Oncorhynchus mykiss (rainbow trout): 110511675 Help Entry 110511675         CDS       T07259                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism omy  Oncorhynchus mykiss (rainbow trout) Pathway omy04020   Calcium signaling pathway omy04260   Cardiac muscle contraction omy04261   Adrenergic signaling in cardiomyocytes omy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110511675    04020 Calcium signaling pathway     110511675  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     110511675    04261 Adrenergic signaling in cardiomyocytes     110511675  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:omy04040]     110511675    04990 Domain-containing proteins not elsewhere classified [BR:omy04990]     110511675 Ion channels [BR:omy04040]  Voltage-gated cation channels   Ryanodine receptor    110511675 Domain-containing proteins not elsewhere classified [BR:omy04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    110511675 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  110511675 NCBI-ProteinID:  XP_036845095 LinkDB All DBs Position 1:94717155..95250071 Genome browser AA seq 5030 aa AA seqDB search MRARQHILGYSTATVSSIPGAAFCRLHTDTPFGSVGSLSRTATMADAGETGEDEIQFLRT DDEVVLQCSATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVR ALQEMLANTEEKAEGKFMMKTAQGGGHRTLLYGHAVLLRHSYSGMYLCCLGTSRSSTDKL AFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNDSLHV DAAFQQTLWSVATVCSGSEVAQGFMIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYE GGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRHVTTGKYLSIMEDKGLLLMDKEKAD VKSTAFCFRPSKEKLDLGPKKEVDGMGVPDIKYGDSVCYIQHVDTCLWLTYQAMDAKCAR MGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFIRGLDTLSKKGKTS TLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECID RLHVYSSAAHFAEVAGREAGEAWRSTLNSLYELLAALIRGNRKNCAQFSGSLDWLISRLE RLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGV AVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYRKWYYELMVDQVL PFVTAEATHLRVGWATTDGYQPYPGGGEGWGGNGLGDDLYSYGFDGLHLWSGCIARTVSS PNQHLLRVDDVVSCCLDLSAPSMSFRINGQPVQGMFENFNSDGLFFPVASFSAGVKVRFL LGGRQGEFKFLPPPGYAPCFEAVLPREKLRVEHSQEYKEDHSETRDLLGPTITLSQAAFT PTPVDTSQVVLPPHLERIREKLAENIHELWVMNKIDLGWTYGAVRDDNKRQHPCLVEFSK LPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKNLKLSATYELSSGYKPAPMDL GHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDERTK KSNKDSLREAVRTLLGYGYNLEAPDQDHARADTSNMSAERFRIFRAEKTYSVNAGKWYFE FEVLTSGEMRVGWARPGCLPDQELGSDQHAFVFDGFKAQLWHQGNEHFGRSWGPGDVVGC MVDLNEHTMMFTHNGEVLLDHSGSELAFKDFEVWEGFIPVCSLGVCQVGRMNFGKDVSTL KYFTICGLQEGYEPFAVNMNRDLTMWLSKRLSQFIPVPPQHEHIEVTRMDGTVETFPCLK VTQRSFGSQNSNPDITFYRLSMPIECNEVLAKSPGGTLQSGGGFSFSSKKDLDDFETVSD FEVLTKSAHCTLGSSLDKEKDQFNNHKDYNQEKPSALKQRFMLKRTKPEFTSSNSSARLS EEVLADRDDLDFFMQTSTYYYSVRIFPGQEPSSVWVGWVTSDFHQYDMAFDLQKVRTVTV TLGDEKGKVHESIKRSNCYMVWAGESTSPGQGRNNNGLEIGCLVDTVNGLLTFTANGKEL STYYQVEPSTKLFPAVFAQATSPSIFQFELGRIKNVMPLSAGLFKSERRNSCPQCPPRLH VQFLTPVLWSRVPNHFLKVDVSRVNDRHGWLVTCSEPLQFMSLHIPEENRSVDILELTEQ KDLLKFHYHTLRLYSAVCALGNNRVAHALCSHADEAQLLYAIENKYMPGLLRTGYYDLLI DIHLSTYATARLMMNNEYIVPMTDETKSITLFPDETKKHGLPGIGLSTSLRPRMHFSSPS FICSGADCFQFSPEFPLDVLKTKTIEMLTEAVSEGSLHVRDPIGGSTEFLFVPLIKLFYT LLIMGVFHNGDLKNILQLIEPSVFSEGGDTPADTPPDTPESDVTKGGRGGEGPGGEERTG KVPKGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAVVGFSDDFVAHLQDNQRFRYNEV MQALNMSAALTARKTKEFRSPPQEQINMLLSFKDEKVDCPCPEHIREQLVDFHEDLMTHC GIEIDEDKLNEADSDFTIRGRLMSLVEKVVYLKKKMTFMPKNKKKDKKPSTLQQLISETM VRWAQESIMEDPELIRAMFVLLHRQYDGIGGQVRALPKAYTINSVSVEDTIKLLASLGQI RSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGESKE ITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAAS VMDNNELALALREPDLEKVVQYLAGCGLQSCSMLVSKGYPDIGWNPVEGERYLDFLRFAV FCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMMEAIKISEDPCRDGPSPTS EASRTLSEVLLEDEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAIL RSLIPIEDLEGVISIPFPMPTLAKDGSVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNF LLHLLEVGFLPDLRAAASLDTAALSSTDMALALNRYLCTAVLPLLTKCAPLFAGTEPYAS LIDSLLHTVYRLSKGCCLTKAQRDAIEECLLATCGQLRPSMMQHLLRRLVFDVPLLNEHT KMPLKLLTNHYERCWKYYCLTGGWGSFGASSDEELHLSRKLFWGIFDALSRKRYDQELFK LALPCLSAVAGALPPDYMESNYVAVMEKQSSMDAEGNFNPQPADTTNVNVPEKLDHFVSK YAEHSHDKWSMDKFSNGWVHGDKVCEASKVHPLLKPYKGLSEKDKELYRWPIKESLKTMV MWCWSIERTREGDPASLHNRARRISQISQQHSVEGAPGFSPRPIDMSNVTLSRDLHSMAE LLAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAREKYKDRGKAQDILKFFQINGYT VSRAMKEQELDTPSMEKRFAYTFLQQLITYVDEAHEHMLESDVGTPPKGESVPHEHQMKF FGKVVLPLVDQYFKNHRLYFLSTAIRPISSGGHASNKEKEMVTSLFCKLGLLVRHRISLF GSHATSIVNCLHILGQTLDARTVMKTGLETVKAALRAFFDNAAEDLEKTLENLKQGQFTH SHSQPKGVTQIINYTSVALLPVLSSLFEHIGQNLFGEDLILDDVQVACYRILNSLYSLGT NNSIYVERQRPALGECLAAFSGAFPVAFLEPELNQFNNYSIYITKGSRDRTALDLPFQVG EMCPVIPSLEKSLEEIMDLAESGLHYTQMPHVMEVVLPMLCSYMSHWWEHGPENNPPETA DSCCTHLTSDHMNSLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIIGKAKGGLLKTHFLP LMEKLRKKAATVLQDEEQMKAEGRGEMSEAELLILDEFTILIRDLYAFYPLLIRFVDYNR AKWLKESNPEAEELFRMVAEVFIFWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSK GAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPVGLNICAPGDQELIALAKIRFSQKDT EDEVREIIRNNLHLQGKLEDPAIRWQMALYKDLPNRSEDTSDPEKTVERVLDIAHVLFYL DQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEE HYFEDKLIEDLARPGGEEPPEEDEGAKRIDPLHQLIQLFSRTALTEKCKLEEDILYMAYA DIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGP MVASTLKLGIAVLNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTT VNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGP CTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLE GNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRD FHKAMESHKHYTQSETEFLLSCAEPDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSE HMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDIGERSAVKEESEKEKPEEE SPEMGFFSVTTVRTALMALRYNVMFLMNVLSMKSLKKQMKRMKKMTVKDMVMTLVSFYWS VIMGLFHFTFSVSRGFCRIMYSTFLGGSLVDGAKTMKVSELLANMPDPTQDEVREEGEKV LLARPSAEEELADLALPVDGTEVLSDIFGLDLRRGEGGQYKITAHNPNASLTDLLNSPVP SSPHLATSPSPELRRRHQAKSPSEEGRTGTEESKEAKSEPEKAQGVDGEKQEEERRKEEE RRKEDKKRKEEKPKAKVRQHHTSKSDEHDMQESAFWKKIIAYQRKLLNYFARNFYNMRML ALFVAFAINFILLFYKVSSSSAVMPESRRPRAGSSVRWDPVTEGSDPQEPQNPQQGPVSV HFVLEESTGYMEPTLRILAILHTVISFCCIIGYYCLKVPLVIFKREKEVARRLEFDGLYI TEQPSEDDIKGQWDRLVINTGSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAAL DFSDAHEKKKPKKDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNRGE EGETPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15093 nt NT seq  +upstreamnt  +downstreamnt atgagagcgaggcaacacatcctgggttattctacagctacggtcagcagcatccccggt gctgccttctgtcgcctccacacggatactccgttcggctctgtcgggtctctgtcgcgg acggcaactatggctgatgcgggagaaaccggtgaagatgaaatccagttcctacgaacc gacgacgaggttgtcctgcagtgttctgccacagtccacaaggagcagcagaagctgtgt ctggcagcggagggtttcggaaatagactctgcttcctcgagtcaacatccaactctaag aatgtccctccagacctgtccatctgtacgtttgtcctggagcagtccctctctgtccgg gccctgcaggagatgctggccaacacagaggagaaggcagaagggaaattcatgatgaag acggcccagggagggggccaccgcaccttactgtacggacacgctgttctgctacgacac tcctacagcggcatgtacctctgttgcctcggtacctcccgatcctcaaccgacaaactg gcgtttgatgttggactgcaggaagacacaacaggagaagcttgttggtggaccatccac cctgcctccaagcagaggtcagagggagagaaggtccgagtcggggatgacctcatccta gttagcgtgtcatcagaacggtacctgcacctgtcgtacggtaacgacagcctgcacgtg gacgcagccttccagcagaccctatggagcgtggctaccgtctgctctggcagcgaggtg gcccaagggttcatgatcggtggggacgtgctgaggctgctccatggtcacatggatgaa tgtctgacagtgccgtcgggagaacatggggaggagcagcgcaggacggtgcactacgag gggggagctgtgtccatccacgcccgctccctctggagactggagaccctacgagtggcg tggagcggcagccacacccgctggggtcaacccttccgtctccgtcatgtgaccacgggg aagtacctcagtatcatggaggataagggcctgctgctgatggacaaggagaaggctgac gtcaagtctactgctttctgcttccgcccctccaaggaaaagctggacttggggccaaag aaggaggtggatggcatgggtgttcctgatatcaagtatggggactccgtgtgttatatc caacatgtggacacctgtctgtggctcacctaccaggccatggacgctaagtgtgcacgc atgggtggcgtgcagagaaaggccatcatgcaccacgagggtcacatggacgatgggttg accctgtcccgctctcaacacgaggagtcccgtaccgcacgggtcatacgcagtaccgtc ttcctgttcaaccgattcatcaggggtctggacaccctcagtaaaaaaggaaagacctcg acactcgacctgccaatcgagtcggtcagtttgagtctgcaggatctgattggctacttc cagcctcctgacgagcacctggagcacgaggacaagcagaaccgcctccgagccctaaag aaccgacagaacctcttccaggaagagggtatgataaacctggtgttggagtgtatcgat cgtctccacgtgtacagcagcgcggctcattttgctgaggtggcggggagggaggccggg gaggcctggagatccacgctgaactcattatatgagctcctggctgccttgataaggggc aacaggaagaattgtgcccagttctccggctcgttggattggttgatcagccggttggag agactggaggcctcgtctggtatcttggaggtgcttcactgtgtcctggtggagagtcct gaagctctgaacatcatcaaggagggacacatcaagtcaatcatctctctgctagacaaa catggacgcaaccacaaggttctggacgtgctctgttctctgtgtgtctgtcatggtgtg gccgtgcggtccaaccaacacctgatctgtgacaacctgctacctggcagagacctgctt ctacagacacgacttgtcaaccatgtcagcagcatgaggcctaacatcttcctgggtgtg agtgaaggctccgcccagtacaggaagtggtattatgagctgatggtggaccaggtgtta cccttcgttacggccgaagccacacatctcagagtgggctgggccaccacggacggctac caaccctacccagggggaggagagggctggggaggaaacgggctcggtgacgacctgtac tcctacggcttcgatggcttgcacctgtggtcaggctgcatcgccaggacagtgagctca cccaatcaacatctcctccgtgtggatgacgtggtcagctgttgtctggacctcagcgct cccagtatgtccttccgtatcaacggtcagcccgtccaggggatgtttgagaacttcaac tctgacggactgttcttccctgtagccagcttctccgctggggtcaaagtgcgtttcctg ctgggtggtcgtcaaggagagtttaagttcctgcccccgccgggctacgctccgtgtttc gaggctgtgctacccagggagaagcttagagtggaacacagccaggagtacaaggaggac cacagtgagaccagggatctactgggtcccaccatcaccctgtcccaggctgccttcacc cctacacctgttgacaccagccaggttgttctgcctcctcacctggagaggatcagggag aagctggcagagaacatccatgagctgtgggtgatgaacaagattgacctgggctggacc tacggagctgtacgggacgataacaagcggcagcatccttgtctggtggagttctccaag ctgcctgagcaggagaggagctacaacctacagatgtctctggaaactctcaagactctc ttggccctgggttgccacgtggggctggctgatgagcacgctgtggagaaggtgaagaac ctcaagctctccgccacttatgagctgtctagtggctacaagcctgctcctatggacctg gggcacatcaagctggcctctacccaggaggccatggtggacaagctggcggagaacgct cacaatgtgtgggccagggatcgcatacgccagggctggacctacggcatccagcaggat gtgaagaatcgtaggaacccccgcttggttccgtacactctgctggacgagaggaccaag aagtccaacaaggacagtctgagggaggctgtccgcaccctgctggggtacggatacaac ctggaggctccggatcaggaccatgccagagcagacaccagtaacatgtctgctgagcgg ttccgtatcttccgagctgagaagacgtacagtgtgaacgctgggaagtggtactttgag tttgaggtgctgacgtcaggcgagatgagggtcggctgggcacggcctggctgtctaccg gaccaggagctgggctctgaccaacacgccttcgtctttgacgggttcaaggcccagctg tggcaccagggtaacgagcacttcggcaggtcctggggtccaggtgacgtggtgggctgt atggtcgatctgaacgaacacaccatgatgttcacccacaacggagaggtgctcctggac cactcagggtcggaactggccttcaaggactttgaggtttgggaaggtttcatcccggtg tgcagcctgggtgtttgccaggttgggaggatgaactttggtaaggacgtgagcacgctg aagtacttcaccatctgtggtctgcaggaaggctacgagcccttcgccgtcaacatgaac agagacctcaccatgtggctcagcaagagactgtctcagttcatccccgtacctccgcag catgaacacattgaggtcacgaggatggacggcaccgtggagactttcccgtgtctcaag gtcacccagaggtcgttcggctcccagaacagtaaccccgacatcaccttctatcgcctc agcatgcctatagagtgtaacgaggtgctggccaagtcacctggcgggacgctacagtct ggcgggggcttctccttctcctctaagaaagacctggacgactttgagaccgtgtccgac ttcgaggtgttgacgaagtctgcccactgcaccctgggctccagcctggacaaggagaag gaccagttcaacaaccacaaagactacaaccaggagaagccctccgcgttaaagcagaga ttcatgttgaagaggaccaagccagagtttaccagcagtaactcttcggcccgtctatca gaggaggtgttagctgacagggatgaccttgacttcttcatgcagacctccacttactac tactcagtgaggatcttcccaggtcaggagcccagcagtgtgtgggttggctgggtgacc tctgacttccaccagtacgacatggccttcgacctccaaaaggtccgcaccgtcaccgta accctgggagacgagaagggcaaagttcacgagagcatcaagcgtagtaactgctacatg gtgtgggctggagagagtacgagtcctggtcagggtcggaacaacaacggtctggagatt ggatgtctggtggacacagttaacggactgctaaccttcactgccaacgggaaggagctc agcacatactaccaggtggagcccagtaccaagctgttccctgctgtgttcgctcaggcc accagccccagtatctttcagtttgaactaggacgtattaagaacgtcatgcccctgtca gcgggactgtttaagagtgagaggaggaattcctgtccccagtgtcctcccaggctgcat gtccagttcctgaccccagtgctgtggagcagggtacccaaccacttcctcaaggtggac gtatcccgggtcaacgaccgccatggctggctggtcacctgctctgaaccgctccagttc atgtccctgcatatacctgaggagaacaggtcagttgatatcctggagttgactgagcag aaggatctgttgaagttccactaccatactctgaggttgtactctgctgtgtgcgctctg gggaacaaccgtgtggcccacgccctctgctcccacgccgacgaggcacagctgctctac gccatagagaacaagtacatgcctggtctcctcaggactggatactacgacctgctcata gacatccacctcagtacctatgcaacggctcgtctcatgatgaacaatgaatacatcgtc cccatgacggacgagaccaagtccatcactctgttccccgacgagaccaagaagcacggc ctgccggggatcggcctgagcacctctctccgccccagaatgcacttctcctccccctcc ttcatctgcagcggagccgactgcttccagttcagccccgagtttcccctggacgtcctg aagaccaagaccatagagatgctgacggaggcggtgagcgaggggagtctacacgtcaga gatcctatagggggcagcaccgagttcctgttcgttcctctcattaagttgttctatacc ttactgatcatgggagtgttccataacggagacctgaagaacattctacagctgatagaa cccagcgtgttctcagagggaggggacacgcccgcggacacgcccccggacacgcccgag agtgatgtcactaagggaggaagaggaggggaggggcctggaggagaggagaggacgggg aaggtgcctaaaggactgctccagatgaaactcccagagcctgtcaaactgcagatgtgc cacctgctccagtacctgtgtgactgtcaggtgcgccaccgtatcgaggcggtggtgggc ttcagcgatgacttcgtggctcatctccaagacaaccagcggttccgctataacgaggtc atgcaggcgctcaacatgtcggctgccctgactgccaggaagaccaaagagttcagatct cctcctcaggaacagatcaacatgctgctgagctttaaggacgagaaggtggactgtccc tgtccagaacacatcagagaacagcttgtagacttccatgaggacctgatgacacactgt ggcatagagatcgacgaggacaagctgaacgaggcagacagtgacttcaccatccgagga agactcatgtctctggtggagaaggtggtctacctgaagaaaaagatgactttcatgccg aagaacaagaagaaagataagaaacccagcacgttgcagcagctgatcagtgagaccatg gtacgctgggcccaggagagcatcatggaggacccagagctgatcagagccatgtttgtc ctactccaccgtcagtacgacggcatcgggggccaggtccgggccctgcccaaggcctac accatcaactcagtctccgtggaggacaccatcaaactgctggcgtcgctgggacagatc agatcgctgttgtctgtacgcatggggcgtgaggaggagaaactgatgatcagagggctg ggagacatcatgaacaacaaggtgttctatcagcatcccaacctgatgagagctctggga atgcatgagacggtcatggaggtgatggttaacgtgctgagtggaggggaatccaaggaa atcaccttccctaagatggtggccaactgctgtcgtttcctgtgttacttctgtcgcatc agtagacagaaccagaaagccatgttcgaccacctcagctacctgctggagaacagcagc gtcgggcttgcgtctccctccatgcgaggctctactccactagatgtggccgctgcctct gtgatggacaacaacgaactggctctggccctgagggaaccagacctggagaaagtggtg cagtacttggctggctgtggtctccagagctgctccatgctcgtgtctaaaggataccct gacatcggctggaaccccgtcgaaggagagagatacctcgacttcctccgctttgcagtg ttctgcaatggtgagagtgtggaggagaacgctaacgtggtggtgaggctgctgattcgt cgtcccgagtgctttggccccgccctgcgcggagagggggggaatggtctcctggcagcc atgatggaagccatcaagatatcagaggacccctgtagagacgggccctcccctacctca gaggccagcaggacactcagtgaggtgttattggaggatgaggaagacgacactattcac atgggaaacgctataatgaccttctacgcagccctcatagacctgctggggcgctgtgcc cctgagatgcacctgattcatgctgggaagggtgaggccatcaggatacgagccatccta cgttccctgatccctatagaggacctggaaggagtgatcagcatcccgttccccatgcca actctggccaaagatgggtcagtggtggagcctgatatgtcagcagggttctgtccagac cacaaggcagccatggtgctgttcctggaccgggtctacgggatagaggaccagaacttc ctgcttcatctgctggaagtgggcttcctgcctgacctcagggctgctgcctcactcgac acagctgctctgagctctacagacatggccctggccctcaacaggtacctgtgtacagcg gttcttcccctgctcactaagtgtgccccgctgttcgctgggacagagccctacgcctcg ctcatagactctctgcttcacaccgtctaccgtctctctaaaggatgctgcctcaccaag gcacagagagacgctatcgaggagtgtctgctggccacctgtggtcaactgaggccgtcc atgatgcaacacctgctgagacgcttggtgttcgatgttcctctcctcaacgaacacacc aagatgcctctcaagctgttgaccaatcactacgagcgttgttggaagtactactgtctg acgggcggctgggggagctttggggcgtcgtctgacgaagagctgcatctctccaggaag ctgttctggggcatcttcgatgctctgtctcgcaagaggtatgatcaggagctgtttaag ctggctctcccgtgtctgagtgccgtggccggggcactaccacctgactacatggagagt aactatgtggccgtgatggagaaacagtcctctatggacgccgagggaaacttcaaccca cagccagcagacaccaccaatgtgaacgtcccggagaagctggatcactttgtcagtaaa tatgctgagcattcacatgacaagtggtccatggacaagttttccaacggctgggttcac ggggacaaggtgtgtgaggcctctaaagtccaccctctcctcaagccctataaagggttg tcagagaaggataaagagttgtaccgctggcctatcaaggagtctctgaagacgatggtg atgtggtgctggagcatagagaggaccagggagggagacccagccagcctacacaacaga gcacgtaggatctctcagatcagccagcaacactctgtcgaaggagctccaggtttcagc cccagacccatcgacatgagcaatgtgacactgtcccgggacctgcactctatggcagaa ctgcttgcagagaactatcataatatttgggcgaagaagaagaaacttgagctagaagcc aaaggaggagggaaccatcccttactggtgccctatgacacgctcaccgccagagagaaa tacaaagacagaggaaaagcccaagacattctcaagttctttcagataaatggctacact gtgtccagggccatgaaagagcaggagttggatactccctccatggagaagcgttttgcc tacaccttcctgcagcagctcatcacctacgtagacgaggcccacgaacacatgctggag tctgacgttgggacaccaccgaaaggagagagcgttcctcacgaacatcagatgaagttt tttggaaaggtggtcctgccattggtcgaccagtacttcaagaatcaccgcctctacttc ctgtccacggccatccgaccaatcagcagcgggggccacgcctccaataaggagaaggag atggtgacaagtctgttctgcaaactgggacttcttgtcagacataggatatcattgttt ggaagccatgctacctccatagtcaactgtcttcacatactgggccagacactggacgcc aggacggtgatgaagacgggtctggagacggtgaaggcggcgttgagggcgttcttcgac aacgcagcagaggacttggagaagactttagagaacctgaaacagggccagttcactcac agtcactcccagcccaaaggagtcacccagatcattaactacaccagcgtagccctgctc cctgtcctctcctccctgttcgaacacatcgggcagaacctctttggggaagacctcata ttggatgatgtccaggtggcctgttacaggatcctcaacagcctgtatagtcttggtacc aacaacagcatctacgtagaaaggcagcgtccagccctaggtgaatgtcttgcagcgttc tcaggggcgttccctgtggccttcctggaaccagagctcaaccagttcaacaactactcc atctacattaccaagggctcccgggacagaacagctctagatctgcccttccaggtagga gagatgtgtccagtcatcccgtccctggagaagtctctggaggagatcatggatcttgct gagtccggcctgcactacacgcagatgcctcacgttatggaggtggtgctgcccatgcta tgcagctacatgtctcactggtgggagcacggcccagagaacaaccctccagagactgca gacagctgctgtactcacctcacctcagaccacatgaatagtctgctgggcaacatcctg aagattatctataataacctggggatcgacgagggggcctggatgaagcgacttgcagtg ttctctcagccaatcattggtaaggcaaagggggggctgttgaagacccactttctgccg ctgatggagaagttgaggaagaaggctgccaccgtactgcaggatgaggaacagatgaag gccgagggacgaggggagatgtctgaggctgaactactcatcctggatgagtttactatc ctgatcagagacctctatgccttttatccgctactcatccgctttgtagactacaacagg gccaaatggctgaaagaatcgaaccctgaggctgaggagctcttccgcatggtagcagag gtcttcatattctggtccaagtctcataattttaaacgggaggagcagaactttgtggtt caaaatgagatcaacaatatgtccttcctcatcacagacaccaagtcaaagatgtccaag ggagccgtgtctgaccaggagaggaagaagatgaagaggaagggtgatcgctactccatg cagaccagcctcatcgtagcagcgttgaagagactacttcctgtaggactgaatatctgc gctccaggagaccaggaactgatcgctctggccaagatccgcttcagtcagaaagacaca gaggacgaggtgcgggagatcatcagaaacaacctgcacctgcagggaaagctggaggac cctgctatccgctggcagatggctctgtataaggaccttcctaacaggagcgaggacacg tcagacccggagaagactgtagagagagtcctggacatcgctcacgtcctcttctatcta gaccaggtggaacatccacaaaggagcaaaaaggctgtgtggcacaagctgctctctaaa cagaggaagagggctgtagtggcctgtttcagaatggcacccctgtataacctacccagg caccgggcggtcaacctgtttctacagggatatgagaagtcctggattgagactgaggag cactactttgaggataagctcatagaggacctggctagacctggaggagaagagcctcct gaagaagatgagggagccaagaggattgaccctcttcatcagctcatacagttattcagc aggacggccctgactgagaagtgtaagctggaagaggacattctctacatggcctatgct gacattatggctaagagctgtcatgatgaagaggatgaggatggagaggaggtgaagagt tttgaagaaaaagagatggagaaacagaagctgctatatcagcaggccaggttacacgac cgaggtgctgcagagatggtgctgcagactatcagcgccagcaaaggtgagatgggtccc atggtggcctctactctgaagctggggatagctgtcctcaatggaggcaactcgactgtt cagcagaaaatgctggactacctgaaagacaagaaggatgtgggcttcttccagagtctg gctggtctgatgcagtcgtgcagtgttctggacctgaatgcgtttgagcgccagaataaa gcagagggactgggcatggtgacagaggagggatcagtcatcactcatgagcgtggagag aaggtgatgcaggacgatgagttcacctgtgacctgttccgcttcctgcagctgctctgt gagggtcacaactcagactttcagaactacctgagaacacagacggggaacaacactacg gtcaacatcatcatctctaccgtggactaccttctgagagttcaggaatccatcagtgat ttctactggtactattcgggaaaggacgtcattgatgaacaaggacagcgcaatttctcc aaggcaattaacgtggcgaaacaggtcttcaatactctcacagagtacatacagggaccg tgtactgggaaccagcagagtctagctcacagccgtctgtgggacgctgtcgttggcttc ctccatgtcttcgctcacatgcagatgaagctgtcacaggactcgagccagatagagttg ttgaaagagttgatggatctgcagaaagacatggttgtgatgctgctgtccatgctggaa ggcaacgtggtcaacggaaccatcgggaagcagatggtggacatgctagtagagtcctcc aacaacgtggagatgatcctcaagttcttcgacatgttccttaaactcaaagacctgacg tcgtccgacgccttcaaggagtacgacccggatggtaaaggggtcatctccaagagagac ttccacaaagccatggagagccacaagcactatacccagtctgagacggagttcctgctc tcctgtgctgagcctgacgagaatgagctgttggactacgaggagtttgtggagcgtttc catgagccggccaaagacatcggcttcaacgtggccgtgcttctgaccaacctgtctgaa cacatgccccacgacacgcgcctgcagaccttcctggagctggctgagagtgtgctgaat tacttccagccgtacctgggccgtatcgagatcatgggcagtgccaagcgcatcgagagg gtctacttcgagatcagtgagtctagtcgtacgcagtgggagaagccccaggtcaaagag tccaaacgccagttcatcttcgacgtggtcaacgagggcggggaaaaggagaagatggag ctgttcgttaacttctgcgaggacaccatctttgagatgcagctggccgcccagatgtcc gacatcggggagcggtcggccgtgaaggaggagagcgagaaggagaaaccggaagaggag agccctgagatgggcttcttctctgtgaccacggtccggaccgccctgatggcgctacgc tacaacgtcatgttcctgatgaatgttctgtccatgaagagcctgaagaagcagatgaag aggatgaagaagatgacagtgaaggacatggtgatgacgctggtctccttctattggtcc gtcatcatgggcctgttccactttaccttcagcgtctccagagggttctgcagaatcatg tacagcaccttcctaggaggcagtctggtggatggagccaagactatgaaggtgtctgag ctgttggccaacatgcctgacccgacccaggacgaggttcgagaggagggggagaaggtg ctcttagctagaccctcggctgaggaggagctggctgatctagccctgcccgtggacggg accgaagtcctctcagacatctttggattagatctgaggagaggagaaggaggacagtat aagataactgctcataaccccaacgccagtctgactgatctgcttaactctccagtcccc tcctctcctcacctcgctacctcaccgtccccggaattgagaagacggcaccaggctaag agcccttcagaggaagggaggacagggaccgaggaaagcaaggaggccaagtcagagccg gagaaagcacagggagtggatggagagaagcaggaggaggagaggaggaaggaggaggag aggaggaaggaggataagaagaggaaggaggagaagccgaaagctaaagtgagacagcac cacacctccaagtctgatgagcatgacatgcaggagtctgccttctggaagaaaatcatc gcctatcagaggaagctgctgaactattttgctcggaacttctacaacatgagaatgctg gcgttgtttgtggccttcgccatcaacttcatcctcctcttctacaaggtgtcctcctcc tcggcggtgatgcctgagagcagaaggccccgggcaggcagcagtgtgcggtgggacccc gtgacggagggtagtgacccccaggagcctcaaaacccccagcagggccctgtgtctgtc cactttgtgctggaggagagcaccggatacatggagcccaccctgcgtatcctggccatc ctacacactgtcatctccttctgctgcatcataggatactactgcctcaaggtcccgttg gtgatcttcaagcgtgagaaggaggtggcgaggaggctggagtttgatggtctctacatc acagagcagccgtcggaggatgacattaaaggccagtgggacagactagtgattaacact gggtcgtttcctaacaactactgggataagtttgtgaagaggaaggtgatggataagtat ggagagttctacggccatgaccgcatcagtgagctgctgggtatggacaaggctgctctg gacttcagtgacgcccacgagaagaagaaacccaagaaagacagctcgttagccgcagta ttaaactctgttgatgtcaagtaccagatctggaaactaggagtcgtcttcacagacaat tcgttcctgtatctggcttggtatatgaccatgtccatcctgggtcactacaacaacttc ttcttcgctgctcatctcctggacatcgccatgggcttcaagaccctccgcaccattctg tcttctgtcacgcacaacggcaaacagctggttctgacagtaggtctactggctgtggtg gtgtatctctacaccgtggtggcgttcaacttcttcaggaagttctacaatcgaggggaa gagggagagacgccggacatgaagtgtgatgacatgctcacatgttacatgttccacatg tacgtgggcgtacgggcaggagggggcatcggtgaccagatcgaggatccagcgggtgat gagtatgagatctacaggatcatcttcgacatcaccttcttcttcttcgtcatcgtcatc ctcctggccatcatccagggtctgataattgatgcgtttggagaactgagagatcagcag gagcaggtgaaggaggatatggagaccaaatgcttcatctgcggaataggaaacgactac tttgacacagtacctcacggcttcgaaacccacaccctgcaggagcacaacttggccaac tatctcttctttgtgatgtatctcattaacaaagatgaaacagagcacacaggccaggag tcgtatgtgtggaagatgtaccaggagcggtgctgggaattcttccctgccggagactgt ttccgcaaacaatacgaagaccagctcaactga

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