Oncorhynchus mykiss (rainbow trout): 110505504 Help Entry 110505504         CDS       T07259                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism omy  Oncorhynchus mykiss (rainbow trout) Pathway omy04020   Calcium signaling pathway omy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110505504    04020 Calcium signaling pathway     110505504  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:omy04040]     110505504 Ion channels [BR:omy04040]  Voltage-gated cation channels   Ryanodine receptor    110505504 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 Motif Other DBs NCBI-GeneID:  110505504 NCBI-ProteinID:  XP_036818165 Ensembl:  ENSOMYG00000030485 LinkDB All DBs Position 25:18538084..18701098 Genome browser AA seq 4895 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGQNSEGAAQGGGHRTLLYGHAILLRHSFSAMYLTC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLTIPGSDQS DEQQRIVNYETGNAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYLALTEERG VVLQDREKSDTSSTAFCFRASKEKLESSPKRDIEGMGMAEIKYGDSICFVMHVATGLWLS YQAPDVKSSRLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSHFIRDL DCLGGKNRASVALPIEEVLQTLNDLITYFQVPNAELEHEEKQIMLRSLKNRQNLFKQEGM LTLVSCCIDRLNVYNSAAHFGECAGAEAGASWKDILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIYLGMSEGSAQYKKWY YELMIDQVDHFLTSDPSHLRVGWATNKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWS GRISRAVASINQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFFPVVSF SAGVKVRFLMGGRHGDFKFLPPSGYAPCYEALLPKEKMKVEPVKEYKRDMEGVRDLLGTT QFISQASFIPTPVETSQIVMLPYLEKVRDRLAENIHELWAMNKIELGWSYGKRIRDDNKR QHPCLVDFSRLPETEKNYNLQMSTETLKTLLALGCHVVQVNANAEEDLKKIKLPKNYMMS NGYKPTPLELSDVKLTPGQELLVDKLAENAHNVWAKDRVKQGWTYGILQDVKSKRNPRLV PYSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEGAGHVVDRLSIDKIRFFRVERTY AVMTGKWYFEFDVVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYKGQRLNMGSRFFGR CWHAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQVGR MNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKNHNHIMVTRID GTIDSPPCLKVSHRTFGTQNSNGDMVYCRLSMPVEFHSFFKTSPVMDMNGVHEDPESLKL KHRHPLKSMRHSHDGIRGTDYSNISTYHYSVRVFAGQDPSCVWVGWVTPDYHYYSNHFNL SKNRTVTVTLGDQRGRVHESVRRSNCYMVWGGDVTSSGHSSSRSNVDLEIGCLIDLATGL VTFTGNGKELATSYQVEPNTKLFPAVFVRPTSPNLFQFELSKIKNAMPLSAAIFKSEHKN PVPQCPPRLDVQTINSVLWSRMPNTFLKVETARVSERHGWVVQCREPLQMLAVHIPEENR CVDIMELSEQEDLRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGM LREGFYNILISIHLETAKEARLMMNNEFIIPITAETRSIRLFSDASKHHSPPGVGLSTSL KPRLNFYPPCFISSKREQQLYSPQIPLDALKEKAITMLTEAVQGGGHHIRDPVGGSVEYQ FVPILRLIGTLLTMGVLGSQDVHKILLLIDPNVFVEHSEDAVAVVMEATEKEGLTGTEEK AVEAGEEEAAKDAKLPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFV SKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSTGEDCPCPEDIQE ELYAFHNELRLHCGIPMEEEEDDQDTSIKGRLLALVYKIKGQPLKTEEEPTEQEQQAPSN LKELISQTMVSWAQECHVQDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAASIQDTI NLLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKIFYQHPNLMRVLGMHETVMEVMVN VLGGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGS TPLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWNPIEGER YLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISENP ALDLPSSAQGVSSDMSAEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEA LRIRAILRSLVPTEDLVGIISVTLKMPVIHKDGTVTEPDMAASFCPDHKAPMVLFLDRVY GIEDQSFLLHLLEVGFLPDLRASASLDTEVLSTTETALAMNRYIGSAMLPLLTRCAPHFA GTEHYATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCRYLRPSMLQQLLRRLVFDV PLLTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLDSLSQRK YDADLFKMAMPCLSAISGALPPDYIDSTISTTLEKPASVDAQGNFDPKPISTANISLPEK LENVANKYAEHSHDKWSAEKVMLGWKYGDCIDEKAKTHPQLRTYKGLTEKEKEIHRLPVR ETLKSMLAMGWNIDRTKDGETMSLRESEKMRKISQSSSQGNGFNPLDTSNVVLSRELQGM MEVVAENYHNIWAKKKKNDLGIRGGATHPLLVPYDTLTAKEKARDKEKAQDLFCFLQING YAITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVNSAQEFIAHLEAMATSGKTDKSPHEQE IKFFAKVLLPLIDQYFKNHCLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRI SLFGSDSTTMVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTFENLKLGK FTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYA LGTGKNIYVERQLPALGECLATLAGAMPVAFLEPLLNKHNPCSVFNTKTARERAILGMPD AVEEMCPEMPRLDVLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWEKGPENQAS PHSVFSTTVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARAVLLKSHF LPTLEKLKKKTVKVVTEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIHYVDN NRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKM SKSGGQDQERKHKRKRGEFYSIQTSLIVAALKKMLPMGLNMCTPGDQELISLAKTRYLLK DTDDEVKEHVRQNLHLQEKSDDPAVRWQLNLYKDVMVKNEGPPDPERTVFRVQSISAAVF HLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLGYQRIWIET ETYSFEEKLVQDLAKTQLKVEEEEEEEAEMQPDPLHQLILHFSHNALTERSSLEEDPLYI AYADMMAKSCAEDEEEEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQMISASK GTLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKGDAGFFKSLSGLMQSCSVLDLNAF ERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQT GNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFSKALAVAKQIFNSLTE YIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMIVMM LSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPESKGV ISKKEFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEEFVKRFHEPAKDIGFNVAVLL TNLSEHMPHDARLATFLDLAESVINYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEK PQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDAVERPEEDDEDS QSVTEEPEEEEEESMMESHSAFTNSCVSMRKNLFSFRQLLTFKSMRRQYRRFRKMSVREM VQGFFSFFWMIITGVFRFLYNLVWGFFHILWSSMFGGGLVEGAKNMKVTDILGNMPDPTQ FGIHGDVLETEKMEASEASSVAEMGHMGQGDKAEADLMAELLNIQTKSQGGKHAPEPGLG DMGEVVGVDAPSLASAVKQKKAKDSMCFLKEAATKEPTNGDHKAEPEKSDPEDGEKKDQD KVKEEAPPEPSPEEKKAPKKRPGLKKESPEEFMASFFSSLDIYQTKMLNYLARNFYNLRF LALFVAFAINFILLFYKVTGDDGDDDDPDPWNGGGATDEQDDEGGMEYFVLQESTGYMAP TLRFLAILHTVISFLCVVGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQW DRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETVVKEA SLVSWLSSIDTKYQCWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKT LRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDNQPDMKCDDMMTC YLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETE HTGQESYVWKMYQERLWDFFPAGDCFRKQYEDQLG NT seq 14688 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaagatgaaattcagttcttgagaactgatgatgaagtg gtgctccagtgtgtcgcctgcatccacaaggagaatcgcaagttctgcctgacagcagag gggctcggcaatcgactgtgctaccttgaacccacgtcagaggcaaagtatgtccctcca gacctatgcatctgcaactttgtgctggagcagtctctctctgtgcgggccctgcaggag atgctggctaagactggccagaacagtgaaggggcggctcagggtggtggacacagaaca cttctgtatggacacgccatcctcctgaggcattcctttagcgccatgtatctgacctgt ttgaagacttcaaggtcacagacagataagctgtcctttgatgtggggctgcaggaggac tcaacaggtgaagcctgttggtggaccatccatcctgcttccaaacagaggtcagagggt gagaaggtacgcatcggagatgacctcatccttgtcagcgtgtcatcagaacgatacctt cacctgtccatctccaatggcaacatccaggtggacgcgtccttcatgcagactctgtgg aacgtccaccccacctgctctggcagcaacgtggaggagggttacctgctgggtggccat gtgttgcgtctgttccatggtcatgatgaggttttgaccatcccagggtctgaccagagt gatgagcaacagaggatagtgaactatgagacggggaatgcaggagcgaaggccaggtct ctgtggaggctggagcctctcagaatcagctggagcgggagtcacattcgctggggtcag cccttccgtctccgccacctcaccacggggcactacctggccctgacggaggagaggggg gtggtgctgcaggaccgggagaagtctgacacttcctccacagccttctgcttcagagcc tccaaggaaaagctggagtcgagccctaagcgggacatcgagggcatggggatggcagag attaagtatggggactcaatctgcttcgtcatgcacgtggctacaggactctggctgtct taccaggcgcctgatgtaaaatcatctcgcctgggccctctcaagagacgggcctgcctc cactctgagggtcatatggatgatgggctgaccttgcaacggtgtcagcacgaagagtcc cgtgctgctcgcatcatccgtaacaccacccgcctcttcagtcacttcatcagagacctg gactgtctggggggaaagaaccgtgcgtcagtagccctgcccatcgaggaggtcctccag acactcaatgacctcatcacctacttccaggtgcctaatgctgaactggagcacgaggag aaacagatcatgctgcgctctctcaagaaccgacagaacctcttcaaacaggaaggcatg ctgactctggtgtcctgctgcatcgaccgtctcaacgtgtacaacagtgcagcccacttt ggggagtgtgccggggcagaggctggggcttcctggaaggacatcctcaacctgctctat gagctgctagcggcgctgatccgaggcaacaggaacaactgcacccagttctccaacaac ctggactggctggtcagcaagctggagagactggagtcttcctcaggcatactggaggtt ctccactgcattctaattgagagcccggaggctctaaatatcatccagagaggacacatc aagtccatcatctccctgctctacaaacatggacgcaaccacaagattttggatgtgctc tgttccctgtgtgtgtgtaatggggtggcagtacgagccaatcagaacctcatctgcgat cacctgctccccaaaagagatctgcttctccagacccgattggtcaatgacgttcaaagc atgaggcccaacatttacctgggaatgagtgagggctcggcccagtataagaagtggtac tacgagctgatgattgatcaggtggaccacttcttgaccagtgacccctctcacctgcgt gtgggctgggccaccaacaagggttacgccccttacccaggtggaggggagggttggggg ggcaacggggtgggggacgacctctactcttacggcttcgacggacttcatctctggtca ggtcgtatctcccgggcggtggcttctattaaccaacacatcctgacctctgaggatgtg gtgagctgttgtctggacctgggagctcccagcatctccttcaggatcaatggacagcct gtacagggcatgttcgagaacttcaacatcgatggactcttcttccctgttgtcagcttc tccgctggcgtcaaggtgcgtttcctgatgggcggtcgtcatggcgacttcaagttcctg cctccgtcgggctatgctccgtgttacgaggccctgctccccaaggagaagatgaaggtg gagccggtgaaggagtacaaaagggacatggagggggtccgagacctgctggggaccaca cagttcatttctcaggcctccttcatacccacccctgtggagaccagccagatcgtcatg ctgccatacctggagaaggtccgggacagactggctgagaatatccacgagctgtgggcc atgaacaagatagaactgggctggtcttatgggaagaggataagggacgataataagcgg cagcacccctgcctggtggatttttccagactgcccgaaacggaaaagaattacaacctg cagatgtcaacggaaaccttgaagactctgctggcattaggatgccatgttgtccaggtc aacgccaacgctgaagaggacctaaagaagatcaaactcccaaagaactacatgatgtcg aatggttacaagcccacgccactagagctgtctgacgtgaagctgaccccaggccaggaa cttctggtggataaactggcggagaacgcccacaacgtgtgggccaaggacagggtcaaa caaggatggacctatggcattctgcaggatgtgaagagcaagcggaaccctcgcctggtg ccatattctttattagacgagcgcactaagaagtccaacagggacagcctccgtgaggcc atccgcactctgattggatacggatacaatatcgaacctccagatcaggagggcgcaggc catgtggtggacagactgagcatcgacaagatccgtttcttccgtgtggaaaggacgtac gcggtgatgacggggaagtggtactttgagtttgacgtggtgacagggggagacatgcgt gtgggctgggccagacctggatgtaagcctgatgtagagctgggcactgatgagctggcc tttgtcttcgacggatacaagggtcaacgtctgaacatgggcagtcgtttctttgggcgg tgttggcacgcgggggacgtggtgggctgtatgatcaacatggaggacaagtctatgatc ttcaccctcaacggagagatcctcatcaccaacaagggctctgagctctgctttgccgac ttcgagacggaggacggttttatcccagtgtgtagtctgggcctgtcccaggtgggtcgt atgaacctggggaaggacgccagtacctttaagtactacaccatgtgtggtctccaggag ggcttcgaaccctttgccgtcaacatgaaccgtgaggtcaccatgtggttcagcaaacgc ctccccacctttgtcaatgtgccaaagaaccacaaccacataatggtgacaagaatagat ggcaccatcgacagccctccatgtctgaaggtgagccacaggacgtttgggacccagaac agtaatggtgacatggtgtactgtcgactgagcatgcccgtggagttccactccttcttc aagaccagccctgtcatggacatgaacggagtgcatgaagatcccgagtccctcaaactg aaacacagacatccattgaagtctatgagacacagtcatgatggaataagaggaacagat tacagcaacatcagcacgtaccactactctgtcagggtgttcgctggtcaggatccatcc tgtgtgtgggtgggctgggtcacccccgactaccattactatagcaaccacttcaacctc agtaagaaccggacggtgacagttaccctgggagaccagcgtggtcgggtccatgagagt gtgaggaggagtaactgctacatggtgtggggtggggacgtcacaagctcaggtcactcg tccagtcgcagtaatgtggacctggagataggctgtctcattgacctggccactggcctg gtgaccttcactggcaacggcaaggagctggccacctcctaccaggtagaaccaaacaca aagctgtttcctgctgtgtttgtgcgaccgaccagccccaacctcttccagtttgagctg tccaagataaagaatgccatgcccctgtcagctgccatctttaagagtgagcataagaac ccagtaccccagtgccctccgaggctggatgtccagaccatcaactcagtgctgtggagt cgcatgcccaacaccttcctgaaggtggagacagccagggtcagtgagagacatggctgg gtggtgcagtgtcgggagcccctgcagatgctggctgtgcacatacctgaggagaacagg tgtgttgacatcatggagctgtctgagcaggaggacctgaggaagttccactaccacacc ctgaagctgtactgtgccctgtgtgccctgggaaacacccgcgtggcacacgccctctgc agccacctggaccaatcccagctgctctacaccatcgacaaccagtacttgtcgggtatg ctgcgcgagggcttctacaatatcctgatcagcattcacctggagacggccaaggaggcc cgcctcatgatgaacaacgagtttattatccccatcaccgccgagacgcgcagcatccgc ctgttctccgatgcctccaagcaccactctcctcccggtgtgggcctcagtacctccctg aagccccggctcaacttctaccccccctgcttcatcagcagcaaaagggagcagcaactg tacagcccccagatccccctggatgccctgaaggagaaggccatcaccatgctgactgag gccgtgcagggcggtgggcatcacatcagggaccctgtagggggcagcgtggagtaccag tttgtgcccatcctgaggctgattggtacactgctcaccatgggtgtgctgggaagtcag gatgttcataagatcctgctcctcatcgaccccaacgtgtttgtggagcatagcgaggat gccgtcgccgtggtgatggaggccacagagaaggaggggctgacaggcaccgaggagaag gcggtggaggccggggaggaggaggcggccaaagacgccaagctgccaatgaaaggtctg ctggagaagaggctgcctgagccagtgaaacgacagatgtgcgagctgctgcactacttc tgtgactgtgagctgaagcatcgcatcgaggccattgtgtccttctcagacagctttgtc tccaagctgcagtataaccagaagttcaggtacaacgagctgatgctggccctcaacatg tctgctgccgtcaccgccaagaagaccaaggagttccgctcgcctccccaagaacagatt aacatgctgttgaacttcagtacgggggaggactgcccgtgtccagaggacattcaggag gagctctatgccttccacaacgagctgcggctgcactgtggaatccctatggaggaagag gaagatgaccaggacacgtctattaaaggtcgtctgctggccctggtctacaaaatcaaa ggtcaacctctgaagactgaagaggagcccacggagcaggaacagcaagccccctccaac cttaaagagctgattagccagaccatggtgagctgggctcaggagtgccacgtccaggac cccgagctggtcagagtgatgttcagcctgctgaggagacagtacgacagcattggagag ctgctccgggccatgaggaagagctacactatcagtgctgcctctatacaggacaccatc aacctactggcctctctgggtcagatcagatcactgctgtccgtacgcatgggcaaggag gaggagaaactcatgatcgacggtctgggtgacatcatgaacaacaagatattctaccag caccccaacctgatgcgtgtgctgggcatgcatgagacggtgatggaggtgatggtcaac gtgctgggaggaggcaagtcccaggagatagcgttccccaagatggtggccagttgctgt cgttttctgtgttacttctgcaggatcagtcgtcagaaccagaaggccatgtttgaccac ctcagctacctcttggaaaacagcagcgtgggcctggcgtctccggccatgaggggctct actcctctagacgtggctgcctcctctgtgatggacaataacggcctggccttggccctg gaggaacccgacctggataaggtggtgacgtacctagcaggctgtgggctccagagctgt cccatgctgctggacaaaggttaccctgacatcggttggaaccccatagagggcgagcgc tacctctccttcctgcgctttgctgtctttgttaatggtgagagtgtggaggagaactcc agtgtggtggtgaagctactgatcaggcgtccagagtgttttggtccggccctgagagga gaggggggtaacgggctgctagcagccatgaaggaggccatcaagatctctgagaaccct gctctggacctgccctcctctgcccagggggtcagctctgacatgtctgctgaggatgat gaggaggaagaggtggttcacatgggaaatgccatcatgtccttctactctgccctcatc gacctattgggacgctgtgccccagagatgcacttgattaacaaggggaaaggggaggcc ctgcgtatccgtgccatcctgcgctccctagtgcccactgaagacctggtgggcatcatc agcgtaaccctcaagatgcctgtcattcacaaagacggcactgtgacagagcctgatatg gcggccagtttctgcccggaccacaaggcccccatggtgctattcctggaccgggtctat ggtatcgaggatcaaagcttcctacttcacctgctggaagtgggcttcttgccagacctg cgagcttctgcttctctggacacggaggtactcagcaccacagagacagctctggccatg aacaggtacattggctctgccatgcttcctctgctcacccgctgtgccccccacttcgct ggcacagagcactacgccacgctaatcgactccacgctacacaccatctacaggctgtcc aagggccgctctctcaccaaggcccagagagatgctatcgaggagtgtctgctggctgtc tgcaggtacctccgcccctccatgctgcagcagctcctgcgccgcctggtctttgacgtg cccttgctgacagagtactgcaagatgcctctcaggctcttgaccaaccactacgagcag agctggaagtactactgtctgccatcaggctggggcagctacggcatggcctcagacgag gaactgctcctcacaaagaagatcttctggggtgtcttggattcgctctcacagaggaag tacgatgcagatctctttaagatggccatgccctgtctgagtgccatatctggggcctta ccacctgactacatagactccaccatcagcaccaccctggagaagcctgcgtctgtggac gctcagggcaacttcgaccccaaacccatcagcacagccaacatatctcttccagagaaa ctggaaaatgttgccaacaaatatgctgagcattcccatgacaaatggtcagcagagaag gtgatgttgggatggaagtacggagactgtatagatgagaaggccaagactcaccctcag ctcaggacctacaaaggccttacagagaaggagaaggagatccacaggttgccggtgagg gagactctgaagagcatgctggctatgggctggaacattgacaggaccaaggatggagag accatgtccctacgggagagtgagaagatgcggaagatctcccagtcctcctctcagggt aacggtttcaacccattagacaccagcaatgtggttctgtctagagagttacagggcatg atggaggttgtggctgagaattatcacaacatctgggctaagaaaaaaaagaatgacctt ggaattagaggtggggcaactcaccctctgctagtgccctatgacaccttgactgccaaa gagaaggcccgggacaaagagaaggcccaggacctgttctgcttcctacagatcaacggc tatgctatcaccagaggtctgaaggacatggagcaggactcttcctccatggagaagagg tttgcctacaagttcctcaagaagctcctcaagtatgtgaactcagcccaggagttcatt gcccaccttgaggccatggctaccagtggtaagacagacaagtcacctcatgagcaagaa atcaagtttttcgccaaagtgctcctccctctgatagaccagtacttcaagaaccactgt ctctacttcctgtcttctcccagtaagaacctgagcagcagcggctatgcatctaataag gagaaggagatggtcaccagcctgttctgtaaactggcagctcttgtcagacacaggatt tccctcttcgggagtgactccaccaccatggtgagctgtctccacatcctggcccacaca ctggacaccaggacggtgatgaagtctggctcagagctggtgaaggcggggttaaggaca ttcttcgagaatgcagcggaggacctggagaagacctttgagaacctgaagttggggaag ttcacccactcccgctcacagatgaagggcgtgtcccagaacattaactacaccacggtg gcactactgcccatcctcactgccctgtttgaacacatcacccagcaccactttggagtg gacctgctcttggacgatgtccaagtgtcatgctatcgtatcctgaccagcctgtatgca ctcgggactggaaaaaacatctatgtggaaaggcagctgccggctctgggggagtgtctg gccaccctggcaggcgccatgcctgtggccttcctggagccactgctcaacaaacacaac ccctgctctgtgttcaacaccaagactgcccgcgaacgcgccatcctaggcatgccagac gcggtggaggagatgtgtccggagatgcctcgtctagacgtcctgatgaaggacatcaac gacatgtctgagtctggggcgcgctacacagagatgccccacgtcatcgaggtggtgctg cccatgctgtgtaactacctgtcctactggtgggagaagggcccagagaaccaggcgtct ccccacagtgtgttttccaccaccgtcacctcagaacacctcagcctcatcctgggaaac atcctgaagatcctcaacagcaacctgggcatcgacgaggcctcctggatgaagaggatc gcagtgtatgcccagcccatcatcagtaaggccagggctgttctgttgaagagtcacttc ctgcctacgctggagaagctgaagaagaagaccgtgaaggtggtgacggaggaggagcta ctgaaggctgacagtaagggagacacccaggaggctgagctcctcatcctggatgagttc gctgtgctctgcagagacctctacgccttctacccgatgctcatccattacgttgacaat aacaggtccaggtggctgaaagaaccagacgctgactccaatgaactcttcagaatggtg gctgagatcttcatcctctggtgcaaatcacataacttcaaaagggaagagcagaacttt gtggttcagaatgaaatcaacaacctgtctttcctgactggtgatagcaagacgaagatg tcaaagtcagggggtcaggaccaggagaggaagcataagaggaagcgaggagagttctac tccatccagacctccctgatcgttgctgccctgaagaagatgctgcccatgggactcaac atgtgcacccccggggaccaggagctcatctccctggccaagacacgttacctcctgaag gacacagatgatgaagtgaaggaacatgtacggcaaaatttgcaccttcaagaaaagtca gacgaccctgcagtgaggtggcagctgaacctgtataaggatgtgatggtgaagaacgag gggcctccagaccctgagaggacagtgttcagagtccagagcatatcggctgcagtcttc catctggagcaggtggaacagccgttgaggtctaagaagtgtgtgtggcagaagctgctg tccaagcagagaaagcgtgcggtggtggcctgtttccgcatggctcctctctacaatctt cccaggcatcgctctattaacctcttcctcctgggctatcagagaatatggatagaaaca gagacgtactcttttgaagagaagctagtgcaggacctggcaaagacccaactgaaggtg gaggaggaggaagaggaggaggcagagatgcagccagaccctcttcatcagctcatcctg catttcagtcacaatgcgctcactgagcggagttctttggaagaggatcctttgtatatt gcatatgcagacatgatggcaaagagctgtgcagaagatgaagaagaagaagatgaagaa ggaaaagagaaaacgtttgaggaaaaagagatggagaaacagaagactctgtaccagcag gccagactgcatgacagaggagctgctgagatggtgttacagatgattagtgccagcaaa ggtacgcttgggcccatggtgacctttaccttgaagctgggcatctctatactcaacgga ggcaacatactggttcagcagaaaatgcttgactatctgaaggaaaaaggagatgctggc tttttcaagagtttgtcaggactcatgcagtcttgcagtgtcctggatttgaatgcattt gaaaggcaaaacaaagcggaaggtcttgggatggtgactgaggaaggatcaatcaacgtg agtgagcggggttccaaagtactgcaaaacgatgagttcactaaggatctctttaggttt ctgcaactgctctgtgagggacacaacaacgactttcaaaacttcctgcggactcaaaca gggaacacgaccacagtaaatatcatcatcagcactgtggactacctgctccgtctgcag gaatccatcagtgatttctactggtactactctgggaaagacatcatggatgaggctggc cagcggaacttctccaaagccctggctgtggccaagcagatcttcaactctctcactgag tacatacagggcccgtgtattgggaaccagcagagtctggcacacagcaggctatgggat gcagtggtgggattcctgcatgtgtttgccaatatgcagatgaagctgtcacaggattca agtcagattgagttattgaaggagctgctggacctgcagaaggacatgatcgtgatgatg ctctcccttctggaaggtaacgttgtcaacggaaccatcgggaaacagatggtggacacc ctggtggagtcctccagcaatgtggagatgatcctcaagttcttcgatatgttcctcaaa ctcaaagacctgaccacatcggacaacttcaaggagtacgacccggagagcaagggagtg atctccaagaaggagttccagaagtccatggagaaccagaagcagtactcccagtcagag atcgagttcttgctctcctgtgccgaggctgacgagaacgacatgttcaactacgaggag tttgtgaagcgctttcatgagccggccaaggacattggctttaacgttgcggtcctgctc accaacctgtcagaacacatgcctcacgacgcccgtctagccaccttcctggacctggcc gagagcgtgataaactacttcgagccctacctgggccgcatagagattatgggtggagcc aagcgcatcgagagggtctactttgagatcagcgagtctagtcgtacacagtgggagaag ccccaagtcaaagagtctaagagacagtttatctttgacgtggtgaatgagggtggagag agcgagaagatggagctgtttgtcaacttctgtgaggacaccatatttgagatgcagctg gcctcacagatctctgagcctgacgcagtggagcgtcccgaagaggacgacgaggacagc cagagtgtgacggaggagcctgaggaggaagaggaggagagcatgatggagtctcactcc gccttcaccaactcctgcgtctccatgaggaagaacctgttcagcttccgccagctgctg accttcaaaagcatgaggcggcagtacaggaggttcaggaagatgagtgtgagggaaatg gtccaaggcttcttctcattcttctggatgattatcactggcgtcttccgcttcctttac aacctggtgtggggcttcttccatatcctgtggtcctccatgtttggcgggggcctggtg gagggggccaagaacatgaaggtcacagacatcctggggaacatgcccgaccccacacag tttggtatccatggtgatgtgctggagacagagaagatggaggcgagtgaggcgtcatct gtggcagagatgggccacatgggccagggggacaaggcagaggcagatctgatggctgag ctgcttaacatccaaaccaagagccaggggggaaagcatgcgcccgagccaggtctgggg gacatgggtgaggtggtgggggtcgacgccccctctttagccagtgccgtcaagcagaag aaggccaaggattccatgtgtttcttgaaggaggctgcgactaaggagcctaccaacgga gaccacaaagccgagccagagaaatcagacccagaggatggggagaagaaggaccaggac aaagtcaaagaggaggctcccccagagccctcaccggaggagaagaaggcccccaagaag agaccgggactgaagaaagagtctccagaggagttcatggccagcttcttctctagcctg gacatctaccagaccaagatgctgaactatctggccagaaacttctacaacctgcgtttc ttggcattgtttgttgcatttgccataaactttattctgctcttctacaaagtgactgga gatgacggggatgacgatgatccagatccctggaatggaggtggagctactgatgaacag gatgatgaaggtgggatggagtattttgtcctgcaggagagcaccggctacatggcacct acactgcgcttcttggccatactacacacagtcatctctttcctgtgtgtggtgggatac tactacctaaaggtgcctctggtggtgttcaagagagagaaggagatcgccaggaagttg gaatttgacggcctctacatcacagagcagccgtcagacgatgacatcaaagggcagtgg gaccgcctcgtcatcaacaccccttccttccctaataactactgggacaagtttgtgaaa cgcaaggtgatcaataagtatggagatctgtatggagcagagaggatagcagagctgctg gggctggataagagtgctctggacttcaaccccacagaggagacggtggtgaaggaggca tcgctggtgtcctggttgagctctattgacaccaagtaccagtgctggaaaatgggtgtg gtgtttacagacaattcgttcctgtacctggtgtggtacaccaccatgtccatcctgggt cactacaacaacttcttcttcgctgcccatctgttggacatcgccatgggcttcaagacc ctccggaccatactgtcctccgtcacccacaatggcaaacagctggttctgactgtaggt ctcctggcggtggtggtctatctgtacactgtggtggccttcaacttcttccgcaaattc tacaacaagagtgaggatgacaaccagcccgatatgaagtgtgacgacatgatgacttgc tacctgttccacatgtacgttggtgtgagggcagggggtggaatcggggatgagatcgag gaccccgcgggcgacccgtacgagctctaccgcatcctcttcgacatcaccttcttcttc tttgtcatcgtcatcctgctggccatcatacagggtctgatcattgatgcttttggagag ctgagagaccaacaggagcaagtgaaagaggatatggagaccaaatgtttcatctgtggc atcggtaatgactactttgacacgacgcctcacggctttgagacacacaccttacaagag cacaacttggccaactacctgtttttcctgatgtatcttatcaacaaagatgagacagaa cacaccggtcaggagtcatacgtgtggaagatgtaccaggagaggctctgggactttttc cctgctggagactgtttcagaaagcagtatgaggaccagcttggatag

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