Oreochromis niloticus (Nile tilapia): 100693556 Help Entry 100693556         CDS       T06104                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism onl  Oreochromis niloticus (Nile tilapia) Pathway onl04020   Calcium signaling pathway onl04260   Cardiac muscle contraction onl04261   Adrenergic signaling in cardiomyocytes onl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:onl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100693556 (ryr2)    04020 Calcium signaling pathway     100693556 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     100693556 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     100693556 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:onl04040]     100693556 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:onl04990]     100693556 (ryr2) Ion channels [BR:onl04040]  Voltage-gated cation channels   Ryanodine receptor    100693556 (ryr2) Domain-containing proteins not elsewhere classified [BR:onl04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100693556 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 GET2 Motif Other DBs NCBI-GeneID:  100693556 NCBI-ProteinID:  XP_025765576 Ensembl:  ENSONIG00000007187 LinkDB All DBs Position LG8:complement(27631577..27899450) Genome browser AA seq 4966 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTQENADGMAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GDEQRRTVHYEGGAVSCHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSMVEDK SLLLMDKEKADVKSTAFCFRSSKEKLDLGVRKDVDGMGTPDIKYGDSVCYIQHVDTCLWL TYQTVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNCFIRG LDILRKKGRSFTLDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFAEAVGKEAGEAWSAILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEACSGILEVLHCVLVESPEALNIIKEEHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHISSMRPNIFLGVSEGSAQYRK WYYELIVDQVLPFVTAEATHLRVGWGNTNGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVSSPNQHLLRSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQDQTATRDLLGPTVT LSQAAFTPIPVDTSQIILPPHLERIREKLAENIHELWVMNKIELGWIYGAVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKNMKLSSTYELSSGY KPAPLDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYT LLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAESGLSNMSAERFRIFRAEKTYCVN TGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAWQ IGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEVGEGFIPVCSLGVCQAGRMNF GKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWVSKRLPQFVPVPPHHQHIEVTRIDETT ESCPCLKVTQKSFGSQNSYTDITFYRLSMPIECAETRSPPNGSLFSPKRELEDFENVSDF EVLMKSSHSHNGPNGPERDEFNNHKDYNQEKPSKLKQRLTLKRNKPDNSCPSSARVSEEV MADDRVSADFLMQASTYYYSVRIFPGQEPSSVWVGWVTSDFHQYDPCFELHKVRTVTVTL GDEKGKVHESIKRSNCYMVWGGESSSPSQGRNNGLEIGCLVDTTNGLLTFTANGKELSTY YQVEPSTKLFPAVFAKATSPNVFQFELGHIKNVMPLSAGLFKSEKKNPVSQCPPRLHVQF LTPVLWSRVSNHFLKVSVSRANDRHGWLVQCNKPLQFMSLHIPEENRSLDILELSEQKDL LKFHYHTLRLYSAICALGNNRVAHALCSHMDEAQLLYAIENKYMPGLLRAGYYDLLIDIH LSSYATARLMMNNEYIVPMTNDTKSITLFPNEKKKHGLPGIGLSTSLRPRMHFTSPNFVS RPGPSCSNNGNSGSGDCFQYSPEFPLHILKVKTIEMLTEAVREGSMHVRDPVGGSTEFLF VPLIKLLYTMLIMGVFQNGDLKNILRLIEPSVFCERRNEQDARCMELEVLKKGEAEGGGK EGVLNVPKEGLLEMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQENQRF RYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEYIREQLLDFHED LMRHCGIELDEERGISCDSDFTIRGRLMSLVEKVAYLKKKMANLPKEKKDRKPSTLQQLI SDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDTINLLAA LGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGG DSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDV AAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWNPVEGERYLDFL RFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIKISQDPSRDGP SPMSESSKALSDMPGEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIR AILRSLIPIEDLVGVISIPFSMPNLAKDGLVVEPDMSAGFCPDHKAAMVLFLDRVYGIED QNFLLHLLEVGFLPDLRSAASLDTVALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEP FASLIDSLLHTVYRLSKGCCLTKAQRDSIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLN EHTKMPLKLLTNHYERCWKYYCLAGGWGNFGVASDEELHLSRKMFWGIFDALSHKQYDQE LFKLALPCLSAVAGALPPEYMESNYMAMMEKQSSMDSEGNFTPQPADTTNVTVPEKLDYF ITRYAEHIHEKWCIEKFSNGWSYGDQMCEISKNHPLLKPYKSLSEKDKETYCWPIRESLK TMLSWGWSIDRIREGDSVNLHNKPRRISQASQLSFEGASAFSPRPTDMSNVTLSRDLQSM AELLAENYHNIWARKKKLELEARGGGNHPLLVPYDTLTAKEKSKDREKAQDILKFLQING YIVSRGVQSQELDTPAIEKRFAYTFLQQIITYVDQAHQHMMEFDVGTRPKGEKIPHEQQI KFFGKVVLPLVDQYFKNHRLYFLSTAIHPICSGGHASNKEKEMVTSLFCKLGVLVRHRIS LFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDSAAKDLEKTQENLKLGQF THSRDQPRGATQIINYTTFALLPVLSSLFEHIGQNMFGEDLILGDVQVSCYRILNSLFLL GTNKSIYVERQRPAMGKCLAAFAAAFPVAFLEPHMNKFNSFSIYNSKGSKDRAALGLPGQ VGEVCSLIPNLEKSLEEIVELAESGMKYTQMPHVMEVVLPMLCSYMSHWWEHGPESDPDK ANNCCTSVTSEYMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFL PLMEKLKKKAAVVLMDEEHSKAEGRGEMSETELLIMDQFTILVRDLYAFYPLLIRFVDYN RARWLKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKCKMS KGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELIALAKNRFTQKD TEDEVREVIRNNLHLQGKSEDPAIRWQMALYRDLPNHYEDTTDPEKTVERILDIGHVLFH LEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETE EHYFEDKLIEDLAKPGEQEPSEEEEGQKHKHIDPLHQLIQLFSRTALTEKCKLDEDHLYM AYADIMAKSCHDEEDDDGEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEM GPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQ NKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNN TTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQ GPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSM LEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDGFKEYDPDGKGVISK RDFHKAMESHKHYTQSETEYLLSCAEPDENELLDYEEFVERFHEPAKDIGFNVAVLLTNL SEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQV KESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAMKEESEREKPD EESPDVGFFSVTTVYMALLALRYNIMLLIKVLSVKSLKKQMKKIKNMTVKDMVTTLVSTY WSVLLGLLHVAFNVARGFCRIFYNTFIGENLVEGAKTIKVSELLANMPDPTQDEVRGEGE NREKRSSDHSSTGEDLADLTVNTSETELLSDIFGLDLRREGGQYKITPHNPNASFTELLN SPVPLPTPSTAPQPEVRWRHQSKSSASEEMESKLESKCEPQKTSESDDVEKQEKQSKNET MKPKMRRHHTSKSDEPDVQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFIL LFYKVSTSSSVTEEREVAHTSHSESSIQWDPLGGATVDAKEEVMDQTSMPQKPVTVRFVL EESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQP SEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGLDKAALDFSD AHKKRKPRKDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAA HLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGEL PDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAI IQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFF LMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14901 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagaaggcgaggatgaaatccagttcttgcgtactgatgatgaagtg gtcttacaatgctcagctacaatccacaaggagcaacaaaaactttgtcttgctgctgaa ggctttgggaacagactctgcttcctcgagtccatttcaaactccaagaatgtacctcca gatctgtcaatctgcacttttgtgctggagcagtcgctgtctgtacgagccctgcaggag atgctggccaacacccaagagaacgcggatgggatggcccagggaggaggtcataggact ctactgtacggacacgctgtgctcctgcgacactcctacagtggaatgtacctgtgttgc ctgtccacctcgcgttcatccacagacaaactggcttttgacgtggggctgcaggaagat accacaggcgaggcatgctggtggaccatccatccagcatcaaagcagcgctcagaggga gaaaaggttagagtgggagatgatctcatcctggtcagcgtctcctctgaaagatatctg cacctgtcctatggtaatggcagtctccatgtcgatgcagccttccagcagacactgtgg agtgtggctcccatctgttctgggagtgaagtagcacaaggtttccttattggaggagat gttctgcgcctacttcacggtcacatggacgagtgcctaacagttccttctggggagcat ggagatgagcaaaggcggacagtgcattacgaaggcggagcagtgtcctgtcatgccagg tcactgtggaggctggagacactgcgagtcgtgtggagtgggagtcatatccgttggggt cagccattcagactgagacatgtgaccacagggaagtatctgagcatggtagaagacaag tctctgttgctgatggacaaagagaaagctgatgtcaagtctacagccttctgcttcagg tcttccaaggaaaagctggacctgggtgtgaggaaggatgtggatgggatggggactcct gacataaagtatggtgactctgtgtgttacattcaacatgttgacacctgtctgtggctt acttaccagactgttgatgccaagtgtgcacgcatgggtggagtacagagaaaggcaatc atgcatcatgaggggcacatggatgatgggctgacactatcgcgatcacagcacgaggag agccgcactgcaagggtcatccgcagtactgtcttcctgttcaactgcttcatcaggggt ctggacatactaagaaagaaaggaaggagctttactttggatctgccaatagactcagtt agcctgagcctccaggatctaattggttacttccaaccgcctggagatcacctagaacat gaagacaagcagaaccgactgcgagctctgaagaaccgtcagaacctctttcaggaagag gggatgatcagcctggtcttggagtgcattgatcggcttcacgtctacagtagtgcagct cattttgcggaggcagttggaaaggaggctggagaggcctggagcgccattctcaactcc ctgtaccagctactggctgcactcatcagagggaacaggaagaactgtgcccagttctct ggttcactggactggctcattagcagactggagcgactggaggcttgctctggtatattg gaggtgcttcactgtgtactggtggagagtcctgaagcacttaacataatcaaagaggaa catatcaagtctatcatatctctgttggacaaacatggtcggaaccacaaggttctagac gtgctatgttcattgtgtgtgtgtcacggcgtggcagtgcgctctaaccagcacctgatc tgtgacaacctgctgccaggaagagatttattactgcagacccgcctgatcaaccacata agcagcatgcgtcccaacatctttttgggcgtcagtgagggctctgcccagtacaggaag tggtactacgagctgattgtggatcaggttttgccatttgtcacagcagaggccactcac ctgagggtgggttggggcaacaccaatggctatgcaccgtaccccagtggaggagagggg tggggaggcaacggagtgggtgatgacctctattcctatggctttgatggactccatctt tggtcaggctgcattgcgcggactgttagctcacccaatcagcatctccttcgatcagag gatgtggtgagctgctgcctggacctcagtgtgcccagtatctccttcagaatcaatggc cagccggttcagggcatgtttgagaacttcaactctgatggccttttcttcccagtggcg agcttctctgctggggtcaaggtgcgatttctccttggtgggcgtcatggcgagtttaag ttcctccctcctcccggttatgccccttgctatgaagcagtgttgcccagggagaagctg aaactggaggctagtcaggatcagactgccaccagagacctgctgggacccactgtcact ttgagccaggcagcattcaccccgatacctgtagacaccagccagattattttgccacct cacttggaaaggatcagagaaaaactagcagaaaacatccatgaactctgggtgatgaac aagatagaattaggctggatctatggtgcagtgcgggatgataataagcggcagcaccca tgtctggtggagttctccaagcttcctgaacaggaacgaagctacaatctacagatgtct ctggaaactctcaaaactctcctggctctgggttgccatgttggcctagcagatgaacac gctgtagagaaagtcaagaacatgaaactttcatcaacctatgagttatccagtggttat aaacctgctcctctggatctgagtcacatcaaattgacctccacccaggaagctatggtg gacaagctagctgagaatgcacacaatgtttgggcaagagatcgcatccgccagggctgg acctatggcatacaacaggatgtaaagaaccgtagaaaccctcgtctggtcccctacact ctgctggatgagagaaccaaaaagtccaacaaagacagtctgagagaggctgtcaggact ctcctgggatatggatacaatcttgaagctcctgaccaagaccatgctgaatctggcttg agtaacatgtcggctgagaggttccgcattttcagagcagaaaaaacatactgtgttaat actgggaagtggtactttgagctggaggttctaacagctggagagatgagggtcggctgg gccaggccaggatgtctaccagaccaggagctgggctctgatgatcaggcatttgtcttt gatggcttcaaggtgcagcgctggcaccaaggtaatgaacactttgggcgagcctggcag ataggagatgtggtgggctgcatggtggatctgaatgagcacaccatgatgttcacactg aatggagaagtgctgctggatgattctggatcagagctggccttcaaggactttgaagtc ggtgaaggttttataccagtttgcagtctgggtgtgtgtcaggctgggagaatgaacttt ggtaaagatgtcagcactttaaagtacttcaccatttgtggcctacaagaaggctatgag ccttttgctgttaacatgaaccgggatgtcaccatgtgggttagcaagaggctccctcag tttgtaccagtacccccccaccaccaacacatcgaggtgacgaggatagacgagacaaca gagtcgtgtccatgcctgaaggtcactcagaagtcctttggctcacagaacagctacacc gacattaccttctacagacttagcatgcccatagaatgtgccgaaaccaggagcccacca aacggcagcctcttctcaccaaagagggagttggaggactttgaaaatgtgtcagacttt gaggtcctgatgaagtcatctcacagtcataatggtcccaacggacccgagagagatgaa ttcaacaaccacaaagattataaccaggagaagccctccaagctcaaacagcggttgacg ctgaagagaaacaagccagacaacagctgtccctcatctgctcgtgtatcggaggaggtg atggctgatgacagagttagcgctgatttcctcatgcaagcctccacttactactattca gtgcggatcttcccaggtcaggagcccagcagtgtttgggtaggctgggtgacttctgac ttccatcagtacgacccgtgctttgagctgcacaaggtccggactgtcacggttaccctg ggagatgaaaaaggcaaagttcatgagagcataaagcgcagcaactgttacatggtgtgg ggtggagaaagcagcagccccagtcaggggaggaacaacggcttagagattggctgtctg gttgacactacaaacggtctgctgacattcacagccaatggcaaagaactcagcacatac taccaggtggaacccagtactaagctcttccctgcagtctttgcaaaggccacaagtcct aatgtcttccagtttgaactgggtcatattaagaatgtgatgcctctatcagctggtctg tttaagagtgagaagaagaacccagtttcccagtgtcctccacggctacacgtacagttt cttactcctgttttatggagtcgcgtttccaaccacttccttaaggtctcagtatccaga gcaaatgatcgacatggctggctggtgcagtgtaacaaacctctgcagttcatgtctctg cacatacctgaggagaacaggtcgttggatatcctagaactgtcagagcagaaggactta ttaaagtttcactaccataccctcagactgtactctgccatctgtgctctgggaaacaac cgagtagctcatgccctctgctcccacatggatgaggcacagctcctttacgctatagag aataaatatatgccaggtcttcttcgtgctggctactatgacctcctcatcgacatccac ctgagcagctatgctacagctcgcctcatgatgaacaacgagtacattgttcccatgacg aatgacacaaagagcatcactctgtttccaaatgaaaagaagaaacatggcctgccaggc attggactcagcacctctttgagacccagaatgcacttcacatccccaaattttgtatcc aggcccggaccatcgtgctctaacaacggcaacagtggatcaggagattgtttccagtac agccctgaattccccttacatatactgaaagtgaaaaccattgagatgttgacagaggca gtacgggagggaagcatgcacgtacgggacccagtaggaggaagcactgagtttctattt gttccactcatcaagctgttatatactatgctcatcatgggcgttttccaaaacggagat ctgaagaatatcctccgactgattgaaccttctgtgttctgcgaacgacgcaatgagcag gatgcacgttgcatggagttggaggtcctaaagaagggtgaagccgaaggaggaggaaag gagggggtgctgaatgtccccaaagaaggactattagagatgaagctgccagagcctgta aaactccagatgtgtcatgtgctacagtacctgtgtgactgtcaggtgcgccatcgtatc gaggcagtggtggccttctctgatgactttgtggcttgcctccaagaaaaccaacgattt cgttacaatgaggtgatgctggcactcaacatgtctgcagcccttactgccaagaagacc aaagagttcagatctcccccacaggaacagatcaacatgctgttaaactttaaggatgag aagcaggagtgtccctgtcctgaatacatccgagaacagctgctagacttccatgaagat ctgatgaggcactgtggtatagagttggacgaggagagaggcataagctgtgacagtgac ttcaccatacgaggtcgactcatgtcactggtggagaaagtggcttatctaaagaagaag atggccaacctgccaaaggaaaaaaaagacaggaaacccagtaccttacagcagctcatt tctgatacgatggtgcgctgggctcaggagtcagttatagaggatccagagctggtcaga gctatgttcgtcctacttcaccgccagtatgatggcattggtggacaggtgcgggctctt cctaaaacctacactataaactcagtatcaatcgaggacaccatcaacctgttagcggct cttggtcagatcagatctctgctgagtgtgcgaatgggaagagaggaggagaaactgatg atcagaggcctgggagatatcatgaacaacaaagtgttttaccaacatcctaacctgatg agagcgttgggaatgcacgagactgttatggaggtcatggtcaatgtgctcagtggagga gactccaaggaaatcacctttccaaaaatggtggccaactgttgtcgttttctatgttac ttctgtcgaatcagccgtcagaaccagaaagccatgtttgaccatctgagttatctgctg gagaacagcagtgttggcctggcatctccatctatgcgaggatccactcccctggatgtg gctgcagcatcagtcatggataataatgagcttgcccttgctttaagagagccagacctg gagaaggtggtgcaatatctagctgggtgtgggctgcagagctgtgtgatgctggtccgt aagggataccctgacattggctggaaccctgtggagggggaacgataccttgacttcctg cgctttgctgtcttctgcaatggtgaaagtgtggaggagaatgccaatgttgtggtaagg ctccttattcgtcgaccagaatgttttggcccggctcttcgaggtgaaggcggtgacggg ttattggcagcaatggaggaggccattaaaatctctcaggatccctccagagatggtccg tctcctatgtctgagagcagcaaggcactcagtgacatgccaggggaagaggaagatgat actattcacatgggaaatgccatcatgaccttctacgctgctctcattgacctgctgggc cgctgtgctccagagatgcatctgatccatgctggtaaaggtgaagctatccgtatcaga gccattttgaggtctcttattcctattgaagacttggtgggagtcatcagtattccattc tctatgcctaacctggctaaagatgggttggttgtggagccagacatgtcagcaggtttc tgcccagaccacaaagcagccatggtgctgttcctggaccgtgtctatggtatagaagac cagaattttcttctccaccttttggaggttgggttcttaccagacctgaggtctgccgcc tctctggacactgttgctctgagtgccacagacatggcactggcactcaacaggtatctg tgtacagcagtgctgcctctcctgactaaatgtgcgccactgtttgcggggacggagccg ttcgcctcactaattgactccctgcttcatacggtttatcgcctgtccaaaggctgctgc ctcaccaaagctcagagggactccatagaggagtgtctgcttgctgtttgtggtaagcta aggccttcaatgatgcagcacctactcaggaggctggtgtttgatgttcctctacttaat gagcacaccaagatgcctctgaagctgttgaccaatcactacgagcgttgctggaagtac tactgtttggctggaggttggggcaattttggagtagcatcagatgaagagctgcacctc tctaggaaaatgttctggggaatatttgatgccctgtcccacaagcagtacgaccaggag ctatttaaactggcgctgccatgtcttagtgctgtggctggagctcttcctccagagtat atggagtccaactacatggccatgatggagaaacagtcgtctatggactcagaaggaaac ttcacaccacagcctgcagacaccaccaatgtgactgttccagagaaactggattatttt ataaccagatatgcagagcacatccatgagaagtggtgtatagaaaagttttccaatggc tggtcatatggagaccagatgtgtgaaatcagcaagaaccatccactcctgaaaccatac aaaagcctgtctgaaaaggataaagagacgtactgctggcccatcagagagtctctgaag accatgctttcatggggttggagcattgacaggatcagagagggagactctgtcaacctt cacaacaagcccagaaggatatcacaggccagtcagctttcttttgaaggagcttcggct ttcagtccaagacccactgatatgagtaatgtgacattgtccagagacttgcagtcaatg gcagagctgcttgcagagaattatcataatatctgggccaggaaaaagaaactggagctg gaagccagaggtggaggaaaccacccactgctggttccttacgacacattgactgccaaa gaaaaatccaaagacagagaaaaagcacaagatatccttaagttcctccaaatcaatggt tacattgtgtccagaggtgtgcagtcacaggagctagacactcctgccatagagaaacga tttgcctacacctttctccagcagatcatcacctatgtggaccaggcacaccaacacatg atggagtttgatgtgggaacacgaccaaagggagagaagattcctcatgagcagcagatc aagttctttggaaaggtcgtcctgccgttggtggatcagtactttaaaaaccacaggctg tacttcttgtccacggccatccatcccatctgcagtggtggccatgcctctaacaaggag aaggaaatggtgaccagtcttttctgcaaactgggagttcttgtcagacataggatatcc ttgtttgggaacaatgccacttccattgtcaactgtctgcagatactgggacaaagcctg gatgccaggacagtgatgaagacgggcctggagtcagtgaaggcggctttacggtcatac ttcgacagcgcagcgaaggatctggagaagactcaggagaacctgaagctcggtcagttc actcacagcagggaccaaccacgaggagcaactcagatcatcaactacaccaccttcgcc ctgctccccgtcctctcctcactgtttgaacacatcggacagaacatgtttggagaagac ctcattttgggtgatgtccaggtttcctgctacagaatccttaacagcctcttccttctg ggaaccaacaaaagcatctatgttgagagacaacgtccagcaatgggaaagtgtttagca gccttcgcagcagcattccctgttgcctttcttgagcctcacatgaacaagtttaacagc ttttccatctataacagcaaaggaagcaaagacagagcagctctaggccttcctgggcag gttggggaggtttgttcactgatccccaatttggagaagtctttggaggaaattgtagag ctagcagagtccggcatgaagtacacacagatgcctcatgttatggaggtggtcttgccg atgttgtgcagctatatgtctcactggtgggaacatggaccggaaagcgacccagacaaa gccaacaactgctgcacctctgtgacctctgaatacatgaacactctgctgggaaacatt ctcaagatcatctacaacaacctgggaatagatgagggcgcctggatgaagagactggct gtcttctcccagccaattatcagcaaagccaaacctcagctgttaaagacccacttcttg cccttgatggagaaactcaaaaaaaaagcagctgttgtgctgatggatgaagaacatagc aaggcggaggggaggggtgagatgtcagagacagagcttctcatcatggaccaatttact atcctggtcagagacctgtatgccttctaccctctcctcatacgattcgttgactacaac agggccagatggcttaaagagtccaatccagaggcagaggagctgttccgaatggtggct gaggtttttatcttctgggccaagtctcacaacttcaagagagaagagcagaactttgtg gtccagaatgaaattaacaacatgtccttccttatcactgacaccaagtgcaagatgtca aagggaatagtttcagaccaggagaggaagaagatgaagagaaaaggtgatcgatactcg atgcagacaagtttgattgttgctactctaaagcgcctgctgcccgtgggactcaacatt tgtgctccaggagaacaagagcttatcgcactggctaagaaccgcttcactcagaaagac acagaggacgaagttcgagaggtcatcaggaacaacctacatttacaaggaaagtcagag gacccagcaattcgttggcagatggctctgtacagagacctcccaaaccactatgaggat actactgacccagagaagactgtggagagaatcctggatattggtcatgtcctcttccac ctggagcaggtggagcatcctcagcgcagtaagaaggctgtgtggcacaaactgctttca aaacagaggaagagagctgtcgtcgcttgcttcaggatggcaccactctataacttgcca aggcaccgggctgtaaacttgttcctgcagggctatgaaaagtcctggatcgagacagag gagcactactttgaagataaactcatagaagacctcgctaaaccaggtgaacaagagcca tctgaggaagaggaggggcagaaacacaaacacatagatcccctgcatcagctcatccag ctgttcagcagaacagccctaacagaaaaatgtaaactggatgaggatcatctctacatg gcctacgcagacatcatggctaagagttgccatgatgaagaggatgacgatggagaagtg aagagttttgaagaaaaagagatggagaagcagaagctgttgtatcagcaggctcggctg cacgaccgtggcgctgctgagatggtgctccaaaccatcagtgctagtaaaggtgagatg ggtcccatggtggcatctactctgaaactgggcatagctattctcaatggtgggaactca accgtacagcagaaaatgttagattatttgaaggacaagaaggacgtgggcttctttcag agtctggctggtctcatgcagtcatgcagtgttctggatctaaatgcatttgagaggcaa aataaagcagagggactgggaatggtgacagaggaaggatcagtcatcactcatgagcgt ggtgagaaggtcatgcaggatgatgagttcacttgtgaccttttccgcttcctgcagctg ctctgtgaaggacacaactcagactttcagaactacttgaggactcaaacggggaacaac acaaccgttaacatcattatctccactgttgactaccttctaagagttcaggagtccatc agtgatttctactggtattattctgggaaagatgtgattgatgagcagggccagcggaat ttctccaaggcaataaatgtggccaagcaggttttcaataccctcactgagtacatccag ggtccatgcaccggcaaccagcagagtttagcccatagtcgactgtgggatgctgtggtc ggctttctacatgtttttgctcacatgcagatgaaattgtctcaggactccagtcagatc gagttactgaaggaactgatggatctgcagaaagacatggtggttatgctgctgtctatg ttagagggtaatgtggtgaatgggaccattggaaagcagatggtggatatgttggttgag tcctccaacaatgtagagatgatcctgaagttcttcgacatgttcctgaaactgaaggac ctgacctcctcagatgggttcaaggaatatgaccctgacggaaaaggtgtcatctccaag agggactttcataaggccatggagagccataaacactacacccagtcagagacggagtac ctgctgtcatgtgctgaacctgatgagaatgaacttcttgactatgaagagtttgtggag cgctttcatgagccagccaaagacattggcttcaacgtggcggttttgctgaccaacctg tcagagcacatgcctcatgacacccggctgcagactttcctggagttggcagaaagtgtc ctcaattacttccaaccatacctaggccgtatcgagatcatgggaagtgcaaagcggatc gagagagtctactttgagatcagcgagtccagtcgtacacagtgggaaaaacctcaggta aaggaatccaagcgtcagttcatctttgatgtggtgaatgaaggaggggagaaagagaag atggagctgtttgtgaatttctgtgaggacaccatatttgaaatgcagctggcggctcag atgtctgacgctggcgagcgctcggcgatgaaagaggagagcgagcgtgagaagccagat gaggagagccccgatgtgggtttcttttctgtcaccactgtctacatggcactactagca cttcgatacaacatcatgctgctaataaaggtactgtccgtgaagagcttaaagaagcaa atgaagaagataaagaacatgactgtgaaggacatggtaaccaccctggtctccacctac tggtcggtgttgttgggcctcctccatgtggcattcaatgtggctcgaggattttgcaga atcttctacaacactttcattggagaaaacctggtggagggggccaagaccataaaggtg tcagagctgttggccaatatgccagaccctactcaggacgaggtacgcggtgagggggag aacagggagaaaagatcatctgatcacagctcaaccggggaagacttggctgacctgaca gtcaataccagtgagacagagctgctgtcagacatttttggtctggacttaagaagggaa gggggccagtacaaaatcaccccccataaccccaatgccagctttactgaacttctcaac tccccggttccccttccaactccatctacagcaccccaacctgaagtcagatggagacat cagtcaaagagctctgcctcagaggagatggaatcaaaactagagagtaaatgtgaacct caaaaaacatctgaaagtgatgatgtagagaaacaagagaaacagtcaaagaacgagaca atgaaaccaaaaatgaggaggcatcacacctcaaagtctgacgaacctgatgttcaggag tcagctttcttaaagaagatcattgcctaccagaggaaactgctgaactacttcgccaga aacttttacaacatgaggatgttggctctgtttgttgcctttgcaataaactttatcctt ctgttctataaggtttctacatcctcatcagtgactgaggagagggaagttgcgcacacc agccattcagagagcagcattcagtgggatccactaggtggagcaactgtggatgcaaag gaagaggtgatggatcagaccagcatgccccagaagcctgtcaccgttcgttttgtcctg gaagagagcagtggctacatggagcccatgttacggatccttgctgtcctgcacacggtc atctccttcttctgcatcattggatactattgtcttaaggtgccactggtgatctttaag cgtgaaaaggaggtcgctaggaagctggaatttgatggcctttatataacagagcaacca tcagaagatgacatcaaaggacagtgggacagactggtaatcaacacacaatctttcccc aataactactgggataaatttgtgaagagaaaggtgatggataaatatggggagttttat ggccatgaccgaatcagtgagctgctgggactggacaaagctgctctggacttcagcgat gctcacaaaaagagaaaacccaggaaagacagctcgcttgctgcagtattgaactctgtt gacgtcaagtaccagatctggaagctgggggttgtgttcacagacaattccttcctgtat ctggcctggtatatgaccatgtccattctgggtcactataacaacttcttctttgctgcc catctactggacattgccatgggttttaagacactgcgtaccattctctcctcagtcaca cacaatggcaaacagctagtgttaactgttggcctattagcagtggtggtgtacctctac acagtagtggccttcaactttttcaggaagttctacaacaagagtgaagatggagaactg ccagatatgaagtgtgatgacatgctgacatgttacatgttccacatgtatgtgggagtg cgagcaggtggaggaattggtgaccagattgaggatccagctggtgatgagtacgagatc taccggatcatcttcgacatcacgttcttcttctttgtcattgtaatcctcctggctatc atccaggggttaatcattgatgcctttggagagctgagggatcagcaggaacaagtgaaa gaagacatggagaccaaatgttttatctgtggaataggtaatgactactttgacaccgtg ccacacggctttgaaacgcacactctacaggagcacaacttagccaactacctattcttt ctgatgtatctcatcaacaaagatgaaacagagcacacaggccaggagtcttacgtatgg aaaatgtaccaggaacgttgttgggagtttttccccgctggtgactgtttccggaaacag tatgaggatcagctcaactga

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