Oncorhynchus mykiss (rainbow trout): 110529657 Help Entry 110529657         CDS       T07259                                  Name (RefSeq) ryanodine receptor 2 isoform X2   KO K04962   ryanodine receptor 2 Organism omy  Oncorhynchus mykiss (rainbow trout) Pathway omy04020   Calcium signaling pathway omy04260   Cardiac muscle contraction omy04261   Adrenergic signaling in cardiomyocytes omy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110529657    04020 Calcium signaling pathway     110529657  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     110529657    04261 Adrenergic signaling in cardiomyocytes     110529657  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:omy04040]     110529657    04990 Domain-containing proteins not elsewhere classified [BR:omy04990]     110529657 Ion channels [BR:omy04040]  Voltage-gated cation channels   Ryanodine receptor    110529657 Domain-containing proteins not elsewhere classified [BR:omy04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    110529657 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  110529657 NCBI-ProteinID:  XP_021467780 Ensembl:  ENSOMYG00000041823 LinkDB All DBs Position 1:76531875..76624063 Genome browser AA seq 4971 aa AA seqDB search MAESGESEDEIQFLRTNDEVVLQCIFTSQQEHLKLCLAAEGFGCRLCCLESTSNCKNVPP DLSVCSFVLAQCLSVRALQEMLANREHQAAGAGQGGGHRTLLYGHAVLLIHSYSRMYLCC LSTSQSSTDKLAFDVGLQDDKTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGSVIDNTSESGSLIVDAAFQQTLWRVAPICSGSGFAQGYLKGGDTLRLLHGHTDEC LTVPSTDQGEELRKVVHYEGGAVSSHARSLWRLEILRVAWSSSHTRWGQPFRLRHVTTGR YLSLTEERGLHLLDRERADVKSTSFCFRPSKEKLECGPKKDTDGMGASEIKYGDSLCYVQ HVDSGLWLTYQAIDAKCARLGAVQRKAIMHSEGHMDDGLSLSRSQWEESHTARLIRSTVL LFTGFIRRLDDLSQRANIPSFNLPLGTVALSLQDLIGYFQPPGEGLGHEARQNSVRALKN RQNLFQEEGVIGLVLDCIDRLHLYSSASHFAAAAGKEAGDDWENILNSFYELLAALIRGN RRNCAQFSGSLDWLVSRLERLEASTGVLEVLHCVLVESPETLNFIREGHIKSIISLLDKH GRNHKVLDVLCSLCVCHGMAVRSNQHLICDNLLPERDLLLQTRLVNQVTSMRPNIFLALG DDSAQYRRWYYEMTVDQVEHFLTAEPTHLRVGWANTEGYNPYLTGGEAWGGNGVGDDLSS YGFDGLYLWSGCVGRRVSSPYHHLLREDDVVSCCIDLVAPCISFRVNGQPVQGMLENFNT DGLLFPVVSFSAGVKVRFLLGGRHGEFRFLPPPGFAPCSEALLPRVKLRLEPCQDFTQEQ YLLGPTVLLTPATFTPNPVDISQVVLPVQLEHIRERLAENTHELWVMDKIDLGWTHGAVR DDSKKQDPCLVEFSRLPEQERNHSLQMSQDTLRTLIALGLHIGLPDGRADEGVRYLRLSN KYEMPSGYRPAPVDLSHIILSPAQEVVVELLAENDHNVWARDRIRQGWTYSSHQDVKAKR SPHLVPYSLLDERSRQSGRDGVREAVCTLLGYGYSLEPLDQDRAVMPDPCHTVAEKFRVF RADKLYAVTRGKWYFEFEAVTAGDMRVGWARPHCPPNGELGSDMQAFVFDGSKAQWCHRG DEPLGRPWQSGDVVGCMVDMGECTMMVTLNGEVLLNDRGSELAAKDFDINQGFLPVCSLG VNQKARLNLGRDVASLCYFTECGLQEGYKPFAVNMARDPALWMSWRQPQFIPVQTDHDSI QVTRITGSTESPPCLKVTQRSLGPQSCGSDMGFYRLSMPIECAEAFSRPVGATLPISSSV STARKDLQEFEVDSDFEMLLKSAHVYTGSRDELNHKDYSHDKTSKLKQRFMLKKPKPELN KSHSSARLLQEVHADKDDYDHLAQSTTYYYSVRVLPGQDPSTVWVGWVTSDFHQHQLTFD LEKIRTVTVTLGNDMGKVHESVKRSNCYMVCAGESTGLGQSRRSAGLAIGCLIDTTTGLL TFSSNGMELGTFFQVEPSTRLFPAVFAKANSSNVFQFELGRVKNMLPLSAGLFRSQRRNA MPQCPPRLQVQVLSPILWTRVPDHTLRVQAAHPEDRLGWRVQCLEPLQVMTLLIPEENRC VDILELSELGDLLSFHHHTLLLYSALCALGNTRVGHALCSHLDQSQLLYAIQSPRLPGPL RSAFYHLLGQVHLNTHATARLAMNHEYIVPMTEQTRAITLYPSPRASRSPQWVPRMGLST SLRPRMHFTSPCFIRGDGMGVNGDTCGDGVVATGEGIHIDSPEIPLELLKDLTGKMLTEA VWAVGQGVRDPEGGSIELLLVPLIRLFHTLLVMGLFRDEDLGKVLTLIEPGVFSRPADCS QEEEEEQEEEEQEDENVPDSDRESVEREADKRRKIPKLPTKGLLQMKLPEAVKLEICHLF QYLCDCQVRHRVEAVVAFSDTFVGYLQENQRFRYNEVMQALHMSAALTARKTKEFRSPPQ EQINMLLGFREEQGDCPCPEDIREQLVDFHQDLMTHCGIEVDHDTEVVEDSNRSIKDRLF SLVGRVISLKMRSADPEEEDRAQNTMTLQQLISDTVVRWAQECVIENPALVRAMFSLLNR QYEGLRGQMGTPLHKAYTISQVSVEDTMALLASLVQIRSLLSVRMGKEEERLMIRGLGDI MNNKVFYQHPNLMRALGMHETVMEVMVNVLGEGESKDITFPKMVAHCCRFLCYFCRISRH NQGSMFEHLSYLLDNSSVGLASPSMRGATPLDVAAASVMDNNELALALREPDLEKVVQYL AGCGLQSCPMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYSVVRLLIRHPE CFGPALRGEGGDGLLAAMEEAIRISEDLTMDGPSTTYESNRTLNVLQDEEDDIIHMGHSI MTFYSALIDLLGRCAPEMHLIQAGKGEAIRIRAILRSLIPIQDLEGVIGIPFQIPSLAKD GTVVEPDPSTVFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLQAVASLDTTDLS ATDMALALNRYLCTAVLPLLTKCSSLFSGTEGQGPLVDALLQAVYRLSRALSLTKAQRDA IEDCMLAICSKLRPSMMQPLLRRLVFDVPLLTIHTKIPLKLLTNHYEQSWKYYCLIGGLG HLGSASEEELHLSRKLFWGVFNALSRKHYDAELSKLALQCLAATAGALPPDHTDPGCVAW IERHPSMDAQGHFDPQPVDTSNVSVPEKLEFVVNKYAEHTHEKWSMDKFANGWVHGELCE KTKVHPLLKPYRALAERDKEAYRWSVKETVRSMLAFGWTIERTKEGDGLGLLTCSHRISQ AGQLSFEGASTFTPKPMDMSSVTLSWDQCSVTELLAENYHNTWSRKKKQEVDAKGGGGHS TLVPYDALPTKEKAKLREKAQDVLKFFQLNGYTVWRDRKAAEMDSPAIANRFAYTFLQQL LSYTEEAQEYMQELELMQARGQMPIVEAPHQQQIDFFSKVALPLLEQYLKNHHLYFLSTA ARSRGNGGHASNKEKEMVTSLFCKLGALVRQRISLFGSEAPSIVSCLLILAQSLDVRTLM KTAPESARVSLRSFFEAAAVDLEMTVENLSMTQNLTQSRGVAQILDYTNTTLLPTLTSIF EHLSHNQYGEDLLVDSVQVSCYKILNSLHSLGISKSFYVEGQRPSAGACLAALSGAFPVC FLEPALNEDNPYSIYNTMSPREREDVGVPDEVEEVCPLLPSLQQLLGEVEELAGAGSGAR QAQYSHVTEITLPLLCSYVSRWWQHGPEGQLESPVCTSLTSQHASTLLGNILRIIHNHLG TGQGDWMKRLAVFSQPIICQAHPQLLRSHFLPLMEKLKKRAESVLQEGEQIKAEGRADAS EAELQIQEKFIVLVRDLYAFYPVLIPFVDYNRASWLREPNHEAEKMFGMVAEIFIFWAKS HNFKWEEQNYVVQNEINNMAFLVNNNNHKMSKVSDQERRKMKRKGDRYSTQTSLIVASLK RLLPVGLSVCSPAERSLITLAKSRFTQKDTEDEIRESIHNGLLRLLSKREAPGARWQDFP GPRRDTSDPLRTVERVLDIACVLYHLDQVEHPQRKKAVWHKLLSKQRKRAVVACLRMAPL YNLPRHRAVNLFLQGYDKSWIYAEDHSFEEKLVDDLARAGKQERSEREEEGDGEDDDKQI DPLLQLITLFSRSALTERSKLGDDSLYMSYAAIMAKSCCGEEDEEVKSFEEKEIEKQKLL YQQARLHDRGAAQMVLQTISASKGDMGSMVASTLKLGISILNGGNTTVQQKMLDYLKEKR DVGFFQSVAGLMQSCSVLDLNAFERQKKAEGLGMVIEESSGEKVMPDEKLTCDLFRFLQL LCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEHGQRN FSKAINVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQI ELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSSNVEMILKFFDMFLKLKD LTSSDAFKEYDHDGEGRISKKDFQKAMEAYKRYSQSETQFLLSCTETDENELLDYEAFVD RFHEPAKDIGFNIAVLLTNLSEHMPYDSRLGTFLQLAECVLSYFQPYLGRIEILGSGKRI ERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGDGKEKMEMFVNFCEDTIFEMQLAAQ ISGTDTGERAAGKEAEEEEEKDRGKNDEEELERSKMRFFSMSTIWLIVFALPYGLIMLMS MLSVKDLKKHIKKTTLRDLVMVFASFFQAMIMGLVHFVCSVVRFFLYVLYIVFVSGGLIE GAKKIRVFDLFGGILDPTLDEVTGGSGGYRERRYSTRSSRDELRGIGQSTVSSSDTNVLS DIFGLRVRREGGQYRLMTHDLTASLTDLFNTTTGQQSPAEPNGKQQVEGAREGDSKEGED KESELEKAEREDSEKKEAKAKRRVRICSSKPEETEPKESAFWEMITTHQKRLLNYFARNF YNMRMLALFVAFSINFILLFYKVSSSSVSEEEEKVAVLYDSSGDLDEEGPLVNDNTSGSM QFVLEESTGYMEPSLRFLSIAHTLISFCCIIGYYCLKVPLVIFKREKDVSRKMEFDGLYV TEQPPDEDIKGQWDRLVITTQSFPSNYWDKFVKRKVMDKYGKFYGCDRISELLGLDKAAL DFSSEGQERRRPRREGAWTALLNSIDVKYQVWKLGVVFTDNSFLYLAWYMTMSVLGHYNN FFFAAHLLDIAMGFKTLRTILTSVTHNGKQLVLTLGLLAVVVYLYTVVAFNFFRKFYNKS EDGVALDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEFEVVRIIFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYLDNVPHGFETHTLQEHNLA NYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLC NT seq 14916 nt NT seq  +upstreamnt  +downstreamnt atggctgaatcaggagaaagcgaagatgaaatccaatttctacgtacgaatgatgaggtg gtgctgcagtgcatcttcacatcccaacaggagcatctgaaactgtgcctggctgcagag ggctttggctgcagactctgctgtctggagtccacctccaactgcaagaatgttcctcca gacctgtcggtgtgttcctttgtgctggcccagtgtctgtctgtcagagctctgcaggag atgctggctaacagggagcaccaagcagcaggggctggtcagggaggtggtcatcgcacc ctcctctacggtcatgctgtactgctcatacactcctacagcaggatgtatctttgctgt ttgtccacatcccagtcttcgacagataagctagcgtttgatgttggtctgcaggatgat aaaacaggtgaggcatgctggtggaccattcaccctgcatccaagcagaggtcagagggg gagaaggtccgtgtcggggacgacctcatcctggtcagtgtgtcatctgagagatacctg catttgtcctatgggagtgtgatagacaatacgagtgagagtggcagccttattgtggac gcagccttccagcaaaccctctggagggtcgcccccatctgttctgggagtggatttgct caagggtatctgaagggcggggacacattgagactgctgcatggacacacagacgaatgt ctgactgtcccgtctacagatcagggggaagagctacgcaaggtggtgcactacgagggt ggagcagtgtccagtcatgcccgctctctctggaggctggagatccttcgtgttgcctgg agtagtagccacacacgctggggtcagccattcaggctccgccatgtcaccacagggagg tacttgagtctgaccgaggagagaggccttcacctgttggacagggagagggccgacgtg aagtccacatccttctgcttccgaccctccaaggagaagctagaatgtggcccaaagaag gacactgatggtatgggtgcctcagagatcaagtatggagactccttgtgctacgtccag catgtggactctggtctgtggctcacctaccaagccattgatgccaagtgtgcccgcttg ggagcggtgcagcgcaaggccattatgcacagtgagggtcacatggatgatggtctgagc ctgtcccgttctcagtgggaggagtcccatacggccagactcatccgcagcaccgtcctc ctcttcacaggcttcatcaggagacttgatgatctcagtcagcgagcgaacatcccctcc ttcaacctgccactgggaacagtggccctaagtttgcaggatctgattggctacttccag ccacctggggaggggctaggacatgaggctaggcagaacagtgtgcgagctctgaagaac agacagaatctatttcaagaggagggggtcatcggtttagttcttgactgcattgaccgt ttacacctatacagcagtgcctctcattttgctgcagctgctgggaaggaggcaggagat gactgggagaacatcctcaactccttctatgaactactggctgctcttatcaggggaaat cgcaggaactgtgcccagttctcaggctccctggactggctggtgagcaggctggagaga ctggaggcctccactggtgtcttggaggttttacactgtgtccttgtggagagtcctgag actctcaactttataagggaaggacacattaaatccatcatctctctactcgataagcat gggcgaaaccataaggtcctggatgtgctgtgttctctttgtgtgtgtcatggtatggca gtgcgttccaaccagcatctgatctgtgataatctgctaccagagcgagacctgcttctc cagactcgcctcgtcaaccaggtcacaagcatgaggcccaacatcttcctggccctgggt gatgactcggcccaatacaggaggtggtactatgagatgactgtagaccaggtggagcac ttcctcacggctgagcccactcacctgcgtgtgggctgggccaacactgagggttacaac ccctatctcacgggtggagaggcctgggggggcaacggggtaggagatgacctcagctcc tatggctttgacgggctgtacctctggtcaggctgtgttggtcggagagtgagctctccc tatcaccaccttctgagggaggacgatgtggtcagctgctgcattgacctcgttgccccc tgcatctccttccgggtcaatgggcagccggtccagggcatgctggagaacttcaacact gacggactgctcttcccagtggtcagcttctctgctggtgtcaaggtgcgttttctgctg ggtgggagacatggagagttccgtttcctgccccctccaggcttcgccccgtgttccgag gctctgctccccagggtgaagctgaggttggagccttgtcaggacttcacccaggagcaa taccttctgggacccactgtactcctcaccccagcaacctttacccctaatccagtagac atcagccaggtggtgttgcccgttcaactggagcatattcgtgagagactagcagagaac acccatgagctttgggtcatggacaagattgaccttggatggacccatggagctgtgaga gatgacagtaagaagcaggacccctgtctggtggagttctccaggctcccagaacaggag cgaaaccacagccttcagatgtcccaggacacactccggactctcattgcccttggtttg catattggtctgccagatggccgtgctgatgagggagtgagataccttaggctctccaac aagtatgagatgcctagtgggtacagaccagccccggttgacctgagccacatcatcctg agtcctgcccaggaggtggtggtggagctgctggctgagaacgatcacaacgtgtgggcc agggaccggatcaggcagggctggacctacagctcacaccaggatgtgaaggccaagcgg agcccacacctggtgccctacagcctgctggatgagaggagcagacaatctggcagagac ggtgtgagggaggctgtgtgcaccctgctgggctacggctacagtctggagcccctggac caggacagagctgtgatgccagacccatgtcacacagtggctgagaagttcagggtcttc agggcagacaagttgtatgctgtgaccagggggaagtggtactttgagtttgaggcggtg acggcaggggacatgagggtaggctgggctcgtccccactgcccaccgaatggggaactc ggatcagacatgcaggcttttgtgtttgacggctccaaggcccagtggtgtcaccgggga gatgagcccctgggtcggccctggcagagtggtgatgtggtgggctgtatggttgacatg ggtgaatgcaccatgatggtcactctcaatggagaggtgcttttgaacgaccgcggatca gagctggctgccaaggactttgacatcaaccagggcttcctccctgtgtgtagtctcggg gtgaaccagaaggccaggctgaatctgggtcgtgacgtggcctcattgtgttacttcaca gagtgtggcctacaggaaggttataagccatttgctgtaaacatggccagagacccagcc ctgtggatgagctggagacaaccacagttcatccctgtacagacagaccatgatagcata caggtgacaagaatcactgggtccactgagagcccaccgtgcctaaaggtaacacagagg tcattggggccccagagttgtggcagtgacatggggttctacagactcagtatgcctata gagtgtgctgaggccttctccagaccagtaggggctactctacctatcagcagcagtgtc tccacagccaggaaagacctgcaggagtttgaggtggactctgactttgagatgctgctg aaatcagctcatgtttacactggctccagggatgagcttaaccacaaggactacagccat gataaaacatccaaactcaaacaacggttcatgttgaagaaacccaaaccagagttgaac aaaagccactcatctgctcgtctactgcaggaggtccatgctgacaaagatgactatgac catctggcccagtccactacgtactattactcagtgagggtgttacctggtcaggacccc tccactgtctgggtgggctgggtcacctctgacttccaccagcaccagctgacctttgac ctggaaaagatccgcacagtgaccgtcaccctcggaaatgacatgggcaaggtccatgag agtgtgaaacgtagtaactgctacatggtgtgcgccggagagagcacaggcctggggcag agcaggaggagtgcaggcctggccataggctgtctgatagacaccaccactggtctgcta acattcagctccaacggcatggagctggggaccttttttcaggtggagcccagcactagg ctgtttcctgcagtctttgccaaggccaacagctccaatgtgttccagtttgagctaggg cgtgtaaagaacatgctgcccctgtcagcgggtctgttcaggagccagaggaggaatgct atgccccagtgtccccccaggctgcaggtgcaggtgctgtcgcccatcctttggacccgt gtaccagaccacaccctgagggtgcaggctgcccaccctgaagaccgcctcggctggagg gtccagtgcttagagcccctgcaggtcatgaccctgctcatcccagaggagaacaggtgt gtggacatcctggaactctctgagttaggtgaccttctgtctttccatcaccacaccctg ctcctctactctgccctctgtgctctgggcaatactcgtgtgggccacgctctctgcagc cacctggaccaatcacagctcctctatgccatccagagcccccgcctccccgggccgctc cgctccgccttctaccacctcctgggccaggtgcacctcaacacccacgccacggcccgc ctcgctatgaaccacgagtacatcgtccccatgacggagcagaccagggccatcaccctc taccccagccccagggctagtcgaagcccccagtgggttcccagaatgggcctcagcacc tccctcagaccccggatgcacttcacctccccctgcttcatcagaggagatggcatggga gtcaatggtgatacctgtggtgatggcgtggttgcgactggggaaggcatccatatagac agcccagagatcccactggaacttctgaaggacctgacagggaagatgctgactgaggct gtgtgggctgtggggcagggtgtgagggatcctgaagggggcagcattgagctgctgctg gtgcccctaattcgactgttccacaccctgctggtgatggggttgtttcgggacgaggac ctagggaaagtactgacactgatcgagcctggagtcttctcccgacctgcagattgttcc caagaagaggaggaggagcaggaagaggaagagcaggaggatgaaaatgtgccagatagt gatagggaaagtgtggagagggaggcggataaaaggaggaaaattccaaagcttccaaca aaaggactgctacagatgaagctaccagaagctgtcaaacttgagatctgccacctgttc caatacctgtgtgactgtcaggtgcgtcacagggtggaggcggtggtggccttctcagac actttcgtggggtacctgcaggagaaccagcgcttccgctacaatgaggtgatgcaggct ctccacatgtctgctgccctcaccgcccgcaagaccaaggagttccgctccccaccacaa gaacagatcaacatgttactgggcttcagagaggagcagggggactgtccctgtccagag gacatcagagagcagctggtggacttccaccaggacctcatgactcactgtggaattgaa gttgaccatgatacagaggttgtggaggattccaatcgctccatcaaagatcgtctcttc agcttggttgggagagtaatcagcttgaagatgagatctgccgatcctgaagaggaagac agagcacagaataccatgactcttcagcagctcatctctgacacggtggtgcgctgggcc caggagtgtgtgatagagaacccagctctggtcagggccatgttctctctgttgaaccgg cagtacgagggcttgaggggccagatgggcactcccctccacaaggcctacaccatcagc caggtgtcagtggaggacaccatggccttgctggcctctctggtgcagattcgctctctg ctcagcgttcgcatgggcaaggaggaggagagactcatgatccggggactgggagacata atgaacaataaggtgttctaccagcaccccaacctgatgagggctttggggatgcacgag acagtcatggaggtgatggtgaacgtcctgggggagggagagtccaaggatatcaccttt cctaagatggtggcccattgctgtcgcttcctttgttacttctgtcgcatcagtaggcac aatcagggatccatgttcgagcacctcagctacctgttggataatagcagtgttggccta gcatctccgtccatgcggggagccacccctctggacgtggcagctgcctctgtcatggac aacaatgagctggccctggccctgagggaaccagacctggaaaaagtggtgcagtacttg gcaggctgtggtctacagagttgtcccatgctggtgtctaaaggctaccctgacattggt tggaaccctgtggagggggaacgctacctggacttcctacgctttgctgtcttctgcaac ggggagagtgtggaggagaatgcctactcggtggtgaggctgctgattcgccatccggag tgttttggccccgccctgcgaggtgagggtggcgatggtctcctggcagccatggaggaa gccatcaggatctcagaggacctgactatggacggaccctccacaacctacgagtccaac agaacactgaacgtgctgcaggatgaggaggatgacataatccacatgggccactccatc atgaccttctactccgccctcatcgacctgctgggccgctgtgccccggagatgcacctg atccaagctgggaagggcgaggccatccgtatccgggccatcctgaggtccctcatcccc atccaggacctggagggagtcatcggcatccccttccaaatcccctctctagcaaaagat ggcacagtagtcgaaccagacccatccactgtgttctgcccggaccacaaggcagccatg gtgctgttcctggaccgtgtatacggcattgaggaccagaacttccttctccacctgctg gaagtgggcttcctgccagacctgcaggctgtggcctccctggacacaactgatctgagt gccacagacatggccctggcactgaacaggtacctgtgtacagcagtgctgcccctgctc actaagtgctccagcctgttctctgggacagagggccaggggccgctggtggatgctctc ctccaggccgtctaccgcctgtccagggccctcagcctcaccaaggcccagagagacgcc atcgaggactgcatgctggccatatgcagcaagctcaggccgtccatgatgcaacctcta ctccgacggcttgtttttgatgtgccccttctgacaatccacactaaaataccactcaag ctgttgaccaatcactatgagcagagctggaagtactactgtctgattggaggtttgggg cacttgggttccgcctcagaggaggagcttcacctctccaggaagctgttctggggagtg ttcaatgctctgtccaggaagcactatgacgctgagctctccaagctggctctgcagtgt ctggcagctacagctggagccctccctcctgaccacacggaccctggctgtgtagcctgg attgagagacacccctccatggacgcacagggacactttgacccccagcctgtagacacc tccaatgtgtcagtaccagagaaactggaattcgtggtgaataaatatgcagaacacacc catgagaagtggtcaatggacaagtttgcaaatggctgggtccatggggagctctgtgaa aagaccaaagtacaccctctcctgaagccttacagagctctggctgagagggacaaagag gcgtatcgctggtctgtaaaggagaccgtgcgaagtatgttggcctttggctggaccata gagagaacaaaagagggagatggccttggcctactcacctgctcacaccgcatctcccag gctggacagctgtcgtttgaaggagcatcaaccttcacccccaagccaatggacatgagc agtgtgacactctcatgggaccagtgttctgtgactgaattgctggctgagaactaccat aacacctggtccaggaagaagaagcaggaagtggatgctaaagggggagggggtcattct acgctggtgccctatgatgccctccctaccaaggagaaagccaaactgagagagaaagcc caggatgtcctgaagttcttccagctgaacggctacacagtgtggagggacagaaaggca gcagagatggactcaccagccatagcaaaccgttttgcctacactttcctacagcagctc ctctcgtacacagaggaggcccaagaatacatgcaggagctggagcttatgcaggcaaga ggtcagatgccaatagtagaggctccccaccaacagcagattgactttttcagcaaggtg gcgttaccccttctggagcagtacctgaagaaccatcacctctacttcctttccaccgca gccagatcacgaggcaacggaggtcatgcctccaataaggagaaggagatggtcaccagc ctgttctgcaaattgggagctcttgtcagacaacggatctctctgtttgggagcgaggca ccttccatcgtcagctgtcttctcatactggcccagtctctggatgtcaggactttgatg aagactgctccagaatcagcaagggtttcgctacggtccttcttcgaggctgcagcggtg gacctggagatgaccgtggagaacctctctatgacccagaacttgacccagtccagaggg gtggcccagatcctggactacaccaataccaccctgctgccgactctcacctccattttt gaacacctcagccacaatcagtatggagaggacctattggtggacagtgtccaggtgtcc tgttataagatcctcaacagcctccactcacttggcatcagcaaaagtttctacgtggag gggcagaggccgtcagcaggagcgtgtctggcagcgctgtcaggggctttccctgtatgt ttcctggagccagctctgaatgaggacaacccgtactccatctacaacaccatgagcccc agagagcgagaggatgtgggagttccagacgaggtggaggaggtgtgtcctctcttgcca tctctgcagcagctcctgggggaggtggaggagctggcaggggcaggctcaggggcacgc caagcccagtacagccatgttaccgagatcaccctacccttgctctgcagctatgtgtcc cgttggtggcagcacggtcccgagggccagctggagagcccggtctgcacctcactcacc tctcagcatgcaagcacactgctgggcaacatcctccgcatcatccacaaccacctggga acaggccagggagactggatgaagcgcctggcagttttctctcagccaatcatctgccag gcccacccccagttgctgaggagccacttcctgcctctgatggagaaactgaagaagagg gcagaatcggtgcttcaggagggggagcagataaaggctgaggggagggccgatgcgtct gaggcggagctacagattcaggagaaattcattgtgctggtgcgagacctctacgccttt taccctgtcctcatcccatttgtggactacaatagagcaagttggctacgggaaccgaac catgaggctgagaagatgttcggcatggtggcagagatcttcatattctgggccaagtct cacaacttcaaatgggaggaacagaactatgtggtccagaatgagatcaacaacatggct ttcttggtcaataataacaatcacaaaatgtccaaggtgtcagaccaggagaggaggaag atgaagcggaaaggggatcgctactccacacagacctctctcatcgtagcctccctgaag agattgcttcctgtgggactgagtgtgtgttccccagcagaacgcagccttatcacactg gccaagagccgcttcactcagaaggacacagaggacgagattcgagagagcattcataat ggcctgctacgtcttctgagcaaacgggaggccccaggggctcggtggcaggacttccca ggccccagacgggacacctcggaccctctgaggacagtagaaagggtcctggacattgct tgcgtgctttaccacctggaccaggtagaacatccccagaggaagaaggcagtgtggcac aagctgttatccaaacagaggaagagagctgtagtggcctgccttagaatggctcctctc tacaacctacccaggcaccgggctgtcaacctctttctacagggctatgacaagtcctgg atatatgctgaggatcactcctttgaagaaaagttggttgacgatttggctagagctgga aagcaggagcgttctgagagagaggaggaaggggatggagaggacgatgacaaacagatt gatccgctcctgcagctcatcacactgttcagtcggagtgctctgaccgagaggagtaag cttggcgatgacagtctttacatgtcctatgctgccataatggcaaagagttgctgtggt gaagaggatgaggaggtgaaaagctttgaagagaaggagatagagaaacagaagctgttg tatcagcaggccaggctgcatgaccgtggagctgctcagatggtcctccagactatcagt gctagtaaaggtgacatggggtccatggtggcctccactctgaagcttggtatttctatt ctgaatggaggaaataccactgttcagcagaaaatgttggattacctgaaagagaagagg gatgtgggtttcttccagagtgtggcaggactcatgcagtcttgtagtgtgctggatttg aacgcgtttgagaggcagaagaaagccgaaggattagggatggtcatcgaggagagctca ggggagaaggttatgcctgacgagaagttgacctgtgatctttttcgcttcctacagctc ctctgtgaaggacacaactcagattttcagaattatttgagaacacaaacaggaaacaac acgactgtgaacatcattatatccactgtggactaccttctcagagtgcaggagtcgata agtgatttctactggtattactctggaaaggatgtgattgacgaacatggccaacgtaac ttctccaaggccatcaatgtggccaaacaggtcttcaactctctcacagagtacatccag gggccgtgtactggtaaccagcagagtctggcccacagtcgcctatgggatgcagtggtg ggctttctccatgtctttgctcacatgcagatgaagctgtctcaggattccagccaaatt gaacttctgaaagaattgatggatttgcaaaaggacatggttgttatgttgttgtccatg ttagaaggtaatgtggtaaatggaacaattggcaagcagatggtggacatgttggtggaa tcatctagcaatgttgagatgatcctaaagttcttcgacatgttcctcaaactcaaagac ctgacatcctctgacgcattcaaagagtatgatcacgacggcgaaggtcgcatctccaaa aaggacttccagaaggccatggaggcctacaagcgctactctcaatccgagacccagttc ctcctctcctgcacggagacggatgaaaacgagctcctggattatgaggccttcgtggat cgcttccacgagccagccaaagacattggcttcaacattgctgttctcctaaccaacctg tctgagcacatgccttacgattcacgtcttggtacctttctgcagcttgcagagtgtgtt ctgagctacttccagccctacctgggccgtattgagatccttggcagtggcaagcgcatc gagagggtctactttgagatcagcgagtccagccgcacgcagtgggagaagcctcaggtc aaagagtccaagagacagttcatatttgacgtggtcaatgagggcgacgggaaagagaag atggagatgtttgtcaacttctgcgaagacaccatctttgagatgcagctggctgcccag atatcagggacagacactggggagagggccgcaggcaaagaggctgaagaagaggaagaa aaagacagggggaagaatgacgaggaggagttggaaagatccaaaatgagatttttctcc atgtctacaatttggctcatcgtcttcgctctaccctatggcttgataatgctgatgtct atgctctctgtgaaagacctgaagaagcatattaagaagacaactctgagagatttagtc atggtatttgcttccttcttccaggccatgatcatgggtctggtccactttgtctgttct gtggttcgcttcttcttatatgtactgtatattgtttttgtaagtggaggactcatagag ggggccaagaagataagggtgttcgacctttttggaggcatccttgaccccacactcgat gaggttacaggggggtcagggggttacagggagaggagatacagcacaaggtcctcccgg gacgagctgagggggataggccagtcaacagtttcctccagtgacaccaatgtcctgtca gacattttcggtctgcgagtgaggagagaaggaggtcaatacagactaatgactcatgac ttaacagccagtctgactgacctgttcaacacaaccactggccaacaatcccctgctgag cccaatgggaaacaacaggttgaaggtgccagagaaggagatagtaaagaaggagaagac aaagagtctgagttggagaaagcagaaagggaagattctgagaagaaggaggcgaaggct aaacggagagttaggatatgctccagcaaacctgaggagacagagcctaaggaatcagcc ttctgggaaatgataaccactcaccagaagagactgttgaattactttgcgaggaatttc tacaacatgcggatgctggctttgtttgttgctttctctatcaacttcattctccttttc tacaaggtgtcatcatcttctgtaagtgaggaagaggagaaggtggcagtgctatacgac agctcaggggacctggatgaagaaggccccttggtcaatgacaacacctcaggcagtatg cagtttgtcctggaggagagcactggttacatggagccctctctccgcttcctgtccatc gctcacaccctcatctctttctgctgtatcattggctactactgcttgaaggtcccgctg gttatttttaagcgggagaaagacgtgtcgaggaagatggagtttgacggcctctatgtc actgagcagccacctgatgaggacatcaaaggccaatgggacaggcttgtcatcaccaca caatcatttcccagtaattactgggataaatttgtgaaaaggaaggtgatggacaagtat gggaagttttatggttgtgaccgcatcagtgagctgctggggctggataaggctgctctc gacttcagctctgagggacaagagaggagaaggcccaggagagagggagcctggactgct ctattaaactccattgatgtcaagtatcaggtgtggaaactaggagtagtgttcactgac aactccttcctgtacctggcatggtatatgaccatgtctgtcctgggccactataataac ttcttcttcgctgctcacctgttggatattgccatgggctttaagacccttagaaccatc ctgacctctgttacccacaatggaaaacagttggtcctgactttggggctgctggcagtg gtggtgtatctctacaccgtggtggccttcaacttcttccgcaagttctacaacaagagt gaagatggagtagctctggacatgaaatgtgacgacatgctcacttgctatatgttccac atgtatgtgggagtgagagcggggggtggaatcggtgatgagattgaggacccggccggg gacgagtttgaggtggtcaggatcatctttgatatcaccttcttcttcttcgtcatcgtc atcctcctggccatcattcagggtttgataattgatgcttttggggagctccgtgaccag caggagcaggtgaaagaggacatggagaccaagtgtttcatctgtggaatcgggaatgac tacttggacaatgtgccccatggattcgaaacacacactctgcaggaacacaacctggcc aactatctattctttgtgatgtacctcattaacaaagatgaaacagaacacacgggccag gaatcctacgtatggaaaatgtaccaggagcgatgctgggaattctttcctgtcggtgac tgtttccgtaaacaatatgaagaccagctctgctga

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