Oreochromis niloticus (Nile tilapia): 100706548 Help Entry 100706548         CDS       T06104                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X5   KO K04963   ryanodine receptor 3 Organism onl  Oreochromis niloticus (Nile tilapia) Pathway onl04020   Calcium signaling pathway onl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:onl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100706548 (ryr3)    04020 Calcium signaling pathway     100706548 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:onl04040]     100706548 (ryr3) Ion channels [BR:onl04040]  Voltage-gated cation channels   Ryanodine receptor    100706548 (ryr3) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Med16_bridge Motif Other DBs NCBI-GeneID:  100706548 NCBI-ProteinID:  XP_013127448 Ensembl:  ENSONIG00000005692 LinkDB All DBs Position LG15:complement(16399507..16512393) Genome browser AA seq 4848 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLESTSEAKYVPP DICICNFVLEQSLSVRALQEMLANTGQNSEGAGQGGGHRTLLYGHAILLRHSFSGMYLTC LKTSRSLTDKLSFDVGLQEDSIGESCWWTIHPASKQRSEGEKVRIGDDLILVSVSTERYL HLSISNGNIHVDASFMQTLWNVQPTCSSSNMAVGYLIGGHVMRLCHGHDESLTIPGADKN EEEQRIVNYEAGKGASKARSLWRVEPLRISWSGSHIRWGQPFRLRHLSTGHYLALTEDRG LVLQDRVKSDTTATAFCFRASKEKGDTGPKRDIDGMGVPEIKYGDSVCFIMHVATGLWLS YQAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTFLFTNFIKAL DSIAAGESTAVAGYVEEVLQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQDLFKEEGM LSLLSKCIDRMNLYDSAAHFGEVAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQFSRK LDWLVSKLERLESSSGILEVLHCILVESPEALNIIQKGHIKSIVSLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDNLLPNRDLLLQTRLVNDVQSMRPNIFLGIAEGSAQYKKWY YELVIDQVDHFVTSEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSFDGLHLWS GRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGFFFPVVSF SAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHDGVRDLLGTT QFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKVRDDNKRQ HPCLVDFAKLPETERNYNLQMSSETLKTLLALGCHVAQVNIHAEDDLKKIKLPKNYMMSN GYKPAPLDLSDVRLNAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSRRNPRLVP YALLDERTKKSNRDSLREAIRTMVGYGYEIDPPDQEVVHVLDDQSVETIRFFRVEQTYAV KTGKWYFEFEALSGGDMRVGWARPGCRPDVELGVDDQAFVFDGYRGRRMHAGSRYFGHPW KKGDVVGCMINMEDKSMIFTLNGELLITNKGSELCFTDFETEDGFIPVCSLSMSQIGRMN LGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFFNVPEEHPDIEVTRIDGT VDSPPCLKVTHKTYGTQNSNNDMVYCRLSMPVEFYSADKLLDESLKLSHPPKEDGSIDFG SITTYYYSVRVFAGQDPASVWVGWVTPDYHYYSKNFSLSKTRTVTVTLGDERGRVHESVQ RSNCYMVCVADAVTPSSSSRSSSDLEIGCLADLATGLVSFTANGKELPTSYQVEPNTKLF PAVFVLPTSANLFQFEFVKIKDAMPLSSAIFKSEHRNPVPQCPPRLDVQTIVAVLWSRMP NIFLNVETARVSERHGWVVQCLEPMQMMAVHIPEENRCLDIMELSEHEDLRKFHYHTLKL YCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAKEARLM MNNEFIIPVTDETRSIKLFPDESKQHSLPGVDLSTSLKPRVNFSPVGIINTKRQQYLYSP QIPLGILKEKAISMLTEAVQGGGTHIRDPVGGSLEYQFVPILKLIGTLLIMGVLTSDEVR LILLLIDPNVFGETKEGEEVKGDEVAMSGEKEEVSKNEEKAVEAGEEETKESKPQVKGLL EKSLPESVKRQMCELLHYFCDCELKHRIESIVSFSDSFVSKLQYNQKFRYNELMLALNMS AAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIQDELNSFHEELRLHCGIPVEEEE EEQDTSIKGRLLALLYKIKGPPQKTEQEPTETEQAAPTNLKELISQTITSWAQESHIQDP ELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVRMGKEE EKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKMVASCCR FLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGLALALE EPDLEKVVTYLAGCGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFAVFCNGESVEENAN VVVKLLIRRPECFGPALRGEGGQGLLAAMEEAIKISEDPALDLPKTPAGVTTGSGEEEGE VIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLVGVISIPL KMPVVNKDGTVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFLPDLRASA SLDTEALSTTETALAMNRYIGSALLPLLTRCAALFGSTEHHAQLVDSTLQTIYRLSKGRS LTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPVLNEYCKIPLRLLTNHYEQNWKY YCLPSGMGSFGTASEEELLLTKKLFWGIFDSLSHKKYDAELFKMAKSCLCAIAGALPPDF VDSSLGATLEKQASMDAQGNFDPKPISTANISLPEKLEYIANKYAEHSHDKWSSEKMSVG WKHGDTVDEQAKTHPLLKPYKSLSEKERETYRWPVRESLKSMLSMGWNIERTKEGEAMFQ QRESEKQRKISESQINGFSPAPMDLHNVTLSRELQGMVEVVAENYHNIWAKKKKTELVSK GGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDMEQDSSSMEKRFSY KFLKRLLKNVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLTDQTFKNHCLYF LSTPSQNLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLHILTHSLDT RTVMKTGSELVKVGLKTFFENAAEDLDKLLEMLKLGKFMQSRAQMKSVSQSINYVTVALL PILTALFEHIKTYEFGVDLLLDDVQLSCYRILTCLYSLGTGKNVFVERHLPALGESLATL VGAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKLLKDVNDVS ESGARYSDMPQVIEVILPMLCNYLSYWWEKGPENSPPDTQCCTMVTSEHLSIILGNILKI LNSNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTLDKLKKKTVKVVAEEELLKAD SKGDNQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDGDSTELFRMVAEIF ILWCKSHNFKREEQNFVVQNEINNLGFLTGEGKTKMSKTGGDQERKHKRRRGEYYSIQTS LIVAALKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEHLRQNLHLQDKSDDPAV QWQMNLYKDVVVKIEEPANPENTVDRVQSISAAVFHLEQVEQPLRNKKCVWQKLLSKQRK RAVVACFRMAPLYNLPRHRAINFFIPAYERLWIEAEEYSFEEKLVQDLAKTPMKIVEEEE EEVAEIQPDPLHQLILHFSHNALTERSHLEEDPLYIAYADMMAKSCAEDEEEEEEEEGKE KTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGISILNGGNV QVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSIHTERG SKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESIS DFYWYYSGKEIIDETGKLNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMVDTLVES SSNVEMILKFFDMFLKLKDLTTSDNFKEYDPECKGIISKKEFHKSMESQKQYIQSEIEFL LSCVEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLATFLDLAESVL SYFEPYLGRIEIMGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGESEKM EMFVNFCEDTIFEMQLASQISEPEVVEQPEEDEEEDGHSILEELTAEEEHALESASAFTT ACRSVSGKIAHVRQMFSIKNMRKKFKKLKKLSIKEIITGFFAFFWMLFTGFFKGIYSLIF GFFHVIWSSMFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDVIEGEKVEAIESLGNLDI AMAPTGDIVEVDMMMEMLNAPKKEGGKHVEPGLGDVSELSAEPSTDHKKKAAAKKVETPE NEPEKADTENQEKEDKPKEEAAKEPVTEEKPKTRSSQPKEPAPAFMSSIFAVLDVYLNKT VNYLARNFYNLRFLALFVCFAINFILLFYKVTGETDEETEGENRWGADEEDDEDTLFDMD EFVLQESTGYMLPTLRFLAIFHTVISLVCLVGYYCLKVPLVVFKREKEIARKLEFDGLYI TEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLGLDKSAL DFDPTVETVEKEASLVSWLSSIDTKYHIWKLGVVLTDNSFLYLIWYTTMSIFGHFNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDE DEPDMKCDDMMTCYMFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESYVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14547 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagatgagatccagttcttgagaactgacgatgaggtg gtgctccagagtgtggccaccatccagaaggagcatcgtaagttctgcctggccgccgag ggacttggaaaccgtctatgttacctggaatcaacatctgaagctaagtatgttcctccg gacatttgtatctgtaactttgtgctggagcagtcactgtcagtgcgagccctgcaggag atgctggctaacactgggcagaacagcgaaggggcgggtcaggggggtggacaccggacc ctgctctacggtcacgccatcctcctacgccactccttcagtggcatgtacttgacctgt ttgaagacatcaaggtctctgacagacaagctgtcatttgatgtcggactgcaagaagat tcaataggagagtcctgctggtggaccattcaccctgcatctaagcagagatctgaggga gagaaagtccgcattggagacgacctgattcttgtcagtgtgtcgacggagagatatcta catctctctatttccaatggcaacattcacgtggatgcctccttcatgcagaccctgtgg aatgtccagcctacctgctcatcaagcaacatggcagtaggttatttaattggtggacat gtgatgcgtctctgtcatgggcatgatgagagcctgaccattcctggagcagacaagaat gaagaggagcagaggatagtcaactatgaggctggtaagggagcatcaaaggcccgttca ctgtggagagtggagccgctgaggatcagctggagtggtagccacatccggtggggccag cccttccgactacgccatctctctactggccattatcttgccctgactgaagaccgtgga ctggtcctgcaggacagagtgaagtctgacaccacggccactgctttctgctttagggcc tccaaggaaaagggagatactggcccaaagagggacattgatggcatgggcgtgccagag atcaagtacggagactctgtgtgcttcatcatgcatgtggcaacaggactttggctgtcc taccaggcgccagatgccaaatcatctcgtcttggtcccctaaaaagaagggcctgccta cattctgagggccacatggatgacgggctcatcctccagcgctgtcagcatgaggagtct cgggctgcacgcatcatccgtaacaccacgttcctctttaccaatttcatcaaagctttg gacagcattgcagcaggagagtctacagcggtggccgggtacgttgaagaggtgctacag acactgaatgatttgattgagtactttaagcagcccgattctgagctggagcatgaagag aagcagtgtcttctccgttcactcatcaaacgtcaggacctcttcaaagaggagggtatg ctgagtcttctgtccaaatgcatcgatcgaatgaacctgtacgacagtgcagcccacttc ggggaggtggctggggaggaagctggcgcagcctggaaggacattctcaacctgctttat gaactcttagctgcactgattcgtggaaaccggaacaactgtacccagttttcccgaaaa ttggactggttggtcagcaaactcgaaagactggagtcttcatcaggtattctggaagtc ctccactgtatcttggtagaaagcccagaagctctgaacatcatccagaaaggtcacatt aaatccatcgtctctctgctctacaagcatggacgcaaccacaagatcctggatgtcctt tgttccctctgtgtatgcaatggagtggcagtgagagccaatcagaatctgatctgtgac aacctccttcccaatagggacctactgcttcagactcgattggtcaatgatgttcagagt atgagaccaaatatcttcctgggcatagctgaaggttcagctcagtataagaagtggtat tatgagctggtcattgaccaagtggaccactttgtaaccagtgagccgacccacctgagg gtaggctgggccaacactaaaggctatgctccgtaccccggtggaggagaagggtgggga ggcaacggtgttggagatgacctgtactcttacagctttgatggactgcatctctggtca ggccgaatcccaagggccgtggcctccattaaccagcacctgctgaactcagacgatgtg gtcagctgctgtctggatttgggagctcccagtatgtccttcaggatcaacgggcagcct gtccagggcatgttcgaggacttcaacacagacgggttcttcttccctgtagtcagcttt tctgcaggtgtaaaggtccggttcctgctaggcggccgccatggagatttcaagttcttg ccacctgccggttactctccgtgttatgaagcactgttgcccaaagagaagatgcatgta gagcctgtgaaggagtacaagagggaccatgatggggtccgtgatttgctgggaaccacc cagttcctctctcaggcctcctttatccccactcctgttgacaccagtcagattgttctt ccccctcacttggagaacatccgggacaagctggcagaaaacattcacgaactgtggggg atgaacaagattgaactgggctggacctatggcaaggttcgtgatgacaacaagaggcag cacccttgccttgtggatttcgccaagctgcctgaaactgaaaggaactacaacttgcag atgtccagtgaaaccctaaagacccttttagccctgggatgccatgttgcccaggttaat attcacgctgaagacgatctgaagaaaatcaaattacccaaaaactacatgatgtccaat ggatataagcctgcgccgctggacctctctgacgtgagactgaatgctggtcaggaggtt ctagttgataaactggccgaaaatgcgcacaatgtgtgggccaaagatagaattaaacaa ggatggacctatggcatccagcaggatttgaagagcaggcgtaatcctcgcctggtgcca tatgctttactggatgaacgcaccaagaaatctaacagggacagtctgagagaggccatc aggactatggttggatatggatatgagatcgaccccccagatcaagaggttgtgcacgtg cttgatgatcagagcgtcgagacgatacgcttcttccgtgtggagcagacctacgcggtg aagacggggaagtggtactttgagtttgaggctctgagtggaggagacatgagggttggc tgggccagaccaggctgcagacctgatgtggagctcggagtggacgatcaagccttcgtc tttgatggatatcggggacgacgtatgcatgcaggcagccgctactttggacatccttgg aaaaagggcgacgtggttggctgcatgatcaacatggaggacaaatcgatgattttcacc cttaacggagaactgctgatcaccaataaaggatccgagctttgcttcactgactttgag acagaggatggtttcatccccgtgtgcagtctcagcatgtctcagatcggccgtatgaac ttgggcaaggacgccagtactttcaagtactacaccatgtgtggtctacaggagggtttt gagccctttgctgttaacatgaacagagaggtcaccatgtggttcagcaagcgcctgccc acttttttcaatgtacctgaggaacaccctgatattgaggtgacgaggattgacggaaca gtcgacagccctccttgccttaaggtcactcacaagacgtatggcactcaaaacagcaac aatgacatggtctactgtagactgagcatgcccgtggagttttattctgcagacaagctc ctggatgaatcactgaagctcagccatcctccaaaagaagatggaagtattgactttgga agcatcacaacttattactactcagtgcgagtgtttgctggacaggaccctgcttctgtg tgggtgggctgggtcacacccgactatcattattatagcaagaacttcagcctcagcaaa acacgcacggtcacagtgacgctgggagatgagaggggaagggtccatgagagtgttcag aggagtaactgctacatggtgtgtgtagcagacgcagttaccccgtcttcctccagccgc tctagctccgacctggagattggctgtctggctgacctggccactggccttgtctccttc actgccaatggcaaagagctccccacatcatatcaggtggaaccaaataccaagctcttc cctgctgtatttgtcctccccaccagtgcaaacctcttccagtttgaatttgttaagata aaggatgccatgccactctcatcagccatattcaagagcgagcacaggaacccggtgcca cagtgtccgccacggttggatgtgcagacaattgtggcagtgctttggagccggatgccc aatatctttctcaatgtggagacggctcgcgttagtgaaagacatggctgggtggtccag tgtctggagcctatgcagatgatggctgtacacatacctgaagaaaacaggtgtttggac ataatggagttatctgagcacgaagacttgaggaagttccactaccacacactaaagctg tattgtgccctttgtgcactgggaaacactcgtgtagctcacgccctctgcagccatttg gaccaatcacagcttctctacacaatcgacaatcagtacctctctggcatgctgagagag ggcttctacaatgtcctcatcagcattcatctcgagacagcaaaggaagcccgtctaatg atgaacaacgagttcattatccctgtgacggatgaaacgcgctccatcaagctgttccca gatgagtccaagcaacattcacttcctggggtggacctaagcacctcccttaaacctcgg gtcaatttctcccctgtgggaatcatcaacaccaaacgccagcagtacctctacagcccc cagatcccattgggcatcctaaaggaaaaagccattagcatgctaaccgaggcagtgcaa ggtggagggacccacatccgagacccagtaggcgggagtcttgagtaccagtttgttccc attttgaaactgattggaacactgttaataatgggagtcctgaccagtgatgaggtgagg ctgattctcctcctgatcgaccccaatgtgtttggagagaccaaagagggcgaggaagtt aagggggatgaggtggccatgtcgggggagaaggaggaggtgagcaagaatgaggagaag gctgtagaagcaggggaggaggagaccaaggagagcaaaccgcaagttaaaggcctgctg gagaagtctctgccggagtctgtcaaacgccagatgtgtgagctgctccactacttctgt gactgcgagctgaagcaccgcatcgaatccattgtttccttctccgacagcttcgtatcc aagctgcagtacaatcagaagttccgctacaatgagctaatgctggctctcaacatgtct gccgctgtcactgccaagaagaccaaagagtttcgttcacctccgcaggagcagataaac atcctgttgaatttcagcgcaggtgaggactgcccctgccccgaggagatccaggatgag ctcaactcgttccacgaagaactgcggctgcattgtggaattccagtggaggaggaagaa gaagaacaggacacttcaattaaaggccgtcttctggctttactgtataagatcaagggc ccaccacagaagacagagcaggaacccacagagactgaacaggctgcccccaccaacctg aaggagcttatctcccagaccataaccagctgggctcaggagtctcacattcaggaccca gagctggtcagagtgatgttcagcctgctgaggagacagtatgacggcatcggggaactg cttcgggccatgaagaagtcgtacaccatcagtgccgcatccgtgcaagatgctattaac ctgctggcatctctgggtcaaatcagatctctgctatcagtgcgaatgggcaaggaagag gagaaactcatgattgatgggctcggcgacatcatgaacaacaaggttttctaccagcat cctaatctgatgagagtgctgggcatgcatgagacagtcatggaggtcatggtgaacgtg cttgggggagacaagtcacaggagatcgctttccccaagatggtagctagctgttgtcgc ttcctgtgttatttctgccgtattagccggcaaaaccagaaagccatgtttgaccacctg agctacctgctggagaacagcagtgtcggattggcctctgaagctatgcggggctccact ccgctggatgtcgcagcgtcttcggtgatggacaacaacggtctggcgctggccctggag gagcctgatctggagaaggtggtgacatacctagcaggctgtggtcttcagagctgcgcc atgctggtggctaagggatacccagacctcggctggaaccccatagagggagagcgctac ctctcattcctgaggttcgccgttttctgcaacggtgagagcgtggaggaaaatgccaac gtggtggtgaagctgctcatcagacgtccagagtgtttcggccccgccttgaggggcgag gggggtcagggtctgctggctgccatggaagaggccatcaagatctctgaagatcctgcc ctggacctgcccaagactcctgctggagtcactactgggtctggtgaggaggaaggggaa gtgattcacatgggcaacgccatcatgtccttctactctgccctcattgacctgctggga cgctgtgctcctgagatgcatcttatcaatgcaggtaaaggtgaggcgctgcgtatcaga gccatcctgcgctctcttgttcccacttcagacctggtgggcgtcatcagcatccccctc aaaatgcctgtcgttaataaagatggcacagtgaccgaaccggacatgtcagcttgtttc tgtcccgaccacaaggcccccatggtgctcttcctggacagagtttatggcatcgaggac cagagcttcctgctccagatgttggaggttggcttcctgcctgacctccgagcctcggca tctctggatacagaggcgttgagcactacagagactgccctggccatgaacaggtacatc ggctcagctctgctgcctctgctgacccgctgtgccgctctttttggcagcacagagcac cacgcacagctggttgactccacgttgcagactatctacaggctgtcaaaaggccgctca ctcaccaaagcccaaagggatgccattgaagagtgtctgctggcaatctgcaaacacctg cgtccctctatgatgcagcagctgctcagacgtctggtgtttgacgttccagtgctcaat gaatattgcaagatacctctccggctgctgaccaatcactacgagcagaactggaagtac tactgcctgccatctggtatgggcagctttggcactgcctctgaggaggagctccttctc accaagaaactcttctggggaatctttgactccctttctcataagaaatatgatgctgaa cttttcaaaatggccaagtcatgcctgtgtgcaatcgctggggccctgcctccagacttt gtggattccagtttaggtgcaacgctggagaagcaggcatcaatggacgcacagggtaac tttgaccccaaacccatcagcactgccaatatctcccttcctgaaaaacttgagtacatt gccaacaaatatgcagagcattcccatgacaagtggtcctcagagaagatgtcagtgggc tggaaacatggagacactgtggatgagcaggccaaaacccatccactcctgaagccctat aaatctctgagtgagaaggagagagaaacgtatcgctggccagtgagagagtcactgaag agcatgttgtctatgggctggaacattgagaggaccaaagagggtgaggcgatgttccag caacgagagagcgaaaaacagcggaagatctccgagtcccagattaatggattcagtccc gctccaatggatctgcacaatgtcaccttgtcgagagagctgcagggcatggtggaggtg gttgcagaaaattaccacaacatctgggccaagaagaagaaaactgagcttgtcagcaaa ggaggagggacccacccactgctggtaccctatgataccttgacagctaaagagaagtac agagacagagagaaggcccaggagctcttcaagttcctgcagattagcggctatgccatc acaagaggcttgaaggacatggagcaggattcatcatcaatggaaaaacgtttttcttac aagttccttaagaggctgctgaagaatgttgactctgcccaggagttcattgctcatctt gaggcgatggccaccagcgggaagaccgacaaatcccctcatgaccaggaaatcaagttc tttgccaaggtgttgcttcccctgactgatcaaacatttaaaaaccactgtctgtacttc ctgtctacacctagtcagaacctgagcagttgtggttgtgcctccaataaagagaaggag atggtcaccagtctgttctgtaagctggcagctcttgtcagacacaggatttctctcttt ggaagtgattcagcaatgatggtgagctgtctgcacatccttactcactcacttgacact agaacagtgatgaagactggctcggagctggtaaaagtcgggttaaagactttctttgag aatgcagcagaagacttggacaagctgctggagatgctgaaactgggaaagttcatgcaa tcccgtgcccagatgaagagcgtcagtcaaagcataaactatgtgacagtggcactgctg cctatcctcactgctctctttgaacatatcaaaacatacgagtttggagtggacttgctt ttggatgacgtccagctgtcttgctacagaattctgacatgtttgtactctctgggaaca ggaaagaacgtgtttgtggagaggcatctgccagcactgggggagagcctggcgactctg gttggagccatgcctgtagctttcctggagcctcatctaaacgctcacaacccactctca gtcttcaacaccaagacccctcgagagcgagccatcctgagtatgcctgacacagtggag gagatgtgcccagagatgcctcgtcttgacaaacttctcaaagacgtcaatgatgtgtca gagtctggtgctcgctatagtgacatgccacaggttatagaggtaatccttcccatgctg tgtaactatctgtcctactggtgggagaaaggtccagagaactcgcccccagatactcag tgctgcaccatggtgacctctgaacacctcagcatcattctgggaaatatcctcaagatc ctcaacagcaacctgggcatcgatgatgctccttggatgaagaggattgccgtctattct cagccaatcatctgcaaagctggagcagatctgctcagaacccatttcctgcccacactg gataaattaaagaagaagacagtgaaggtggtggctgaagaggagctgctgaaagctgac agcaaaggtgacaaccaggaggcagaactgctcatcttggacgagtttgctgtgctctgc agggacctctatgctttctaccccatgctcattcgttatgtggacaacaacaggtccagg tggctgaaggagccggacggagactccactgagctctttaggatggtggctgagatcttc atcctctggtgcaagtcacataactttaagcgtgaggagcaaaactttgtggttcagaat gaaatcaacaatttgggcttcctaactggtgaaggcaagactaagatgtccaagacaggt ggggaccaggagaggaaacacaagcgccgacgtggtgaatactactccattcaaacgtct ctaattgtagccgccctgaagaagatgctacccatcggccttaacatgtgcaccccggga gaccaggagctcatctctttggccaagatacgctacagcctgaaagacacagatgatgag gtgaaggagcatttgcgtcagaatctccatctccaggacaagtctgacgacccagcggtc cagtggcagatgaacctgtacaaagatgttgtggtgaagattgaggaaccagcaaaccca gagaacacagtggacagagtccagagcatctctgctgcagtcttccatctggagcaggtg gagcaaccacttaggaataaaaagtgtgtgtggcagaagctgctgtcaaaacagcgtaaa cgtgctgtagtggcttgtttccgcatggctccactctacaatttacccaggcatcgtgct atcaacttcttcatcccggcctatgagagactttggatagaggcagaggagtactccttt gaggagaagctagttcaggatctggcaaaaacaccaatgaagattgtggaggaggaggaa gaggaggtggctgagatccagcccgaccctctccaccaactcattctccacttcagccac aatgctctgacagaaagaagtcacttggaagaagatcctttgtatattgcgtatgcagac atgatggcaaagagctgtgcagaggatgaggaagaagaagaagaggaagaagggaaagaa aagacattcgaggagaaggagatggaaaagcagaagatcctttatcagcaggcgaggctg cacgctcgtggggctgctgaaatggtgctgcagatgatcagcgccagtaaaggtcgtctg ggccccatggtgacctgcaccctcaaactgggcatctccatcctaaatggaggcaacgtg caagttcagcagaaaatgctcgattacttgaaagaaaaaagagatgcaggctttttcaag agtctttcaggactaatgcagtcctgcagtgtcctggacttgaatgcatttgagagacag aacaaagcagaaggactcggcatggtgacagaggaaggttctatccacactgagcggggc tccaaggtgctacagaatgatgagtttactaaagatcttttccggtttttgcaacttctg tgcgagggccacaatggagatttccagaattttctgagaacccaaactggaaacacaacc acagtcaacatcattatcagcactgtggactatctgctccgtcttcaggaatctatcagt gacttctactggtactactctggcaaagaaataattgatgaaaccggaaagctcaacttt tccaaagctttatctgtagcaaagcagatatttaactcgctgactgagtacatccagggt ccatgtattgggaaccagcagagtttagcacacagcagactgtgggatgcagtggtgggc ttcttgcatgttttcgcaaacatgcagatgaagctgtctcaggatgccagtcaaattgag ctgctgaaggaactgatggacttacagaaagacatggtggtcatgctgctgtctctgctt gagggtaatgtggttaatggaacaattggaaagcagatggttgacaccctggtggagtct tccagcaatgtggagatgattcttaagttcttcgacatgttccttaaattgaaggatctc acgacctctgacaacttcaaggagtatgaccctgagtgtaaaggcatcatttctaagaag gagttccacaagtccatggagagccagaagcagtacatccagtctgagatcgaattcttg ctctcgtgtgtagaggcggacgagaatgacatgttcaactacaaggagtttgtggagcgg ttccacgagccggccaaagacatcggtttcaatgtggcagtccttttgaccaacctgtct gaacacatgccgcatgactcccgacttgccactttcttagatctggctgaaagtgtgctt agttactttgagccttacctgggtcgtattgaaatcatgggcagtgcaaagcgaatcgag agggtttactttgagatcagcgagtcgagccgtgagcagtgggaaaagccgcaggtgaaa gaatccaagcgtcagttcatctttgacgtggtgaacgagggcggagagagcgagaagatg gagatgtttgtgaatttctgcgaagacaccatttttgagatgcagctggcctcacagatc tctgagccagaagtggttgaacagcccgaagaggacgaagaggaagatggacacagcatc ctggaggagctgactgcagaggaagagcacgccctggagtctgcctctgccttcaccacc gcatgtcgctcagtcagtggcaagattgcacacgtccgccagatgttttccattaaaaac atgcgcaagaagtttaagaaactcaagaagctgagcatcaaggagataatcacaggcttc tttgccttcttctggatgctcttcactggcttttttaagggtatctacagcctcatcttt ggtttcttccacgtcatctggtcctccatgtttggtggaggtttagtcgagggagccaag aacataaaggtgacggacatcctcggaaacatgcctgacccgactcagttcggcatccat ggagatgtgatagagggagagaaagtggaggctatagaatcattaggaaacctggacata gccatggcaccaacaggggacatcgtagaggttgacatgatgatggagatgctgaacgcg cctaaaaaagaaggaggaaaacatgtggagccaggcctgggggatgttagcgagctgagt gctgagccctccactgatcataagaagaaagctgctgccaagaaggttgaaacccctgag aatgaaccagaaaaagcagacacagagaaccaagagaaggaggataaaccaaaggaggag gcggctaaggagccagtgacagaggagaagcccaagaccaggtcaagtcagcctaaagag ccagcaccggcgttcatgtccagtatttttgcagttctggatgtctatctgaacaagacg gtgaactacctggctcgtaacttctataacctccgcttcctggccctgtttgtgtgtttt gccatcaacttcattctgctcttctacaaggtcactggtgaaactgatgaagaaactgaa ggtgaaaaccgctggggtgctgacgaagaggatgacgaggacacgctctttgacatggat gagtttgtgcttcaggagagcaccggctacatgttaccaacgctgcgcttcttggctata ttccacaccgtcatctcgctcgtctgcctggtcgggtactactgcctgaaggttcctttg gtggtttttaagagggagaaggaaattgccagaaagcttgaatttgatgggctgtacatc actgagcagccatctgacgatgatatcaaaggccagtgggatcgacttgtcatcaacacc ccatccttcccaaacaactactgggacaaatttatcaagcgcaaggttattaataaatat ggtgatctctatggagcagaacgcattgctgagcttttaggcctagataagagtgctttg gactttgaccccacagtggaaactgtcgagaaggaagcgtccctggtctcctggctgagc tccattgatacaaagtaccacatctggaaactgggcgtggtcttgactgacaattctttc ctgtatctcatctggtacaccaccatgtctatttttggacacttcaacaacttcttcttt gctgctcatctgctggacatcgccatgggattcaagacccttcgcaccatcctgtcatct gttactcacaatggcaagcagctcgtgctgactgtgggtttgctggcggtggtcgtctat ctctacaccgtggtggccttcaacttcttcaggaagttttacaataagagcgaggatgaa gacgagcccgacatgaagtgcgacgatatgatgacgtgctatatgttccacatgtacgtg ggtgtgagagctggaggaggtattggagatgagttagaggacccagctggagatccatac gagctctaccgcatcctgttcgacatcaccttcttcttctttgtcatcgtcatcctgctg gccatcattcagggtttaatcattgatgcctttggtgagctgagagaccaacaggagcag gtgaaagaggacatggagaccaaatgtttcatctgtggaattgggaatgattactttgac cggacgcctcatggctttgaaactcacaccttacaagaacacaacctagccaactacctg ttcttcctgatgtatctgattaacaaggatgagactgagcatacgggtcaggagtcatac gtgtggaagatgtaccaggagagatgctgggacttcttccccactggagactgcttccgt aagcaatatgaggaccagctgggttag

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