Oryzias melastigma (Indian medaka): 112150726 Help Entry 112150726         CDS       T07439                                  Symbol obscna Name (RefSeq) obscurin isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism oml  Oryzias melastigma (Indian medaka) Pathway oml04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:oml00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     112150726 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oml01001]     112150726 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:oml04131]     112150726 (obscna) Enzymes [BR:oml01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      112150726 (obscna) Protein kinases [BR:oml01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    112150726 (obscna) Membrane trafficking [BR:oml04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     112150726 (obscna) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 PK_Tyr_Ser-Thr Ig_4 SOS1_NGEF_PH Ig_6 C1-set V-set_CD47 RhoGEF Ig_CD22 BiPBP_C ABC1 PH C2-set_2 fn3 Kinase-like Kdo IQ IQ_SEC7_PH APH Motif Other DBs NCBI-GeneID:  112150726 NCBI-ProteinID:  XP_036067361 LinkDB All DBs Position LG4:complement(7793715..7839200) Genome browser AA seq 5468 aa AA seqDB search MHINIISVFFLFIFLSGQKVLILEELEDAECLEGDTVTFKCRICPHDYAGVKWYLDETLL YTNELNEIKMITGGYHTLTFTQLARKDTGTISFSAGDKRSYASLLVRERRPTITKALEDC EAVEGGGLILSCVTSKPCHILWYKDGCLMWSSSRYFASRSGCEARLTIREVCSTDAGVYE CSAGSVTTTAVVRVKAIPAEFTQSLSAVEAKEGETITLTCEYSLPGVQFQWRKGFEMIRP TDRFVMKQRKTVISLTIKALRLEDSGEYICQCRDHHTTASLKVQAIPITFTKHLKSLQAE EGSSVILRCEISKPGVPLEWRKEQELLRNGVKYQIRRRETTLELLIWKPVPEDSGLYSCV CADQMTSATVKITALPVTFKQKLRNVTIEEGSTATLRCELSKPGHSVEWRKRGNEVIRNG EKYHMKQRDMLFELKIFNVTLEDSDIYTCTCGDAETSATLTVNVLPITFNQKLKNLQVEE GHNITLHCEISKPGAPVEWRLGGEPLENEEKYQIKQREGLLELTIIDAVPEDSGIYSCVC RDQKTKATVKVVAVPASFMVPLKSQEAEEGKSVTLVCELSKAGVPVQWLKDGVALTKEGK YEMNLEGKKALMTILNVQPEDAGRYSCIVGDEKTTAEIRVKRLPVIFERAIQSMVVIEGD SGTFSCELSKPGAPVQWRKGKIILKSGEKYDMKQEGRVTQLLINNVEESDGGKYTCKTKD SLSTAELIVQALPPKFKTALANQAATEGNSVVLRCELNKHAPSVEWRREGEPLKNGDKYQ IRKKDLQIEMKITDLAVEDTGEYTCICGEERTTARIEVNERPVKFLQELRNLQVQEGNGV TLCCELSKTGLPVQWKKGDKVLTVGEKYQMKQSGCMQELLIRKSLPEDGGMYSCECDDVR TTATVTITAIPVSFKQKLKNQEAVEESSLTLHCELSKPGVEVEWRRDAQLLKEGEKYQMK LEGRVAEMLIRNVTLADAGEYSCFAGAVGTSADIKVRALPVTFRRELGDVEVKEGDSGVL CCELSKPGARVEWRKGRVILKPGYKYEMKQEGCVAKLIINNIEESDAGKYICKTEDSQSS AELTVKAPPVTFKTKLRNQQVEEESSVILSCELSKPGLAVEWRKGKELLANDFKYQIKNR NSLMELIIKNAQLEDSGLYSCVYGDTKTTANVTITSIPLTFKMGLKNQEAPEGGNVCLRC ELSRAGVPVQWWKGEDQLSHGGRFQMSQKGKTAEMTIRNIQPEDVGEYSCVFGGQKTTAE VNVRAAASVFFEKELESQAVMEGKPVLLSCEVSSANVPVTWRKDNTVMEAGGRYNLKKKG SIHTLEIDNIQPEDAGEYCCVTRGKKTTAKLVVRERVRIVKELQDMRVTAGEDAVFVCEL SHADVSEGVWWLGSSPLQKNEMNQMTCRGRQHRLVLSMTTPEESGIVAFVVGDERTSARL LVDPKPKVFFEERPKDVAVIEGETASLCCTTSDHTSLVTWRRNQVPLQNSDKYEMQKKGK VNLLLIHDVEPQDAGSYSCDTGDEHSSVKLTVTELPPFFQEELQNVEAEEGGSAALYCEL SKLGVPIQWKKDRLALKSSRKHEMRQDGCFLQLYIKELKLEDSGTYSCQAGSAETAASLR VTELPPFFKKELRSVVVDEGGTASLKCEMSKAGVCVQWKKNKMLLKASRKYEMKQDGCLH QLHISELDPADGGTYTCQAGRAETTANVTVKELPPYFKRHLQNMEAEEGGTISLCCELSK PGVSVQWKKNKLPLRASRKCEMKQDGCMVQLHLKNLTLEDSGSYTCHADNAETSANLSVK ELTPFFKQDLKDVVVQEGATVSLCCEVSKEGLPVQWKRNRLPLRENRKYTMKNNGCFLQL QIKDATPEDGGSYSCQAGAAVTTAAVTVEELPLFFKEKLVNLEVEEGGTVSLHCEVSKPG ASVLWKKNKTPLRANKKYEVKQDGCILQLHIKEVKAEDSGSYICQAGSAETAATVSVKEV PPFFKKHLQSMEAEEGGTISLCCELSKPGVSVQWKKNKLPLRASRKCEMKQDGCMVQLHL KNLTLEDSGSYTCHADNAETSADLSVKELTPFFKQDLKDVVVQEGATASLCCEVSKEGLP VQWKKNRLPLRENRKYTMKNNGCFLQLQIKDATPEDGGSYSCQAGAAVTTAAVTVEELPP FFKEKLVNMEVEEGGTVSLRCEVSKPGAPVQWKKNKTPLRANKKYEVKQDGCILQLHIKE VKAEDSGSYICQSGSAETAATVSVKEVPPFFKKHLQSMEAEEGGTISLCCELSKPGVSVQ WKKNKLPLRASRKCEMKQDGCMVQLHLKNLTLEDSGSYTCHADNAETSADLSVKELTPFF KQDLKDVVVQEGATASLCCEVSKEGLAVQWKKNRLPLRENRKYTMKNNGCFLQLQIKDAT PEDGGTYSCQAGAAVTTAAVTVEELLPFFKEKLVNVEVEEGGTVSLRCEVSKPGAPVQWK KNKTPLRANKKYEVKQDGCILQLHIKEVKAEDSGSYICQAGSAETAATVSVKEVPPFFKK ELQSMEAEEGGTISLCCELSKPGVSVQWKKNKLPLRASRKCEMKQDGCMVQLTIKELQPN DTGNYSCSAGNVETFAFVQVKVATPQIQQKSEPPPLLPRLKGNASKPAQAPPSEVNSAPP EPKKRSNRKASFTNSEKDEELISDFKATLLKEKNEVQPGNQPTERNVEQDLRKLERNKEK DGEMHKKTERAQPQEDCRDARKAEDTKNEVFIEGRQPRENLKELVQSGFEVSLPERILGK SEVKLKEKEEEHKREEKLKQNGKDLEELSKSWLQDKQLMFKKRQEVEEPVKVQGITAKRE TDPKAVENKANADEPLKPPERLKVTDRSVKTLSEEPQKSVHHLVKGRMNDSEKEHKCVEV SSENQQAQPEKLDEKTVVFASPKAPKRTRSKERAALGRQLSRDTEMNREDQQTKTSAEER MKSKEIEEKSRLQTNQMITTDSQTGGKTKQPIKQRVKPMPKEPEKIEERKLPLETTRASE QSSTTSPEIPLLFTSEDETFSEALAELPTVQVLAPEAEGQREHLPPEHSPEVNFEDEPQM KEAAVKIQAAFKGYKTRKEMRPFFKEVFKTQNADLHGTLTLKCTVEGKPSSVRWLKNGQH ITNDQRCRITTTENGECTLVIKNLIDSDSGVYTCEATNKFGSISYNGNVTMVKSQPAAQM PLHPPLAAITPLQLAPTKPEPQNEALTSVTGTASFVESFTLWETYNLTEQDPVPRLQERR QSSLIAVSSMSSPSDYETAPDMMETPETRPILPREVPKLADESTLNEKEKILASQPLKKL LKVEGLQESKLRTPSPKQRRAHTPMTSTVSGSESEEEGDRREIFEIYVARADCSPTTGNK DSFILKEGQFVEVLDSVHPDRWLVKTKPTKTNPTRQGWLCPAYLEKKRKETFLPLRAPQE DLDGIGSSGEEYRRALSQLIQGLIDGEDEFVNAMRTFISNQLIRLESRHQVPVNILSQKE IIFRNIKDIVLLHEGSILPALRECATDDDVAALLIKHREDFEKYLHYMVGQAQAEACITD KAVQQCFKELIGSEKLGFPVMDVLTFLQQPVERIQTYQALLKELIKNKAKSGQSCYLLED AFSVVSCLPWRSNNLHQVSLIENYPAPLTALGEPVRQGVFTVREESPEIKAASRGHQRQV FLFKECVVLCKLKKDSNMNKDTYTFKNKMKLNDVEIRESVGGDERSWGLWHEHRGSIRRY ILQAHSSLAKLSWLKDLKELQQRCSLNTNSSPVFESELLDFVAKIGQTIKLTCRVSGSPK PLISWIKDGLPLEDDPRHIITADRSGRCSLILDSLTPDDSGQYLCYATSCMGSAGTLAKV VVQAPPRFVSRLESACLIEGEDIQFCCSTFPIPLPRVRWLKDGRELTDQHKYSIVSDARS GILSLTVIAATEADIGQYECELWNELGCVKCKAGLCPAFVPPTDNEKDQPHDLPAKDADS EGWSAAFVKKWLQTDFSPTSIAQKIFPQGNSEHPELNPEAEVSEPHRAVQHPLYLEEEEE EIYISEQMQDITDAPPFIQVSTEDLCVQPGQQATFTAIVTGRPAPKIQWFKDGEELIANE NVKIVQHGARCSMTIVCSEGEDSGIYTCYAHNDSGHACCEAQLTVEEGPLESQEREVELG KRRKLFSVYDVHDEIGRGTFGVVKRVIHRRTGEVFAAKFLPLRSSNRTRAFQERDLLSRL AHPRIACLLDFFCTRRTLVLISEMCCSHGLLDHLFLQSSVSEKEIQSYIQQILEGVGHIH SMNILHLDITPDNILMVYPPRDEIKICDFGFCQEIDASRHQYSMYGTPEFVAPEIVHQEP VTVASDIWAVGVVTYLCLVGRCPFVGETDRATLLMVGEGTLNWDTPDVNCRSPEAKKFLR MVLQPDPEKRPSAFDCLSHEWFQDESAGEDTDDINTRSLKVFISKRKWQRSLMCIGSVLT LRPIPELLDSPLRDTSVTVPREPQAHSSTSLSSGSSSEYDEADSWDFFQHCSQTEEEVET EEEFDPMAERARIPEPFSKYQFGGEDDEGTLGEEEDGELSERRTGMERSISRQSFASSTT TDLGTPQRERRFSKDSNPSLYLSEGDEGSGSDGGRIPRGSVIRSTFYNNSQQLSPMSARH MTMRDKFQAKKQERGRKPLRRSFSGRLNEPLIEYVEDETETGRSQRRGSVQAAMQKSCSF DSGVSLAHINLPPHRRSRSLDEYSRRSPSSPTHVRRSDEEGSQSMKEDFTDCEASGRTLP SAPSSQRATRRRGSVAPGQRSQTLSGSSAASDFIAGGRMGQAETEGEALTGSQGSLAESF ILEHGGSESSSRLGSFEELSHGHLRESRRSGESDGYDEQAELLLPPSPCSFQRVTPRSSV PQAPPRNRTRSNPNLANSRGQSGTPSPSPSLCSLQTPNRPPRARDRKDGLQRHASAPALE APPPSGKSPKLGILKFFRRQSWTGHSYSQLDSTELGPTLGEIMKPDTPTMSLRKKMRASA SSLTKLFSKSSSKEDLSKKGPIVKGSDLIPPEKERRSSLEKKSSKMFSSFKIPAFKRTQV HPNKPEVLQLHRGGVLLVWRPVQSSDPVSYCVQYCTDGGEWTILADQVTDSCYAVKDLPR GASYVFRVGCITKSGSGPFSEASSPVVMATHPEETPIPLVQIESLESKVTIEDGQTSKSY SFLSEINRGRFSVLTLCRDAETSQVFAAKITSYQSEQRQLVLREYQLLRRLHHPHLVQLH DALIAPSHVVLVEELCPGKELLHSLAARDLYAETHVTELLVQILGAVDYLHSRRVVHLDL KSDNMLVDDCNHLKIVDFGSAQCFVPGQPLHIEHIHGLSDSKDCRSKVYIVLPKAPEILE GQGVGPETDVWAIGVLSFIMLSADSPFQADHSREEDRNIKKGKIQFGCCYPGLSEGALTF MKSSLNNKSWGRPTAAECLQNPWLRAHRATHRARYSKVCFSTDKLKAYLEQKEEKRDQVR TKIHSPLR NT seq 16407 nt NT seq  +upstreamnt  +downstreamnt atgcacataaacattatttctgtgttttttttatttatttttttgtcaggccagaaagtt ttgatcttagaagaactggaagatgcagagtgtctagagggtgacaccgtcacctttaaa tgtcgtatctgtccccatgactatgctggggtcaagtggtacctggatgagactctgctt tacaccaatgagctcaatgagatcaagatgattacaggaggctaccacacactaactttt acccagcttgctcgcaaagacactggaactatttccttttcagccggagacaaaagatcc tacgcctccctgttggtcagagaaagacgtcccacgattaccaaagctctggaggactgt gaggccgttgaaggagggggcttgattttgtcctgtgtgacctctaagccgtgtcacatc ctgtggtacaaagatggatgcctgatgtggagctcctccagatactttgccagtcgctct ggctgtgaggctcggctgactattcgggaagtctgcagcacagatgctggggtgtacgag tgcagcgctggatctgtcacaactacagcagttgtcagagtcaaagccattcctgcagag tttacccagtctctatctgcagtggaagccaaagaaggagaaactattactttaacctgt gaatactctttgcctggagtccagttccaatggaggaaaggttttgagatgatcagacct acagacaggtttgtcatgaaacagaggaaaactgttatttctctgacaatcaaagccctg aggctggaagattcaggagagtacatatgtcagtgcagagaccaccacacaacagcaagc ctgaaggtacaagcgattccaatcacattcaccaaacatctaaagagcctgcaggctgag gaaggcagtagtgttatcctgcgttgtgaaatttccaaacctggagtaccattggaatgg agaaaggagcaggaactcttgaggaacggtgtgaagtaccagataaggaggagagagaca accctggagctcctgatatggaagcccgtgccagaggacagcggactctacagctgtgtt tgtgctgatcagatgacatcggcgactgttaagatcactgctctaccggtaaccttcaag caaaagttgaggaatgtgacgattgaggagggaagcactgcaacgttacgctgtgagctt tcgaagcctggacacagtgtagagtggaggaaaagagggaatgaagtgatcaggaatgga gaaaagtaccacatgaagcagagagatatgctttttgagctgaagatcttcaatgtaacg cttgaggacagtgatatctacacgtgcacttgtggggatgctgagacttctgctacacta acagttaatgtccttcctattacattcaatcaaaagctgaagaaccttcaagtggaggag ggacacaacatcacactgcactgtgagatctccaaacctggtgctccagtggagtggagg ctgggaggagagccgctggagaatgaagagaagtaccagataaagcaaagagaaggcctc ctggagctgacgatcattgatgctgtaccagaggacagtggcatctacagctgtgtgtgc agagaccagaaaacaaaagctactgttaaagtcgttgcggttcctgcctcattcatggtg cctcttaaaagtcaagaggcagaagaagggaaaagtgtcacgttagtgtgtgaactgtca aaggcaggagttcctgttcagtggctaaaggatggagtggcgctgacgaaggagggaaag tatgagatgaaccttgaaggaaagaaagctctgatgactattttaaatgtgcagccagaa gatgcaggaaggtacagctgcattgtgggagatgagaagaccacagcggaaattcgggta aaacgacttcctgtcatctttgaacgggcgatccagagcatggtggtaatagaaggagac agtgggactttctcctgtgaactctccaaacctggagctccagtacagtggagaaaaggt aaaatcatcctgaaatctggagagaaatatgacatgaaacaggagggccgtgtcactcag ctgctcattaacaacgtggaggaaagtgatggcggcaaatacacctgcaagaccaaagac agcctgtcgacagctgagctcatcgtccaagctttaccaccaaaatttaagacggcatta gcgaaccaagcggcgacagagggtaacagcgtagttctgcgctgtgagcttaacaagcac gctccatcagtggagtggaggcgagaaggagaaccgctgaagaacggagacaagtaccag atcaggaagaaggacctgcaaatcgagatgaaaatcaccgacctcgccgtggaggacacg ggagaatatacctgcatctgtggagaagagagaacaactgcgaggattgaagtaaatgaa cggccggtcaaattccttcaagagctgaggaaccttcaggtgcaggaaggaaatggagtg accctttgctgtgagctctccaaaacggggctgccagtgcagtggaagaaaggcgacaaa gtgctgaccgtcggagagaaataccagatgaaacagagcggctgcatgcaggagctgctc atcaggaaaagtctgcctgaagacggcggcatgtacagctgcgagtgtgacgacgtaaga accactgcaaccgtcaccataaccgcaattccagtgagcttcaaacagaagctgaagaac caggaggccgtggaggaaagttctttgacgttgcactgtgagctttctaaaccaggagtg gaagtggagtggaggagagatgctcaactgctgaaggaaggagaaaaatatcaaatgaaa ctggagggtcgggtggccgagatgctgattagaaatgtaactctggctgatgctggggag tacagctgctttgcaggagcagttgggacttctgccgacatcaaagtcagagcccttcct gttacgtttagacgagagctcggagacgtggaggtgaaggaaggagacagcggggttctc tgctgtgagctctccaaacctggagctcgggtggaatggagaaaaggcagagtcatcctg aaacctggttacaagtacgagatgaaacaggagggatgcgtagccaagttgatcatcaac aacattgaggagagcgacgccgggaaatacatctgcaagactgaagacagccagtcatct gctgagctcacagttaaagccccaccagtgactttcaaaacaaagctgaggaaccagcag gtggaggaggagagcagtgtgatcctgagctgtgagctctccaaacccggcctcgccgtg gagtggaggaaaggaaaggagctgctcgccaacgacttcaagtaccagatcaaaaaccga aacagcctcatggagctgatcatcaaaaatgcacaactggaggacagtggactctacagt tgtgtctatggagacaccaagaccacggccaatgttactatcacatccattcctctcacc tttaaaatgggcctgaagaaccaggaggcccctgaaggaggaaacgtatgcttacgctgt gagctgtcccgggccggcgtccctgtgcagtggtggaagggagaagatcagctgagtcat gggggacgatttcagatgagccagaaggggaagacggctgagatgaccatccgtaacatc cagccggaggacgttggagagtacagctgcgtctttggtggccagaaaacgacggcggag gtcaacgtcagagcggcggcgtccgttttctttgagaaagaactggagagccaagcggtg atggagggaaaaccggttctgctttcttgtgaggtctccagcgccaacgttcctgtcacc tggaggaaggacaacaccgtaatggaagcaggaggtcgttataatctaaagaaaaaaggc tccatacacactctggagatcgataacattcagccggaggatgctggggagtactgctgt gtgaccagaggaaagaagaccaccgccaagctggttgtaagagagcgcgttcggattgtt aaagagcttcaggacatgagagtgacagctggagaggacgccgtttttgtgtgtgagctg agccatgcagatgtgagtgaaggtgtctggtggctcggatccagccctctgcagaagaat gagatgaaccagatgacgtgccgcggtcgacagcaccgcctggtcctcagcatgacaaca cccgaggaatctgggattgtggcgtttgtcgtcggtgacgagaggacctctgcacgtctg ctagtggatcctaaacccaaagttttctttgaggagaggccaaaagatgttgctgttata gaaggagaaacagccagcttgtgttgcaccacctctgaccacacctccttggtcacctgg aggcgcaaccaagttccccttcaaaatagtgacaaatatgagatgcagaagaaaggaaaa gtcaacctgctgctcattcatgatgtcgagcctcaagatgcgggctcttacagttgtgat acaggcgatgaacacagcagtgtcaaactcacagtaacagaacttcctccatttttccag gaggagcttcagaatgtggaggcagaagaaggaggttcagcagctttgtactgcgagctt tccaaactaggtgttcctattcagtggaagaaggacagactggcactcaaatcaagcagg aaacatgagatgaggcaggacggctgcttccttcagctttacatcaaagagctgaagctt gaggacagcggaacgtactcctgtcaggccgggagcgcagaaaccgctgcgtctttgagg gttacagagctcccaccgttctttaagaaagaattgagaagtgtggtggtcgatgaagga gggacggcctcactgaagtgtgaaatgtccaaggctggtgtctgtgtgcagtggaagaag aacaagatgcttcttaaagcaagcagaaagtatgaaatgaaacaagatggatgtctccac cagcttcacatcagtgagctcgatcctgcagacggtggaacgtacacatgccaggcggga agggcggagacgactgcaaatgtcacagtcaaagagctgcctccatatttcaaaaggcac ctgcagaacatggaggctgaggagggaggtaccatctccctgtgctgtgaactgtctaag cctggagtgtcagtgcagtggaagaagaacaaacttcctctgagagccagcaggaagtgt gagatgaagcaggacggctgcatggtccagctccacctgaagaacctcactctcgaggac agtggcagctacacttgtcatgcagacaatgcagagacttcagcaaatctatcagtgaaa gagctcactccatttttcaaacaagacctgaaggatgtggttgttcaggagggagctaca gtctctctgtgctgtgaggtgtctaaagaaggccttccagtccaatggaagaggaacagg ctgccgctaagagagaacaggaagtacaccatgaagaacaacggctgcttcctccagctc caaatcaaagatgctacacctgaagatggtggcagctactcatgtcaggctggagctgca gttaccacagcagcagtgacagtggaagagcttcctctcttcttcaaagagaagttggta aacctggaagtggaggagggaggtacagtctcactgcactgtgaagtgtccaaacctgga gcttcagttctgtggaaaaagaacaagacgccactgagagccaacaagaaatacgaggtg aagcaggacggctgcatcctccagctccacatcaaggaggtcaaagctgaggacagtgga agctacatctgtcaagcaggaagtgcagagactgcagccactgtgtctgtgaaagaggtt ccaccttttttcaagaagcatttgcaaagcatggaagctgaggagggaggtaccatctcc ctgtgctgtgaactgtctaagcctggagtgtcagtgcagtggaagaagaacaaacttcct ctgagagccagcaggaagtgtgagatgaagcaggacggctgtatggtccagctccacctg aagaacctcactctggaggacagcggcagctacacttgtcatgcagacaatgcagagact tcagcagatctatcagtgaaagagctcactccatttttcaagcaagacctgaaggatgtg gttgttcaggagggagctacagcctctctgtgctgtgaggtgtctaaagaaggccttcca gtccaatggaagaagaacaggctgccgctaagagagaacaggaagtacaccatgaagaac aacggctgcttcctccagctccaaatcaaagatgctacacctgaagatggtggcagctac tcgtgtcaggctggagctgcagttaccacggcagcagtgacagtggaagagcttcctccc ttcttcaaagagaagttggtaaacatggaagtggaggagggaggtacagtctcactgcgc tgtgaagtgtccaaacctggagctccagttcagtggaaaaagaacaagacgccactgaga gccaacaagaaatacgaggtgaagcaggacggctgcatcctccagctccacatcaaggag gtcaaagctgaggacagtggaagctacatctgtcaatcaggaagtgcagagactgcagcc actgtgtctgtgaaagaggttccaccttttttcaagaagcatttgcaaagcatggaagct gaggagggaggtaccatctccctgtgctgtgaactgtctaagcctggagtgtcagtgcag tggaagaagaacaaacttcctctgagagccagcaggaagtgtgagatgaagcaggacggc tgcatggtccagctccacctgaagaacctcactctggaggacagcggcagctacacttgt catgcagacaatgcagagacttcagcagatctatcagtgaaagagctcactccatttttc aaacaagacctgaaggatgtggttgttcaggagggagctacagcctctctgtgctgtgag gtgtctaaagaaggccttgcagtccaatggaagaagaacaggctgccgctaagagagaac aggaagtacaccatgaagaacaacggctgcttcctccagctccaaatcaaagatgctaca cctgaagatggtggcacctactcatgtcaggctggagctgcagttaccacggcagcagtg acagtggaagagcttcttcccttcttcaaagagaagttggtaaatgtggaagtggaggag ggaggtacagtctcactacgctgtgaagtgtccaaacctggagctccagttcagtggaaa aagaacaagacgccactgagagccaacaagaaatacgaggtgaagcaggacggctgcatc ctccagctccacatcaaggaggtcaaagctgaggacagtggaagctacatctgtcaagca ggaagtgcagagactgcagccactgtgtctgtgaaagaggttccaccattcttcaagaaa gaactacaaagcatggaagctgaggagggaggtaccatctctctgtgctgtgaactgtct aagcctggagtgtcagtgcagtggaagaagaacaagcttcctctgagagccagcaggaag tgtgagatgaagcaggacggctgcatggtccagctcaccatcaaggagcttcagcctaat gacactggcaactactcctgctctgctggaaatgtggagacctttgcatttgttcaagta aaagtagcaacaccgcagattcaacaaaagtcagaacctcctccattactaccacgacta aaaggaaatgcctctaagccagctcaagctcctccatcagaagttaactctgctcctcct gagccaaaaaagaggtctaacagaaaagcatcgttcacaaattcagaaaaagatgaggag ttaatttctgactttaaagcaactttgctaaaggagaaaaatgaagtccaaccaggcaac cagccaacggaaagaaacgtcgagcaagatctaaggaaattggagaggaacaaagagaaa gatggtgagatgcacaagaaaactgaaagggcacaacctcaggaggattgtagggatgcc agaaaggctgaagatacaaaaaacgaagtgtttatcgaaggacgacaaccaagagagaat ttaaaagaattagttcaatctggctttgaagtcagtctaccagaaaggattttaggcaaa agtgaggtcaaactgaaagaaaaggaagaagaacataaaagagaagagaaactgaagcag aatggaaaggatttagaagaattaagcaaatcctggttgcaggataaacagctgatgttt aaaaagaggcaagaggtggaagaacctgtgaaagtacaaggtatcacagcaaagagagaa acagatccgaaagctgtagaaaataaagcaaatgcagatgaacctctaaagcccccagaa agacttaaggtaacggatcggtcagtcaaaactttatcagaagaacctcagaaaagtgtc catcatttggtaaaaggtaggatgaatgattcagaaaaagagcacaaatgtgtagaagtg tcttcagagaatcagcaagcccaaccagaaaagctggatgagaagacagtggtctttgct tcacctaaggcaccaaagaggacgagaagcaaagaaagagcggcattgggaagacaatta tcaagggatacagagatgaatcgagaagatcagcagacaaaaacatcagctgaagaaagg atgaagtccaaagagattgaggagaaatcaagattacagaccaaccaaatgattacaaca gacagtcaaacaggtggaaaaacaaagcagccaataaaacagagagtgaaaccgatgcca aaggaacctgagaagatagaggaaaggaagctgccgcttgagacgacaagagcaagtgaa cagtcatcaaccacgtcccctgagatccctctcctgttcacttctgaggatgaaaccttc tcagaggcattggctgagctgccaactgtccaggttcttgcccccgaagctgagggacaa agggaacatctaccacctgagcattctcctgaagtcaactttgaagatgaaccacaaatg aaggaggctgccgtcaagatccaggcagccttcaaaggctacaagacccgcaaggagatg cgaccctttttcaaggaagtcttcaagacccagaacgcagaccttcatggtaccctgact ctaaaatgcaccgtcgagggaaaacccagcagtgtgcgctggttgaaaaatggccagcac atcaccaacgaccagcgatgccggattacgaccacagagaatggcgagtgcacacttgtc attaaaaacctgatcgacagtgacagtggggtttatacgtgtgaggcaacaaataaattt ggttcgatttcctacaacggtaacgtcactatggtaaagtcacagccagcagcacagatg ccattacatccacctcttgcagctataacccctctccagctcgctccgacaaagcctgaa cctcagaatgaagcactcacatccgttactggaactgcaagttttgtagagagctttacc ctgtgggagacctacaacctgacagagcaggacccagtgccaagactgcaggagaggaga cagtcctcgctcatcgctgtcagctccatgtcgagtccatcagattatgaaacggctcca gacatgatggagactcctgaaactaggccaatcctgcccagggaagtaccaaaacttgca gatgaaagcactctgaatgagaaggagaagatcttagcttcacaacctctcaagaaactc ttgaaagttgaaggactccaagaaagtaaactaaggacaccctctccgaaacaacggcga gcccacacccccatgaccagcactgtgtctggatcagaatcagaggaagaaggcgacagg cgagagatctttgaaatctacgtagctcgagccgactgcagccccactactgggaacaag gacagttttattctgaaggaggggcagtttgtggaggtcctggactctgttcaccctgac agatggttggtgaaaaccaaacccaccaaaacgaacccaactcgacagggctggctgtgt ccggcctatctggagaagaaaaggaaggagacctttctacctttgagggcacctcaagag gatcttgatggaatcgggtcgtcaggagaagaatacaggagagctctaagtcagctgatc caaggcctaattgacggagaagacgagtttgtgaacgccatgaggacttttatctccaac cagctcatccgcctggaatccaggcatcaggtcccggtcaacattctcagtcagaaagaa ataattttcaggaacatcaaggacattgtgcttctgcatgaaggctccatccttccagct ttgagagagtgcgccacagacgacgacgttgccgctcttctgatcaaacatcgagaagat ttcgagaagtatcttcactacatggtgggacaggcacaggccgaggcctgcatcactgac aaggctgtccagcagtgtttcaaagagttaataggatctgagaagctcggcttcccggtt atggatgttcttaccttccttcaacaaccagtagagaggattcaaacctaccaagctttg ttaaaagaattgatcaagaacaaagctaaaagtggccaaagctgctacctgttggaagat gctttctctgtggtgtcctgcttgccttggaggtccaacaacctccatcaagtgtctctc attgagaactacccagcccctcttacagctctgggggagcccgtgcgacagggagttttc acagtgagagaagagtctcctgaaataaaagcagcctctagagggcatcagaggcaagtc tttctctttaaggaatgtgttgttctgtgtaagctgaagaaagactccaacatgaacaaa gatacttacacatttaaaaacaagatgaagctgaatgatgtggagatacgagagtctgta ggtggagatgaaaggtcttggggcttgtggcacgagcacagaggctctattcgcagatac attctccaggcccactcctcgttagctaaactgtcctggctgaaggacctaaaggagctt caacagcgctgcagcctcaacaccaacagctcaccagtttttgagtcagagctgttggac tttgttgcaaaaataggtcaaactataaaactgacctgcagagtgtctggatctccaaaa cctcttatcagctggatcaaagacggtcttcctttggaggacgacccgcgtcacatcatc accgcagaccgctcaggaaggtgcagtctgattctggacagcctcactcctgatgactct ggacagtatttgtgctacgctacgagctgtatgggtagtgctggcactctggctaaggtg gtggtgcaggctccaccacggtttgttagtcgattggagagcgcttgcctgatagaagga gaggatattcagttctgttgttccacgttccccattcctttaccacgagtcaggtggctg aaagatggcagagagctgactgaccagcacaaatactccatagtgagtgatgctcggagt ggtattttatctctgacagtcatcgcagcaacagaggctgatattggacagtatgagtgt gagctttggaatgaacttggctgcgtgaagtgtaaggccggcctgtgtcctgcctttgtc ccgccgactgacaatgagaaggaccagccgcatgacttacctgctaaagatgctgactcg gagggttggtctgctgcgtttgtgaaaaaatggttacagacagattttagccccacctct attgcacagaagatttttccacagggaaactctgaacatccagaattgaatcctgaagct gaagtctcagaaccgcatcgtgccgtccagcatcctctttatctagaagaggaagaggag gagatctacatctcagagcagatgcaggatattactgatgctccacccttcatccaggtt tccactgaggacctgtgtgtacaaccagggcaacaggcaacattcacagcgattgtgaca ggaagacctgctccaaagatacagtggttcaaggatggagaggagcttatagcgaatgag aatgtaaagatagtacaacatggtgcacgttgctccatgaccatagtgtgcagtgagggc gaggacagtggcatatacacctgttatgctcacaacgactctggccacgcctgctgtgaa gcacagcttacagttgaagagggtccacttgagtctcaagaaagagaggtggagctgggt aaaagaagaaaacttttctccgtgtatgatgtccatgatgagattggaaggggaacattt ggggtggtgaagcgtgtcattcacagaagaacgggcgaagtcttcgctgccaagtttctg cctctgcggagcagcaatcgtacccgagcatttcaggagagggacctgctctcccgcctg gctcatcccaggatcgcctgtctgctggatttcttctgtaccaggcggacgctggttctg atctcagaaatgtgttgctcacatggactcctggatcatttgtttctgcaaagctccgtc tcagagaaagagattcagtcctatatccaacaaattctcgagggagttggtcatattcac agcatgaacattttgcatcttgacattacgcccgataatattttaatggtttatcctcca cgagatgagatcaagatctgcgactttggcttctgccaagaaatagacgcatcccgacat cagtatagtatgtatggaacacccgagtttgttgcccctgaaattgttcaccaagaacct gtcactgtggcctccgatatttgggctgtgggtgtggtaacatacctgtgcctggtgggt cgatgcccttttgttggagaaactgaccgtgcaacgctgttgatggttggggagggaact ctaaactgggacactccagacgttaactgcagaagtcctgaagccaagaagtttcttcgt atggtccttcaaccagatccagagaagcgtccatctgcttttgattgtttgagccatgag tggttccaggatgaaagtgctggagaagacacagacgacatcaacacaaggagtctgaaa gtcttcatctctaagaggaaatggcagcgttctctgatgtgcatcggttcagttctcacg ctcagacccattcccgagctgctggattctcctctcagagacacctctgtgacagttccc agagagcctcaggcgcacagcagcacctccctgagcagcggctcctcgtctgagtatgac gaagcggactcctgggacttcttccaacactgcagccagactgaggaggaggtggaaaca gaagaggagtttgatcccatggcggagagggcacgaatcccggagccgttttctaaatac caatttggaggggaggatgatgaaggcacacttggggaggaagaggatggggagttgtcg gaaaggaggactggaatggagcggagtatcagcagacagtccttcgcttcatcaacaaca acagatctaggaactcctcaaagagagcgtcgcttcagcaaagacagcaatccctccctt tatctttctgaaggggacgaggggtcgggcagcgatggaggacggatccctcgagggagc gtcatccgcagcaccttctacaacaactcccaacaactttcccccatgtctgccagacac atgacaatgagggacaaattccaggcaaagaagcaggagagaggccgcaaacccctgcgg aggagcttctcgggacgtctcaacgagcctctcatcgaatacgtggaggacgaaaccgaa acgggtcgtagtcaaaggcggggatccgtccaggccgccatgcagaagtcttgctctttt gacagtggagtgagccttgcccatattaatctaccacctcacagaaggagtaggtctctg gatgagtattcacgaagatctccctcgtcacccactcacgtcaggagaagtgatgaggag ggttctcaaagcatgaaggaggacttcacagattgtgaagcgtcaggaagaaccctgccg tctgcgccgagctctcagcgagcaacaagaaggagaggttctgtcgctcccggacaaagg agtcagactctgagtggatcatctgcagcctcagatttcattgctggaggcagaatgggg caggcggagacagagggagaagcgctcactggttcccaaggctctttggctgagtcattc attctagagcatggtggctctgagtcctcaagccgacttggctcgtttgaggagctgagt catggtcacctgagagaaagccgcagatccggagagagtgacggatatgatgaacaggcc gagctcctccttcctccgtctccatgctcatttcagcgagtaacacccagaagctcagtg cctcaagcaccgccgcgtaatcgcacacgctctaacccgaatctagctaacagcaggggt caatcggggacacctagcccaagtcccagcctctgctcgctacagactcccaacaggccc ccaagagcccgggatagaaaggacggccttcagagacacgcttccgctccagccctcgaa gctccgcccccttcaggaaagtcaccaaaactgggaatcctcaagtttttccgtaggcag tcctggactggtcattcctactcccagctggatagcacagagttgggccccacactggga gaaatcatgaaacccgatacccccaccatgtctctgagaaagaagatgagagcttcggca tccagcctgacaaaactgttttcaaagtcgtccagtaaggaggatttgagtaaaaaaggg ccaatagtaaaaggatcagacctgatcccacccgagaaagagcgcagaagttccctggaa aagaaaagctcaaagatgttttcatcttttaaaattcctgcatttaagagaacacaagtt catcccaacaagcccgaggtgctgcagttgcacagaggtggggttctgctggtgtggagg cccgttcagtccagtgatcccgtcagttactgtgtacagtactgcacagacggtggggaa tggaccattctggcggatcaggtgaccgacagctgttatgcggtgaaggacctaccaaga ggggcttcttatgtgttcagggtgggttgcatcaccaaatcaggatcaggacctttcagt gaagcttcatctcctgtcgtcatggcgactcaccctgaagagactcccattcctcttgtt cagattgaatcactggagtcgaaggtcaccatagaagacggccagacgtcaaagagctac agcttcctatctgagatcaacaggggtcgttttagtgttctaaccttgtgcagggacgct gaaaccagccaagtgtttgctgctaagatcacttcttaccagtcagagcaaagacagctg gttttacgggaataccagctgctgaggaggctccatcaccctcacctggttcagctgcac gatgctctcatcgccccttcacatgtggttctggtggaggagctgtgtcctggcaaggag ctgctccacagtctggctgccagagatctgtatgcagagactcatgtcacagagttgctg gttcagatcctcggcgccgtcgactaccttcacagccggcgggtcgttcacttggacctg aagtctgacaacatgctggtggacgactgcaaccacctgaagatcgtggacttcggctcg gctcagtgcttcgtccccggtcagccgctccacatcgagcacattcacggcctctccgac agcaaagactgccgcagcaaagtctatattgttcttcctaaagctcctgaaatcctggaa ggacagggtgtgggtccggagacggatgtgtgggctatcggagttctgtctttcatcatg ctgagtgctgacagcccgtttcaggcggaccacagcagggaagaggaccggaacatcaaa aaggggaagatccagtttggatgctgctacccgggtctttctgagggagccttgaccttc atgaagagcagcctgaacaacaaatcctggggaagacccaccgccgccgagtgtctccag aacccgtggctgcgggcccatcgggccacgcacagagccaggtactccaaagtgtgtttc tccaccgacaaactcaaagcctacctcgagcagaaggaggagaagcgagatcaggtgcgc acaaagatccatagccctctccgctag

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