Oryzias melastigma (Indian medaka): 112147271 Help Entry 112147271         CDS       T07439                                  Symbol obscnb Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism oml  Oryzias melastigma (Indian medaka) Pathway oml04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:oml00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     112147271 (obscnb)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oml01001]     112147271 (obscnb)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:oml04131]     112147271 (obscnb) Enzymes [BR:oml01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      112147271 (obscnb) Protein kinases [BR:oml01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    112147271 (obscnb) Membrane trafficking [BR:oml04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     112147271 (obscnb) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Ig_4 Ig_5 Ig_6 Izumo-Ig V-set_CD47 SOS1_NGEF_PH fn3 C2-set_2 RhoGEF Ig_DSCAM-DSCAML_C PH IQ Adeno_E3_CR1 SH3_2 RHG20_PH Motif Other DBs NCBI-GeneID:  112147271 NCBI-ProteinID:  XP_024129294 LinkDB All DBs Position LG17:complement(5359654..5452785) Genome browser AA seq 6253 aa AA seqDB search MDQNFFGGAPRFLTRPKAFSVCVGKDATLSCTIVGSPTPVVSWEKDKLKLTSGGRFKTVE DGDVYRLTIYDLTLEDSGQYMCRAKNSVGEAYAAVTLKVALPAEMSQRAPVFMVKPSSTR VGLGGDVVFHCRVAAHPEANFEWEKDGRYLGETNRIKIVSDSDSSTLRIQSVRNLDGGTY TCRAQNAVGRSQAAATLAIDTQDARHTSVDKNTSLLSHLQKRKEEMKKDISIYRSEEKSS SVSSSSTTNMADVLTSLNLEHELRASALAKLPKGVFTRTCTVTEGKHAKLSCFVTGHPKP HIIWRKDGTNIGEGRRHVIYEDQAENFILKILYCKQSDNGLYTCNATNMAGQTYSAVLVT VKEPKVPFRRKLQDVEVQEKASAKLMCEVPLVATQANWFMEETRLEQSYKYHMEEDGTVR RLTIHNVTTNDDGVYICEMKEGSRTVAELTVLGNITKKLPRRTVVPVSDTVIFCVELEHP CPDAYWTRNGEKLKQDSRISIASTLRQYTLTIRDCQADDSGEVAFVAGDCKTSTRFSVTA ARKHPPDPPIDAAVQNKTDSSITFRWSPPDSDRPVPIKGYIMERRKVGASTWQRCNAGEL IVTTEISISNFTEEASYQFRLSAVNDFGQSPYLEVPGSFYLEPTADLRTGLVNSSAVSGE EFSLSVELSAACSGFWSLNGRLLRSGADYLITRSKTTHTLVIRNVTTEMNGAEVKFVGGG SESSCILTVKAAPVRFTNKSDLPAEVTCSVQDAAELTAEVSDYEAEVVWMKDGREVKVGK KYEYVVVDRKRILVVHNVTEEDVGIYECVLGSEKLPIKLNLKDEPAKFLNKARGPMGLSS SLKGDLELSCEVSPASAVVVWRKDQVEITEDQRTIIFSKGTQRKLIIKGAKKNDEGHYSC ETAADRVTFHVKIKETQAQALFTNKESVQKEVRATLSQKVTLSCEVSDSKVEVKWHKDGK LLGSSRAVYPEAKGAVRQLVIEKAEKSDAGEYTCEAGGEKLSFKIFVSDVQPAFLNKDSV QREVKATVSQKTTLSCEVVDAKTEVKWFKDGKQLTSSKSIHTESKGKLRQLVIDSVEKKD AGEYVCEAGSEKMDFKIQVAEIQPVFNKDSVQKEMKANVSQKATLSCEVFDSKTEVKWYK DNKLITSSKTVHVEAKGKIRQLVIDSLKKKDAGEYTCESGTEKLVFRLQVADMQAQSAFL KKESVQKEVKAAISKTATLTCEVANAKTEVKWFKEGKLLTSSKTVHTESRGKTRQLIIDS VEKKDAGEYTCEAGTEKMTFKIHLDEGQSKSSFSNKESVQKEVKAAISKTATLTCEVADA KTEVKWLKEGKLLTSSKTVHAESRGKTRQLIIDSVEKKDAGEYTCEAGTEKMTFKIHLDE VQSKSSFSNKESVQNEVKAAISKTATLTCEVADAKTEVKWLKEGKLLTSSKTVHTESRGK TRQLIIDSVEKKDAGEYTCEAGTEKMTFKIHLDESASAFSNKDSVQKEVKAALSEKVALK CEVADVKTEVKWYKDNKLLSSSKTVHVESKGKSRMLVIDSVEKKDAGEYACEAGSEKLGF KLKLADVPVKFQKKPVKDKYIVEAGENIVLSTELTAESGSVRWFRDEVELKEGGKYEVRK DGLSRTLTVKCSETKDSGTYSCQTSGDKVEFKVQVEDAALKFVVPLKAASVESGGTLSLV CELNKASGDVVWKHDGKEIKPGGRNCIGTEGAKRALTVTGMTKEDEGEYSCECRSDKTSA KVTSKAPRLVRLTTKLNNVVATEGKDAIFKCAVTPADANVRWFHKNIPITVGPKYKTEHG AGSHSLTITSVTQKDAGEISVDAEGKTCKATLQVQHEPVTFKKKLENLTVEEQSEVKLEV ELSKASDEVRWMKNSVVLQPAGNIQIRLDGAKQALIFKKVSYDDRGIYSCETLDDKTQAK LTVEMKKIHVVKGLAETKAHETESATFEVELSQEDVEGSWTRDGTKLKTGANCRISVQGK KQSLTLSNLKKEDAGTVSFKAEGVHTSAKLVVTELPAMICKPLTDVKVPEKETAAFECEV SRANAEVRWFKDDVELKPGRNFSLHSSGQKRTLTISKCTPEDAGTYVCRTADDNTSAKLS IHARDIKIVKKLEDLEVTEKESATFVCEVSHEDVEGHWYKGSTKLKVSDNIKMRQEGKTF VLLFKCVSPEDTGEIKFTAEKASSAAKLRVKELPVKFVKKLRDKIAMYKHRVHLECHVSR ASAGVKWFKSKTEIKASKKYEIKSEDVYRTLTINDVDSGDEETYTCDATDDRTSCKLLVE EQSISIVRELSPVEVTEPFAAVFEVEISMELVKPPAWTLNGVAIQEGPDVEMEKEGTMHR LTFKKTKAAMTGLVQFTAGKSKSSAQLTVKERPLEIAEPISNVNAKEKGSATLTCKFSAT PKEVKWFKGQELLTASDKYSMKQKAAMAQLAIQRLTEEDSGEYRCQSGPAETKGALTVEA RDIKITKHLADIEVDEDGDAAFTCEINYADEEAQWLLNDKVLCTNEVNTITHEGKLHKLT LKNLAPNDGGTITFQVRKVKESVTLKVKEKRAVFLKSLDDVTGEEKGMITLTCEASKPRV SPVWKKEGKVLKAGPKYELLHTGKSLGLIIKDVTREDAGEYSCDLGTEVSKSKVIVREIG IGITKWLKSAEVNEGETCSFECILSRESSDDFLWTINGKPAANDGRVKIANQGRKYMLTV KDVTPDDAGEVVFSIRDLSSKAKLTVEGKASSISKALQAVAAVQGEDAVFTCEVTQAGSS VKWTKDGKAMKTSQKYEISQQDKVRKLIVRNVTTKDGGEYSCEVVGGATTKAKLEIKEPV HKFVKALEDSQAEEKSSVTLKCETAQTPSTVIWLKGHTELKAGGRYVMSQKEGVITLTIK DLEETDTDIYTCDVGTAKSMAKVTVKVLPATFTEKLKDQSKTEGEVVSLSCGLSKPAATV QWRKGSELLKPGEKYEMTQKGTSCLLQIKSLVVEDSGEYSCVVGDQTTSATLKVTALPPN FVQKLKSEEAEEGAAVTFTSELSKAGVSVEWRKGAAVLKSGEKYQMRQKAAVHELIINNV VPEDSGEYSCVSGTQKTTANLKIKVKPVTFKQTLKSQEAEEGASMTLSCELSKPGLPVEW KKGTQVLKSGEKYQMKQKASVYELVITEVIPEDSGEYSCECGDQKTTASINIKAQCVTFT QKLKSQEAEEGASMTLSCELSKPGLPVEWKKGTQVLKSGGKFQMKQKASVYELVIKEVIP EDSGEYSCECGDQKTTASIKINASPAVFSKELENQTVEEGHSVTLQCELSKPDVPLEWRK GQLGLCPCAKYEIRQTGRLAGLVIHDVDAEDSGSYTCDTGDHQSTAKLAVKAKPVLFKTQ LHNLEREAGQSASFRCETTKPGAIVVWRCCDRVLATSSKYQLKQDGAVVELVVYKLQRSD AGEYSCDTGCQRTSAVLTVKEVEVSILKFLESCVVYEGEDVSFQCLLSQEDTPPVQWKLQ DVPLQMNEMNLIKAEGRLHSLTLRGVTTADSGTVTFTVGNHNSTASLTVKAAPVTFRTEL ENQVSAEGGEASLSCETSSSECKVTWRRDSTIITHGEKYTMQQRDTTHILTIHKLVKEDS GEYTCEAGDKKSTATLSVKEKVRIVRDLCDVTVSTGQDACFEVELSHVGVTNWEWWLGDN LLQNNDLNQMSSQGRVHRLVLKMVTTDESGDVAFVVGEEKSVACLLVEEKPKVLILENPQ NTVALEGESATLACSISDPTGSVTWIRNNAAIRAGLKYELKRNGAFHQLHIHNLSPDDSG TYTVDTGDARCDVTLTVEGAPAFFKKELKNQDAIEGDDITLHCELSKPGVHVEWRKGGVV LQSGKKYEMKQEKYVQELCIRNLEPEDSGYYTCDAGNQLTTASLAVQVKEVFIVSGLKTT DVFVGEWAVFSCQLSGRAPGKVQWWLDGTLLENGPNAEIGEGEGHIHTLTLKNLATDDSG TVTFKGGSLTSAAKLLVKDPAVEVVSQMEDLWVLENLPAEFICQYSRPVKPEWKKDGQPL QPDGQRVVVEQDWNVARLYIKRVSAEDGGTYSCEAGGTSVAASLHVEAKPITIVQGLENV EIFDGGEALFECALSRPESKDCRWLLDGKPVKESPTAEVVTFESGRRHLLLLKELRVKDS CTVTFKAGTASTSAQLTIKDWKVNIVKGLEDRVAAVGEKVEFSAQLEEAIPAAEVAWYAN GVELKPGDLWTMRADGSVYHLVLKQVPLLPQQEITFAARDALSLAKLTIITVPDPPEDPE VLSKTEESVTLSWFTPLYDGGSPILGYRVEMRLVDSALWLPCHSEPVFNTEYVVGNLTSG SGYRFRVAAINRAGTGEPVELPLTVQLDSAKQVLASQDTKQEKALEQPNLPPEAAEDSDL HELWEASTKKRRMSREPTLDSITEQPEEDGKKGRAKKAETELVSSQKVEIKSSEKTQTIE SKTAESKQAINVEEEIVSGGSTLVSYLKKSSETAVAETSETETLSTEKFFAHFQVAEQKT VQQTEVKKVVTEQIEKKLISSESSSIMEISKEDEPELKDAAIKIQAAFKGYKARKDMRPV FREVFKDQTFEPNGTIHLDCVTEGKPDKVRWLKDGEPVVDGKHHHVDIYSDGTCSLVITA VTTKDTGVYTCEVSNKFGTTSHSAKVTVGTAREPSGRRPLTVGYSADSEPESSSGSEMDD SLKQARRRLRRLLRTCLPPDVEEEPFVSADEGDLHPPDPQSYREDDTYIYIRFDSRSEAE VASKRFQEMFTIHGVPIDAAIIAAGHHKVELRIKKIGYIQDGTQTPTQDRQAPAFMVGAT AAPVFLTELRSQDVPDGYPVSFDCVVIGKPPPTVRWYKDGKLLEENDHYMINEDQEGCHQ LIITSVLPTDMGVYRCTAENSSGIAATKAELKVDMSCSSDYDTAVDATETSSYVSAKGYA SSRETETFESVAEDDQLPQVVDELHDVHVCPGSPIAKMQLRVKGFPKPRVYWFKDGQPVH ASERVQLSAERDVHSVEITEVKREDMGEYSAYISNVAGSAYSSARLIVLNPGEMMPKDKK DSKEPLVPPRFVEKFCNRKVKQGASITLSVKVEGSPTPMVSWLKEKSEEDVLWIKPETPR YKIASSGRQHSLILMDVNSEHSGVYTCIATNRAGQSVCTAHLQVDDTPQPKKETMPLGAL GITVSPPEGKSSRGTEGKIPYLGEVGTEEFLMKLTSQITEMVSAKITQDSLQNQEVLQWM KSWPKNSTSLRVPGVDSDDETKTPSPSPHHGRSRPPSLIADSSSESDEGDARGEMFDIYV ATADYTPTLASKDSISLKEGQYVEVLDSAHPLKWLVRTKPTKTTPSRQGWVSPAYLDKKL KLSADSGDLPETSTEEVSEGEYKRKLFQLIQDLINGESEFVREVDFFTSHHQKHADCPDA PPDISSQKETIFRNIDDIKTFHSKTFLPKLNDCETDDDVAMCFLRNKAGFEKYLQYLVGQ SQAESAVSDKTVHRFFKEYTDTEQASADPAGPPVRSINTHLKQPLERIQKYKSLLKDFIR NKARNGQNCCLLEEAFAMVSALPQRSDNTHHVSMIENYPATLEVLGEPIRQGPFQVWEGA PGIRSSSRGHHRHVFLFKNYCIICKPKRDSSTDTQAYVFKNMMKLNNIDVNETVEGDDRA FEIWHEREDSVRKYTLQARTVTIKNSWLRDFRELQQRFSTPAWNPPDFVEILANCTAELG QTVKLACKATGVPKPVITWYKDGRQVEADPHHIIIEDPDGSCTLILDNMTADDSGQYMCF ATSSAGNASTLGKITVQVPPRFVTKMKNSVFVAGEDAQFTCVIQSAPTPKIRWFKEGRLL TDQEKYQTYSELRSGVLVLVIKNVTERDLGHYECELSNRLGSAKCAADLVLPSAAARTGE PAIVIEVTEQETKIPKKTIIIEETITTVVKNPRMRRHRSPGLIVAGAHRSETSTPEPSSG RPRRMPAPRKTTIPTLYVTEPAGAEARPVESKPRWVEVEEVIEYKVNKSPRLSRRRGVSP AGSDRSATSSRARRSGENPNANNSNNKLVEQPLVQEDVGEHLLPQEEEGTLAAAGEPSEL SSVLTEEDSEDLDDQTVVFESDEENSEPITLKQGDHVLTLEDLEDYVPEEGETYRSSSSH RGAEEKPCEVSVLQREIGGSTVGQPVLLNVGRPDAVPRQRSGFFCRFKEQLSGSLFPSPF PQGGETRRRPERRVPIQVSHAKLEVQPSYCSEVQRVEGGQQSFKTKVSTQTYGYTSVGNP VTLQIKDNVYQNQ NT seq 18762 nt NT seq  +upstreamnt  +downstreamnt atggatcagaacttcttcggaggggccccccggtttctcacccggcccaaggctttctcg gtgtgcgtggggaaggacgccacactcagctgcactatcgtgggcagccccaccccggtc gtcagctgggaaaaagacaagctcaagctcacgtctgggggccgcttcaagaccgtggag gacggagacgtgtaccgcctgaccatctacgacctgacgctggaagacagcggccagtac atgtgccgagccaaaaacagcgttggggaggcgtacgccgccgtgaccctgaaggtggcc ctgccagcagagatgtctcagagggcccccgttttcatggtgaagccttcctccacgcgt gtcgggttggggggggacgtcgtcttccactgccgggtcgctgctcaccccgaggccaac tttgagtgggagaaggacgggcgctacctcggagagaccaaccgcatcaagatcgtgtct gacagcgacagcagcacgttgaggattcagagtgttcggaatctggacggcggcacctac acctgcagggcccagaacgccgtgggccgctcccaggccgcagccaccctcgccatagac acgcaggacgctcgccacacgtccgtggacaaaaacacctccctgctgtcccatctgcag aagcgcaaagaggaaatgaagaaggacatttccatctatcgctcggaagagaagagcagc tccgtctcttcctcctccacaaccaacatggccgacgtgttgacctccctcaacctggag cacgagttaagggcgtccgctctggccaagcttcccaagggcgtgttcacccgcacgtgc acagtgaccgagggcaagcacgccaagctcagctgcttcgtgacaggccaccccaaaccg cacatcatctggaggaaggacgggacgaacattggcgagggccgcaggcacgtcatctac gaggaccaagccgagaacttcatcctgaagatcctgtactgcaagcagagcgacaacggc ctttacacctgcaacgccacgaacatggctgggcagacgtacagcgctgtgttggtgaca gtgaaagagcccaaagttccgttcaggaggaagctgcaggatgtggaggtgcaggaaaaa gcctcagctaagctcatgtgtgaggtccctctggtcgccactcaggccaactggttcatg gaggagacgcggctggagcagagctacaagtaccacatggaggaggacggcaccgtgcgc cgcctcaccatacacaacgtgaccaccaacgacgacggcgtctacatctgcgagatgaag gagggcagccggactgtggctgagctcaccgtcctgggtaacatcactaaaaagcttcct cgaaggacagtagttccggtcagcgacacggtcatcttctgcgtggagctggaacatccg tgcccggacgcgtactggactcggaacggcgagaagttgaagcaagattcccgcatttcc atcgcttccacgctgagacagtacaccctgaccatcagggactgtcaggcagatgactcc ggagaggtggcctttgtggctggagactgcaagacctccacgcgcttctctgtcaccgcc gcacggaaacatcctcctgatcctcccatcgatgctgcggtccagaacaagaccgactcc tccatcacctttcggtggtcccccccagacagcgaccgtcctgtacccatcaaaggctac atcatggagcgaaggaaagtcggcgcctctacctggcaaaggtgcaacgccggagagctt attgttacgaccgagatctcgatctccaacttcactgaagaagctagctaccagttccga ctctctgctgtcaatgactttgggcagagtccttacctggaggttcctggaagcttctat cttgagcccacggcagacttgaggacaggtctggtgaacagctctgcggtttccggcgag gagttctctctgtctgtggaactgtccgcagcttgctcgggtttctggtctttaaacgga cgcctcctgcgtagtggagccgactacctcatcaccaggtccaagaccacccacacgctg gtcatccgcaacgtcaccacggaaatgaacggagccgaagtgaaatttgtgggtgggggc tcagagagcagctgcattttgactgtgaaagccgctcctgttcggttcaccaacaagtca gatcttcctgcagaagtgacctgcagcgtccaagacgccgctgagctgactgctgaggtc tcagactatgaagccgaggttgtttggatgaaagatggtcgggaggtaaaagttggcaag aagtacgagtacgtggtggtcgatcgaaagaggatcctggtggttcacaatgtgacagag gaagatgtgggcatttatgagtgtgttttaggaagtgaaaagttacccataaaactcaac ctgaaagatgaacctgccaagtttctaaacaaagcacgaggtcctatgggattatcatcc tcactcaaaggagatctggagttgagctgtgaagtgtctcctgccagcgctgtcgttgtt tggagaaaggatcaagtagagattacggaggaccaaagaactataatcttttctaaaggg actcaaaggaagctcatcatcaagggcgccaagaaaaatgatgaaggccactactcctgt gagacagcagctgacagagtcacattccatgtcaaaatcaaagaaactcaagctcaagct cttttcaccaacaaggagtcggtccagaaggaggtgagagcgactctttcccagaaggta acactgagctgtgaggtgtctgacagcaaggtggaggtgaaatggcacaaagacggaaag ctgctagggtccagtcgggcggtgtacccggaggcgaagggcgctgtccgtcagctggtg attgaaaaggccgagaagagtgatgctggggagtacacgtgtgaagctggaggagagaag ctgtccttcaagatctttgtgtcagatgttcaaccggcgttcctcaacaaagactcggtt cagagggaagtgaaagccaccgtctcccagaaaaccacgttgagttgtgaggtcgttgat gccaaaacagaagtcaaatggttcaaagatggcaagcagctgacctccagcaaaagcatt cacaccgagtcaaaaggaaaacttcgtcagctggtgattgacagtgtggagaagaaggat gctggagagtacgtttgtgaggctgggtcggagaagatggactttaagatccaagtagca gagatccagccagtcttcaacaaagattcagtccagaaggagatgaaagccaatgtatcc cagaaggccactctcagctgtgaggtgtttgattccaagacagaggtgaaatggtacaaa gataacaagctcatcacttccagtaaaaccgttcatgtcgaggcgaaggggaagattcgc cagttggtaatcgacagcttgaagaagaaagacgccggagagtacacctgtgaatctggg actgaaaaacttgtctttaggcttcaggtggcagacatgcaggcgcagtcggcttttctt aaaaaagagtctgtccagaaggaggtgaaggccgccatctccaagaccgccaccctgacc tgtgaggtggctaatgccaaaacggaggtgaaatggttcaaggagggaaaactgttgacc tccagcaagacggttcatacagagtctagagggaagacgcggcagctgatcattgacagt gtggagaagaaagatgctggagaatacacctgtgaggctggaactgagaagatgaccttt aagatacacctggatgaaggtcaatccaaatcttccttctccaacaaagagtctgtccag aaggaggtgaaggccgccatctccaagaccgccaccctgacctgtgaggtggctgatgcc aaaacggaggtgaaatggttgaaggagggaaaactgttgacctccagcaagacggttcat gcagagtctagagggaagacgcggcagctgatcattgacagtgtggagaagaaagatgct ggagaatacacctgtgaggctggaactgagaagatgacctttaagatacacctggatgaa gttcaatccaaatcttccttctccaacaaagagtctgtccagaatgaggtgaaggccgcc atctccaagaccgccaccctgacctgtgaggtggctgatgccaaaacggaggtgaaatgg ttgaaggagggaaaactgttgacctccagcaagacagttcatacagagtctagagggaag acgcggcagctgatcattgacagtgtggagaagaaagatgctggagaatacacctgtgag gctggaactgagaagatgacctttaagatacacctggatgaatcggcgtcggccttctcc aacaaagattctgttcagaaggaggtgaaggcggcgctctctgagaaagtcgccctgaag tgcgaggtggccgatgtgaagacggaggtcaaatggtacaaagacaacaaactgctgagt tccagtaagaccgttcatgtggagtctaaggggaaaagtcgcatgttggtgatcgacagc gtggagaagaaagacgctggagaatatgcctgtgaggctggaagtgagaagttaggattc aagctcaagttagcagatgttcctgtgaagttccagaagaagccagttaaggataaatac atagtggaagcaggtgaaaacattgttttatccaccgagctgaccgcagagagcggcagc gtcaggtggttcagagacgaggtggagctcaaagagggcggcaagtacgaagtgagaaaa gatggcctctcccggactctgacggtgaaatgttcagagaccaaagacagcgggacgtac tcctgtcagacctcaggcgacaaggtggagttcaaggttcaggttgaagatgcagctttg aagtttgtggttcctttgaaagctgcttcagtggaatccggcggcacgctgagtctggtg tgtgagttaaataaggcgtcgggggatgttgtctggaaacacgacggcaaggagatcaaa cccggaggcaggaactgcatcggaacagaaggcgctaagagagctctcactgtgaccggc atgacgaaagaagacgaaggagaatacagctgtgaatgtaggagtgacaagacttctgct aaagtgacctctaaagcaccaagactcgtgaggctgaccaccaagctgaacaatgttgtg gctacggagggaaaagacgcaatttttaagtgcgccgtaacgccagcggatgcaaatgtc aggtggttccacaaaaatattcccatcactgttggtccaaagtacaagactgaacacggc gccgggagtcactcgctcaccatcacctccgtcacccagaaagacgccggcgagataagc gtcgacgccgagggcaaaacttgcaaagcgactctgcaagttcagcacgagcctgtgacc ttcaagaagaagctggaaaacctgacggtggaggagcagagtgaggtgaagctggaggtg gagctcagtaaggcgtcggacgaggtcaggtggatgaagaacagtgtggtgctgcagccg gcaggaaacatccagatccggctggacggagccaagcaggctctgatcttcaagaaggtc tcttatgacgaccgaggaatctactcctgtgaaactctggatgacaaaactcaggccaaa cttaccgtggaaatgaagaagatccatgtcgttaagggtctcgcagaaactaaagcgcat gaaacagagagtgcaacgttcgaggtggaactcagtcaagaggatgttgaaggttcgtgg accagagatgggaccaagttgaagacaggagcaaactgcaggatctcagtccagggaaag aagcagtccctgacgctgtctaacctgaagaaagaagacgctggaactgtttccttcaag gcagaaggagtccatacgtcagccaaactggttgtcacagaacttcccgcgatgatctgc aaaccgttaacggacgtaaaagttccagagaaggaaacagctgcttttgagtgtgaggtt tctcgagccaacgcagaggttagatggttcaaggacgatgtggaactgaaaccagggagg aactttagccttcattcctcaggacaaaaacgcactttgaccatcagcaaatgcacacct gaggatgcgggcacctacgtctgccgcacggctgacgacaacacctccgctaagctcagc attcacgccagggacattaagattgtgaagaagctggaagacttggaagtaacggagaag gagagcgcgacttttgtttgtgaggtttcacatgaggatgtggaaggtcactggtacaaa ggaagcacgaaactgaaagtcagtgacaacatcaagatgagacaggagggtaaaaccttc gtgttgttgtttaagtgtgtctcccctgaagatacgggtgagattaaatttacagctgaa aaggcatcttcagctgcaaaactcagagttaaagagctgcccgtcaagtttgtgaagaag ctcagagataagatagccatgtacaaacaccgggtccacctcgagtgccacgtgtcccgc gccagcgcaggcgtcaagtggttcaaaagcaagacggaaattaaagccagcaaaaaatac gagattaaaagtgaagacgtgtaccgaacgctcaccatcaacgacgtggactctggcgat gaagagacttacacctgcgacgccaccgatgacaggacgtcctgtaaactgctggtagaa gagcagtccatcagcatcgtgcgggagctcagccccgtggaggtgaccgagcccttcgct gctgtttttgaggtggagatcagcatggagctggtcaaacctcctgcttggactctgaac ggggttgccattcaggagggtcctgatgttgagatggagaaggaaggcaccatgcaccgt ctgacgttcaaaaagaccaaagccgccatgacggggcttgtgcagttcaccgctgggaaa agtaaatcctcagctcagctcacagttaaagagcgtccgcttgagatcgctgagccaatc tctaacgtgaacgcaaaggagaaaggttcagccacgctcacctgcaagttctcagccaca ccgaaagaggtcaaatggttcaaaggtcaggagctgctgacagcgtcagacaagtacagc atgaagcaaaaagctgcgatggcgcaactcgccatccaacgactgacggaggaggacagc ggcgagtatcgctgccagtccggaccggctgagaccaaaggcgctctgaccgtagaagcg cgagacattaagatcaccaaacacctggccgacatcgaggtggatgaagacggcgatgcg gccttcacgtgcgagatcaattatgcagacgaagaggcgcagtggctcctgaacgataag gtgctctgcacaaacgaggtcaacaccatcacacatgaaggaaagctccacaaactcacg ctgaagaacctggcgccaaacgatggagggaccatcacctttcaagtgcggaaggtgaaa gagtcagtcacactcaaggttaaagaaaagcgtgcagtgttcctcaaatcactggatgat gtcaccggcgaggagaaaggaatgataactctgacatgcgaagcatcaaagccaagagtc tctccagtctggaaaaaagaaggtaaagtcctgaaagccggacccaagtacgagctcctg cacacgggcaagtctttagggctcatcataaaagacgtgaccagagaagatgctggcgag tacagctgtgacctcggtacagaggtctccaagtcaaaggtcatcgtgagagaaatcggt atcggaatcacaaagtggctaaaatcagccgaagtgaacgaaggagagacctgcagcttc gagtgcattctgtctcgagaaagcagcgacgacttcctgtggacgatcaacggcaaacct gcggcaaacgacggccgcgtgaagatcgccaatcaaggtcgcaagtacatgctgaccgtc aaagacgtcacccccgatgacgctggcgaggtggtcttcagcatcagagacctgagctcc aaagcaaagctaacagtcgaaggaaaagcgtcgtccatatcaaaagcgcttcaggccgtt gctgccgttcaaggcgaagatgcagttttcacctgtgaggtgacacaggccggttcttct gtgaagtggaccaaagacggcaaagccatgaagacgagccagaagtatgagatcagtcaa caggataaggtcaggaagctgatcgttcgcaatgtgacgaccaaagacggcggcgaatac agttgtgaagtcgttggaggcgcaacgaccaaagccaagctggagatcaaagaaccggtc cataaattcgtcaaagcactggaggacagccaagcagaagagaagagctccgtgacttta aaatgtgagacggcacagaccccatccacggtaatctggctcaaaggccacaccgagctc aaggccggaggtcgatatgtgatgtcccagaaggagggagtgatcaccctcaccatcaaa gacctggaggagacggatacggacatctacacgtgtgatgtgggaaccgccaagagcatg gccaaagtgacggttaaagtccttccagccacttttactgagaagctgaaggatcagagc aaaactgaaggagaagtcgtgtctttgagctgtggactatccaaaccggccgccactgtc cagtggagaaaaggctctgaacttctaaaaccaggagaaaaatatgagatgacgcaaaag ggaacttcctgtctacttcaaattaaaagtttggtggttgaagatagtggagaatactct tgcgtggttggggaccagacaacatctgctaccttaaaagtcactgcgttgcctccaaac ttcgtgcagaagctgaaaagtgaagaagctgaagagggagcagctgttactttcactagt gagctctcgaaagccggagtctcagtggagtggaggaaaggagcagcggtcctgaagtct ggagagaaataccagatgaggcagaaggccgctgttcatgaactcataatcaacaacgtt gtcccagaagacagtggagaatacagctgtgtgtccggaacccagaagacaacagcaaac ctaaaaatcaaggtcaagccagtgacgttcaaacaaactttaaagagtcaggaggctgag gagggagccagcatgactctgagctgtgagctctccaaacctggacttcctgtggagtgg aagaaaggaactcaggtcctgaagtctggagagaagtaccagatgaagcagaaggcctct gtttacgaactggtgatcacagaggtgataccagaggacagtggagagtacagctgtgag tgtggagaccagaagaccacagccagcatcaacataaaggcccagtgcgtgaccttcaca cagaagctgaagagtcaggaggctgaggagggagccagcatgactctgagctgtgagctc tccaaacctggacttcctgtggagtggaagaaaggaacgcaggtcctgaagtctggaggg aagttccagatgaagcagaaggcctctgtttacgaactggtgatcaaagaggtgatacca gaggacagtggagagtacagctgtgagtgtggagaccagaagaccacagccagcatcaag atcaacgcttctccagctgtgttctctaaagaactggagaaccagaccgtggaagagggc cacagtgttaccttacaatgtgagctctctaaacctgacgttcctttggagtggagaaag ggccaactcggtctttgtccttgtgccaaatatgagattagacaaacgggacgcctggct ggattagtaatccatgatgttgatgctgaggattctggaagttacacgtgtgacactggt gaccatcagagcacggccaagttagctgtgaaggccaagccggtccttttcaaaacccag ctacacaacctggaaagagaggcaggacagagtgctagttttcgatgtgagaccacaaag ccgggagccattgtggtgtggaggtgttgtgacagggtgctggcgaccagtagcaagtat cagctgaaacaggacggcgctgtggtcgagctggtcgtctataaactgcagagatctgac gcaggggaatactcgtgtgacacgggctgccagaggacgtcagctgtcctcactgtgaag gaggtggaggttagcattctgaaattcttggagagctgcgttgtttatgagggagaagac gtcagcttccagtgtctgctttctcaagaagacacgcctccggtccagtggaaactgcag gacgtccctctgcaaatgaatgagatgaacttgattaaagctgaggggcggctgcacagt ctcacacttagaggagtcactacagctgactctggaaccgtcactttcacggtgggaaac cacaactccactgcctccctgacagtcaaagcagcaccagttacattcaggacggagctg gaaaatcaagtgtccgcagaaggtggcgaagcctcattgtcctgcgagacatccagctcc gaatgcaaggtgacctggcggagagactccacaataatcacccatggagagaagtacaca atgcagcaaagagacactactcacatccttaccatacacaagctggtaaaggaggatagt ggtgaatatacatgtgaggcaggagacaagaaaagcactgccactcttagtgtaaaagag aaagtccgtatcgtccgagatctctgtgatgtaaccgtgtccaccggtcaggatgcttgc tttgaggtcgagctgtcacacgtaggcgtcaccaactgggaatggtggctcggagacaac ctccttcaaaacaatgatctaaatcaaatgagcagccaaggcagagtgcaccgcctggtt ctgaagatggtaaccacagatgaatcaggggatgttgccttcgtagttggagaagagaag agtgtggcttgtcttttggtggaggaaaagcccaaagtgttgatactcgagaatccacaa aacactgtggcgttagaaggagaatcggccacacttgcctgctccatttctgatcccacc ggctcagtcacctggatcaggaacaatgcggccatccgagcaggtctcaagtatgagctg aagaggaacggggctttccatcagcttcatatccacaatctgagccctgatgattcagga acgtacaccgtcgacaccggagatgctcgctgtgacgtcaccttgaccgtggaaggtgct cctgcgttcttcaagaaagaactcaagaaccaggacgccatagagggtgatgatatcacc ttgcactgtgagctatctaagccaggtgttcatgttgagtggagaaagggaggtgttgtc ctccagtctggtaagaagtatgagatgaagcaggaaaaatacgttcaagagctctgtata cgaaacctggagccggaagacagtggctactatacttgtgatgcaggaaaccagctcacc acagcttctttagcagtgcaagtgaaagaagtcttcattgtgtctggtcttaagaccacc gatgtctttgttggggaatgggcagttttctcctgccagctctctggcagggcgcccggt aaggtgcagtggtggctggatggtacgctgctggagaacggccccaatgctgaaataggg gagggggagggccacatccacacactcaccttaaagaacctggccactgatgattctggc actgtcaccttcaaagggggcagcttaacctcagcagccaagctcttagtcaaagatcca gcagttgaagtggtgagccagatggaggacctttgggtgcttgaaaaccttccagctgag ttcatctgtcagtactcacggccggtgaagcctgagtggaagaaagatggacagcctttg cagcctgatggccaaagggtggtagtggagcaggactggaatgtggctcgcttgtacatt aagcgcgtgtccgctgaggacgggggtacatactcctgtgaggcaggggggacgagcgtc gctgcctcacttcatgtggaagccaaacccatcaccatcgttcaaggcctggaaaatgtg gaaatatttgatggaggtgaagcgctctttgagtgtgcgctgtctcgacctgaaagcaaa gactgtcgctggctgctggatggcaaacccgtaaaggaatcccctactgctgaagttgtg acatttgagagtggccgtcgccatcttctcctcttgaaggaactgcgtgtgaaagacagt tgtacggtgacatttaaagctggtacagcttctacctccgcccaactcaccattaaagac tggaaagtgaacattgtgaagggtttggaggacagagtggctgcagttggagagaaagtg gagttctccgctcagttggaggaagccattcctgccgcagaagtggcctggtatgccaac ggagtggaactcaaacccggtgacctctggacaatgagagccgatggcagtgtttaccat ctcgtcctgaagcaagtgcccttgttgccccaacaagaaatcacttttgctgctcgggat gctctctctttggccaaacttaccatcattactgttcctgatcctccagaggacccagag gtcctcagtaaaactgaagagtccgtcaccctctcctggttcactcctctttatgatgga ggaagtcccattctgggctacagagtggaaatgcggctggtggacagcgcgctttggctt ccatgtcattctgagccggtgttcaacacggagtacgtagttgggaatctgacgtcaggg agcggatacaggttcagagtggcagccatcaacagagccgggactggagagcctgttgag ctgccgctgactgtgcagctcgattccgctaaacaggtgctcgcttctcaagatacaaaa caggaaaaagcgctggaacaacccaatcttcctcccgaagctgcagaagactctgatctc cacgagctttgggaagcatcaacaaagaaacggagaatgagtcgggaaccgactttggac tcgatcactgagcagcctgaggaagacggtaaaaaaggtcgggcaaaaaaagcggagaca gagctcgtatcatctcagaaagtggaaataaaatcctcagaaaagacgcagaccattgag tccaagacggcagaatccaagcaggcgatcaacgtcgaggaggaaatcgtttctggaggt tcgacacttgtgtcttacctcaaaaagagtagcgagactgccgtcgcagagaccagcgag accgaaaccttaagcacagagaagttctttgctcatttccaagtggcagaacagaaaact gtgcagcagactgaggtgaagaaagttgtaaccgagcaaatagagaagaaactgatatcc tcagaaagttcgagcattatggagatctcaaaagaagatgagccggagcttaaagacgcc gccattaagattcaagctgcctttaaaggttacaaggctcgcaaggacatgcgccctgtc ttcagagaagtcttcaaagatcagacctttgaaccaaacggcaccatccacctcgactgt gtgacggaaggcaaacctgacaaggtgcgctggttaaaagatggggagccagtggtggac ggcaagcatcaccacgttgacatctacagcgatggtacttgttctctagtcataactgcc gtcaccactaaggacacgggagtgtacacgtgtgaggtcagcaacaagtttggaacaacg tctcacagcgcaaaggtcacagtggggacggcgagagaaccgtcagggcgccgacctttg acggtcggctacagtgccgacagcgagcctgagagctcgtctggcagtgagatggatgac tctcttaagcaggcgaggagacgcctcaggcgcctcttacggacatgtcttcccccggat gttgaggaagaaccgtttgtcagtgcagacgagggagaccttcatcccccggacccccaa tcgtatcgcgaagacgacacctatatctacattcgctttgattcacggtctgaggctgaa gtcgcttccaagagattccaggagatgttcaccatccatggagtccccatcgatgcagca atcatagcagcagggcatcacaaagtggagctgcgaatcaaaaagataggatacatccaa gacggcacacagacccccacacaggatcgacaggctcctgctttcatggtcggagctaca gctgctccagtcttcctgacagagctgcgaagtcaggacgttcctgacggatatccagtc agcttcgactgtgtggtgattggaaagccccctcctactgtccgctggtataaggatgga aaactgctggaggagaacgaccattacatgatcaatgaggaccaagagggctgccatcag ctcatcatcacctctgtgttacccaccgacatgggcgtgtaccgctgcacggccgagaac agcagtggcattgcagccacgaaagccgaactcaaggttgacatgtcttgcagctcagat tatgacaccgcggttgacgccaccgagacttcctcctatgtcagtgccaaaggttatgcg tccagcagagaaacggagacctttgagtctgtagctgaagacgatcagcttcctcaagtg gtggatgagcttcatgatgttcacgtgtgtccgggttcacctatagcaaagatgcagctt agagtgaaaggctttcccaaacccagagtgtactggttcaaagatggacagcctgttcat gcctcagaaagggtccagctctcagcagagagggatgtccacagtgtggaaatcacggag gtgaagagagaagacatgggggagtactctgcttacatcagcaatgtagcgggatctgcc tactcatctgcccgactgatcgtgctgaatccaggagagatgatgcctaaagacaaaaaa gactccaaggagcccctggtgccgccacgctttgtggaaaagttctgcaaccgaaaagta aaacaaggagcaagcatcactctgtctgtcaaagtagaaggatctcctacaccgatggtc tcctggttaaaggaaaaatccgaggaggacgtcttgtggattaagcctgagacgccgaga tacaaaatagcaagttctggacgccagcacagcctgatcctgatggacgtgaactctgag cacagcggcgtgtacacctgtattgctactaacagagccggacagtccgtctgcaccgct catcttcaggtggatgacacaccacaaccaaagaaggagacaatgcctttgggagctctt gggatcacagttagtcctccagaagggaagagtagcagaggaacggagggtaaaatacct taccttggtgaagtaggtactgaggagtttctcatgaaactcacatctcagatcactgaa atggtttcagcgaaaatcacacaagacagtttacagaatcaggaagtcctccagtggatg aaatcttggcccaaaaattccacatcgttacgcgtcccaggcgtcgacagtgatgacgag acaaaaacgccttcgccgtctcctcaccacggcagatccagaccgccgtccctcatcgct gactcctcctcagagtctgatgaaggagacgcccgaggagagatgtttgacatctacgta gcaacggcggactacacgccgactctcgccagcaaagactccatctctctaaaggagggt cagtatgttgaagttctggattctgctcatcctctgaagtggttagttcgtaccaagccc acaaaaacaaccccgtcccgccaaggctgggtctcacctgcttacctggacaagaaactc aagctttctgccgactcgggagatcttcctgagaccagcacagaggaggtctcagagggg gagtacaagaggaagttattccaattgattcaagatctgataaacggagaatccgagttc gtcagggaggtggatttcttcacgtcccaccaccagaagcacgccgactgccccgatgcc ccccccgacatttccagccagaaggaaaccattttcaggaacatcgatgatatcaagacc ttccacagcaagacattccttcccaagttgaatgactgtgaaactgatgatgatgtagcg atgtgtttcctgaggaacaaagcgggctttgagaagtatctccagtatctcgtaggtcag agtcaggcggaatctgcggtcagtgacaagactgtgcaccgtttctttaaggagtacaca gacacggagcaggccagtgcagaccctgcaggtcctccagtgcgaagcatcaacacccat ctcaagcaaccactggagaggattcagaagtacaagagccttcttaaggatttcattcga aacaaggcgagaaatggacagaactgctgcctgctggaggaagcgttcgccatggtgtca gcgctgcctcagcgctctgacaacacccaccacgtctccatgatagagaactatcctgct accctggaagttcttggagaaccaataagacagggacctttccaagtgtgggaaggagct cctgggatccggtcgtcctccagggggcaccatcgccacgtcttcctctttaaaaactac tgcatcatctgcaaacctaagagagacagtagcactgatacacaagcctacgtttttaag aacatgatgaaactcaataatatcgacgtgaatgaaacagttgagggcgacgaccgagct ttcgagatctggcacgagcgggaggattctgtaaggaaatacacgttacaggcccggact gttaccatcaagaactcgtggttgagggatttcagagaactgcagcagcgattcagcacg cctgcgtggaatcctcctgattttgtagaaattttggcaaactgcacagcagagttgggc caaacggtcaaactcgcctgcaaagctactggagtgcccaaacctgtcatcacctggtac aaagatggtcgtcaagtagaggcggaccctcatcacatcatcatcgaggaccccgatggc tcctgcactctgatcctggataacatgaccgctgacgactccggccagtacatgtgcttt gccaccagctcagctgggaacgccagcacgcttggaaagatcaccgttcaagtacctcct cgttttgtgacgaagatgaagaattcggtgtttgttgccggtgaagatgctcagtttact tgtgtcatacaaagcgcccccactcctaaaataaggtggttcaaggagggaaggctgctg actgaccaggagaaatatcagacctacagtgaactccgcagtggagttctggttctggtc attaaaaacgtgacagagagagaccttggccactacgagtgtgagctgtccaaccgtctg ggcagtgccaagtgtgcggctgatttagtcctcccctcggctgcggctcggactggcgag ccagccatcgtcattgaagttaccgagcaggaaaccaaaatcccaaagaagaccatcatc attgaggagaccattaccaccgtggtgaagaacccgcggatgaggagacaccgctcgccc ggtttgattgtcgccggtgcgcaccgctcagagacgtccacccccgagccctcgtcgggc cggcccagaaggatgcccgccccgaggaagaccaccatccccacgctttacgtcaccgag ccggcgggcgcagaagccaggccggtggagagcaagcccaggtgggttgaagtggaggag gtcatagagtacaaggtcaacaagtccccccggctgtcgaggaggaggggggtttcaccg gcggggtccgatcgctccgccacgtcctccagggcgaggaggtctggggaaaaccccaat gccaacaattccaacaacaagctggtggagcagccactcgtgcaggaagacgtcggcgag cacctgctgcctcaggaggaggaggggactcttgctgccgctggagaaccgagcgagctg tcgtctgttctgactgaggaggacagtgaagatctggatgatcaaactgtcgtctttgag tctgacgaggaaaactctgaacccatcaccctgaaacaaggagatcacgttttgactctg gaagacttggaggattacgtcccggaggaaggagagacgtacaggtcttcaagctcccac cgaggcgctgaggagaagccctgcgaggtctccgtgctccagcgggagatcggggggtcc acggtggggcagccggtgcttctcaacgtgggccggcccgacgccgtgcccaggcagagg agcggcttcttctgccgcttcaaggagcagctctccggcagccttttcccgtctcctttc ccacaaggcggcgagacccgacgccggccggagaggagagtcccgatccaagtgagccac gccaagctagaggtccagccctcgtactgctccgaggtgcagagggtcgagggcggccag cagagcttcaaaaccaaagtgtcgactcagacttacggttacacgtccgtcggaaacccc gtcactcttcaaatcaaagataatgtttatcaaaaccagtaa

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