Oryzias melastigma (Indian medaka): 112140439 Help Entry 112140439         CDS       T07439                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism oml  Oryzias melastigma (Indian medaka) Pathway oml04020   Calcium signaling pathway oml04260   Cardiac muscle contraction oml04261   Adrenergic signaling in cardiomyocytes oml04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oml00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112140439 (ryr2a)    04020 Calcium signaling pathway     112140439 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     112140439 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     112140439 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oml04040]     112140439 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:oml04990]     112140439 (ryr2a) Ion channels [BR:oml04040]  Voltage-gated cation channels   Ryanodine receptor    112140439 (ryr2a) Domain-containing proteins not elsewhere classified [BR:oml04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    112140439 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  112140439 NCBI-ProteinID:  XP_024119162 LinkDB All DBs Position LG19:17124525..17247502 Genome browser AA seq 4983 aa AA seqDB search MTGCARARGHSPSQHLSGAAAPASPADLTMADGGDGEDEIQFLRTDDEVVLQCSATVHKE QQKLCLAAEGFGNRLCFLESISNSKNVPPDLSICTFVLEQSLSVRALQEMLANIEEKADG GGGHRTLLYGHAVLLRHSYSGMFLCCLSTSRSSTDKLAFDVGLQENNTGEACWWTIHPAS KQRSEGEKVRVGDDLILVSVSSERYLHLSYGSSSLHVDAAFQQTLWSAAPICSGSEVAQG FLIGGDVLRLLHGHMDECLTVPSGEHGDEQRRTVHYEGGAVCTHARSLWRLETLRVMWSG SHIRWGQPFRLRHVTTGKYLSLTEDKSLLLMDKEKADVKSTAFCFRSSKEKSDPGVKKEV DGMGTPDIKYGDSVCYIQHVDTCLWLTYQTVDAKSVRMGGVQRKAIMHHEGHMDDGLTLS RSQHEESRTARVIRSTVFLFNLFIRGLDMLRKKGRSSALDLPIDSVSLSLQDLIGYFQPP GEHLDHEEKQNRLRALKNRQNLFQEEGMISLVLDCIDRLHVYSSTAHFADVVGQVAAEAW SSILNSLYQLLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEAL NIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQT RLVNHVSSMRPNIFLGVSDGSAQYRKWYYEVIVDQALPFVTAEPTHLRVGWANTSGYAPY PSGGEGWGGNGVGDDLFSYGFDGLHLWSGCIARTVSTPNQHLLRSEDVVSCCLDLSVPSI SFRINGQPVQGMFENFNSDGLFFPAASFSAGVRVRFLLGGRHGEFKFLPPAGYAPCCEAV LPREKLKLEASQDQTAARDLLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIH ELWVMNKIELGWTYGAVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHV GLADENAVGRVKSMKLSPKYELSSGYKPAPLDLNHIKLTPSQEAMVDKLAENAHNVWARD RIRQGWTYGIQQDVKNRRNPRLVPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQD HAAQSDSSSLSAERFRIFRAEKTYCVNTGKWYFELEVLTFGEMRVGWARPGCLPDQELGS DDQAFVFDGFKVQRWHQGNEHFGRAWQAGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSEL AFKDFEVGDGFIPVCSLGVCQVGRMNFGKDVSTLRYFTICGLQEGYEPFAVNVNRDVTMW LSKRLPQFVPVPPNHQHIEVSRIDGTVECSPCLKVTQRSFGSQNSHTDITFYRLSMPIEC AECRSGVSLFSPKRDLDDFETVSDFEVLMKSSHGHSVPSIPSVPGGPEKDEFNNHKDYNQ EKSSKIKQRFTLKRNKTDSISHPSAHLSEEAGPDDSIGYDLLMQTSVYYYSVRIFPGQEP SSVWVGWVTSDFHQYDPSFELHKVRTVTVTLGDEKGKVHESIKRSNCFMVWAGESSSPGG QGRSNNGLEIGCLVDTTTGLLSFTANGKELSTYYQVEPSTKLFPAVFAKATSPNVFQFEL GCVKNTMPLSAGLFKSERRNPVPQCPPRLHVQFLTPVLWSRVPNHFLRVSASRVNDRHGW LLQCDQPLQFMSLHIPEENRSVDVLELSEQKDLLRFHYHTLRLYSAICALGNNRVAHALC SHVDEAQLLQAIQNKYMPGLLRAGYYDLLIDIHLRSYATARLMMNNEYIVPMTEETKSIT LFPDEGKKHGLPGIGLSTSLRPRMHFSSPSFIRAAGSMLSSSTGSGSCFQFSPEFPLDTL KVKTIEMLTEAVQEGSMHVRDPIGGSTEFLFVPLIKLVYTMLIMGVFQDGDLKKILQLIE PSVFSEHREEEPGAMKNLEKLNRGEDGGKSIPKEGLLEMKLPEPVKLQMCHVLQYLCDCQ VRHRIEAVVAFSDDFVACLQDNQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLL NFKGEKQEGPCPEFIREQLLDFHEDLMRHCGIELDDDGAIDGDNDFTIRGRLMLLVEKVS ALKKKIGNPPKEKDRRPSTLQQLISDTMVRWAQESVIEDPDLVRAMFVLLHRQYDGIGGQ VRALPKTYTINSVSVEDTINLLAALGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQH PNLMRALGMHETVMEVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHL SYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCI MLVHEGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGE GGDGLLAAMEEAIRISEDPSRDGPSPTSESNKSLDLLGEEEDDTIHMGNAIMTFYSALID LLGRCAPEMHLIHASKGEAIRIRAILRSLIPIEDLVGVISIPFSMPNVAKDGVVVEPDMS AGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALN RYLCTAVLPLLTKCASLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDSIEECLLAVC GKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAGGWGSYGAASEEE LHLSRKLFWGIFDALSCKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDA EGNFTPQPADTSNVTIPEKLDYFISRYAEHNHERWCTEKISSGWSHGESMCESSKSHPLL KPYKSLTEKDRDMYCCSVRESLKTMLSWGWCIDRSREGDPASLHNKSRRISQGSQLSFEG APAFTPRPIDMSNVTLSRDMQSMAELLAENYHNIWARKKKMDLEAKGGGSHPLLVPYDTL TAKEKSKDKEKAQDILKFLQINGYTVSRGPKSQELDTPAIEKRFAYTFLQKLIAYVEHAH QHMMDFDVATRRKGEKIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTVIHPISSGGHAS NKEKEMVTSLFCKLGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAAL RSFFTSVAEDLEKTQENLKLGQFTHNREQPRGVTQIINYTIFALLPVLSSLFEHIGQNMF GEDLMLDDIQVSCYRILNSLYFLGTNKSIFVERQRPALGKCLAAFSAAFPVAFLEPHINK FNSFSVYNSKGSSDRAALGLVGPVGDVCPLVPNLQKSLEEIMELAESGVKYTQMPHVMEV VLPMLCSYMSHWWEHGPESNPEKADTCCSCVTSEHMNTLLGNILKIIYNNLGIDEGAWMK RLAVFSQPIISKAKPQLLRTHFLPLMEKLKKKAAVVLMDEEHSRAEGRGEMSETELLIMD QFTILVRDLYAFYPLLIRFVDYNRARWLKESNPDAEELFGMVAEVFIFWAKSHNFKREEQ NFVVQNEINNMSFLISDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVG LNTCAPGEQELIALAKSRFSQKDTEEEVRETLRSNLHLQGKLEDPAIRWQMALYRDLPHH QEDTSDPDKTVERVLVIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLY NLPRHRAVNLFLQGYEKSWIEAEEHYFEDQLIEDLAKAGEQEPAEEEEGMKHMDPLHQLI QLFSRTALTEKCKLDEDHLYIAYADIMAKSCHDEEEEDGEVKSFEEKEMEKQKLLYQQAR LHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFF QSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVISHERGEKVMQDDEFTCDLFRFLQ LLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQR NFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQ IELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLK DLTSSDAFKEHDPDGKGVISKRDFHKAMESHKHYTQTETEFLLSCTETDENELLDYEEFV ERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKR IERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAA QMSDAGERLAMKEDGEREKSEEDSADAGFFSMSTVCMALLALRYNILLLIKVLSMKSLKK QMKKIKNMTMKDIVTTLVSFYWSLLLALLHVVFSVTRGFCRIFYNTFMGGNLVEGAKTIK VSELLANMPDPTQDEVRGEGEDREKRPPERTSPSEDLADLAVNTGESELLSDIFGLDLRR EGGQYKITPHNPNASLTELLNSPAPPASPPAAAQPELRQRHQSKSCSDEKEATTEAAAET EKSSEGMETPEKPQKNEKMKAKVRRHHSSRCDEPDLQESAFLKKILAYQRKLLNYFARNF YNMRMLALFVAFAINFILLFYKVSTSSSLVEGKEAVYSSSSSSVQWDHQPEEWSDAKDRG MEGNGKPAKPVTVRFVLEESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREK EVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHD RISELLGLDKAALDFSDAHKKRKPRRDSSLATVLNSIDVKYQIWKLGVVFTDNSFLYLAW YMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRI IFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHG FETHTLHEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYED QLN NT seq 14952 nt NT seq  +upstreamnt  +downstreamnt atgaccggatgcgcgcgcgcgcgcgggcactcgccgtctcagcatttgtccggcgcagca gctccagcctctcccgcagacctcaccatggctgacggaggagacggcgaggacgagatc cagttccttagaacggacgatgaggtggtgctgcagtgctcagccacggtccataaggag caacagaaactctgcctcgctgctgaaggttttggaaacagactctgcttccttgagtcc atctccaactctaagaatgttcctccggatctttccatttgcactttcgtcttggagcag tcgttgtctgttagagcgctccaggagatgctggccaacatcgaggagaaggccgatggg ggagggggccatcgtaccctgctgtacggtcacgctgtcttactgcggcactcctacagt ggaatgttcctctgctgcctgtccacgtcccgctcttccactgacaaactggcctttgat gttggactgcaagaaaacaatacaggagaggcgtgctggtggaccattcatcctgcatca aaacagcggtcggagggagagaaggtcagagtgggagatgatctcatcctggtcagcgtc tcctctgagagatacctgcacctgtcctacggcagcagcagcctccacgtggacgcagcc ttccagcagacgctgtggagcgcagcgcccatctgctctggtagtgaggtagcacaaggt ttcctgattggtggggacgtcctacgcctcctccatggtcacatggatgaatgtctgact gttccatctggggagcacggggacgagcagaggaggacagtgcactatgaggggggagca gtttgcactcacgctcggtccctgtggaggctggagactctgcgggtcatgtggagtggc agccatattcgttggggtcaacctttcagactcagacatgtgaccacggggaagtatctg agtctcacggaggataagtcgctgctcctgatggacaaagagaaggctgacgttaaatcc accgccttctgcttcaggtcctcaaaggaaaagtcagaccctggtgtgaagaaagaggtg gacggcatgggaactcctgacataaaatatggcgactcggtgtgttatatccaacatgtg gatacctgcctttggctcacctaccagactgttgatgcaaagtccgttcgcatgggcggg gtgcagaggaaggccatcatgcatcatgaaggtcacatggacgatgggctcaccctgtcc aggtcgcagcatgaggagagtcgcactgccagggtcatccgcagcaccgtcttcctcttc aacctcttcatcagaggtctggacatgctgaggaagaaagggaggagctccgccttagat ttaccaatagattcagtgagcttaagtctgcaggacctcattggttacttccagccacct ggagagcacctggaccatgaggagaagcagaaccgtctgagagctttgaagaacaggcag aacctcttccaagaggagggcatgatcagcctggttctggactgtattgaccgtctgcat gtgtacagcagcaccgctcactttgcagacgtggttggacaagtggcagcagaggcctgg agctcaatccttaactccctctatcagctgttggctgcacttataagaggaaaccgaaaa aactgtgcccagttttctggttcacttgactggctgattagccgactggagcggctggag gcgtcttcaggtatactggaggttcttcattgtgtgttggtggaaagtcctgaagctcta aacatcataaaagaaggacatataaagtctatcatctccctcctggacaagcatggacga aaccataaggtcctggatgtgctgtgctccctgtgtgtgtgtcacggcgtggccgtgcgc tccaaccagcacctgatctgcgacaacctgctgccaggaagagacctgctgctgcagacg cgcctcgtaaaccacgtcagcagtatgcgacccaacatcttcttgggcgtcagtgatggc tccgcccaatacaggaagtggtactatgaggtaatcgtggaccaggctttgccatttgtc acggcagaacccactcacctcagagtgggctgggccaacaccagtggctatgctccttac ccaagtgggggagagggctggggaggcaacggggtgggggacgacctcttctcctacggc tttgatggacttcatctgtggtcaggttgcatcgctcggactgttagtacaccaaaccag cacctgctgcgctctgaggatgtggtcagctgctgcctggatctgagcgttcccagcatc tccttcaggatcaacggccagccggttcagggcatgtttgagaacttcaactctgacggc cttttcttcccagcagccagcttcagtgcaggtgtcagggtgcgtttcctcctcggtggg cgtcatggggagttcaaattcctcccccctgcaggctacgccccatgctgcgaggcggtg cttcccagggagaagctgaagctggaggccagtcaggaccagactgcagccagagacttg ctgggacccactgtcactttgagccaggcagcgttcacccccacgcccgtggataccagc cagatagttctgcctcctcacctggaaagaatccgagagaaactggcagaaaatatccat gagctgtgggtgatgaacaagattgaactgggctggacatatggagcggttcgagatgat aacaagcggcagcacccttgtctggtggagttttctaagctccctgagcaggagcgaagc tacaacctgcagatgtccctggagacgctgaagactctgctggccctggggtgccatgtt ggactggctgatgaaaacgctgtgggaagagtgaagagcatgaagctgtcaccaaaatac gagttgtcgagtggttacaaacctgcacctcttgacctgaaccacatcaagttgaccccc agccaggaggccatggtggacaagctggcagaaaacgctcacaatgtctgggcacgagat cgcattcgccaaggctggacttatggcatccagcaggatgtgaagaaccgcaggaaccct cgtctggtcccctatactctgctggatgaaagaaccaagaagtccaacaaggatagtcta agagaggctgtccgaacgctactgggatacggatataacctggaagctcctgaccaggac catgcagctcagtctgattccagcagcttgtctgcagagagattccggatcttcagagca gagaaaacttactgcgttaacactgggaagtggtactttgaactggaggttctgaccttt ggagaaatgagggtgggctgggccagacccggctgtctgccagaccaggagctgggatcc gatgaccaggccttcgtttttgacggtttcaaggtccagcgctggcaccagggcaacgag cactttgggcgcgcttggcaggcgggtgacgtggtgggctgcatggtggatctgaacgaa cacacgatgatgttcacgctcaacggggaggtgctcctcgatgactccggatctgagctg gccttcaaagactttgaagttggagacggtttcatccccgtgtgcagtctgggagtgtgc caggtggggaggatgaactttgggaaggacgtcagcaccctcaggtacttcaccatctgt ggcctgcaggagggctacgagccgttcgccgtcaacgtgaaccgggacgtgaccatgtgg ctcagcaagagactgcctcagttcgtgcccgtcccccccaaccaccagcacatcgaggtc tccaggatcgatgggacggtggagtgtagtccctgcttgaaggtcacccagaggtcgttc ggctcccagaacagccacacggacatcaccttctacagactgagcatgcccatcgagtgt gccgagtgcagatctggagtcagcctcttctcacccaagagggacctggacgattttgaa accgtctccgactttgaagtcctgatgaagtcgtcccacggccacagtgttcccagcatt cccagtgttcccggcggaccggagaaggatgaatttaacaaccacaaagattacaaccag gagaagtcgtccaaaatcaaacagcggttcactttaaagcggaacaagacggacagcatc agccatccatcagctcatctgtctgaggaggcggggcctgatgacagtattggctatgat ctcctcatgcagacgtctgtgtactactactcggtgcggatcttcccgggtcaggagccc agcagcgtgtgggtaggatgggtgacctctgacttccatcagtacgatcctagttttgag ctccacaaggtccgaaccgtcacggttacgctaggggacgagaagggaaaagtccatgaa agcataaagcgcagcaactgcttcatggtgtgggccggagagagcagcagccctgggggt caagggaggagcaacaacggcttggagatcggatgtctggtggacactacaactggtctg ctgagcttcacagccaacgggaaggagctcagcacctactaccaggtggagcccagcaca aagcttttcccagcagtctttgcaaaggccaccagtcccaatgtcttccagtttgaactt ggctgtgtaaagaacaccatgccgctgtctgctggtctgtttaagagcgagagaaggaac cccgtcccccagtgtcctcctcggctccatgtccagttcctcactcctgtgctgtggagt cgtgttcctaaccacttcctcagggtttcagcttccagagtgaacgaccgtcacggctgg ctgctccagtgcgaccagcctcttcagttcatgtctctgcacatacctgaggagaacagg tctgtggacgtcctggagctgtcggagcagaaggacctgctgaggtttcattaccacacc ctcagactgtactccgccatctgtgctctgggaaacaaccgcgtggctcacgctctctgc tcccatgtggacgaggcgcagctgctgcaggccatccagaacaagtacatgccaggttta ctccgagcaggctactacgacctcctcatcgacatccacctgaggagctacgccaccgcc cggctcatgatgaataacgagtacatcgttcccatgaccgaggaaaccaaaagcatcact ctgttccctgatgaagggaagaagcacggcctgccaggaatcggactcagcacctctctg cgacccagaatgcatttctcctctccaagttttatccgtgcggcgggatccatgctgagc agcagcaccggatcaggaagctgcttccagttcagcccagagttccccctggacactctg aaggtcaaaactatcgagatgctgactgaggcagtgcaggaggggagcatgcacgtgagg gaccccatcggcgggagcacagagttcctctttgtgcccctcatcaagctggtctacacc atgctcatcatgggagtcttccaggatggagacctgaagaagatcctgcagctcattgaa ccgtctgtgttctccgagcacagagaggaggagcctggggcgatgaagaacctggagaag ctcaacagaggagaggatggagggaagagcattccaaaagaaggactgctggagatgaag ctgccagagccagtgaagctgcagatgtgccacgtacttcagtacctgtgcgactgccag gtgcgccaccgcatcgaggcggtggtggctttctccgacgacttcgtggcttgtcttcag gacaaccagcgcttccgttacaacgaggtgatgctggcgctcaacatgtcagcggccctc accgccaagaagaccaaagagttcagatcccccccacaggaacagatcaatatgttgctg aactttaagggtgaaaagcaggagggaccatgtccggaattcatccgggaacagctgctg gacttccatgaagacctgatgagacactgcggcatcgagctggacgatgacggagccatt gatggcgacaacgacttcaccatccgaggtcgccttatgctattggtggagaaagtatcg gctcttaagaaaaaaatcggcaacccgccaaaggagaaggacagacggcccagtacgtta cagcagctcatttcagacacgatggtccgctgggctcaagaatccgtgatcgaggatcca gatctggtcagggccatgtttgtcctgctgcaccgccagtatgatggcataggcggccag gtgcgcgctcttccaaagacctacaccataaactctgtatccgttgaggacaccatcaac ctgctggctgccctgggtcagatcagatctctgctgagcgtccgcatgggcaaagaggag gagaagctgatgatccgggggttgggtgacatcatgaacaacaaggtgttctaccagcat cccaacctgatgagagctctgggcatgcacgagactgtcatggaggtcatggtcaacgtt ctcagtggtggagactccaaggaaatcaccttccccaaaatggtggccaactgttgtcgc ttcctgtgctacttctgtcgaatcagccgtcagaaccagaaggccatgtttgaccatctc agctatctgctggagaacagcagtgttggcctggcatctccatcaatgagaggctccacc cccctggatgtagctgcagcgtctgtcatggataacaatgagctggccctggccttaaga gagccagacctggagaaggtggtgcagtacctggctggctgtgggctgcagagctgcatt atgctggtccatgaaggctatccggacatcggctggaatccggtggagggcgagcgttac ctggacttcctgcgctttgctgtcttctgtaacggtgagagcgtggaggagaacgctaac gtcgtggtgaggcttctcattcgccgaccggaatgttttggccccgcccttcggggtgag ggcggtgacgggttgctggcagcaatggaagaagcgattaggatctctgaagatccctcc agagacggtccttctccaacatctgagagcaacaaaagccttgacctgttaggggaggag gaagatgacaccattcacatggggaacgccatcatgaccttctactccgctctcattgac ctgctgggtcgctgtgctccagagatgcatctcatccatgccagcaagggtgaggcgatc cgcatccgagccattctgaggtctctgattcccatcgaggatctggtgggcgtcatcagc attcccttctccatgcccaacgtggccaaagacggggtggttgtggagccagacatgtcg gcaggtttctgtccagaccacaaagcggccatggtcctgtttctggatcgggtttatggg atagaagaccagaattttctcctgcacctccttgaagttgggttcttgccagatttaaga gctgccgcctcactggacactgttgctctcagcgccaccgacatggcgctcgccctcaac cggtacctgtgcactgcagtgctgcctctcctgaccaagtgtgcttctctgttcgccggc accgagcccttcgcttccctgatcgactccctcctccacacggtgtaccgcctgtccaaa ggctgctgcttgaccaaagcccagagggactccatcgaggagtgtctgctggcggtgtgc ggcaaactgaggccttctatgatgcagcacctcctgaggaggctggtgtttgacgtcccg ctgctcaacgaacacaccaagatgcctctgaagctgctaaccaatcactacgagcgatgc tggaagtattactgcctggctggaggctgggggagttatggagcagcgtctgaggaagaa cttcacctctccaggaaactgttctgggggatttttgatgccctgtcctgtaagcgctac gaccaggagctgtttaagctggctctgccgtgcctcagcgccgtggctggagctcttcct ccagactacatggagtccaactacatggccatgatggagaagcagtcgtccatggacgcg gaaggaaacttcacaccgcagccagcagacacgtccaacgtgaccatccctgaaaaactg gactatttcatcagcagatatgcagaacataaccatgagaggtggtgcacagagaagatt tccagtggatggtcacacggagaaagcatgtgtgagagcagcaagagccatcctctcctg aagccgtacaagagcctcaccgaaaaggacagagacatgtactgctgttcagtcagagag tctctgaagaccatgctgtcgtggggctggtgcatcgaccggagccgggaaggagacccc gccagtctccataacaagtccagacggatatctcagggcagccagctttcttttgaagga gctccggctttcactccgagacccatcgacatgagcaacgtcaccctgtccagagacatg cagtccatggcagagctgctggcagagaattaccacaacatctgggccaggaagaagaag atggacctggaagccaaaggtggaggaagccatcccctgctggtcccatacgacactctg actgccaaagagaaatccaaagacaaggagaaggctcaggacatcctcaagttcctccag atcaacggatacactgtttctagaggcccaaagtcacaggaactggacactccagctata gagaagagatttgcctacaccttcctgcagaagctcatcgcatatgtggagcacgctcac cagcacatgatggactttgatgttgctacgagaagaaaaggagagaagattcctcatgaa cagcagatcaagttctttggaaaggtggtcttacccttggtagaccagtacttcaaaaac caccggctgtacttcctgtctacagtcattcatccaatcagcagtgggggccatgcctcc aataaggaaaaggagatggtgacaagtctcttctgcaaacttggagttcttgtcagacac aggatatccttatttggaaataatgcaacatccattgtcaactgcctccagatcctggga caaagtcttgatgccaggacggtgatgaagaccggtctggagtcggtgaaagcggctctg cggtcgttcttcaccagtgtggctgaggacttggagaagacccaggagaacttgaagctg ggtcagttcacgcacaatcgagagcagccgcggggcgtcacccagatcatcaactacacc atctttgccttgctgccggtgctctcctcgctttttgagcacatcggacagaacatgttt ggagaggacctcatgttggatgatatccaggtctcctgctacagaatcctgaacagcctc tactttctgggaaccaacaagagcatctttgtggagaggcagaggccagcattagggaag tgcctggctgccttctcagcagcgtttcctgttgccttcttggagcctcacattaacaag ttcaacagcttctcggtctacaacagcaaaggcagcagcgacagagcagctttaggcctc gtcgggccggtgggggacgtctgtcctttagtcccaaacctgcagaagtctctggaagaa atcatggaactggcagagtctggagtgaaatacacgcagatgcctcatgtcatggaggtg gtgctgccaatgctgtgcagctacatgtctcattggtgggagcacggaccagaaagcaac ccggagaaggccgacacctgctgttcctgtgttacctctgaacacatgaacactctgctg ggaaacattctaaagatcatctacaacaacttaggcatcgacgagggcgcctggatgaag aggctggcagtcttctcacagcccatcatcagtaaagccaaacctcagctgctgcggacc cacttcctgcctctgatggaaaaactcaagaaaaaagcagcagttgtgttgatggatgag gagcacagccgggctgaaggcagaggcgagatgtccgaaacagagctgctcatcatggac cagttcaccattctggtcagggacctgtacgccttctacccacttctcatccggtttgtg gactacaacagggcccgctggttgaaagagtccaacccggatgcagaggagctgtttggg atggtggcagaggtcttcatcttttgggccaagtctcataacttcaagagagaagaacag aacttcgtggtccagaatgaaatcaacaacatgtccttcctgatctctgacacaaagtgc aagatgtcaaaggggatagtttcagaccaggagaggaagaagatgaagaggaagggagac cgatactccatgcagacgagtctgattgttgccaccttgaagcgtctgctacctgtgggc ctgaacacatgcgctcctggagagcaggagctcatcgcgctcgctaagagccgcttctct cagaaagacacggaggaggaagtcagagaaacattgaggagcaatctgcacctgcaggga aagctggaggatccagctatccgctggcaaatggcgctgtaccgggacctcccccaccac caagaagacacctcagacccagacaagactgtggagagagtcctggtcatcgctcatgtg ctcttccacctggatcaggtggagcatccccagcgcagcaagaaggcggtgtggcacaag cttctgtccaagcagaggaaacgagccgtggtggcctgcttcagaatggcgccgctctac aacctgcccaggcaccgcgctgtgaacttgtttctccagggctacgagaagtcatggatt gaagccgaggagcattattttgaagaccagctgattgaggacctggctaaagcaggggag caggagcccgctgaggaagaggaggggatgaagcacatggaccctctgcatcagctcatc cagctcttcagccggacggcgcttacagaaaaatgtaaactggacgaggaccatctctac atcgcctacgctgacatcatggccaagagttgccatgacgaggaggaagaagatggggaa gtcaagagttttgaagaaaaggagatggagaagcagaagctgttgtaccagcaggctcgg ctgcatgaccgcggagcagcagagatggtgcttcagaccatcagcgctagtaaaggtgag atgggaccaatggtagcatctactctcaaactgggcattgcaattctcaatgggggaaac tccacagtgcagcagaaaatgttggattatttgaaagacaagaaggacgtgggcttcttt cagagtctggcgggtttgatgcagtcgtgcagtgttctggacctgaatgcgttcgagcgg cagaacaaagcggaggggctggggatggtgacggaggaaggatcagtcatcagtcatgag cgtggtgagaaggtcatgcaggatgatgagttcacctgtgaccttttccgcttcctgcag ctgctctgtgaaggacacaactcagacttccagaactatttgaggacacaaactgggaac aacacaacagtcaacatcatcatctccaccgtggattacttactcagagttcaggagtcc atcagcgacttttactggtattattctgggaaagatgtcattgacgagcagggtcagaga aacttctccaaggccataaacgtagcaaagcaggtgttcaacactcttacagaatacatc cagggaccgtgcacaggcaaccagcagagtctggcgcacagtcgactgtgggacgccgtc gttggttttctgcacgtttttgctcacatgcagatgaaattatctcaggattccagtcag atcgagttactgaaggagctgatggatctgcagaaagacatggtggtcatgctgctgtcc atgctggaaggaaacgtggtgaacggcacaatagggaagcagatggtggacatgttggtg gagtcttccaacaacgtggagatgatcctcaagttctttgatatgtttctcaaactcaaa gacctcacatcgtcagatgccttcaaggagcatgaccctgacggaaaaggcgtcatctcc aaaagggacttccataaggccatggagagtcataagcactacacccagactgagacggag ttcctgctctcctgcactgagacggatgagaacgaattgctggactatgaggagtttgtg gagcgctttcacgaaccagccaaggacattggctttaatgtggccgtcctgctgaccaac ctgtcggagcacatgcctcacgacactcggctgcagaccttcctggagctggcagaaagt gtccttaactacttccagccatacttgggccggatcgagatcatgggcagcgccaagcgg atcgagagggtctactttgagatcagcgagtccagccggactcagtgggagaaacctcag gtcaaagagtccaagcgtcagttcatctttgacgtggtgaatgaaggaggggagaaggag aagatggagctgtttgtgaatttctgcgaggacaccatctttgaaatgcagctggcggct cagatgtccgacgccggcgagcggctggctatgaaggaggatggcgagcgcgagaagtcg gaggaggacagcgcggacgcaggcttcttctccatgagcacggtgtgcatggctctgctc gctctgcgatacaacatcctgctgctgatcaaggttttgtctatgaagagcttaaagaag cagatgaagaagataaagaacatgacgatgaaggacatcgtgaccactctggtctccttc tactggtccctcctgctggcccttctccatgtggtgttcagcgtgacgcgagggttctgc aggatcttctacaacaccttcatgggaggaaacctggtggagggcgccaaaaccataaag gtgtcggagctcctggctaatatgcccgaccccacccaggatgaggtgcgaggcgaaggg gaggacagggagaagaggccgcccgagcgcacctcccccagcgaggatctggccgacctg gcagtgaacaccggcgagagcgagctgctgtcggacatttttggtctggacctgaggagg gagggggggcagtacaagatcacccctcacaaccccaacgccagcctcaccgagctcctc aactcgccggcgccacctgcatcgccgcctgctgcagcccagcctgaactccggcagagg catcagtccaagagttgttcagatgaaaaagaagcaacaacagaagctgcagctgaaact gagaagtcctccgaaggtatggagacccccgagaagccgcagaagaacgagaagatgaaa gcaaaagtgcgacgacaccacagctccaggtgtgacgagcccgatctgcaggagtccgcc ttcctgaagaagatcctcgcctaccagaggaagctcctgaactactttgccaggaacttc tataacatgaggatgctggcgctgttcgtcgccttcgccatcaacttcattctcctcttc tacaaggtttccacctcctcatcgctggttgagggaaaggaggccgtttacagcagcagc agcagcagtgtccagtgggaccatcagcctgaagaatggtcagacgccaaagacagaggg atggaggggaacgggaagccagcgaagcccgtcacagtccgctttgtcctggaggaaagc agcggatacatggagcccatgctgcggatcctcgccgttctgcacacagtcatctccttc ttctgcatcatcggatactactgcttgaaggtccccctggtaatattcaagcgggaaaag gaagtagcgcggaagctggagtttgatggtctctacatcacagagcagccctcggaggac gatatcaaaggacagtgggacagactcgtgatcaacactcaatctttccccaacaactac tgggacaagtttgtaaaaagaaaagtgatggacaagtacggagaattttatggccatgac cgcatcagtgagttgctgggtttggataaagcagctctggacttcagcgacgctcacaag aagagaaaacccagaagagacagctcactggcaactgtgctcaactccattgatgtcaag taccagatctggaagcttggcgttgtatttacagacaactccttcctgtacctggcctgg tacatgaccatgtccattctgggtcactacaacaacttcttctttgctgctcatctgctg gacatcgccatgggattcaagacgctgcgcaccatcctgtcgtcagtcacgcacaatgga aagcagctggtgctgacggtcggcttgttggcggtggtcgtgtacctctacacggtcgtc gccttcaacttctttaggaagttttacaacaagagtgaagacggcgagctgccggacatg aagtgtgacgacatgctgacgtgttacatgtttcacatgtacgtgggtgtgcgggccggc gggggcatcggagaccaaattgaagacccagcaggcgacgaatacgagatctaccgcatc atcttcgacatcaccttcttcttctttgttatcgtcatcctgctggccattattcaggga ctgatcatcgatgcctttggagagctgagggaccagcaggaacaagtgaaggaggacatg gagactaaatgcttcatctgtggaatcggtaacgattattttgacaccgttccacacggc tttgaaacgcacacgctgcacgagcacaacctggccaactacctattcttcttgatgtat ctcatcaataaggatgaaacggagcacacaggccaggagtcttacgtctggaagatgtac caggagcgctgctgggagttcttccccgccggcgactgtttccggaagcagtacgaggat caactcaactga

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