRDLHITIVKRIRTTTVLEGENCRFECVLSHEIIDEA SWILNGQLIVSNGRIIVANNGCKYTMSIQEVTISDAGEVVFTVKELSCRTMLFVKEKPVR VFRDMLNVKATPGEDPELSCEITKPDATVKWLKNGQLIRVSPKYEFTQNNYLVKLIIHNA AIMDSGEYCCEADGIATRARLDVRDLQHTFAKELKDMRAEEKGMVTMECETRRPAATVTW LKGLMVLSSGQKYTMKKKDVVLTLTIINLEKSDSAVYTCDVGTMQSRALLTIQGQKVVIV DELEDKECLEGDTISFKCRICPSDYTDVKWYLDETLLYTNDLNEIKMIPGGYHTLTFKQL ARKDTGTISFEAGDKRSYASLLVRERRPTITKALEDTEAIEGGSLVLLCKTSKPCHIVWY KNGCLIWNSSKYLVCRSGNEARLAIRDVKDSDAGVYECDAGSVSTKATLTVKVIPAEFTK ALENQEVKEGESVTLMCEYSIPGVQFVWRKGPETLKSSEKYHMRQRKSCISLTIHNLKPE DSGNYTCICRDQRTMATLIINAVPISFIKELKNQETDEGKNVTLRCELSKPGIPVEWLKG EQTLSPGEKYQMRHIVTILELVIRSPVPEDSGTYVCVCEDQRTKATVKIRTQPITFKQKL RNQMAEEGNSVILHCEISKPDTPVQWRKGSNLLRSGEKYKIRQRGCMLELKIFNLTQEDS GVYSCTSETAETSANITVSAQPVIFKEKLKNLVAEEGKMITLHCELSKTGVPVEWWNGEE LLQPGEKYKMRERDTSVELIICEAMPEDSGVYRCVCGDQKTKATVKIVGAPATFKQNLKN QEALEGKSITLHCELSKIGVPVEWWRGDKPLLPGSRYQMRLDGKTAELEITNVFPDDAGI YSCVTGGQKTTAEVKVKSLPITFKRELQNQISTEGESAVFTCELSKPGAPVEWRKGRVML KSGAKYQMTLEGRLTKLLINNLVEGDAGNYTCKTKDSQSTAELTVRGLPATFKTTLKNQE TQEGNGVTLHCELSKTGVRVEWWKEKELLKTGEKYQLRQKEATVELLIRKAQPEDSGVYR CVCGDHKTEATIKVNAFPITFKQELKNQEGEEGNNITLRCELSKASADVKWLKGEEVLKH GEKYQLRQIATKMELVIRKATPEDSGVYFCVCPDQTSKATVKINALPITFKQNLRNQEAV EGNTVAFHCELSKPGATVKWWRDEKVLQVGEKYQMRTEGRIAELLIKNVNSEDVGFYSCT TGKEKTTAEVKVRALPVTFKRELQNEVTKEGGQAVFSCELSKPSAQVDWRKGRVILKPDD KYEMKQEGTFTKLVIRNVEASDAGNYSCKTKDSESTAELTVKVPPITFKVKLKNQEVEEE NKLVLHCELSKAGCPVEWRKGEELLRSGYKYQIQEHDVTRELIIIKAMPEDSGVYSCICG EQKTKATIRVSATPVTFKQNLKNQEAPEGGVVILHCELSKAGVPVTWLKVDEELCNGTRY KIKQEGLVAELHIKNVLPMDVGEYSCIVGDQKTTAEVNVRAAASVFFEKELEAQEAMEGD SVLFRCLLSSDNAPVTWRKDANQITQGGRYTLHRKGATQELEIRRLRVQDAGMYSCSVRG KKTSATLRVIERVRIMKGLRDLTVTAGESAHFMCELSHENILDGVWLLGSNELQENEMNQ MSICCREHHLVLTMTTTEESGVVSFVVGNEKTSARLRVNSKPTVFIEERLKDMTIFEGDS ATLSCVTSDTCTPVTWKRNNVTLLSGEKYEPLKHGKRNVLLIHKVRKEDAGIYMCDTGDM QSSATLTVKERPLFFCRELQNQEAEEGETTFLCCELSQPGVAVEWKKGAVLLRSGNKYEM KQDGCDLQLQINDLTSQDSGAYRCCADGIETRASIAVKERPLFFHEELQNQEAEEGESAF LCCELSKPGVTVQWKKGAMLLKNGQKYEMMQEGNEVQLQIHDLTSQDSGTYRCCAGNIET RANIIVKEQPLFFCEELHNQEAEEGETAFLCCELSKPGVEVLWKKGAIRLRPGDKYEMKQ DGCKVQLQIHDLTRQDSGTYKCCSGCLVTTASIVVKEHPLYFIKMLECQEAEEGETAFLC CELSKPGAAVQWKKGSVLLKPGRKYEIKQNGSELQLQIHELTSQDSGVYTCCVGSLVTSA SLEVKEQPLYFCEELQKQEIEEGETAILSCELSKPGVEVQWRKGIVLLRPGNRYEMKQDG CKLQLLIHELNSQDSGVYKCCAGSLVTAASIDVKESPVVFQEELQSLEAEEGETATLTCE LSKPGVAVQWKKGTVRLKPGNKYEMKQDGCLQQLQIYDLKHEDSGSYKCCAGSLVTTASL VVKEHPLFFSKELQNQEAEEGRTAIFCSELSKPGVSVQWKKGTVLLKPSRKYEIKEDGCQ LQLQIHELTAQDSGAYKCCAGSLVTTGSLVIKEKPLYFSEELQNHKAEEGKTAILCCELS KPGVSVQWKKGTVLLKPSNKYEIKEVGRKLQLQIHELTAQDSGAYKCCAGNLVTTASLVI IEQPLFFSEELQNQEVEEGNTVTLHCELSKPGDSVQWKKGTVLLKPSKKYEIKQDGQQLQ LQIHELTTQDSGAYKCCVGSLVTTASLVVKEHPLFFSEELHNQEAEEGKTVTLCCELSKP GVLVQWKKGTVLLKPSKKYEIKQDGRQLQLQIHELTAQDSGAYKCCVGNLVTTASFVVKE KPLFFSDELQNQEAEEGETAILCCELSKPGVSVQWKKGTGLLKPSKKYEIKQDGHQLQLR IHELTTQDSGAYKCCVGSLVTTCSVTVNEKPIFFCKNLQSLEAEEGETVTLTCEISKPVV SVQWKKGTVLLKPGNKYEMKQDGCVLQLQIRDLKSDDSGSYKCCSGIMVTTDSLVVKEHP LFFSKELHNQEAEEGKTVTLHCELSKPGVSVQWKKGAVILKPCKKYEIKQDGCQLQLQIH EVTAQDSGAYKCCAGSLATNGSIKVTEQPVFFCKILQNLEAEEGETAFLTCELSKPGVAV QWKKGTVLLKPGNKYEMKQNGSELHLQIHDLKCQDSGVYKCCAARMETTASVVVKESPPK IKDIPQAPPRIKGKNIMEETHSGLVHKKQAAVIEESDISILEPSEVHFQDLCEKSTDDQE VKRKSLVRQKGKDVSSKMVINESSWTMGEPEIPSLATNVPEEPRKKGLDTASKWVTKISV DQHNEEISGQVQKKTPSIDTNEQSKEPPRDVPLPPPRSKGKATHPDDSLQDQRGKEQDVV IKATVETTKASKHVDLTVSLPKENVSQLHVETKRQPYVLETKIQDMDIKETVDTTLKISE HDLNTPVFKEITAKHIESSQEQSCNLEENNQYIKLESTVNKEPKKEKIVNKETELEEPKQ KSLDKNAAHENQNFQSVKRSEIEKVQSMDEHHGQITKNITEKAPSIAIASQKPPQARDTT MPIRYMQKELQAGELNLPHIDSGEQKHVKQVVDEHHGKVPKHVTGKATHIAITSQKFKEE IITAEKTTAIKEVQKYSEEGELNLPHTDSEDVKNVKQALDEDKVKASQHVIGKVTNIAIT NQKPKEQIIFAQKDTTMPIRNVHKELQAGDPNLLHIDSGELKHVKWNVEEHHGKVPKHAT GKATNIAIASQFKEEIIPAEKAMSIRDVQRDSQVFEPNLLHIDSRDEKNVKQVTDKCNVK VPKHVKEKAPSITRQHLREQIIPAEKAITTSFRDVQKASQEVEPNLPHMDNKNQKNVKEV VLEEDVSRGSNTQPEEMMPEQITSVDTDKQKSLKAEQGGAGIDIDFEDEPEMLEAAIKIQ AAFKGYKTRKDMRLIFKEVFKNQNIDLGGTAFLECVVEGQISTAHWLKDGVDLKPGKRHK ITHNAYGRCLLEISSFTNKDAGIYTCEVANKFGAISYNGNVMVGKPQKPSQTIQTAQTPG TEMVSEKEVLPTINTEEESLRLVYDLPADATYSKIQEKRRSLISVSSISCYSDYDTAPDV ETEYQSRGKEAEKSKTEASTTQNCEEEKRISVQFPNNTDQLKVKGGDSQSQTPSPKRIHS YKSSANAESFSESDGDDDRGETFDIYVAKSDCQPLGGNKEVFVLKEGQFVEVLDSAHPVR WLVRTKPTKITPSRQGWVSPAYLEKKTREIFSLAHEAETKESPEKSKIVFTKDEHSLIQS RLIKGLLDGENNFVREINFFVEHHLQYLETSSQVPLTILSQKEYIFRNIRDIASFHECCI LPKLEMCFSDDDVAQCFVSYALDFEMYLQFITGLPQAEACISDKNTQHFFKQYANTELAH LDTQVFNVSTYLQRPMERIQTYKNVLKELIRNKAKSGQNCCLLENAFAIVSSLPWRAENL HHLSMIENYPAPLKGLGEPIRQGHFTVWEEIPDVKISQRGHHRHVFLFKDCIVFCKLKRE LGTYTEAYIFKNKMKLSDIDVKDTVEGDDRSFGLWHEHRGMVRKIILQARSILLRLSWLK DLRDLQQRSKQPTWTAPCFEQHLTDYPAKLGQTVKLVCKVTGTPKPVIKWYKDGHSVEED EHHITSEGQLGACYLVLTGVTEVDSGQYMCYATNPAGNASTLANIMIDVPPSFTTRLHNS VFVKGQDVQFKCSTQSAPLPSIRWFKDGIQLEDNRKHQIQSDVQTGILTLTIKRAEEADL GQYQCELQNEVGSAKCKAELCPPAPLPVTVRTQKQSQTTPTPEPQSEGWSTSFVKNLFHI LFQPGNPEPPAAGVEDTETLKEQDDVERQVQAAQEEAPMEPEEHFYSDTEEELLTEPPAV QVAIEDLTVRPGQPATFSAIITGQPTPDIQWFMDDKEILSNDYTEIFQSSARCSLTLLNT QIEDCGTYTCIASNSAGQASCLAKLSVDTGPGDVEEEREVEFGKRRKLHSVYDVHEEIGR GTFGVVKKVTHKASGEFFAAKFLPLRSSTRTRAFQERDLLSRLAHRRLACLLDFFATRRT LVLVVELCSTQGFLDHLFLKGSVSEREVQLYIQQVLEGIGYIHSMNILHLDIKTDNILMV SPVREDIKICDFGFCQEIDNSRHQYSKFGTPEFVAPEIVHQEPVTVATDIWSLGVVTYLC LTCHCPFFGENDRATLMKVAEGMLYWDTPEITSRSVEAQDFLHRVLQPDPEMRPSASECL SHEWFQGYYEDEEPEDINTKNLKSFISRRKWQCSLTCLGSVMTLRPIPELLEAPLRDVSI TATRETQEPSSTSLSSGSSSEFDEADAWDFFQQVSQEDEDDLEEEKEEYNPYAHVSKTPT VLKRDEEDVLIGEDRIHSGPLVIPMTAPSTEPVSLESRDSSPYLHLSERDEGLDPIPRRS LIKSTFHCSSEQLSPMSARHMTLRDKILAKKQERGRKPLRASLSGRLNEPLIEYVEDSPD LEANRNQRRGSMHSSFLKSSSFDSGVSAAQPSIHTQRRSRSLDVYTQRSPASTETTVQGE DEHDVEESQKPDVTDEEEEKTEEVEVRRKLCHRNAFLSKKGPVIVRKVRAQVHEPEEGHQ PVLQSSCEDDNQLQVTETETRHLGDEESMDGSQLSLACSLDHGSEASSRIGSHEELSHRH HHDGTLIAGSSGKTSPCSLLQDSEDEDMERVLRSLRQDLPQAPPRRRSNSSSSGLNEMRN KSDILLRRSSSAVPVQAAVAGRESKELLQRHASAPALQAKPPSGKSSKPGFMKIFRKHSW ASHSSPHLEGSENKQTEGASSQPKTPLLTLRKKMRASASSITKLFTRQSSKEDEEKKGRP IVKNSSPVMPEKMTTVIAATSSESPQKKSKLFSLKVPIFKKSKESPVKPSRPDVIQLAGG GALVFWKPVPSKELVTYCIQYSVNGVEWRMLSENVTDSCFTANALPRGPGYMFRVSHNTK TGLAPFSDPSPPAFMAMPYEDSHNPLIKMESIGSKVTVPGGLGTEKSYSFLSEINRGRFS VVMQCEDSRSSQMLAAKMTHYRPEQRQLVLREYQLLRRLNHPRIVQLQSAILTPTCLVLI EELCSGRELLYNLAERNLYSETEVTDLLEQILSAVDYLHSRRIVHLDLKSDNMLVTGRNV VKIVDLGSAQPFTPGQALNIEHIKEMTDNKGYIVLPKAPEILEGQGVGPETDIWAVGVLA FIMLSADSPFHADINWERDRNIKKGKIQFNRCYPGLSEGAINFMKNTMSNKAWARPTAAE CLQNPWIQGDRPSSKHTDSVVCFSTDKLQAYLREREVKRDHVRTKINLPFP NT seq 20316 nt NT seq  +upstreamnt  +downstreamnt atggcattgaatagaattcaattggtaaaagggcttgaagatgtgacgctgtgtgagaaa gaagcctgtacatttgaggtgctcctcagtcatgcgtacgtccagggtcaatggagcagg gatggagtcccacttaaatccaggcctgtgtgtcgaattgccacgcagggaaaaaaacac acactcacactcacgcgcgtcacggttgctgacatgggtgtcatcagcttcaaggctgaa gggattgaaagctctgctatgctgtcagtcacagccaggaatataaagattgtgaaggct cttcagaatgtcagtgtgaccgagagggagagtgtggcatttatctgtgaggtcaactgg gaagatgtggatgggaagtggtacaaggacgacagccggttgagagctggggacaatgtt aaaataagatgtgagggtaaaatacactccctaacctacaaatcagtcaaaccagaagat gctggagagatcagattcactgctgagagggtctcttcaatagcaacactacgagtcaaa gagcttccagttcatattgtgaagcccctgagagtgaagattgccatgtacaaacatcgt gccttgctggagtgccaggtctctcgtgccaatgctgcggttaaatggtacagaagaaat catgaaattgtgccaaataggaagtaccaaactatcagtgaaggcgtgtaccgacagctt attatagatgatgtgggatcctcagatgaagacacttttatttgtgatgctgtcgatgac aggacttcctgccaactgtttgtagaggagcaggccatcagcattttgaaaggactcagt tctgtggaggtcatggagcctaaagaggctcgttttaaagtggaaaccagcattaagtta gagagggcaccgaaatggaccctgaatgggcagatactatgtccctgtcctgaaatcagg attgagaggcaaggaacctcgaacagacttattttcacccaaaccgacagtagtatgtgt ggcactgtgcagttcgcctcgggaaagagcaagtcagaagctcaactcacagttacagag cgccctttgattgtcaaacagcccatttctgatgtggaggtgaaggagaacgggtcagtt actctcagctgtgagttctgtccatcccccagagtggtgcgctggttcaagggtagaacc cccctgtttgcttccaaaaagcacacaatgaagcaggtgaagaaccaggttgagatgacc atcgtgggtgtgaaagcagcagattcaggagagtatcgctgtctggctggtggcttagag acaagaggaagagtcactgtggaggtgaaaaggttgaagatcataaaacacttagagcaa gtagaggtcgaggaggatggaactgcagtgttcagctgtgaactgaatcacgagtcaccc agtgtccagtggctgctcaatgaccgagttctatacaccaactacatcaacaaagtccag aactctggaaaagtctacagtctgattctaaaacgactagctcctcaagagagccgtgta acattcaaaacatttgatatcagcgagtctgcgtttctcagggtcagagagaagccagca gtgtttctcaggtcactggaggacatagcaggtgaggaacgtggtgaaatacttttgcag tgtgacgtttccaagccattagtgacacctgtctggaggaaagatggtgaaattctgact gccaatgagaagtatgagattctccatgtgggaaagtcattgactcttataattcacaag ctgagaaaggacgatggaggggagtacagctgtgatattggctgcagccaaaccaaagca aaagtcatagttcgtgacctgcacattaccattgtcaaacgcatacggacaacaactgtg ctggaaggggaaaactgcaggtttgagtgtgtcctgtcccatgaaatcattgatgaagca tcgtggattttgaatggccaactgattgtgagcaatggacggatcatagtcgctaacaat gggtgcaaatacacaatgagcattcaggaagttacaatatctgatgctggcgaagtggtc tttaccgtaaaagagctcagctgcaggactatgctatttgttaaagagaaacctgtgaga gtttttagggatatgctaaatgttaaagcaacacctggtgaagatccagagctcagctgt gagatcacgaaacctgatgcaacagttaaatggctgaaaaatgggcagctaattagagtc agcccaaaatatgaatttacccaaaataattatctggtgaagctcatcatccataatgca gctataatggactcaggagagtactgctgtgaggctgatgggattgctacaagggcaaga ttagatgtcagagacttgcagcatacatttgcaaaggaactgaaggatatgcgtgcagag gaaaagggtatggtgaccatggagtgtgaaaccaggaggcctgctgctacagtgacctgg ttaaaaggcctaatggtgctcagctcgggacagaagtacacgatgaagaagaaagatgtt gtcctcactcttaccatcatcaatctggagaaaagtgacagtgctgtctacacctgtgat gttgggacaatgcagagcagggctttacttacaattcaaggtcaaaaagtggtcattgtg gatgaactagaagataaagagtgtctagaaggagataccatctcctttaagtgtcggatc tgcccaagtgactacactgatgtcaaatggtacctggatgagaccttgctctacactaat gatcttaacgagatcaagatgatacctggtggataccacactcttaccttcaaacagctt gcacgtaaagacacgggcaccatctccttcgaggctggggacaaaagatcatacgcatca ctattagttagagagagacgccccacgataactaaagcattggaggacacagaagcaatt gaaggaggaagtttggtgctgttatgcaagacctcaaagccatgtcatattgtttggtac aaaaatggctgtttaatctggaattcctcaaagtacttagtgtgtcgatcgggaaatgag gccaggctggccatccgtgatgtgaaagacagtgacgcaggggtgtacgagtgcgatgca ggatctgtcagcactaaagccaccttgactgttaaagttattcctgctgagtttacaaaa gcgcttgagaaccaagaggtcaaagagggagagagtgtaacgctgatgtgcgaatactct atacccggggtccagtttgtgtggcgcaaaggacccgagacactaaaatctagtgagaag taccacatgaggcagaggaaatcttgcatttctcttacaatacacaatctgaagccagaa gattcagggaattacacatgcatttgcagagaccaaagaactatggctactcttataatc aatgcggttcctatatcatttattaaagagctcaagaaccaagagacagatgaaggtaaa aatgtgacattacgctgtgagctttctaaacctggaatcccagtggaatggttgaaaggt gaacaaactctctcgcctggagagaagtatcagatgaggcacatagtcaccatactagag ctggtaatcagaagtccagttcctgaggacagtggaacatacgtctgtgtgtgtgaggat caaaggaccaaagccactgtcaaaatacgaactcaacctatcacgttcaaacagaagtta agaaatcaaatggctgaagagggaaacagtgtaatcttacactgcgagatatccaaacca gacacccctgtccagtggagaaaaggaagcaaccttctcaggtctggggagaagtacaaa atcaggcagagaggctgcatgctagagctgaagatttttaatttgacgcaagaggatagc ggagtctatagctgtacgagcgaaactgctgagacatcagccaacatcacagttagcgct caacctgttatttttaaagagaagctgaaaaacctggtagccgaggaagggaagatgata acattgcactgtgagctttccaaaaccggtgtcccagtagaatggtggaatggagaggaa ctgctccagcctggagagaagtataagatgagagaacgagacacatcagttgagctgatc atctgtgaggccatgcctgaagacagtggagtctacagatgtgtctgtggagaccaaaag accaaagctacagtcaaaattgttggtgctcctgctacttttaagcaaaaccttaagaac caagaagctctggaaggcaaatctataaccctacactgtgagctctccaaaattggagta cccgtggaatggtggagaggagataaaccgctccttccagggtcacggtaccagatgagg ctggatggaaagactgcagagttagaaataactaatgtttttcctgatgatgctgggata tacagctgtgtgactggaggccaaaagaccacagctgaagtgaaagtcaaatcccttcca attactttcaagcgagagcttcagaatcagatatctacagagggtgagagtgcagtattt acctgtgaactttcaaagcccggtgctccagtcgagtggaggaagggtagagtgatgctg aaaagcggagccaaatatcagatgacgcttgaggggcgattaaccaaactgctgataaat aatcttgttgagggtgatgcaggaaattacacctgcaaaaccaaagattcacaatcgaca gccgaattgacggttcgaggactccctgctacctttaaaacaactttgaagaaccaagaa actcaggaggggaacggtgtcactctgcactgtgaactttctaagactggagttcgagta gagtggtggaaagaaaaagaactgctcaagactggagaaaaatatcagttgagacagaaa gaagcaacagtagagttgttaataagaaaggcacaaccagaagacagtggagtgtatcgc tgcgtatgtggagatcacaagactgaagccaccatcaaagttaatgctttccccatcact ttcaaacaagaacttaagaatcaagaaggtgaagaagggaacaacatcacattgcgctgt gaactctctaaggccagtgctgatgtgaagtggttgaagggagaggaagtcctcaagcat ggagaaaagtaccagttgagacagatagcaactaaaatggagcttgttatcagaaaagcc acacctgaagacagtggagtgtacttttgtgtatgtcctgatcagacatccaaagctaca gttaaaatcaatgctctcccgatcactttcaaacaaaacttgagaaatcaagaagcggtg gaaggcaacacagttgctttccattgtgagctttccaaaccgggagccacggtgaaatgg tggagggatgaaaaggtgctgcaggttggagaaaagtaccagatgaggactgaaggacgg attgctgaacttctcatcaaaaatgttaactctgaagatgtcggcttctacagttgcact accggaaaggaaaaaacaacagcggaggtcaaagtcagggctctacctgtcacttttaaa cgagaacttcaaaacgaagtaaccaaagaaggtgggcaagctgtgtttagctgtgagctc tctaaacccagtgctcaagtcgactggagaaaaggaagagttattctcaagcctgatgac aaatatgaaatgaagcaagagggcacattcaccaaactggtcatacgtaatgttgaagca agtgatgctgggaactattcatgtaaaaccaaggattctgagtcaactgctgagctaacc gtgaaggttccacctatcacttttaaagtcaagttgaaaaatcaggaagttgaagaagaa aataaactcgtgttacactgtgagctctcaaaagctggatgtcctgttgaatggaggaag ggggaagagcttcttaggtcagggtataaatatcaaatccaagaacatgatgttacaagg gagctgatcatcataaaggccatgcctgaagacagtggagtctacagctgcatttgtggg gagcagaagaccaaagccacgatccgagtgtccgccacaccagtaacgttcaaacaaaac ctgaagaaccaagaggcccctgagggaggtgttgttattctgcattgtgagctgtccaaa gctggagtaccggtaacatggttaaaagtggacgaggagctctgcaatgggactagatac aagatcaagcaggagggattggttgccgaattacacattaaaaacgttcttcccatggat gttggggaatacagctgcattgttggagaccagaagactacagctgaagttaatgttagg gctgctgcctctgtgttctttgagaaagagcttgaagctcaagaagcaatggagggggat tctgtcctgtttcgttgtttgctctctagcgataatgccccagtgacttggagaaaagat gcaaatcagatcacacagggtgggcgatataccctccaccgtaaaggtgcaactcaggag cttgaaatcaggagactgagagtgcaggatgctggcatgtactcatgcagcgtcagaggc aagaagacctctgcaaccctcagagtgatagagcgtgtgaggattatgaaaggactgcgt gacttgacagttactgcaggcgagagcgcacactttatgtgcgagctttcacacgagaac 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actctggctaatatcatgattgatgtgcctccaagttttacaaccagactgcacaactca gtgtttgtaaagggacaagatgtgcagttcaagtgctccacacaatctgctcctttacca tcaataaggtggtttaaggatggtattcagcttgaggataacaggaaacaccagattcaa tctgatgtccaaacaggaattctcactctcactataaagagagctgaagaggcagatcta ggtcaataccagtgtgagctacagaatgaagtaggcagtgctaagtgtaaagctgaactc tgccctccagcaccattacctgtgacagtcaggacccaaaagcaatcacaaactacccca actccagagccccaatcagaaggttggtccacttcctttgtgaagaacctgtttcatata ctctttcagcctggaaaccctgaaccacctgctgctggtgttgaagacacagaaacactt aaagaacaggatgacgtggagaggcaggtacaggcggcacaggaagaggcacccatggag cctgaggagcacttttactcagacacagaggaggagttgctgacagagcctccagctgtg caagttgccattgaagacctgacagtccggcctggtcagcctgcaacgttctctgccatt attactggccagcccaccccagatattcagtggtttatggatgacaaggaaatcttatcc aatgactacacagaaatatttcaaagtagtgcacgttgctctctcactttgctaaatact caaatagaggattgtggcacctacacctgcatagctagtaacagtgcaggacaagcatct tgcctcgctaaactcagcgttgacacaggtccaggtgacgttgaggaagagagagaagtg gagtttggaaaaagacggaaattacattctgtatatgatgttcatgaagagatagggagg 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gaccacggttcagaggcttctagcaggataggctcacatgaagaactctcccacagacac caccatgatgggaccttgatcgctggatcctctgggaaaacatctccatgctctttacta caagactctgaggatgaagacatggagagggtcctgagatctcttcgccaagacctccca caagccccgccaagacggcgctccaacagttcaagctctggactaaatgagatgcgcaat aagagtgacatccttctgagaagaagctcatctgcggttcctgtccaggctgcagtagca ggacgagaaagcaaagagttacttcaaagacatgcctcagccccagctcttcaagccaaa cctcctagtgggaaatcttccaagcctggattcatgaagatcttccgtaaacattcatgg gctagccattcttctcctcatctagaaggctcggaaaacaaacaaacagaaggagcatcc tcacaacccaagacccctcttctaaccctgaggaagaagatgcgagcttcagcctctagc attaccaaactgtttacccgacagtccagcaaagaggatgaagagaagaaaggcagacca attgtgaagaactcctcccctgtcatgccagagaaaatgaccacagtaatagccgccacc tcatccgaaagtccacagaagaagtccaaattgttctcgctgaaagtgccaatatttaag aaatccaaagaaagtccagtcaaaccatccaggccagatgtcattcagctagcaggggga ggagcgcttgtgttctggaaacctgtgccatcaaaagaacttgtcacatattgtattcag tatagtgtaaatggtgtggagtggagaatgttgtcagagaatgttacagacagctgtttt acagcaaatgcccttccgagaggaccgggatatatgttcagagtgtcccataacacaaag 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gtctgtttctcaacagacaagctgcaggcctatctcagggaacgagaagtcaagcgagac catgtccgcacaaaaattaatctgcccttcccataa

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