Oreochromis niloticus (Nile tilapia): 100702813 Help Entry 100702813         CDS       T06104                                  Name (RefSeq) ryanodine receptor 3 isoform X4   KO K04963   ryanodine receptor 3 Organism onl  Oreochromis niloticus (Nile tilapia) Pathway onl04020   Calcium signaling pathway onl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:onl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100702813    04020 Calcium signaling pathway     100702813  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:onl04040]     100702813 Ion channels [BR:onl04040]  Voltage-gated cation channels   Ryanodine receptor    100702813 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 DUF1189 Med16_bridge Motif Other DBs NCBI-GeneID:  100702813 NCBI-ProteinID:  XP_019204642 Ensembl:  ENSONIG00000012087 LinkDB All DBs Position LG19:9302902..9408828 Genome browser AA seq 4877 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGAAQSGGHKTLLYGHAILLRHSFSSMYLAC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISSGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVTIPGSDQS EEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYLALTEDRG LVLQDRERSDTVATAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSICFIMHVATGLWLS YQAPDVKSARLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLFKRFIRDL DCLGVKNRALVALPVEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLFKQEGM LTLVSNCIDRLNVYNSAAHFGECAGSEAGAAWKDILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQYKKWY YELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWS GRIPRAVASMNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSF SAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDVDGVRDLLGTT QFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRDDNKRQ HPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRIVHMNPNAEDSLKKIKLPKNYMMSN GYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNPRLVP YALLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQEGGQVSERLSIDKIRFFRVERTYAV KTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGHCLNMGSRLFGRCW HAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLSQVGRMN LGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHNHIAVTRIDGT IDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKISPVVDMNGVHEEETLKVKHR YPLRSVRHSDESRRVDYSSITTYYHSVRVFAGQDPACVWVGWVTPDYHYYSNNFNLSKNR TVTVTLGDERGRVHESVKRSNCYMVWGGDVTSTSHTSGRSNVDLEIGCLIDLATGLLTFT VNGKEISTSYQVEPNTKLFPAVFVRPTSPSLFQFELAKIKNAMPLSSAIFKSEHKNPVPQ CPPRLDVQTINAVLWSRMPNSFLKVETARVNERHGWVVQCVEPLEMLAVHIPEENRCVDV MELSEQEDMKKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREG FYNVLISIHLETAKEARLMMKDEFVIPVTAETRSIRLFSDASKKHLPPGVGLSTSLKPRL NFTPPCFISTKREHLYSPQIPLDALKEKAILMLTEAVQSGGHHIRDPVGGCVEHQFVPIL KLISTLLTMGVLGSEDVRKILLLIDPNVFKEAREEGATGTTDKEGLTGAEEKAVEAGEEE AIKEAQQPMEGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSKLQYNQK FRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGEDCPCPADIQEELYDFHNQ LQLHCGIPMEEDEDEQDTSIKGRLLMLVNRIKGQAHKAEEPTKMEQAAPSNLKELISQTM VSWSQECHIQDPELVRKMFSLLRRQYDSVGELLRAMRKTYTISAASVQDTINLLASLGQI RSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGGDKSQE IAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAASS VMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFAV FVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDLPGSVQ GVSSDVSGDGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRS LVPTEDLVGIISIPLKMPITNKDGSVTEPDMSASFCPDHKAPMVLFLDRVYGVEDQSFLL HLLEVGFLPDLRAATSLDTEGLCTTETALAMNRYIGSAMLPLLTRCAPLFAGTEHYATLI DSTLHTIYRLSKGRSLTKAQRDAIEECLLSVCKHLRPSMLQQLLRRLVFDVPLLTDYCKM PLRLLTNHYEQNWKYYCLPSGWGSFGTASEDELLLTKKIFWGVFDSLSQRKYDPELFKMA MPCLSAIAGALPPDYVDASISTTVEKPVSVDAQGNFDPKPINTANIALPEKLEHFANKYA EHTHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRTYKGLTEKEKDIYRWPIRESLKSMLAM GWSIDRTKDGESMSQQRETEKMRKISQASQANGFNPSPIDTSNVVLSRELQGMVEVVAEN YHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLLINGYSITRGL KDLEQDSSSMEKRFAYKFLKKLLKCVDSAQEFITHLEAMAASGKTDRSPHEQEIKFFAKV LLPLIDQYFKNHSLYFLSSPNKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSDS TTMVSCLHILAHTLDTRTVMKSGSEQVRVGLRTFFENAAEDLEKTFENLKLGKFTHSRSQ MKGVSQNINYTTAALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYALGTGKNI YVERQLPALGQCLATLAGALPVAFLEPQLNPYNPCSVFNTKSARERATLGIQDSVEEMCP GMPRLDRLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPASGGSICC TTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLLKSHFLPTLEK LKKKTVKVVAEEELLKADCKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWL KEPDSDSNDLFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKTKMSKSGGQ DQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYLMKDTDDEV KDHIQQNLHLREKSDDPAVRWQLNLYKDIVMRTEGLSDPEKVVDRIQRISAAVFNLEQVE QPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLAYQRIWIETEEYSFE EKLVQDLAKIQPKVEEEEEEEVRKQPDPLHQLILHFSHNALTECSSLEEDPLYIAYADMM AKSCAEGEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISASKGRLGATVTV TLKLGISILNGGNILVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLDLNAFERQNKAEGL GMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNII ISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSKALAVAKQVFNSLTEYIQGPCIGN QQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMVVMMLSLLEGNVV NGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEYDPESKGVISKKDFQKS MENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAVLLTNLSEHMPH DARLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQ FIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPVERPEEEEDDIQTMMENQEE EDEESAMMESSSAFTIACISMRKSLCHFRQLLTLKSMRRQFRKFRKMSVKEMVRGFFSFF WMIITGLFHFVYSLIWGFFHILWTTMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVL ETEKMEASEASALAEMGQMAQGEAAEADLMAELLNIQPKKEGKHGAEPGLGDVSEVVVGD APSIASAVKQKKAQMAANTRAVNGDYRSDTEKGDSEDGEKKDHDKTRDEAPPELSVEEKK APKKRLGLKKEAPEAFMASFFAGLEVYQTKMLNYLARNFYNLRFLALFVAFAINFILLFY KVTGDYSDDEDPWNGRGRVGEEEDEGALEYFVLQESTGYMAPTLRCLAILHTIISFLCVV GYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKF VKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEASLVSWLSSIDTKYHVWKM GVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLT VGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDE IEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFI CGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWD FFPAGDCFRKQYEDQLG NT seq 14634 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggagaaggagaggatgagatccagttcctcagaactgatgacgaagtg gtgctccagtgtgtggcttgcatccagaaggagaatcgcaagttctgcttggctgccgag gggctcggcaatcgactgtgttacctggagcccacatctgaggcaaagtatgttccccca gacctttgcatctgcacctttgtgctggaacagtccctgtcagtgcgagccctgcaggag atgctggctaagagcggacagaacagcgaaggggcagcgcagagtggcggacacaagact ctgctgtacggacacgccatcctcctgcggcattccttcagctctatgtacctggcctgt ttgaagacatcaaggtcacagacagataagctttcctttgatgtcggcctgcaggaggat tcaacaggtgaggcttgctggtggacaatccatccagcctccaagcagagatcagaggga gagaaagtacgcatcggcgatgacctcatcctcgtcagcgtgtcctcagagcgatacctc cacttatccatctccagtggcaacatccaggtggatgcttccttcatgcagactctgtgg aacgtccatcccatctgctctggtagcaacatagaagaaggctacctgttaggtggtcac gtgatgcggctgttccacggacacgacgaggttgttaccatcccgggatcagaccagagt gaagagcagcagaggatagtcaactatgagacgggtaaagctggtgccaaggcgaggtcc ttgtggaggctggagccactccgaatcagctggagcgggagccacatccgctggggtcag cccttccggctacggcacctgaccaccggtcactacctggctctaacggaggacaggggg ctggtgctgcaggatcgggagaggtctgacaccgtcgcaacggccttctgcttcagagcc tctaaggagaagctggagcagagccccaagcgcgacatcgagggaatgggagtggccgag attaaatacggggactcgatctgcttcatcatgcacgtggccacgggtctctggctctcc taccaggcgcccgatgtcaaatctgctcgtctgggtcccctcaagagaagagcatgcctg cattctgaaggtcacatggatgatggattgaccctccagcgctgtcagcacgaggagtcc cgcgccgcgcgcatcatccgcaacaccacgcttctctttaagcgattcatcagagacctg gattgtctgggtgttaagaacagggcactggtcgctctgcccgtggaggaggtgctccaa acccttaatgacctcatcacttatttccagctccccgatgccgagctggagcacgaagaa aggcagatcaagctgcgctcgctcaaaaacagacagaacctcttcaaacaggaaggcatg ctgactctggtgtccaactgtattgaccgactgaacgtctataacagcgctgcacatttc ggggagtgcgcgggctcggaggccggagcggcctggaaagacattctcaacctgctgtat gagctgctggctgcgttaatccgagggaaccgcaacaactgcacacagttctccaacaac ttggactggctggtgagcaagctggagagactggagtcttcttcagggattctggaagtt ctgcactgcattttaatcgagagccccgaggcgctcaatatcatccagaaaggacacatt aaatccatcatatcgctgctgtacaagcatggacgcaaccacaagatactagatgtgctc tgttcactgtgtgtgtgtaacggcgtagctgtgcgaaccaatcagaacctcatctgcgat cacttgctgcccaagagagatctgctgttgcaaacccagctggtcaatgatgtccagagc atgagaccgaacatcttcctgggcgtgagtgaaggctcggctcagtacaagaagtggtac tatgaactcatgatcgaccaggtggaccactttgtgaccagcgagccctcccacctcaga gtcggctgggcgaacacaaaaggttatgcaccctacccgggaggaggagagggctggggt ggtaatggagttggtgatgatctctactcgtatggctttgatggactccacctctggtca ggtcgtatcccgcgggcggttgcgtccatgaaccagcacattctgacctcagaggacgtg gtgagctgctgcctggacctcggagcccccagcatatccttcaggatcaacggacagccc gtccagggcatgtttgaaaatttcaacacagacggactgttcttccctgtcgtcagtttc tccgcaggtgtcaaggttcgtttcctgttgggtggacggcacggtgactttaagttcctg cctccatcaagctacgcaccgtgttatgaggctctgctgccaaaagagaagatgaaggtg gagccggtgaaagagtataagagagatgtggacggagttcgagatctgctgggcaccacc cagttcatgtcgcaggcctccttcatccccacacctgtggaaaccagccagattgtcatg ccgcctcatttggagaaggttcgggacaagctggctgagaatatccatgagctctggggc atgaataagattgagcttggctggtcttatggcaagataagggatgataataagcggcag catccgtgcctggtggatttctccaagctgccggaaacggaaaaaaactacaatctgcag atgtcaacggagactctgaagaccctgctggcgttaggctgtcgtatagttcacatgaat ccaaatgctgaggactctctcaaaaagataaaactccctaagaactacatgatgtccaat ggttataagccgtcccctctggacctgtccgatatcaaactgactccggggcaggagctg ctggtggacaaactggcagagaacgctcacaatgtgtgggccaaggaccggatcaaacag ggatggacatacgggattcagcaggatcttaaaagtaagcgtaaccctcgcctggttcct tatgctctgctggatgaacgcaccaagaagtcaaacagggacagcctgcgggaagctatc cgcactctgattggctacgggtacaacatcgagccctcggaccaggaaggcggacaagtc tcggagcgcctcagcattgataagatccgcttctttagggtagaaagaacgtacgcagtg aagaccgggaagtggtacttcgaatttgaggcagttaccggtggagacatgagagtgggc tgggccagacctgggtgtaagccagatgtggagcttggcacagatgagcttgcgtttgtc tttgatggatacaggggccactgcctgaacatgggcagccggctgtttgggcgctgttgg catgctggggatgtggtgggctgcatgatcaacatggaggacaagtccatgatcttcacg ctgaacggggagatcctgatcaccaccaagggctctgagctctgcttcacggactttgaa actgaggatgggtttattccagtgtgtagcctcggtctgtcgcaggtgggtcgtatgaat ctcgggaaggatgctagcacctttaagtactacaccatgtgcggcttgcaggagggattc gagccatttgccgtcaacatgaatcgagaggtcacgatgtggttcagcaagcgtctgcct acttttgtcaacgtgccgaaagaccacaaccacattgcggtaaccaggatcgacggcacc atcgacagccctccttgtctcaaagtcacccacaagacatttgggacacagaacagtaac gccgacatggtgttttgtcgtctgagcatgcctgtggagttccactccttcttcaagatc agccctgtggtggacatgaacggtgttcatgaggaagaaacccttaaagttaaacacaga tatccactgagatctgtgaggcacagcgatgaaagtagacgagtggactacagcagcatc actacgtactaccattcagtgagggtcttcgcaggtcaggaccctgcctgtgtgtgggtt ggatgggttactcctgactaccattactatagcaacaacttcaacctcagcaagaatcga acagtgactgtaaccctgggcgacgaacgtgggcgagtccacgagagcgtgaagaggagt aactgctacatggtgtggggtggtgatgtcaccagcacttcccacacctccggtcgcagc aatgtggatctggagatcggctgtctaatagatttggccactggcctgttgacattcacc gtcaatggcaaagagatctctacgtcctaccaggtggaaccaaacaccaagcttttccct gccgtgtttgtgcgacccaccagccccagcctctttcagtttgaactggctaaaataaag aacgccatgcctctgtcatcagccatcttcaagagtgagcataagaacccggttccacag tgtccgccccgactggatgtccagaccataaatgccgtgctgtggagccgcatgcccaac agtttcctcaaagtggaaacggccagggttaatgagaggcatggctgggtggttcagtgc gtggagcccctggagatgttggcagtgcacatacctgaagagaacaggtgcgttgacgtc atggagctctcggagcaggaggacatgaagaagttccactatcacaccttgaaactgtac tgtgccctctgtgctctgggaaacactcgtgtggcccacgccctttgcagccacctggac caatcacagctcttatacacaatcgacaatcagtacctgtctggcatgttacgcgagggc ttctacaatgttctgattagcatccacctggagacagccaaagaggcgcgactcatgatg aaagatgagttcgtcattcctgtcacggccgagacacgctccattcgtctcttttctgat gcttctaaaaagcacctcccgcccggggtggggcttagcacctccctgaaacctcgcctc aactttaccccaccgtgcttcatcagcaccaaacgggagcatctgtacagtccccaaatc ccactggatgcactgaaggagaaagcgattttgatgttgacagaggctgttcaaagcgga gggcaccacatccgagatcctgtcggaggatgcgtggagcaccagtttgttccaatccta aagctcattagcaccttgctgacgatgggtgttttaggaagcgaggacgttcgtaagatt ttactgctcattgacccgaacgtcttcaaagaggcaagagaggagggagccacggggaca acagacaaagagggactaacaggggcagaggaaaaggcggtggaagctggagaagaggag gcaatcaaagaggctcaacagccaatggaaggactgctggagaagaggctgccagagccg gttaaacgacagatgtgcgagctgcttcactatttctgtgactgcgaactgaagcaccgt atcgaggccattgtgtccttttctgacagcttcgtgtccaagctgcagtacaaccagaag ttccgctacaatgagctgatgctggccctcaatatgtctgctgctgttacagcaaagaag accaaagagttcagatcaccgcctcaagaacagatcaacatgctgctgaacttcagtatg ggagaggactgcccatgccctgcagacatccaggaggaactctatgattttcataatcag ctgcagctccactgtggaatccctatggaggaagacgaagacgagcaggatacatcgatt aaaggtcgcctccttatgctggtgaacaggatcaaaggccaggcgcacaaagcagaggag cccacgaagatggagcaagctgcaccctccaatctgaaagagcttatctctcagaccatg gtcagctggtcccaggagtgtcacatccaggaccctgaacttgttcgcaaaatgttcagc ctgctgaggaggcagtacgacagcgttggagagctcctccgggccatgaggaagacgtat accatcagcgctgcctcggtccaggacaccatcaacctcttggcctccctgggtcagatc agatctctgctgtcagttcgaatgggaaaggaggaggaaaagctcatgattgatggactg ggtgacattatgaacaacaaggtcttctaccagcacccgaacctcatgagaatactgggc atgcatgagactgtcatggaggtcatggtcaatgtcctcggaggagacaagtcccaggaa attgcctttcccaagatggtggccagctgttgtcgcttcctgtgctacttctgccggatc agccgtcagaatcagaaggccatgtttgaccacctcagttacctactggagaacagcagc gtgggcctagcttcgccagctatgaggggctccactcctctagatgtggctgcttcctca gtgatggacaataacgggctggctctggcactggaagaacctgacctggacaaggtggtc acctacttggctggctgtggtcttcagagttgtccaatgcttctggctaaaggttatcca gacatcggctggaaccccattgagggagagcgctatctgtccttcttgcggtttgctgtc tttgtgaacggcgagagtgtggaggagaactcgagcgttgtggtgaagctgctgatccgt cgtccggagtgtttcggacctgctctgagaggagagggagggaacggtctcctggctgcc atgaaggaagctattaagatctctgagacgcccgctttggacctcccaggctccgtccag ggagttagctctgatgtgtctggtgatggtgacgatgaagaggaagtggtccacatgggc aatgccatcatgtcgttctactcagctctcatcgacctgttaggacgttgtgcccctgag atgcatctcatcaacaaagggaaaggcgaagctctgcgcattcgtgctatcctgcgctct ctggtgcctaccgaggacctcgtgggaatcattagcataccgctcaaaatgcccattacc aacaaagatgggtcagtgacagagccggacatgtcggcgagcttctgtccggaccacaag gcccccatggtgctgtttttagacagagtgtatggtgtggaagaccagagctttctgctt cacctgcttgaagttggcttcctccctgacctgagggctgctacttctctggacacggag ggtctgtgtaccaccgagacagccctggctatgaaccgctacatcggttcagccatgctg cccctcctcacccgctgcgcccctctcttcgctggcaccgagcactacgccaccctcata gactccaccctgcacaccatctaccgcctgtccaaaggccgttcgctgaccaaggcgcag agagatgcgatagaggagtgcttgctgtctgtttgcaagcaccttcgtccctccatgctg cagcagctcctgcgccgcctcgtctttgatgtgcccttgttgactgattactgcaagatg cctctaaggctgctaaccaaccactatgagcaaaactggaagtactactgcctcccttca ggctggggcagctttggaacagcctctgaagatgaactactgcttaccaagaagatcttc tggggagtgtttgactctttgtctcagaggaagtacgaccccgagctgttcaagatggcc atgccttgtctcagtgccatagctggagctttgccaccagactatgtggatgcctccatt agtaccactgtggaaaagcctgtttctgtggatgctcagggcaactttgaccccaaacca atcaatacggctaacatcgctcttccagagaaacttgagcattttgccaacaagtacgcc gagcatacccatgagaaatggtctgcagagaaggtgctgctggggtggaaatatggagac tgtgttgatgagaaggcgaagactcatcctcagctgaggacctacaaaggcctgacggag aaggagaaggatatttacagatggcctattagagagtccctgaagagtatgctggcaatg gggtggagtattgataggaccaaagatggagagagcatgtctcaacagagggagactgag aaaatgagaaagatatctcaggcctcacaggctaacggcttcaatccgagcccaatagac acaagcaacgtggttctatccagagagctgcaagggatggtggaggtggtggctgaaaat taccataacatctgggccaagaagaagaaaagtgaccttggaagtcgaggagggggaaca catcctctgttggtgccctacgacacgctgacggccaaggagaaggcccgcgatcgagag aaggctcaggacctttttcgcttcctgctaatcaatggatatagcatcacaagaggtttg aaggacttggagcaggattcctcctccatggagaaaaggtttgcctacaaattcctcaag aagctgctgaaatgtgttgactcagcccaggaattcattacccacttagaagccatggct gccagcggcaagacagacaggtcacctcatgagcaagaaatcaagttttttgccaaagtg ctcctcccactcattgaccagtactttaagaaccactctctctacttcctgtcctcccct aataagaatctaagcagcagcggctatgcctccaacaaggagaaagaaatggtcaccagc ctcttttgtaaactggcagctcttgtcagacataggatttcactttttgggagtgactcc accaccatggtcagctgtctgcatatcctggcacacacactcgataccaggacagtgatg aagtcgggctccgagcaggtgagggtggggctgaggacgttcttcgagaacgccgcagag gatctggagaaaacgttcgagaacctgaagctggggaagttcacccactcccgctcgcag atgaaaggagtgtcacagaatatcaactacaccaccgcagctctgcttcccatcctaact gctctgtttgaacacattactcaacaccactttggagtcgacctgctcctggatgacgtc caagtgtcctgctatcgaatcctgaccagcctctatgctctgggcactgggaaaaacatc tatgtagaaagacagctgccagctctcggtcagtgtctggcaactctggccggcgccttg cccgttgccttcctagagccgcaactcaacccgtacaacccctgctcagtttttaataca aagagcgccagagaacgagccaccctaggaatacaagactcagtggaggagatgtgtcct ggcatgccacggctggaccgcctcatgaaggacatcaatgacatggcagagtctggagcg cggtacacagagatgcctcatgtgattgaagtggtgctgcccatgctgtgtaactatctg tcctactggtgggaaaggggtcctgaaaaccagccggccagcgggggaagcatctgctgt accacagtcacctcggagcacctcagtctgattctcggcaacatcctcaagatcctcaac aacaacctgggcatcgatgaggcttcgtggatgaagagaattgcagtgtacgtacagccc atcatcagcaaggcccgtgcagacctgctgaagagccacttcctgcccacgctggagaaa ctaaagaagaagacagtgaaagtggtggctgaggaagagctcctcaaggccgactgtaaa ggagacactcaggaggccgagctgctcatcctggacgagtttgccgtactctgcagggac ctgtacgcgttttaccctatgctcattcgttatgtggacaacaacaggtcaaggtggctg aaagaaccagattcggactccaatgacctcttcaggatggtcgcagagatatttatcctt tggtgcaagtcacataatttcaaaagagaagaacaaaactttgtggtccagaatgaaatc aacaacctttcattcttgactggagataataaaacaaagatgtccaagtctgggggacaa gatcaggagaggaagcacaagaagaggcgaggtgagttctactccatccaaacctcactg attgtagccgccctgaagaagatgctgcctatcggtcttaacatgtgcaccccgggagat caggagctcatctctctggctaagacacgctacctcatgaaagatacagatgatgaagtt aaagaccacattcagcagaacctgcaccttcgcgaaaagtctgatgaccctgccgtgagg tggcagctcaacctgtacaaggacatagtgatgaggaccgaggggctttcagaccccgag aaggtggtggatcgtatccagaggatctctgctgccgtctttaacttggagcaggtggaa caaccactgagatccaaaaaatgtgtatggcagaagttgctgtccaagcagaggaagcgc gccgttgtcgcctgtttccgaatggctccgctttacaatctgccgaggcatcgctctatt aacctcttcctcctggcctatcagagaatatggatagaaacagaagagtactcttttgaa gagaaactagtgcaggaccttgcaaaaatacagcctaaagtggaggaagaggaggaggag gaggtgagaaagcagccagaccctcttcaccagctcattctgcatttcagccataacgct ctgactgaatgcagttctctggaagaggatcccttgtatattgcctatgcagatatgatg gcaaagagttgtgctgaaggtgaagaagaggaaggaaaagagaaaacatttgaggaaaag gaaatggagaagcaaaagatgctgtatcagcaggccagacttcatgaccgaggggctgcg gagatggtgcttcaaatgatcagcgccagcaaaggtcggctgggtgctacggtaactgtc acgctcaagctgggcatctccattctcaatggagggaacatcctggttcaacagaaaatg ctggattatctcaaggaaaaaagagatgttggcttctttaaaagcttgtccgggctcatg atgtcatgcagcgttctggacttgaacgcttttgaaaggcaaaacaaagctgaaggtctg ggtatggtaactgaagagggatcaatcaacgtgagtgagcggggttccaaggtactgcag aatgatgaattcactaaggatctttttaggtttctgcagcttctctgcgagggacataac aatgattttcaaaacttcctaaggacgcagacagggaacacaactacagtcaatataatc attagtactgtggactacctgctaagactgcaggaatccattagtgatttctactggtac tactctggcaaggatgtcattgatgaggccggtcagaggaacttctccaaagcactagca gtggccaaacaggtgttcaactctttaacagagtatatacagggtccgtgtatagggaat cagcagagtctggctcacagcaggctgtgggatgcagtggtgggcttcttgcatgttttt gccaatatgcagatgaagttatctcaggactccagtcagattgaattactaaaggagctg ctggacctgcagaaggacatggtcgtcatgatgctctcgctacttgaaggtaatgttgtg aatggaactatcggcaaacagatggtggacaccttggtggaatcttccagtaacgtggag atgatcctgaaatttttcgacatgttcctcaagttgaaggacttgaccacttcggacagc ttcaaggagtacgaccccgagagcaaaggcgtcatctcaaagaaggatttccagaagtcc atggagaaccagaagcagtattctcagtctgagattgagtttcttctctcctgcgccgag gctgacgagaacgacatgttcaactacgagcagtttgttgagaggtttcacgaaccggca aaagacatcggctttaacgtcgccgtgttgctaaccaatctttcagagcacatgcctcac gatgcccgcctctcaactttcctggacctggccgaaagcgtcctcagctacttcgagcct tacttgggtcgcattgagatcatgggcggagccaagcgcatcgagagagtgtacttcgag atcagcgagtcgagtcgcacgcagtgggagaagcctcaggtgaaagagtcgaagcggcag ttcatctttgacgtggtcaacgagggcggagagagcgagaagatggagctgtttgtaaat ttctgcgaggacacgatcttcgagatgcagctggcctctcagatttcagagccagacccc gttgagcgcccggaggaagaagaggatgacatccagaccatgatggagaaccaggaagag gaagacgaggagagcgcgatgatggagtcttcctcggcatttacaatcgcatgcatctcc atgaggaagagcttgtgtcacttccgccagctgcttactcttaaaagcatgcggcggcaa ttcaggaaattcaggaagatgagcgtgaaggagatggtgcggggcttcttctccttcttc tggatgatcatcacgggcctctttcactttgtttacagcctaatttggggattcttccac atcttgtggacaactatgtttgggggtggcctcgttgaaggggctaagaacatgaaggtt acagatattttgggaaacatgcctgaccccactcagttcgggatccacggagatgtgtta gaaacggaaaagatggaggcaagcgaagcgtcagcgttggcagagatgggtcagatggct caaggggaagcagcagaggcggatctgatggctgagctactcaacatacagccgaagaag gagggcaagcatggggccgagccaggtttgggggatgtgtctgaggtggtggtgggagat gccccatcaatagccagtgcagtcaagcagaagaaggcacagatggctgcaaacacgagg gctgtgaacggagactacagatctgatacagagaagggagattcagaagatggtgagaag aaggaccacgacaagactagagacgaagctcctccagagttgtctgtggaggagaagaaa gccccgaagaaaaggctcggcttgaagaaggaggcaccggaggctttcatggcgagcttc ttcgctggcttggaagtctaccagactaagatgctgaactacctggcaagaaatttctac aatctccgcttcttggcactttttgttgcctttgctatcaactttattcttctcttctac aaagtgaccggtgattactcggatgatgaagacccctggaacggtcgaggcagagttggg gaggaggaagacgagggagcgcttgagtatttcgtcttgcaggagagcacaggttacatg gcaccaacacttcgctgtctggcaatactacacaccatcatatctttcctgtgtgtagtg ggatactactacctgaaggtgcctttggtagtgttcaagcgggagaaggagatagcaagg aagttggagtttgcgggcctctacatcaccgagcagccgtctgatgacgacattaaagga cagtgggacagactggtcatcaacactccctcctttcccaacaactactgggataaattt gtcaagcgcaaagtgataaaaaagtatggagacctttacggagcagagaggatagcagag ctgctggggttggacaagagtgccctggatttcaaccctacagaggaaactgttgccaag gaggcttcactggtgtcatggttgagctcaatcgatacgaagtaccacgtctggaaaatg ggggttgtgtttacagataattcattcttgtatctagtttggtacaccaccatgtccatc ctgggtcactacaacaacttcttctttgccgcccatctgctggacatcgccatgggcttc aagaccctccgcaccatcctttcgtctgtcacgcacaacggcaaacagctggtgctgaca gtgggcctgctagctgttgtggtctatctctacactgtggtggccttcaacttcttcagg aagttttacaacaagagtgaggatgaggatgagccggacatgaagtgcgacgacatgatg acgtgctacctattccacatgtatgttggggtaagagcaggaggcgggataggggatgag atcgaggacccagctggcgacccctatgagctctaccgcatcctgtttgacatcacgttc ttcttcttcgttattgtcatcctcttggccatcatccagggtttgatcattgatgccttt ggagagttaagagaccaacaggagcaggtcaaagaggacatggagaccaaatgtttcatc tgtgggatcgggaacgattacttcgacacaaccccccacggctttgagacccacacctta caagagcacaatttggccaactatctgtttttcctgatgtacctcatcaacaaggatgag acagagcacactggacaggagtcctacgtgtggaagatgtatcaggagcgctgctgggac tttttcccagctggagattgcttccgcaaacagtacgaagatcagcttggatag

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