Oryzias melastigma (Indian medaka): 112158266 Help Entry 112158266         CDS       T07439                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism oml  Oryzias melastigma (Indian medaka) Pathway oml04020   Calcium signaling pathway oml04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oml00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112158266 (ryr3)    04020 Calcium signaling pathway     112158266 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oml04040]     112158266 (ryr3) Ion channels [BR:oml04040]  Voltage-gated cation channels   Ryanodine receptor    112158266 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  112158266 NCBI-ProteinID:  XP_024147292 LinkDB All DBs Position LG24:complement(20920771..21076788) Genome browser AA seq 4848 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSAATIQKDHRKFCLAAEGLGNRVCYLEPTSEAKYVPP DMCICNFVLEQSLSVRALQEMLANTGQNSEGSADHEKWAAQGGGHRTLLYGHAILLRHSF SGMYLTCLKTSRSLTDKLSFDVGLQEDSVGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSISNGNIQVDASFMQTLWNVQPTCSSSSMAVGFLIGGHVMRLCHGHDESLT IPGADKSEEEQRIVNYEAGKGASRARSLWRLEPLRVSWSGSHIRWGQAFRLRHLSTGHYL ALTEDRGLVLEDREKSGTKATAFCFRPSKEKVDTGPKRDIDGMGVPEIKYGDSVCFVMHV ATGLWLSYMAPDAKSSRLGPLKRRACLHSEGHMDDGLTLQLCQHEEARAARIIRNTTFLF STFIKALDSVKDPESSTVAGYIEEVLQTLNDLIEYFKQPDSELEHEEKQSLLRSLIRRQD LFKEEGMLTLLSKCIDRMNLYESAAHFAEVAGEEAGAAWKDILNLLYELLAALICGNRNN CTQFSRNLDWLVSKLERLESSSGILEVLHCILVESPEALNIIQRGHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNDVQSMRPNVFLGMAEGS AQYKKWYYELVIDQADHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHQLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMRVEPVKEYKRDHDGV RDLLGTTQFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFAKLPETERNYNLQMSSETLKTLLALGCHVAQVNVHAEDDLKKIKLP KDYMMSNGYKPAPLELSDVKLNPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYALLDERTKKSNRDSLREAIRTIVGYGYDIDPPDQEAVHVVDDHSVETIRFFR VEQTYAVKTGKWYFEFEVLSGGDMRVGWARPGCRPDVELGSDDQAFVFDGYRGRRMHAGS RYFGQPWKKGDVVGCMINMEDKSMIFTLNGELLITSRGSELAFTDFETQDGFIPVCSLGM AQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMKREITMWFSKRLPTFFNVPQDHVHIE VTRIDGTVDSPPCLKVTHKTYGTQNSNSDMVYCRLSMPVEFYSADKMLDESVKLSQPPKE GADYSSITTYFHSVRVFAGQDPTCIWVGWVTPDYHYYSKNFSLGKTQTVTVTLGDERGRV HESVQRSNCYMVCAADAVSPSSSRSNSDLEIGCLIDLATGLVSFTANGKELPTAYQVEPN TKLFPAVFVLPTSANLFQFEFVKIKDAMPLSSAMFKSEHKNPVPQCPPRLDVQTIVAVLW SRMPNTFLSVETARVSERHGWVIQCLEPLQMMAVHIPEENRCLDILELSEHEDLRKFHYH TLKLYCALCALGNTRVSHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAKE ARLMMNNEFIIPVTDETRSIKLFSDESKQHSLPGVTLSTSLKPRVNFSPVGVINTKRQQF LYSPQIPLGVLKEKAISMLTEAVQGGGSHIRDPVGGSLEYQFVPILKLIGTLLIMGVLTS EEVRLILLLIEPNVFGESKEGEEAKGEVLAVAGEKEEVSKNEEKAVEAGEEETKESKSPS KGLLEKSLPEPVKRQMCELLHYFCDCELRHRIEAIVSFSDRFVSKLQFNQKFRYNELMQA FNMSAAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIQDELNVFHEELRLHCGIPM EEEEEEQDTSIKGRLLALLYKIKGPPQKAAEEPTETEQAAPTNLKELISQTITSWAQESH IQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVRM GKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQKIAFPKMVA SCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGLA LALEEPDLEKVVMYLAGCGLQSCAMLVAKGYPDIGWNPIEGERYLSFLRFAVFCNGESVE ENANVVVKLLIRRPECFGPALRGEGGQGLLAAMNEAIKISEDPALDLPKTPAGDAAGSAE EEEEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLVGII SIPLNMPVVHKDGTVTEPDMSASFCPDHKAPMVLFLDRVYGIEDQSFLLQLLEVGFLPDL KASASLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFANTEHYAQLVDSTLETIYRLS KGRSLTKAQRDAIEDCLLTICKHLRPSMMQQLLRRLVFDVPMLSEYCKIPLRLLTNHYEQ NWKYYCLPSGMGSFGIASEEELLLTKKLFWGIFDSLSQKKYDSELFKMAKSCLCAIAGAL PPDFVDTSLAASLEKQGSVDAQGNFEPKPISTANISLPEKLEYAANKYAEHCHDKWSSEK MSAGWKHGDSLDEQAKAHPLLKPFKALSEKERETYRWPVREALKSMLAMSWNIERTKEGE AMFQQRESEKQRRVSESQGDGFTPAPMELHNVTLSRELQGMVEVVAENYHNIWAKKKKTE LQSKGGGAHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDLELDSSSMEK RFSFKFLKRLLKYVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLIDQTFKNH CLYFLSTPNKNLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLHILTN SLDTRTVMKSGSELVKASFKAFFENASEDLEKLVEMLKLGKFMQSRAQMKSVSQSINYVT VALLPILTALFEHIRTHEFGVDLLLNDVQLSCYRILMCFYSLGTGKNIFVERLLPALGES LATLVGAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKLLKDV NDISDSGARYSDMPQVIEVVLPMLCNYLSYWWEKGPENSPPDTDCCTMVTSEHLSIILGN ILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRSHFLPTLDKLRKKTVKVVAEEEL LKADSKGDNQEAELLILDEFAMLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSTELFKMV AEIFILWCKSNNFKREEQNFVIQNEINNLAFLTGEGKAKMSKSGGDQERKHKRRRGELYS IQTSLIVSALKKLLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEHLQQNLHLQEKSD DPAVQWQMNLYKDVMVKSGELTNPEHAVDRIQSISAAVFHLEQVEQPLRNKKCVVQKLLS KQRKRAVVACFRMAPLYNLPRHRAINFFIPAYQRLWIEAEEYSFEEKLVQDLAKTPMKIV EEEEEEVAEIKPDPLHQLILHFSHNALTERSHLEVDPLYIAYADMMAKSCAEDEEEEEEE GKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGISILNG GNVHVQQKMLNYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSTHT GRGSKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRLQE SISDFYWYYSGKDIIDETGKLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDA VVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMVDTL VESSNNVEMILKFFDMFLKLKDLTTSDNFKEYDPEFKGIISTKEFQKSMESQKQYTQSEI EFLLSCAKADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLSTFLDLAE SVLSYFEPYLGRIEILGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGES EKMEMFVNFCEDTIFEMQLASQISEPDVVEQPEEEEEEEHSLLEELAGDEEALETPSAFT SACRSVKKKISDVRQIFAIKNIRKKFKKIRKLSVKEMITGFFSFFWMIFIGFFKGIYSLI FGFFHIIWSSMFGGGLVEGAKNIKVTDILGHMPEPTQFGIHGDAVEGDKAETTESSGSMD TAMAPTGDIVEVDTMMEMLAPKKEGGKHVEPGLGDVSELSGDSSADHKKKGSSKLADTIE TGKEKADSENQEKEDKPKEEEVKEPAAEEKPRVKSSQPKEASPAFMSTIFAVLDVYMTKM LNYLARNFYNLRFLALFVCFAINFILLFYKVTEESEEEEEDEHRWGEEEENDENTLFDMD EFVLQESTGYMLPTLRFLAIFHTVISLLCLFGYYCLKVPLVVFKREKEIARKLEFDGLYI TEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDMYGAERIAELLGLDKSAL DFDPTVETVEKEASLVSWFSSIDTKYHIWKLGVVLTDNYYLYLIWYTTMSIFGHFNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDE DEPDMKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14547 nt NT seq  +upstreamnt  +downstreamnt atggccgagggcggagagggggaggacgagatccagttcctgagaactgacgatgaggtg gttcttcagagcgccgccaccatccagaaggaccatcgcaagttctgtctggctgcagag ggcctcggaaaccgtgtgtgttacctggaacccacgtctgaagccaagtatgtccctccg gacatgtgcatctgtaactttgtgctggagcagtcgctgtcggttcgggccctgcaggag atgctggctaacacggggcagaacagtgaagggagtgctgaccatgaaaaatgggccgct caaggaggtgggcatcgaaccctactgtacggtcacgccattcttctgcggcactccttc agtggcatgtatttaacctgtttgaagacatcaagatctcttactgacaagctgtcattt gacgttggactgcaagaagattcagttggagaggcctgctggtggaccattcaccccgca tccaagcagagatccgagggagagaaagtccgtatcggagatgatctgattcttgtcagc gtgtcaacagaaagatatctgcatctctccatctccaacggcaacattcaggtcgatgca tcgttcatgcagactctgtggaacgtgcagccaacctgctcttcaagcagcatggccgta gggtttttgattggtggacatgtgatgcgcctctgtcacggacacgatgagagcctgacc atccccggagccgacaagagtgaagaagagcagagaatcgtaaactacgaggcggggaaa ggagcatcgcgggctcgctctctgtggaggctggagcctctcagagtcagctggagcggc agccacatccgttggggtcaggccttccgcctgcgccatctctccacgggtcattatctg gctctaacggaagaccgaggtctggttctggaggacagagagaagtctggcaccaaggcc acggcgttctgcttcaggccctcaaaggaaaaagtggacaccggtccaaagagagacata gacggcatgggggtgccagaaatcaagtacggagactccgtctgctttgtcatgcatgtg gcgaccggactctggctgtcctacatggcgcctgatgccaaatcctcccgccttggccca ttgaaaagaagggcctgcctgcactctgaaggccacatggacgacggcctcacgctgcag ctctgccagcacgaggaggctcgggctgctcgcatcatccgaaacaccacattcctcttc tcaaccttcatcaaggctttggacagcgtcaaggacccagagtcgtccaccgtggccggg tacatcgaggaggttctgcagaccctgaatgacctgatcgagtatttcaaacagcccgac tctgagctggagcacgaggagaagcagagtcttctccgctcactcatcagacgtcaggac ctcttcaaggaggagggcatgttgaccctcctgtccaaatgcatcgaccggatgaacctg tacgagagtgctgctcactttgcagaggtggccggcgaggaggcgggcgcagcgtggaag gacatcctcaacctgctctatgagctgttggctgcactcatttgtggaaacaggaacaac tgcacccagttctcccgcaacttggactggttggtgagcaaactggagagactggaatcc tcgtcaggaatcctggaagtccttcattgtatcctggtggaaagtccagaagctctgaac atcatccagaggggtcacatcaaatccatcatatctctgctctacaagcacggacggaac cacaagattctggacgttctttgttctctatgtgtgtgcaacggggtggcagtgagagcc aatcagaatctgatctgtgacaacctgcttcccaaacgggatctgctgcttcagactcga ctggtcaatgatgttcaaagcatgcgtccaaacgtcttcctgggcatggcggaggggtcg gcccagtataagaagtggtactatgagctggtcattgaccaggcggaccattttgttact ggagagccgacccacttgagggtgggatgggccaacacaaaaggctacgctccgtaccct ggtggaggggaagggtgggggggcaatggagtgggagacgacctttactcctacagcttc gatggactccatctgtggtcaggtcgaatcccgagggccgtggcctccatcaaccagcac cagctgaactctgacgacgtggtcagctgctgtctggatctgggcgctcccagcatgtcc ttcaggatcaacggtcagcctgtccagggaatgtttgaggatttcaacacagacgggttc ttcttcccggtcgtcagcttttctgcaggagtcaaagtccggttcctgctgggtggacgc catggagactttaagtttctgccccctgctggttactctccgtgctacgaagccctgctg cccaaagagaagatgcgggtggagcctgtgaaggagtacaagagggatcacgatggagtc cgagacctgctgggaaccacacagtttctgtctcaggcctccttcatccccacacctgtt gacaccagccagattgttctgccacctcatctggaaaacattcgggacaaactggcagaa aacatccatgaactttgggggatgaacaaaatcgaactgggctggacttatggcaaggtt cgggatgacaacaagcgtcagcatccgtgtcttgtggattttgccaaactgcctgaaaca gaaaggaactacaacctgcaaatgtccagtgaaacattaaaaactctgttagctctggga tgtcatgttgcccaggtcaacgttcacgcagaggacgatctgaagaaaatcaaactgccc aaagactacatgatgtcaaacgggtacaagcctgcgccactggaactctctgacgtcaag ctgaatccaggtcaagaggttctagttgataaactggccgaaaatgcacataatgtgtgg gccaaagaccgaattaaacaaggatggacctacggcatccagcaggatctgaaaagcaga cgaaatcctcgcctggtgccgtatgctttactggatgaacgcactaagaagtctaaccgg gacagtctacgggaggccatcaggaccatcgtgggatacggatatgacatcgatccccca gaccaggaggcggtgcatgtggtggatgatcacagcgtggagaccatccgcttcttccgc gtggagcagacgtacgccgtaaagacggggaagtggtactttgagtttgaggttctgagt gggggtgacatgcgcgtcggctgggccagaccgggctgcaggcctgacgtagagctggga tcagacgaccaggccttcgtctttgacggatacaggggccggcgcatgcacgcaggcagc cgctactttggacaaccgtggaagaaaggagacgtggtcggatgtatgatcaacatggag gacaagtccatgattttcaccctgaatggagaactgctgatcacaagcagaggctctgag ctcgccttcaccgactttgagacccaggatggcttcatccccgtgtgcagcctgggcatg gctcagatcggccgcatgaacctggggaaggacgccagcaccttcaagtactacaccatg tgtggtctgcaggaaggcttcgagccttttgccgtcaacatgaagagagaaatcaccatg tggttcagcaaacgtctgcccaccttcttcaacgtcccccaggatcacgtccacatcgag gtgaccaggatcgacgggacagtggacagccccccctgcctgaaggtcacccataagaca tacggcacgcagaacagcaacagcgacatggtgtactgcagactgagcatgcccgtggag ttctactctgcagacaagatgctggatgaatctgtgaagctcagccaacctcctaaagaa ggtgctgactacagcagcatcacaacatacttccactcggtgagagtgttcgcgggacag gaccccacctgcatttgggtgggctgggtgacgcccgactatcactattacagcaagaac ttcagcctcgggaaaactcagactgttactgtcaccctgggagatgagagggggcgggtc cacgagagcgttcagaggagtaactgttacatggtgtgtgcggcagacgccgtcagcccg tcctccagccgctccaactcggatctggagatcggctgtttgatcgacctggccaccggt ctggtctccttcactgccaatgggaaggagcttcccacagcgtaccaggtggagccaaat acaaagctcttcccagctgtctttgttcttcccaccagcgcgaacctcttccagtttgag tttgttaaaattaaggacgccatgcctctgtcgtcagccatgtttaagagtgaacacaag aaccctgtgcctcagtgtccgccgcggctggatgtgcagaccattgtagccgtcctgtgg agccggatgccaaacaccttcttgagcgtggagacagctcgagtcagtgaaaggcacggc tgggtgatccagtgtttggagccgctgcagatgatggctgtgcacatacctgaggagaac agatgtttggacatcttggagctgtcagagcatgaagacctcaggaagttccactaccac acgctgaagctctactgcgccctctgtgctctgggaaacacgcgcgtcagccacgccctg tgcagccacctggatcaatcccagctcctgtacactatcgacaaccagtacctgtctgga atgttgagggaagggttttacaatgtcctcatcagcattcacctggagacggcaaaagag gctcgcctgatgatgaataacgagtttatcatccctgtgacggacgagactcgttccatc aagctgttctcagacgagtctaagcagcactcgctgccaggtgtgactctgagcacctcc ctcaaacccagagtcaacttctcgcctgttggcgtcatcaacaccaagcgccagcagttc ctctacagcccccagatccctctgggggttctgaaggagaaggccatctccatgctaacc gaggccgtgcagggcggggggtcccacatccgagatcccgttggggggagtttggagtac cagtttgtccccatcctgaaactgattgggaccctgctgataatgggggtcctaaccagt gaggaggtgaggctgattctcctcctgatcgagcccaacgtctttggagagagcaaggag ggcgaggaggccaagggagaggtgttggctgtggcgggggagaaggaggaggtcagcaag aacgaggagaaggctgtggaggcgggagaggaggaaaccaaggagagcaagtccccctcc aaaggcctgctggagaagtctctgcctgagccagtgaaacgtcagatgtgcgagctactc cactacttctgtgactgcgagctgaggcaccgcattgaagccatcgtctccttctccgac cgctttgtctccaagctgcagttcaaccagaagtttcgctacaatgagctgatgcaggcg ttcaacatgtctgctgccgtcacggccaagaagaccaaggagttcaggtctcctccacag gagcagatcaacatcctgctaaacttcagtgcaggagaggactgtccgtgtcccgaggag atccaggacgagctcaatgttttccacgaggagctgcggctgcactgtggaatcccgatg gaagaggaggaggaggagcaggacacttccattaaaggccgactcctggctctgctctac aagatcaaagggccgcctcagaaggcagcggaggagcccacggaaacggagcaggccgct ccgactaacttgaaggagctgatttctcagaccataacaagctgggcgcaggagtcccac atccaggaccccgagctggtcagggtcatgttcagcctgctgaggaggcagtacgacggc attggagagctgctccgcgccatgaaaaagtcgtacaccatcagcgccgcatccgtgcag gacgccatcaacctgctggcctctctgggtcagatccggtctctgctgtcagtgcgcatg gggaaggaggaggagaagctgatgattgatgggcttggggacatcatgaacaataaagtt ttctaccagcatcctaatctgatgcgggttctgggcatgcacgagaccgtgatggaggtc atggttaatgttctaggaggagacaaatcccagaagatcgccttcccaaagatggtggcc agctgctgtcgtttcctgtgttacttctgccgcatcagccggcagaaccagaaagccatg tttgaccacctgagctacctgctggagaacagcagcgtgggtctggcctctgaagccatg cgaggctccactcccctcgatgttgccgcctcctcggtcatggacaacaacgggctggct ctggctctggaggagcctgacctggagaaggtggtgatgtacttggcgggatgtggcctg cagagctgtgccatgctggttgctaaaggttaccctgacattggctggaaccccatagag ggagaacgctacctgtccttcctgaggttcgccgtcttctgtaatggtgaaagcgtggag gaaaacgccaacgtggtggtgaagctgctgatccggcgtcccgagtgtttcgggcccgcc ctccggggggagggggggcagggtctgttggctgccatgaacgaagccatcaagatttct gaggaccctgctctggacctgcccaagacccccgctggagacgctgctgggtctgccgaa gaggaagaagaggttattcacatgggaaacgccatcatgtccttctactctgccctcatt gacctgctgggacgctgtgctccagagatgcatctcatcaatgctggtaaaggggaagcg ctgcgtatccgggccatactgcgctccctggttcccacctctgacctggtcggcatcatc agcattcccctcaacatgccggtggttcataaagatggcaccgtgacagaaccggacatg tctgcctctttctgtccggaccacaaggcccccatggtgcttttcctagacagagtgtac ggcatcgaggaccagagcttcctgctccagctgttggaggtcggcttcctccctgacctg aaagcatctgcgtctctggacactgaggtgctcagcaccacagagacggctctggccatg aacaggtacatcggctcggcgctgctgccgttgctgacgcgctgcgccgccctgtttgcc aacactgagcattacgctcagctggtggactctacgctggagaccatctaccggctgtcg aaaggtcgctcgctcaccaaagcccagagggatgccatcgaggactgtctgcttaccatc tgcaaacatctgcgtccgtccatgatgcagcagctgctcaggcggctggtattcgacgtt cccatgctttcagagtactgcaagatacctctgcggctgttgaccaaccactacgagcag aactggaagtactactgtctgccgtcgggtatgggcagcttcggcatcgcctctgaagag gagctgctgctcaccaagaaactcttctggggaatttttgactctctgtctcagaagaag tacgatagtgaactcttcaaaatggccaaatcctgcctgtgtgccatcgccggagcgctg ccgccagactttgtggacaccagcttagcggcgagtctggagaaacagggatcggtggac gcgcagggcaattttgagcccaagcccatcagcacggccaacatctcccttcctgagaaa ctggagtacgctgccaacaagtacgcagagcactgccatgacaagtggagctcagagaaa atgtctgcaggctggaaacatggagacagtctggacgagcaggccaaagcccatccactg ctcaagcctttcaaagctctgagtgagaaggaacgagagacgtaccgctggcctgtgagg gaggcgctgaagagcatgctggccatgagctggaacatcgagaggaccaaggagggagaa gccatgttccagcaacgagagagtgaaaagcagagacgcgtgtcagagtcgcagggagac ggattcactcccgcccccatggaactccataacgtcactttgtctcgagagttgcagggc atggttgaggtggtggcagagaattatcacaacatctgggccaagaagaagaaaacagag ctgcagagcaaaggagggggcgctcacccgctgctcgtgccgtacgacaccctgactgct aaggagaagtacagagacagagagaaggctcaggagctcttcaagttcctgcagataagt ggctatgccatcacaagagggctgaaggacctggagctcgactcgtcttccatggagaag cgtttttccttcaaattcctcaagagactcctgaaatacgtggactctgctcaggagttc atcgcccatctagaggccatggccaccagcggtaagacggacaagtcgccgcatgaccag gaaatcaagttcttcgctaaggtgctgctccccctgattgaccaaaccttcaagaaccac tgcctctacttcctgtccacacccaacaagaacctgagcagctgcggctgcgcctccaac aaggagaaggagatggtgaccagtctgttctgtaagctggcagctctggtcagacacagg atttctctcttcgggagtgactccgccatgatggtcagctgcttgcacattctcacaaac tcgctggacaccaggacggtgatgaagtctggctcagagctggtcaaagccagcttcaag gcgttctttgagaacgcctcggaggacctggagaagctggtggagatgctgaagctgggg aagttcatgcagtcacgtgcgcagatgaagagcgtcagccagagcatcaactatgtgact gtggcgctgctgcccatcctcactgcgctcttcgagcacatccggacacacgagtttgga gtggatttactcttgaacgacgtccagctgtcctgctacagaatcctgatgtgcttctac tctctgggaaccggaaagaacatctttgtggagaggctgctgccagcactgggggagagt ctggccactctggtgggggccatgccggtagccttcctggagccccacctcaacgcccac aaccccctttcagtgttcaacaccaagaccccccgggaaagagccatcctgagcatgccc gacacggtggaggagatgtgtccggagatgcctcggctggacaaactgctcaaagacgtc aacgacatctctgactctggagcacgctacagcgacatgccgcaggtcatcgaggtcgtc ctccccatgctctgcaactacctgtcctactggtgggagaaaggtccagagaactccccc ccagatacagactgctgcaccatggtgacctccgaacacctgagcatcatcctaggaaac atcctgaaaatcctcaacaacaacctgggtatcgatgacgccccctggatgaagaggatt gcagtctactctcagccaatcatctgcaaagctggagcagatctgttgagaagccacttc ctgcccacgctggacaaactgaggaagaagacggtgaaggtcgtggctgaagaagagctg ctgaaggccgacagtaaaggtgacaaccaggaggcggagcttctcatcctggatgagttt gcaatgctctgcagggacctgtatgccttctaccccatgctcatccgatacgtggacaac aaccgatccagatggctgaaggagccggacgcagactccaccgaactcttcaagatggtt gctgagatcttcatcctctggtgcaagtccaataactttaagcgtgaggagcagaacttt gtgatccagaatgagatcaacaacttggctttcctaaccggagaaggaaaagcaaagatg tctaagtcgggaggggaccaggaaaggaagcacaagcgtcgtcgtggcgagctgtactcc atccaaacctctctgatcgtctctgcgctgaagaagctgctgcccatcggcctgaacatg tgcacacctggagatcaggagctcatctctttggctaagatccgctacagcctgaaagac acggatgacgaggtgaaggagcatctgcagcagaacctccacctgcaggagaagtcggac gacccggcagtgcagtggcagatgaacctttacaaagacgtgatggtgaagagtggcgag ctgaccaacccagaacatgcagtggacagaatccagagcatctctgcggccgtcttccac ctggagcaggtggagcagcctctgaggaataagaagtgtgtggtccagaagctgctgtct aagcagcggaagcgcgccgtggtggcttgtttccgcatggctcctctctacaacctgccc aggcatcgtgctatcaacttcttcatcccggcctatcagagactttggatagaagcagag gagtactcctttgaggagaagctagttcaggacctggcaaagaccccaatgaagattgtg gaggaagaggaggaggaggtggcagagatcaagcccgaccctcttcatcagctcattctc cacttcagccacaacgccctgacagagagaagtcacttggaagtagatcctttgtatatt gcatatgcagacatgatggcaaagagctgtgcagaggacgaggaggaagaggaagaagaa gggaaagaaaagacgttcgaggagaaggagatggaaaagcagaagatcttgtatcagcag gctaggctgcacgcgcgaggagcggctgagatggtgctgcagatgatcagtgccagcaaa ggtcgtttgggtcccatggtgacctgcaccctcaaactgggaatctccatcctcaacgga ggcaacgtgcacgttcagcagaaaatgctcaattacctaaaggaaaaaagagacgcagga tttttcaagagtctctcaggactgatgcagtcgtgcagtgtcctggacttgaatgcattt gagaggcagaacaaagcagaaggacttggcatggtgacagaggaaggttcaacccacact ggacggggctccaaggtgctgcagaatgacgagttcaccaaagatctcttccgctttttg caacttctttgtgagggacacaatggagatttccagaacttcctgagaacccagacagga aacaccaccacagtgaacatcattattagcactgtggactatttgcttcgccttcaggaa tccatcagtgatttctactggtactactctggcaaagacatcatcgatgagactggaaag ctgaacttctccaaggccttggcggtagcaaagcagatcttcaactctctgactgagtac attcagggcccgtgcatcgggaaccagcagagtctggctcacagcagactgtgggacgca gtcgtgggatttttacacgtgtttgctaacatgcagatgaaactgtctcaggatgccagt cagatagagctgctgaaggagttgatggacctgcagaaggacatggtcgtcatgttgttg tctctccttgagggtaacgtggtgaacggaaccatcgggaagcagatggtagacaccctg gtggagtcctccaacaacgtggagatgatcctcaagtttttcgacatgttcctgaagctg aaggatctgacaacctctgacaactttaaggagtacgaccccgagttcaaaggcatcatt tccaccaaagagttccagaagtcgatggagagccagaagcagtacacccagtcagagatc gagttcctgctctcctgcgccaaagcagacgagaacgacatgttcaactacaaggagttt gtggagcgattccatgagccggccaaagacattggcttcaacgttgctgtgctgctgacc aacctgtccgaacacatgccccacgactcgcggctcagcaccttcctggacctggcagaa agcgtgctgagctactttgagccgtacctgggtcgtattgaaatcctgggcagcgcaaag cggattgaaagggtttactttgagatcagcgagtccagccgggagcagtgggagaagccg caagtcaaggaatccaagcggcagttcatctttgacgtggtgaacgagggcggagagagc gagaagatggagatgtttgtgaacttctgcgaggacaccatctttgagatgcagctggcc tcgcagatctctgaacccgatgtggttgagcagcctgaggaggaggaggaagaggagcac agcctcctggaggagctggctggagatgaagaagctctagagactccctcagcttttacc agtgcgtgccgttcggtgaagaagaagatctccgacgtccgtcagatttttgccattaaa aatatacgcaagaagtttaagaaaatcaggaagctgagtgtgaaggaaatgatcacgggc ttcttctccttcttctggatgatcttcatcggcttcttcaagggaatctacagcctcatc tttggtttcttccacatcatctggtcctccatgtttggtggaggtctagttgaaggagcc aaaaacattaaggtgacggacatcctgggacacatgcccgaacccactcagtttggtatc catggagacgcggtggagggagacaaagccgaaacgacggagtcatcaggaagcatggac acagccatggcgcccactggagacatcgtagaggtagacaccatgatggaaatgctggcg ccaaaaaaagaaggaggcaagcatgtggagcctggcctgggagacgtttctgagctgagt ggagattcttctgcagatcacaaaaagaaagggtcttccaaactggccgataccattgag actggaaaagagaaagcagactccgagaaccaggagaaggaggacaagccaaaagaggag gaggtgaaggagccggcagcagaggagaaacctcgggtgaaatccagccagcctaaagaa gcgtctcctgccttcatgtcaaccatctttgctgttcttgatgtctatatgaccaagatg ctgaactacttggctcgtaacttctacaacctccgtttcctggctctgtttgtgtgcttt gccatcaacttcatcctgcttttctataaggtcactgaagagagtgaggaggaagaggag gatgagcaccgttggggtgaagaagaagaaaatgacgagaacacgctctttgacatggac gagtttgtgcttcaggagagcacaggttacatgctgccaacgctgcgcttcctggctatt ttccacacggtcatctcgctcctctgtctgttcggctactactgtctgaaggttcctctg gtggtcttcaagagggaaaaggagatcgccaggaagcttgagtttgatggtttgtacatc actgaacaaccttccgatgatgacatcaagggtcagtgggatcggctcgtcattaacacg ccgtctttcccgaacaattactgggacaagtttattaagcgcaaggtcatcaacaaatat ggcgacatgtatggggctgagcgcatcgctgaactcctgggtctggataaatctgctctg gactttgatccgacggtggagacggtggagaaggaggcctccttggtttcctggtttagc tccatcgacaccaaataccacatctggaagctgggcgtggttttgactgacaattactac ctgtatctgatctggtacaccactatgtccatctttggacacttcaacaacttcttcttt gctgctcacctgctggacatcgccatgggcttcaagaccctccgcaccatcctgtcgtcc gtcacccacaacggcaagcagctggtgctgacggtgggtctgctggccgtggtggtttat ctctacaccgtggtggccttcaatttctttagaaagttctacaataaaagcgaggatgaa gacgagccggacatgaagtgtgacgatatgatgacgtgttacttgttccacatgtacgtg ggcgtgagggctggaggaggaatcggagacgagttggaggatccagctggagatccctac gagctctaccgcatcctgttcgacatcaccttcttcttctttgtcatcgtcatcctcctg gccatcattcagggtttgatcattgacgccttcggtgagctgagagaccagcaggagcag gtgaaggaggacatggagaccaaatgcttcatctgtggcatcgggaacgactactttgac cggacgcctcacggctttgaaacccacaccttacaggagcacaacctcgccaactacctg ttcttcttgatgtacctgatcaacaaggacgagactgagcacacgggtcaggagtcgtac gtgtggaagatgtaccaggagagatgctgggacttcttccccgccggagactgcttccgc aaacaatatgaggaccagctgggttag

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