Oreochromis niloticus (Nile tilapia): 100693242 Help Entry 100693242         CDS       T06104                                  Symbol ubr4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism onl  Oreochromis niloticus (Nile tilapia) Brite KEGG Orthology (KO) [BR:onl00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:onl04121]     100693242 (ubr4) Enzymes [BR:onl01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      100693242 (ubr4) Ubiquitin system [BR:onl04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     100693242 (ubr4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR DUF7637 Motif Other DBs NCBI-GeneID:  100693242 NCBI-ProteinID:  XP_019204867 Ensembl:  ENSONIG00000002035 LinkDB All DBs Position LG20:24276170..24323861 Genome browser AA seq 5161 aa AA seqDB search MASSGGDGEHEWTAAVRPLLSASYTAFETKELPQLIGSIINSESDILHHDKQYEPFYSSF VALSAHYITTVCGQIPRNQLLSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLC TGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKDLPSAVNPELRQKEVQMNFFNQL TSVFNPDLTTILASPSATHMQAESDCDEQNTDQAVQTKMKNAFVSQNVSSLQELGGSEKL LRVCLNLPYFLRYINRFQDAVSANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLP VLEPLTPGRLLDMTVLALSCLYAGVSVATCMAILQVGSGLQLRSASTGTKEEDYENDAAT IVQKCLEIYEMIGQAISNSRRAGGEHYQNFQLLGAWCLLNSLYLILNLSPTALADKGKEK DPLAALRVRDIASRTKDGAGSPKLGPAKGHQGFGVLSVILANHAIKLLTSLFQDLQVEAL HRGWASDGPPAELNIMAQSTSSQRVQRLIDSVPLTNLLFTLLSTSYKKVQSVIFVICICN LYTADDFSSTEEDSSQAERRQEKTSAACVSDDDSEPILGLWFEETISPSKDKVAPPPPPP PPPLETSPRLKSPSKQNPSENGNILAGRKDPELFLSLASSILNFITTSMLKSRNNFIRNY LSVSLTEQHMATLASIIKDVDKDVKGSSDEVFSLALYHFNHTLVTSDLPSPALQSTLLQQ LGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKATVQGEPDVPECMKVWERFLGTLKQHA IQGSIHGEDDLNVEHLQLLLLLFHNLSERGRRSVLTLVTQAITEVAQSRDSQLKAVPLNL ARLLLVFDYLLRHYSKAPLYLFEQVQYNLLTPPSTGASSVQEGGKRSNVPLYYGFKEVEE NWAKHCSTDSNVQPKFYCVLSPEASEDDISRLDSKVFPKLFNGAVKYDELYAWLISLLAA GSQFDTARRQENKPITPMEACSLQYYFLILWRILGVLPPSKGFMEQLKTGCSDPSESDIL HTLRWSSRLRVSTYVNWIKEHLVKQGMKTDQAASLVEVTAAKCSTVKYDVELAEEYIARQ ISTFSSVDPHVILPLHQLPSLQAIYTLDAVISKIQVSLDEHLSKVAIEADTHKSSEIAKN LLPATLQLTDIYSAFTRSYLLMNIPEEGENKLTDAKLQGYAAVLAIGSTRCKANILGHNI MQNLPTAVQTVCETWNGVHTTEFPNIGSWRNAFANDTIPSESYISAIQAAHLGTLSCQSL PLASSLKHILLSLVRLIGDLIVTEELNPSQVVSTLLPLLLESSTESVAEISTTSLERILG PSESDAFLARIYERLVTGCYNIIASHSDPNSGLDESILEECLQYLEKQLESSQVRKAMEE FFSFSGELVQIMMATANENLSPKFCNRVLKFFTKLFQLTEKNPNPSLLGLCGSLAQLACV EPSRLQSWLTRMTATPPKDSEQLEIVQENRQLLQLLTTHIVRDNSQVGEGVCTVLLSTLI PMATDMLANGDGTGFPELMVIMATLASAGQGAGHLQLHRAAIDWLTRCKKYLTQKNVVEK VSTNLSHGKHASMLECSCHIISYLADVMNALRQSSGQGNSAMLMEGEEKAMEVDSDWVEE LVVEEDDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCH KDHEISYAKYGSFFCDCGAKEDGSCQALVKRSPSSGMGSTLKESSAFQSELRMPESAIRH QNSSPSDKGKVTICDGKSSDEDRPKKSSVCKSIEGCQEELLAQVTGSSTAAVILEMLMFL MEAIQTNFQQASAVGSSSRAQQALNELHTQDKIVEMTDQLMVPTLGSQEGAFENVRMNYS GDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSTLLKQADSSKR KLTLTRLASAPVPFTVLSLTGNPCNEDYLAVCGLKDCHVLTFSSTGSVSDHLVLHPQLAT GNFIIKAIWLPGSQTELAIITADFVKIYDLSVDALSPMYYFLLPSSKIRDATFLFNEEGK NIIVIMSSAGYMYTQVMDESSSAQHGPFYVTNVLEITHEDLKDSNGQVAGGGVSVYYSHV LQMLFFSYSQGKSFAATVSRSTTDVQRLFAINVKGSNGGSSKMSPALCQWSEVMNHPGLV CCVQQTTGIPLVIMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTASNEQQRTTMILLCEDG SLRIYMANVDNTSYWLQPSLQPSCGISIMKPVRKRKAAAATTRTSSQVTFPVDFFEHNQQ LTEVEFGGNDLLQVYNGQQIKHRLNSTGMYVANTKPGGFTVEAVNNNSSMVMTGMRVQVG TQAIERAPSYVEVFGRTMQINLTRARWFDFPFTREEALQADKKLSIFIGASVDPAGVTML DSIKIYGKTKEQFGWPEDPPEDFSSASVNNVCSPSLNQGNGTSDGDIATPTTTSGTVLER LVVSSLEALESCFAVGSSSEKEKNKAAALELATLLLSMPTPVGVQQQTKGLLASLHTSRT AYHNHKDQSLLSNAVQCLNSCSREGKELDPDVFQRLVITARSIAIMRPNNLVHFTETKSL HHDSEVTEDGQKHVDSENCNFIAQLMNNFWKLHALKPKNAFLAPACLPGLTHVEATVNAL VDIIHAYCTCELDYINVASKIYMQMLLCPDTAVSFSCKQALIRVLRPRNKRRHVTLPSPP RSNTPMGDKDDDDDDDADDKMQSSVLTGGEEGRQESQEQNEVDHGDFEMVSESMVLETAE NVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQS LGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPAEHGGSVGSESGGS AIDSVAGEHSVSGRSSAYGDTTAEGHPAGPGSVSSSTGAISTTTAQQEGEGSEGEGETEG DIHTSNRLHMVRLMLLERLLQHLSQLHNVGGVQAIPYMQVILMLTSDLDGEDEKDKGALD DLLAQLIAELGMHKKDVSKKNERSSINEVHLVIMRLLSVFMSRTKSGSKSSSESSSLISN ATATALLSLGSIDYCLQVLKSLLEFWKSQQGEEEPVTASQLLRTHTASSPPDMSPFFLRQ YVKGHAADVFEAYSQLLTEMVLRLPYQIKKIADANPRIPPPVFDHSWFYYLSEYLMIQQT PFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRSIKKLLEEQGIFLRAGVVTASSGSA LQYDTLINLMEHLKACAEIATQRTINWQKFCMKDDSVLYFLLQVSFLVDEGVSPVLLQLL SCALCGSKVLASSSSTSSSFSGGGSGSAGQTGASQSSQSKSSSKKSKKEDKEKEKDGDGV GSQEDQLCMALVSQLNKFADKETLIQFLRCFLLESNSSAVRWQAHCLALHIYRNSSKSQQ ELLLELTWAIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRAQNHIL TNHPNSNIYNTLSGLVEFDGFYLESDPCLVCNNPEVPFSNIKLSSIKVDTRYTTTQQVVK LIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQ TEVKIDLPLPIVASNLMIEFSDFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQC HKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTNINTLLD KADRVYHQLMGHRPQLESLLSKVNEAAPEKPQDDTGAGAGLGTSSANVNRYIQQLAQEYS GDCKTSFDELSKIIQKVLASRKELLEYDLQQREAATKSSRSNSSHQPTFTASQYRALSVL GCGHTSSTKCYGCASAVTGHCITLLRALATNPALRQILVLQGLIRELFEYNLRRGTAAMR EEVRQLVCLLTRDHPEATQQMNDLIIAKVSAALKGHWANPDLVSNLQYEMLLLTDSISKE GGCWELRLRCALSLFLMSVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDAAIESL TTVRPYSNEIHAQAQLWLKKDPKASYEAWKKCLPARCQETMSKPQGKAELRKQYLLEKYV WKWKQFMRSRKGEGLFPRLLKLSHNNWLRQVLFTPATQAARQAACTIVEALTTIPSRKQQ VLDLLTSYLDELSVAGECAVEYLGLYQKLIKPTHWKIYLAARGVLPYIGNLITKEIANLL ALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRT KLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYP EENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLE DDSGMELLVNNKIISLDLSVAEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLDS TTDEEEDDEEVYKMAGVMAQCGGLECMLNRLSGIKDFKQGRHLLTVLLKLFSYCVKVKIN RQQLVKPEMNTLNVMLGTLNLALVAEQESKDSGGASIAEQVLSIMEIILDEANAEISEDK GNLLLTGDKDQLVMLLDQINTLFVRSNPSVLQGLLRIIPYLSFGELEKMRILVERFKPCC NFDKYDEEHSADDKVFLDCFCKIAAGIKNNSNGHQLKDLILQIGITQSALDYMKKHIPNA KNLDADVWKKFLSRPALPFILRLLRGLATQHPPTQVLIGTDSITNLHKLEQVSSDEGIGT LAENLLEALREHSDVNLKIEAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTS LLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEFENKPRKQQGYSTVSH FNIVHYDCHLAAVRLARGREEWDSAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTY LQECTGQREPTYQLNIHDTKLLFLRFATEQSFSVDTGGGGRESNIHLIPYIIHTVLYVLN TTRATSREEKNLQSFQEQPCEKWVESSYEVEGPHYYTILAMHIMPPERWRSSRLYFLRRL LVTAHARKVSAACANKVTDKTPKEYAVYRSPLLFWGLVDLVYDMFRKVPTSNTEGGWSFS LAEYVRHNDMPIYEASERVLRAFQDELMPAESLSEFFDVVGLLSEIPDPDLFLQDLLNSL P NT seq 15486 nt NT seq  +upstreamnt  +downstreamnt atggcgtcgagcggaggagatggggaacacgaatggacagcggcagttcggccgctttta tcagcttcgtacactgcttttgagacgaaggagctacctcagcttattgggtctataatc aacagtgaatcagacattcttcaccacgacaagcagtatgaacctttctactcatcattc gtggcactctcagcacattacatcaccacagtatgtggacaaataccaagaaatcaattg ctgtcagttgctgcagcgtgcaaagtattgattgaattctcattgctgcgcttggagaac cctgatgaggcatgtgcagtttcacagaaacacctgatccttttaataaagggactctgc actggctgcagcagactagatcgcacagaaatcattactttcactgctatgatgaagtct gccaagttgcctcaaactgtcaagacactttcagatgtggaagatcagaaggatttaccc agtgctgtgaacccagagcttcgacaaaaagaagtacaaatgaacttctttaatcagctg acatcagtttttaaccctgaccttaccaccatcttggcctctccatcagcaacacacatg caggctgaaagtgattgcgatgaacaaaatacagatcaagctgttcagaccaaaatgaaa aatgcctttgtgtcccagaatgtgtcaagcttacaggaactaggtgggtctgagaagttg ttacgagtatgcctcaacctgccctactttctacgctacatcaaccgcttccaggatgct gtgtcagccaactcattctttatcatgccagccacagtggctgatgctactgctgttcgc aacggatttcactcactggtgatagatgtgaccatggctttggacacactttccttgcct gtactggaacccttgacaccaggaagactactggatatgaccgtgctggctctaagctgt ctctatgctggtgtaagtgtggccacttgcatggccattctacaggtgggtagtggcttg caacttcgctctgcctccactggtaccaaagaagaggactatgaaaatgatgcagccaca attgtccagaaatgtctggagatttatgaaatgattgggcaagccatcagcaactctcgc agagctggaggagagcattatcagaacttccaactgcttggagcctggtgcctcttaaac agcctgtacctgattcttaacctgagcccgacagccttggcagataaaggaaaagagaag gatcccctggctgctttgcgtgtccgtgatattgcaagtcgcaccaaggatggcgcaggg tcacctaagcttggtcctgccaaaggacaccaaggctttggagtgttgtctgttatcctg gccaaccatgcaatcaaacttttgacttcacttttccaggatctgcaggttgaagctctg cacagaggttgggcaagtgatggaccaccagctgagctcaacatcatggcccagagcact tccagccagagggttcaaagactcattgactctgttcccttgacaaatctgctcttcacc cttctctccacctcctacaaaaaggtgcagtcagttatatttgtaatttgcatttgcaat ttgtatactgcggatgatttcagcagtacagaggaggacagcagccaggcagagagaaga caggagaagacaagtgcagcttgtgtctcagatgatgacagtgaacctatcctggggctt tggtttgaagagacaatttcaccaagcaaggacaaagtggctcctccaccgcctccccct ccaccacctttggagacttctcccagactgaagagtcccagcaagcaaaatccaagcgag aacggcaacattttagctggccgtaaagatcccgaactgttcctcagcttagcatccagc attctgaatttcatcaccacctcgatgctaaagtccaggaacaactttattcgtaactac ctgagtgtgtctctcacagaacaacacatggctacacttgcaagtatcatcaaagatgtg gacaaagatgtcaaaggctcttcagatgaagtcttttctttagcactgtatcacttcaac cacaccctagtgacctcagatcttccctccccggctttgcagagcactcttctacagcaa ttaggtgttgcacccttttcagagggtccatggcctctgtacattcatcctcaatcattg tcagtgctctccagacttctcctcatatggcagcacaaagctactgtgcagggagaaccg gacgttcctgagtgtatgaaggtctgggaaagatttttgggaaccttgaagcaacacgcc atccagggttctattcatggcgaagatgaccttaatgtggaacacctccagctgctgctg ctccttttccacaatctgtcagagcgtggtcgtcgatcagtcctcaccttagtcacacag gccattacagaggtggcacagagcagagactcccagctgaaagctgtgcccctcaatttg gcacgcctgttgctggtttttgactacctgctgcgccactactccaaggctcctttatat ctttttgaacaggtgcagtacaaccttcttaccccgccatctactggcgcaagttctgtt caggaaggtggaaaacgcagcaacgttccactttactatggattcaaagaggtggaggag aactgggctaaacactgttcgacagattcgaatgtccagcccaaattctactgcgttctg tctcctgaggcgtccgaagatgatatcagcagactagatagcaaggtctttccaaagcta tttaatggagcagtgaaatatgacgagctgtatgcatggctcatctcactcctggctgcg ggctctcagtttgacacagcaagaagacaagagaacaagcccatcactcctatggaggcc tgctcccttcagtactacttcctgatactgtggaggatccttggtgttttaccaccttcc aaaggcttcatggagcagctaaagactggctgcagtgaccccagtgagagcgacatctta cacacactgcgatggtcatcacgtctccgcgtatctacgtatgtgaactggatcaaggag cacttggtaaagcaaggaatgaaaacagaccaagctgcttctctggttgaagtgaccgct gctaaatgcagcactgtgaaatacgatgtggagctagcagaagagtacattgccagacag atttccacattctcaagtgtagacccacatgtcatccttccacttcatcagttgccctct ctacaagccatctatacgctggatgcagtcatctctaaaattcaggtttctttagatgag catttgtccaaggttgccattgaggccgacacccacaaatcctctgagattgcaaagaat ctgctgcctgccacactacagctcactgacatttactcagctttcacaagatcttaccta ttaatgaacatcccagaggaaggggagaacaaactgaccgatgccaagctccaaggttat gctgcagttctggccataggttccacccgatgcaaggccaacatacttggtcataatatt atgcagaacttgccaacagctgtgcagacagtttgtgagacttggaatggtgtccacacc actgaatttcccaacattggctcatggcgcaatgcatttgcaaacgataccattccatca gagagctacatcagtgccatccaagcagctcacctgggcacactgagttgtcagtccttg cctctggcctcttctcttaaacacatccttctctcactggttcgcctgattggagacctc attgttactgaggagctgaacccctcacaggttgtgagcaccctgctgcctctgctcttg gagagcagcacagagagtgtagctgagatcagcaccacttcactggagcgcatccttggc ccatcagagtctgatgcctttctagcccgcatctacgagcgtttggtgaccggatgttac aacattattgccagtcactcagatcccaacagtggtttggatgagtccatccttgaggaa tgccttcagtacctcgaaaaacaacttgaaagcagtcaggtccgaaaggcaatggaagaa ttcttttcattcagtggtgagcttgtccaaattatgatggcaacggccaatgaaaacctg tctccaaagttttgtaacagggtgctgaaattcttcaccaagcttttccagctcacggag aagaacccaaacccaagcctgttaggcctgtgtggctctttggcccagctggcttgtgtg gagccctctcgtctgcagtcctggctgacacgtatgactgctacaccaccaaaggactca gaacaactggaaattgtgcaagaaaacagacagcttctgcagctactaaccactcatatt gtgcgtgacaatagccaggtgggcgaaggagtgtgcactgtgcttctcagcacgcttatt cccatggcaacagacatgctggccaatggtgatggaacaggttttcctgagctcatggtc atcatggccacacttgccagtgcgggacagggtgcaggccacctccagctgcacagggca gctatagactggctgactagatgcaaaaagtatttaacacagaagaatgtcgtggaaaaa gtgagcacaaacctgtctcatggaaagcatgccagcatgctggaatgctcatgtcacatc atctcctatctggctgatgtgatgaacgctttgcgtcaaagcagcggtcaaggcaactca gcaatgctgatggagggagaggaaaaagccatggaagtagactcagactgggtggaggaa cttgtagtagaggaggatgattcccaggcagaggactctgatgaagactcactttgcaac aaactttgcactttcaccattactcagaaggaattcatgaaccagcactggtaccactgt cacacctgtaagatggtggatggggtaggtgtgtgcacagtgtgcgccaaggtctgtcac aaagaccatgagatctcctatgccaaatatggctctttcttctgtgactgcggtgccaaa gaggatggcagctgccaggccctggtcaaacgcagtcccagcagtggcatgggctctact cttaaagagtcttcagcttttcagagtgaactgcgtatgcctgagagtgctattcgccac caaaattcctcaccgtctgacaagggcaaggtcaccatctgtgatggcaaatccagtgat gaagacagacctaagaagagcagcgtgtgcaagagtatcgaagggtgtcaagaagagctg ctagcacaagtgacgggatcatctactgctgcagtcatactggaaatgctcatgtttctc atggaagctatccagaccaacttccagcaagcatcagcagtgggaagcagcagccgggca cagcaagccctcaatgaactgcatactcaggacaaaattgtggagatgacggaccagtta atggtccccacacttggctcccaggaaggagcttttgagaatgtgcgaatgaattacagt ggtgaccaggggcaaactatacgccagctcatcagtgcacatgttctgcgccgtgttgct atgtgtgttctgtcttccccccatggacgccgtcagcacctggcagtcagccatgaaaag gggaagataacagttcttcagctgtctactctcctgaaacaagctgactcaagcaaaagg aagttgacactgacccgtttggcttcggccccagtcccattcactgtccttagtctcaca ggcaacccctgcaatgaagattacctggctgtgtgtggccttaaggactgccatgtacta actttcagcagcacaggttctgtgtctgaccacctggtgttgcatccacagctggccact ggcaacttcatcatcaaagctatctggttaccaggctcacagactgaacttgctatcatc actgctgactttgtcaagatctatgacttgtcagtggatgccctgagtcccatgtactat ttcctgctcccaagttccaagattcgtgatgctacattccttttcaatgaagaggggaag aacattattgtcatcatgtcatcagcaggttacatgtacacccaggtcatggatgaatct agcagtgctcagcatggccctttttatgtcacaaatgtattggagataacccacgaagac ttgaaggatagcaatggacaggtagctggcggtggtgtttctgtctattactcccatgtc cttcagatgcttttcttcagctacagccaagggaagtcattcgctgccacagtgagccgc agcacaactgatgtgcagaggctctttgccatcaatgtgaaaggctccaatggtggcagc agtaagatgtcacctgcactgtgccagtggtctgaggtcatgaaccatccaggccttgtg tgctgtgtgcaacagacaacaggcatacctctggttatcatggtcaaacctgacaccttc ctcattcaggagattaaaactctgccagctaaagctaagattcaagatatggtagctatc cgacacactgccagtaatgagcagcagagaactaccatgattcttctctgtgaggatggc agcctgcgaatctacatggcaaatgtggacaacacctcctactggctccagccctcattg cagcccagctgtggcataagcatcatgaagccagtccgtaagcgcaaggctgctgctgcc accacccggacttccagtcaggtgacattcccagtggatttctttgaacacaaccagcaa ctgacagaggtggagtttgggggtaatgacttgctgcaggtctacaacggacagcagatc aaacacaggctcaactccacagggatgtatgtggccaacacaaagcctggagggttcact gtagaggcagtaaacaacaacagttcaatggtgatgacaggcatgcgggttcaggtgggc acccaggccattgaaagggctccttcttatgtggaggtctttggacgcaccatgcagata aatctgacaagagctcgctggtttgacttccccttcacaagagaggaggccctgcaggct gacaagaagctgtctatatttattggagcatccgttgacccagctggagtcaccatgctt gattcgattaagatctatggaaaaaccaaggagcagtttggctggcctgaggatccacca gaagacttctcatctgcctcagttaacaatgtctgcagtcccagcctcaaccagggcaat gggacctctgatggagacatagccaccccaactacaactagtggcactgtattagagagg ttggtggtcagctcccttgaagctttggaaagctgttttgcagttggttcgtccagtgaa aaggaaaaaaacaaggctgcagcactggagttggcaactttacttctgtcgatgccaaca cctgtaggtgtgcagcagcagacgaaggggcttcttgccagtctgcacacaagccgtact gcctaccacaatcacaaggaccagtccttgctgagcaatgcggtgcagtgtctgaatagt tgcagccgggaagggaaagagcttgaccctgatgtcttccaaagacttgtgatcactgcc cgctccattgcaatcatgagacccaacaacttggtgcatttcacagaaacaaaatcattg caccacgactcggaggtgacagaggatggacaaaagcatgtggatagtgagaactgtaat tttattgcacaactgatgaataacttctggaagctccatgccctaaaaccaaagaatgcc tttcttgctcctgcttgcttgcctggtctaactcatgtggaagcaacagtgaatgccttg gtagacattatccatgcatactgcacatgtgagctggattacatcaatgtagcctccaaa atctacatgcagatgttactgtgtcctgacactgctgtcagcttttcttgcaagcaggct ctgatcagagtgcttagaccaagaaacaagcgacgccatgtgacccttccatctccccca cgttccaacacacctatgggagacaaggatgatgatgacgacgacgatgcagatgacaaa atgcagtcatcagtgttgactggtggagaagagggtcgacaggagagccaagaacaaaat gaagtggaccatggcgactttgagatggtgtccgagtctatggtcctggagacagcagaa aatgtcaacaatggaaatccgtctcccctagaggctctgcttgctggagccgaaggtttc ccccccatgcttgacatacctcctgatgcagatgatgaaaccatggtagagttagcaatt gctctaagcctgcagcaggatcaacagggcagtagcagcagtgctcttgggcttcagagt ctaggcctgtctggccaggccccaagctcctcttcacttgatgctggcaccctgtcagac accactgcatcagccccggcatcagatgatgagggcagcacagctgctactgatggttcc acattgcggacctccccagctgagcacggcggcagcgtgggctcagagagtggaggttct gctatcgactctgtagcaggggagcacagtgtgtcaggtcgcagcagtgcatatggagac acaacagcagaaggccaccctgctggtccaggcagcgtgagttcaagcactggagccatt agtaccaccacagcccagcaggaaggtgaaggctcagaaggtgaaggagagactgaagga gacattcacacaagcaacaggttgcacatggttcgtcttatgctgctggagcgtttgctt cagcacctttctcagctccacaatgtaggtggagtgcaagctatcccttacatgcaagtt atcctcatgttgacctctgaccttgacggtgaggatgaaaaggataaaggtgctttggat gacctgcttgcacagctcattgccgagcttggtatgcacaagaaggatgtttccaagaag aatgagcgtagttccataaatgaagttcatttggtcatcatgaggctgctcagtgtcttc atgtctcgaacaaagtctggatccaaatcttcctctgagtcatcctccctcatctccaat gccacagcaactgccttgctcagcctgggttctattgactattgcctccaagtgctcaag tcacttctggaattttggaagagtcaacagggtgaagaagagccagtgactgccagccag ctcctccgcacacacacagcctcctctccccctgacatgagccccttcttcctgcgccaa tatgtaaaggggcatgctgctgatgtgtttgaagcctactcccagttgttgactgaaatg gtgcttcggctgccgtatcagataaagaaaattgctgacgccaacccacgtatcccacct cctgtatttgatcattcctggttctactatctgtctgaatatctgatgatacaacagaca ccattcgtcaggaggcaagtcagaaaactgttgctgttcatctgcggctcaaaggaaaaa tatcgtcagctacgagacctgcacactcttgactctcatgtgcgcagcatcaaaaagctt ctagaggaacagggcatcttcctccgggctggtgtggtcaccgcctcatctggctcagcc ctacagtatgacacactcatcaatctgatggaacacctgaaagcttgtgctgaaattgcc actcaaaggacaatcaactggcaaaagttctgcatgaaggatgactctgtcttgtacttc ttgctccaagtcagtttcttagtggatgagggcgtttccccagttttgctgcaactcctc tcctgtgctctgtgtggcagcaaggtgctggccagctcttcctctacctcatcctcattc tcaggtggagggtctggtagtgctggacagacaggagcctctcagtcctctcagagcaag tcttctagtaaaaagagcaaaaaagaagacaaagagaaagaaaaagatggggatggtgtt ggcagccaggaggatcagctttgtatggctctggtcagtcagcttaacaaatttgcagac aaggagacgctcattcagttcctacgctgtttcttgctggagtcaaactcatctgctgtg cgctggcaagcccactgcttggcgctgcatatctacaggaactctagcaaatctcagcag gagctgctgcttgaactgacttgggctatctggccagagcttcctgcatatggccgtaaa gctgcccagtttgtcgacctacttggttacttctcactcaaaacccctcaaactgagaaa aagctgaaggagtattcccagaaggctgtggaaatcctgagagcacagaaccatatcctg acaaatcaccccaactccaatatctacaacacactctctggattagtggagtttgatggc ttttatctggaaagtgacccctgcttggtgtgcaacaatccagaagttccattctccaat ataaaactgtcatccatcaaagtagacacccgctatacgaccacacaacaggttgtcaag ctcattggtagccacaccatcagcaaagtcacagtgaagattggggacctcaaacgcacc aaaatggtccgcaccatcaatctctattacaacaacaggacagtccaggcgatcgtggag ctgaagaataaacctgctcgttggcacaaagccaagaaagttcagctcaccccaggacaa acggaagtgaagattgaccttcccttacctatcgtcgcttccaacttgatgattgagttt tctgatttctacgagaactaccaggcttccactgagaccctgcagtgtccacgctgcagt gcttctgtaccggccaaccccggtgtgtgtggcaactgcggtgagaatgtgtatcagtgc cacaagtgcaggtctatcaactatgatgaaaaagaccccttcctgtgcaacgcctgtggt ttctgcaaatatgcccgatttgacttcatgctgtatgctaaaccatgctgtgctgtggat cctattgaaaatgaggaagacaggaaaaaggctgtgaccaacattaacaccctgctggac aaagctgaccgggtctaccaccagctgatgggtcaccggcctcagttggagagtctcttg tctaaagtcaatgaggcagcaccggagaagccccaggatgacactggagcaggagcagga cttggtacatcctctgctaatgtgaacagatacattcagcagctggctcaggaatacagt ggagattgcaagacctcatttgatgaactctccaagattatacagaaagtgcttgcatct cgtaaagagctcttggagtatgacctacaacaaagagaggctgccactaagtcatctcgg agcaacagtagccaccagcccaccttcactgccagtcagtaccgcgccctctctgtgctg ggctgtggccatacatcttcaaccaagtgttacggctgtgcctcagctgttacaggtcac tgcatcacactgctccgcgcactggccaccaatccagcccttcggcagatcctagtcctt cagggtctcatccgtgagctgtttgagtataacttgcgtcgaggtacagcagctatgagg gaggaggtgcgccagctggtctgtctccttactagagatcacccagaagctactcagcag atgaacgatctgatcattgccaaggtgtcagctgccctcaaaggtcactgggccaatcct gatctcgttagtaatttgcagtatgaaatgctgctgctgacagactccatttcaaaagag ggtggatgctgggaattacggttgcgttgtgccctcagcctgttcctcatgtctgtgaac ataaagacacctgtagtggtggaaaacatcacactgatgtgcctgagaatcctgcaaaag ctgattaagccccctgctcctactagcaagaagaacaaggatgctgctattgagtctctg actacagtcaggccctacagtaatgaaatccacgcccaggcccaactctggctcaaaaaa gatcccaaagcatcttatgaggcctggaaaaagtgtcttccagcaagatgtcaggaaacg atgtcaaaacctcaggggaaggctgagttacggaaacagtatctgcttgagaagtatgtg tggaagtggaagcagttcatgaggtctagaaaaggagaaggccttttcccacgcctgctt aaactgagccacaacaactggctgcgacaggttcttttcacacctgccacccaggctgca agacaggcagcttgcactattgtggaggcacttaccacaatccccagccgcaagcaacag gtcctggacctgctcaccagttatctggatgaactgagtgtcgctggagagtgtgcagtg gagtatctcggcctgtaccagaagctgattaagccaacacactggaagatttatctggct gcccggggagtcctaccctacattggcaacctgatcaccaaggaaatagccaatctgttg gctcttgaggaggctacactgagcacagacttgcagcaaggctacgccctcaagagcttg actggattgctgtcatcttttgtggaagtggagtccattaagcggcatttcaaaagtagg ttggttggcacggtgcttaatggttatctgtgcctgaggaagttggtggttcagcgaact aaactcattgatgaaactcaggatatgctacttgagatgctggaagacatgacgacagga accgagtctgaaaccaaagctttcatggcagtgtgcatagagactgcaaagcggtacaac ctggatgactacagaacacctgtgttcatttttgagagactctgcagcatcatctatcct gaagagaatgaggtgacagagttctttgtgactctggaaaaggatcctcagcaagaggac ttcttgcagggtcgcatgccaggaaacccctacagcagcaacgagcccggcatcggtcct ctgatgagagacatcaaaaacaagatctgccaagactgcgacctggtggctcttcttgaa gatgacagtggcatggagcttctggtaaacaacaaaatcattagtttggatttgtcagtg gcagaggtctataagaaggtgtggtgtcctacaaatgagggtgagccaatgagaatcatc tatcgcatgagaggactacttggagatgctactgaggagttcatagagtcactggattca actacagatgaggaggaggatgatgaagaagtgtacaagatggcaggagtgatggcacag tgtggaggactcgagtgtatgctcaaccgcctgtctggaatcaaagactttaaacaagga agacatctgctcaccgttttgctgaagttgttcagttactgtgtgaaggtgaagatcaat aggcagcagcttgtaaaaccagagatgaacacactcaacgtcatgctgggaactctaaac ttggccttggtggcagaacaagagagtaaggatagtggtggagcctccatagcagagcaa gtcctgagcatcatggagataattctggatgaggccaatgctgagatttcagaggacaag ggtaaccttctgctcacaggagacaaagatcagcttgtcatgttgttagaccagatcaac accctgtttgtgcgctccaaccccagcgtgctccagggtcttctgcgcattattccatac ctgtcatttggcgaactggagaagatgaggattttggtggaacgcttcaaaccatgttgc aactttgacaagtacgacgaggagcatagtgctgatgacaaagtgtttttggactgcttc tgtaaaatcgctgctggaatcaaaaataacagcaatggccatcaactgaaagatcttatt ctgcaaataggaatcacacagagtgcactggactacatgaagaaacatatcccaaatgcc aaaaatctggatgctgatgtctggaagaaattcctctctagacctgctctaccctttatt ctcagacttctccgtggtttggctacccagcatccccccacacaggtcctcataggcaca gattcaataacaaacttgcacaagctggagcaggtatccagtgatgaaggcataggaact ctagcagagaaccttctagaggctctgagggaacacagtgatgtcaacttgaagattgaa gcagcccgcagagaaaccagagctgagaaaaagcgcatggctatggctatgaggcagaag gctctgggaactcttggcatgacgaccaatgaaaaggggcaggtggtgacaaagacctca ctgttgaagcaaatggaagagctgatagaggaaccaggcttgacctgctgtatctgtaga gaaggttacaagttccagccaaccaaagtcctgggtatttacactttcacaaagcgtgtg gccttggaggaatttgaaaacaagcctcgcaagcagcagggctacagcactgtgtcgcac tttaacatagtccactatgactgccatctggcagcagtcaggctggctcgtgggcgagag gaatgggacagtgctgctctccagaacgctaacaccaagtgcaatggcctgcttcctgtg tgggggccacatgtgccagaatcagcctttgctacatgcctagcaaggcacaacacatat cttcaggagtgcacaggccagcgagagcccacataccaactcaacatccacgataccaaa ctgctgttccttcgctttgctaccgagcagtcattcagcgtggacacaggaggcggaggt cgagagagcaacatccacctcatcccctacatcatccacactgttctctatgtcctcaac actacaagggctacgtcccgagaggagaagaacctgcagagtttccaggagcagccatgt gagaaatgggttgaaagctcatatgaagttgaagggccccactattacaccatcctggcc atgcacatcatgccacccgaacggtggagaagttctcgtctgtacttcctgcggagactt ctggtcaccgcgcatgcccgtaaagtctcagcagcctgtgcaaacaaagtcacagataaa acaccaaaggaatatgcagtgtatcgctcacctcttctcttctggggcctggtggacctg gtctacgacatgttcaggaaagtaccaaccagcaacacagagggcggctggtccttctca ctggcagaatatgtccgtcacaatgacatgcccatctatgaggcctcagagcgtgtgctc agggctttccaggatgaactcatgcctgctgaatccctgtcagagttctttgatgttgta ggtctcctctctgaaattccagacccggatctcttcctgcaggatttgttgaactctttg ccctaa

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