Oreochromis niloticus (Nile tilapia): 100710196 Help Entry 100710196         CDS       T06104                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism onl  Oreochromis niloticus (Nile tilapia) Pathway onl04020   Calcium signaling pathway onl04260   Cardiac muscle contraction onl04261   Adrenergic signaling in cardiomyocytes onl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:onl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100710196    04020 Calcium signaling pathway     100710196  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     100710196    04261 Adrenergic signaling in cardiomyocytes     100710196  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:onl04040]     100710196    04990 Domain-containing proteins not elsewhere classified [BR:onl04990]     100710196 Ion channels [BR:onl04040]  Voltage-gated cation channels   Ryanodine receptor    100710196 Domain-containing proteins not elsewhere classified [BR:onl04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100710196 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 Motif Other DBs NCBI-GeneID:  100710196 NCBI-ProteinID:  XP_013127204 Ensembl:  ENSONIG00000000653 LinkDB All DBs Position LG13:12812938..12897728 Genome browser AA seq 4978 aa AA seqDB search MTDSGEGDDEFQFLRTGDEVVLQSTFTSQEEHVKLCLAAEGFGSRLCRLEPTSNCKNVPP DLSVCGFVLAQCLSVRALQEMLAHSEHLAAEVGAGGSHRTLLYGQAVLFLHSYSGMYFSC LPSSQSSTDKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDDLILVNVSSERYL HLSFGTASDNKSLSDSLIVNAAFQQTLWSVAPICSGRAVAQGYLKGGETLRLLHSHSDAC LTVPSTEHGEELQRIMHYEIGSVSGHARSLWRLEILRVVWSGRHTCWGQPFRLCHVTTGR YLGLTEEKGLQLVDRDKADINTTSFCFRSSKEKLDTNTKTDVDGMGIPEIKYGDSICFLQ HVASGLWLTYQAADAKSHMGGAQRKAILHSEGHMDDGLTLSRSQREESHIARLIRSAVLL FTRFVRKLDGFNQEVNIPSVSLSVETVTRSLQDLIIYFQPPLEGLGHEAKQNSMVALKNR QNMFQKEGVIDLVLDCIDRLHQYSSASHFAEAVQSDTGEEWETIVNHFYELLAALLRGNR ANCANFSGSLDWLISRLERQEASSGVLEVLHCVLVESPEALNAIKDQHIQSVISFLDKHG CNHRVLEVLCSLCVCHGVAVRSNQNLICDSLLPDRDLLLQTRLVNQVTSMRPNIFLAMGE DSSQYRRWYYELVVDHVNPFLTSEPTHLRVGWACMKGYQPRPTGGEGWGGNGVGDDLCSY GFDGLHLWSGCVSRKVSSPFPHLLKDDDVVSCCLDLSIPCISFRVNGLPVQGMFENFNAN GLLYPVVSFSAGVKVRFLFGGRHGEFRFLPPPGYASCSEALLPKVKLKVQLCQEYILGHG EGKQELIGPLVPVTPVTFTPTPIDISKVVLPPQLEDIREKMAENIHELWVMDKIDLGWTH GLVRDEGKKHDPCLVEFSKLPEHERNQNLQMAQDTLRTLLALGFHIGLMDDHAEKHMKYM RLPVKYEQMTGYRPAPVDLSQVSLSSDHEEAVNLLAEHEHNVWARERIKQGWTYGVQQDI KAKQSPYLLPYSLLDERTRRVGRESVREAVCTLLAYGYSLEPLNQERTTLSKPCFFSAEK CRVFRPDKSYAVTRGKWYFEYEILTAGNVRVGWARPGCTPDKELGSDDQAYVFDGFEAQW YHQGGEPLGRPWLRGDVVGCLVDMDECTMMVTLNGQLLFNDRGSELAAKDFDIRDGLLPV VSVGVNQVGRLNLGRQVGSLQYFTVCGLQEGYRPFAVNMARDTALWMSWKQPQFTSILPD DHYLQVTRVSGSVDSLSSLRVSQCMQPHHGGESEMGYYRLSMSVDCAAVLGSPPGGVLPV ASSALSPSSERKEQEEVDSDFEVLMKSAHSYAGSRDELNHKDHSHDKTSRLKQRFMLKKT KPGLVSSNSSARLLEDVVVDKDNYDHLIQSSRYYYSVRVLPGQEPFSVWVGWVTSDFHQH DMTFNTDNVHTVTVTLGDDSGKVHESVKRSNCYMVCAGEATGLSQSRRSTGLEIGCLIDT TTGLLTFTSSGVEMATFYQVEASTKLFPAVFVKPTTKNMFQFELGRIKNVMPLSSGLLRS QSRNVTPQCPPRVQVQRLRPASWTRVPDRALKVLVDRPDERHGWRIQCHEPLQAMILHIP DENRCVDILELSELDDLLTFHHNTLLLYCSLCALGNTRVCHALCSHVDQSQILYAIQDPY LPGLLRSAFYQLLFQVFLSSYTTACLMMNHEYIVPMTDQTREITLYPSPINGGDRQPPEG ISSASCSTSLKPQMHFSTPCFIRSDCMEGASALEIACKDSPEIPLDVLKNLTVEMLTAAV WAVGQDVRDPAGGNIELLLVPLLRLFYSLLVMGVCRDEDLGKILRLMEQGAFARPGTPIE KLEEETSDDEEEQKGVITEESNTVKQGLLQMKLPEAVKLELCHLLSYLCHCQVRHRVEAV IAFSDSFVGQLQENQRFRYNQVMQALNMSAALTARKTKEFRLPPQEQINMLLSFREDTQQ ENSPCPVEIQELLQDFHHLLKTHCGIDLASTSEDEEDAEMSLKERLLGLVARVIGRNKSS VDIDGCSSHSPKSLKKMISETMVRWAQESEIEDPELVSAIFSLLHRQYQGLRSLMERPLF KAYTIKQSSLEDTMALLSSLGQIRSLLSVRMGKEEERLMIRRLGDIMNNKVFYQHPNLMR ALSMHETVMEVMVNVLGEGQIKEITFPKMVASCCRFLCYFCRISRHNQGALFDHLSYLLE NSSVGLASPSMRGSTPLDVAAASVMDNNELALALRESDLEKVVQCLAGCGLQSCPMLVAK GYCDIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALRGDGGNGL LAAMEEAIKISEDPSMDGPCTTYQSNRALDVVQDSDDDVIHMGHAIMTFYSALIDLLGRC APEMHLIQGGKGEAIRIRAILRSLIPIQDLQGVISISFQIPSVSKDGTLVEPDLSTVFCP DHKAAMVLFLDRVYGVESQSFLLHLLEVGFLPDLQAAVSLDTADLGSTDMALALNRYLCT VVLPLLTKYSVLFHDLEDHILLVDSLIQAVYRLSRALSLTKAQRDTTEECLLALCSKLQP PMMQPLLRRLVFDVLHLTDHSKMPLKLLTSHYEQRWKYYSQSGRQGEQGCASEEELYLST KLFWGVFKALAKKPQMLQLSSLCVQCLSAVALALPPDHMEQNCLSHIERITSMDTDGHFD SQPVDTSNVSVPERLEFVVNKYAEHTHEKWSLEKFVSGWVHGEHLCENTKVHPRLKPYRA LAEKEKEAYRWAIKETIKTMLAFGWNIERTKEGDAFSMHPCTRRVSQSGQLSFEGASTFS PKPVDMSCITLSWDQCAMAEQLAENYHNAWAKTKKLELESKGGGSHSLLVPYDTLSAKEK AKFRERAQDVLKFLQLNGYTVWRDRKSVEMDFPAIANCFAYTLLQRLLSHTEEAQENLLK LELMQARGQMSKGERAPHEQPVIFFHKVILPLLEQYVKSHRLYFLSASSSDNRSHASRKE KEMIACLFCKLAALVRHRISVFGREASSVASSLHVLAQALDARTLMKSAPESIQTSLHSF FKAAASDLEMTVETLSESLVSLPQSRSQLARGVAKVLNYTTSILLPTLTSLFLHLGNQNH GVDLLAGGIQVSCYRILNSLYALGTSSSIYMEGHRSAAGACLAALTGAFPVCFLEPDLNQ NNPYSIYNMMTATQIKDQGLPDQVEDMCPLLPSLGQALREVEELAGAGAHQAHYIHVAEV TLPMLCSYISHWWNLGPEGQPERPVCTSVVPKHASDLLGNILRIIHNHVGASQGDWMKQL AVFSQPVICKVHPELLKSHFLPLMEKLRKRTECVLAEEEQMKAEGGDTSDAELQIQEKFA MLVRDLYAFFPLLIPFVDTHRARWLKDLNPEAEQLFSMVAEVFIFWAKSHNFKWEEQNYV VQNEINNLSFLANNDKTFKLDNEKRKMRRKRGCYSTNTSLIVALMKRLTPVGLRVCFPSD HSLIILAKNAFSQKTTENEIRDHIFNCVVHLQNQGSDSLRQKILTELPNQPGYISDAEKT VDRIMEIARVLYYLDQVEHPLRNKKPARHTVLSKQRKRAVVACLRMTPLYNLPRHRAVNL FLQAYNKSWISAEEHSFEETLVENLAKRGVMEPYVGGRGEEKDVKEGAKPIDPLLQLITL FSRSALTESSKLEIDSLYKSYAAIMAKSCSREGEEEEQEVESFEEKEMEKQKLLYQQARL HCRGASEMVLQTISASKGAIGSMIAPTLKLGIAILSGGNATVQQKMLDYLKEKRDVGFFQ SMSGLMQSCSVLDLNAFERQNKAEGLGMATDESSGEKVMPDKDLTCDLFRFLQLLCEGHN SDFQNYLRTQTGNNTTVNIIISTVDYLLRIQESISDFYWYYSGKDAIDSQGQHNFSKAIE VAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHLQMKLSQDSRQIELLKEL MDLQKDMVVFLLSMLEGNVVNGTTGKQMVDMLVESSSNVEMILKFFDMFLKLKDLTSSEA FTEHDPDRQGSISRKDFQKAMENCKHLSQTEIHFLLSCMETDDGEIVNYEAFVDRFHEPA KDIGFSITVLLTNLSEHMPNDSRLKTFLELAESVLTYFEPCLGRIEILGSGKRFERVYFE ISEYSRTQWEKPQVKESKRQFIFDVVNEGAEREKMEMFVNFCEDTIFEMQLAAQISGSNT GERNTGKQVEDKRHLDDQGMFFMIHWWLFLSTLLSLTNLKTLMKMTLKDILTSAALFVRF ICMAQVRCIYVLFRSILYVLYIAFVSGGLIEGAKRMRISDLLGGILEPTLDEVTEVPSGV DQPRRYSASFSSHRELREIGQMGAVTSPREVDVLSGIFGLKLKKEEGRYKLVAQDLTASL DDLFSTSSRTSASSDIEKHQITQQIKDHTTTEEKNEDKKMKTEEKKSEKKIGNEKAKARG RAKIFSNKLKEPQSQQSALWETIGTHNKSLLNYFARNFYNLRLLALFVTFAINFILLFYK VTSFPNLKEEEGMTTSVYGEDLNSDADNSEGRVYFVLEKNSGYMEPSLNFLAVAHTIISF CCIIGYYCLKVPLVIFKREKEVARRLEFDGLYVTKQPPEEDIKGQWDRLVINTPSFPSNY WDKFVRRKVMDKYGDFYGCEKISELLGLDKATLDLSSETKTKKRLKRDAAWSALCNSIDM KYQVWKLGVVFTDNSFLYLAWYMTMSFLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHN GKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSDDKDIQDMKCNDMLTCYMFHMYVGVRA GGGIGDEIEDPAGDEFEVERIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKED METKCFICGIGSEYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKM YQERCWEFFPVGDCFRKQYEDQLDPYPPVFAVPPSCVPSAPLQFLVSSSFPPSLSAVV NT seq 14937 nt NT seq  +upstreamnt  +downstreamnt atgactgacagtggagaaggcgacgatgaattccagtttctacggacgggagatgaggtg gttttgcagagtaccttcacctcccaggaggaacatgtgaagctatgtcttgctgccgaa ggatttggcagcagactttgccggcttgagcccacctctaactgtaagaatgttccacca gacttgtctgtgtgtggctttgtcctggcccagtgtctttctgtgcgagccctgcaggag atgttggcccacagcgaacacctggctgcagaggtgggagctggaggtagccatcgcacc cttctatatgggcaggcggtattgtttctacactcatacagtggcatgtacttcagctgc ttgccttcttctcagtcttcaactgacaagctggcttttgatgttggcctgcaagaggac aaagcaggggaggcgtgttggtggactgtccacccagcatccagacagaggtcagagggt gagaaggtgcgcgtaggtgatgacctcatacttgtgaatgtgtcttcagagagatacttg cacctttcctttggcactgcatctgacaacaaaagcttgagtgacagtctgattgttaat gcagccttccagcagaccctctggagtgttgctcccatctgctctggacgcgccgttgct caaggatacctgaaggggggtgaaacacttcggctactccacagccacagtgatgcgtgt ctgactgttccctctacagagcatggagaggagcttcaaaggataatgcattatgagatt ggatcagtctccggtcatgcccggtctctctggaggctggagattctgcgagttgtctgg agtggtaggcatacatgctggggccagccatttagactgtgccacgttactactggaaga tacctgggtcttacagaggagaaaggtctgcagctggttgatcgggacaaagctgacatc aatacaacctccttctgctttcgatcatcaaaggagaagcttgacaccaacacaaagact gatgttgatgggatgggaatcccggagatcaaatatggagattccatttgttttcttcaa catgtagcctctgggctctggctaacataccaagctgctgatgccaagtcccatatgggt ggagctcagcgaaaggcaattttgcacagtgaagggcatatggacgacgggctgacactg tctcgttctcagagggaagaatctcatattgccagactaatccggagtgctgttctcctc ttcactcgctttgtaaggaaacttgatggttttaaccaagaagtaaatatcccctctgtc agcctgtcagtggagacagtgacacgcagtctgcaggatctgataatctatttccagcct ccactggaggggctaggccatgaagctaaacagaacagcatggtggcgctaaagaatcga cagaacatgtttcaaaaagagggtgtgatagatttggtcttagattgtattgaccgtcta caccagtatagtagtgcttctcattttgccgaggctgttcagagtgacacaggagaggag tgggagaccatcgtcaaccatttctatgagctgttggctgctctgctccggggaaaccgt gcaaattgtgctaatttctcaggttcgctggactggctgattagcaggctagaacggcag gaggcctcttctggagtcttggaggttcttcactgcgtccttgtggaaagccctgaagct ctcaatgccatcaaggaccaacacattcagtctgtcatctcatttctggacaagcatgga tgcaaccacagggtgctggaggtgctttgttctctgtgtgtgtgccatggtgtggcggtg cggtccaatcagaacctcatctgtgacagtctgctgccagacagagatttgctactccaa acacgtctcgttaatcaggtcaccagcatgaggccaaacatcttcctagctatgggagaa gattcatcccagtatcgcaggtggtactacgagctggttgtggatcacgtcaaccccttt ctcacatctgagcccacacacctgcgtgtcggctgggcttgcatgaaaggctaccagccc aggccgacaggcggcgagggctggggggggaatggagtgggagatgacctctgctcgtat ggctttgatggacttcacctctggtcaggctgtgtgagccggaaagtcagctccccgttt cctcacctactaaaagatgatgatgtcgttagctgctgccttgacctcagcattccctgc atctcattccgggtcaatggtctacctgtgcagggcatgtttgagaacttcaatgctaat ggacttctttatcctgtggtcagcttctctgccggagtaaaagttcgttttctgtttggg ggaaggcatggagagtttcgcttcctgccacctccaggttatgcttcttgctccgaagct cttctcccaaaagtcaaactgaaggtacagctgtgtcaggaatacattttgggtcatggt gaagggaaacaagagcttattggccccttagtgcctgtcactccagttaccttcactcca acaccaatagacatcagtaaggtggtattgcctccacaacttgaggacattcgagaaaaa atggctgagaatatccatgagctctgggtaatggacaagattgatctcggatggacacat ggactagtgagggatgaaggtaagaaacacgatccttgtctggtggagttctccaagttg ccagagcatgagagaaaccagaaccttcagatggcacaggacacactcaggaccctgctg gcacttggtttccacatcggattgatggatgatcatgctgagaaacacatgaaatacatg agacttcctgtcaagtatgagcagatgactgggtacaggcctgctccagtagacctgagc caggtgtctctgagctcagaccacgaggaagcagttaacttgctggcggagcatgaacac aacgtatgggccagagagcgaatcaaacagggatggacttatggagtgcaacaggatata aaagcaaagcagagcccttaccttctgccctacagccttcttgatgaaagaactcggaga gtgggaagagagagtgtcagagaggctgtctgtaccctgctggcatacggctacagcctg gagcccctaaaccaggaacgcactacattatcaaagccatgtttcttctctgctgagaaa tgcagagtgttcagaccagataaatcatatgctgtgacccgggggaagtggtattttgaa tatgaaatactgacagcagggaatgtgagagtgggctgggcccgaccaggctgtacccca gataaagagcttggctcagatgaccaagcatatgtctttgatggatttgaggctcagtgg taccatcagggcggcgagcccctgggacgtccgtggctgagaggtgatgtggtgggttgc ttggtggacatggatgaatgcaccatgatggttacgctcaatggacagctgctgtttaat gacagaggatcggagctggctgccaaggactttgatattagagatggcctattacctgtg gttagtgttggggtgaaccaggtggggaggctgaacctgggacgccaagtaggctccttg cagtactttactgtgtgtggcctgcaggaggggtatagaccctttgccgtcaacatggcc agagacacagctctgtggatgagttggaaacagcctcagtttacctccatactacctgat gatcactatttacaggttacaagagtcagtggctcagtagattccttatccagcctgagg gtctcccagtgtatgcaaccgcaccatggtggagaaagtgagatgggctattatcgcctc agcatgtctgtcgactgtgctgcagtcctcggtagcccaccagggggggtgcttcctgtg gcctccagcgctctctccccaagctcagaaaggaaagagcaggaggaggtggactctgac tttgaggtgctgatgaagtcagcccacagctatgctggttcaagagatgagctcaaccat aaagatcatagtcacgacaaaacatcaagactgaaacagcggtttatgctgaagaagacc aaaccaggcttagtcagcagtaactcatctgcacggctcctcgaagacgttgtagtcgac aaggataactatgatcaccttatccagagctccagatattactactcagtgcgggttctt ccaggtcaggagccattcagtgtgtgggtaggctgggtgacctctgactttcatcagcat gacatgacatttaacactgacaatgtccacactgtgactgtcacccttggagatgacagt ggcaaagtccacgaaagcgtaaagcggtctaactgctatatggtttgtgctggagaggca acaggcctgtctcagagtcggagaagcacaggattggaaattggctgtttgattgacaca accactggtctgcttacatttacctccagtggagtggagatggccactttctaccaagtg gaggcaagtacaaagctctttcctgctgtttttgtcaaacccacaaccaaaaacatgttt cagtttgaactgggacgcatcaagaacgtgatgccactgtcctcaggtttgcttcggagc cagtcaaggaacgtcactcctcagtgtcctcctagggttcaggtccagcggctgaggcct gcttcatggactagagtaccagacagagcactgaaagtgttggttgatcgaccagatgaa cgtcatggctggagaattcaatgccatgagcccttacaagccatgatccttcacattcct gatgaaaacaggtgtgttgacattttggaactgtcggagcttgatgacctcttgaccttt caccacaataccctcctgctctactgctctttatgtgcccttggcaacaccagagtttgc cacgccctctgcagtcatgtggaccagtcgcagattctttatgctattcaggatccctac ctccctggcctgctccggtctgcattttatcagctgctttttcaggttttcctcagcagc tacaccacagcctgtttgatgatgaaccatgaatacatagttcctatgactgaccaaacc agagaaatcaccctttatcccagtcctattaatggtggggatagacaacctccagaggga atatcaagtgctagttgtagcacatcccttaaacctcagatgcatttttcaactccttgc tttatcagaagtgattgcatggaaggagctagtgcactggaaatagcctgcaaagacagc ccagaaatccctctggacgtattgaagaatcttaccgtggagatgctgactgctgcagtt tgggctgtgggtcaggatgtaagggatcctgcaggaggcaatatcgaacttttgcttgtt cctttattaagacttttctacagcctcttggttatgggggtgtgtagggatgaagactta gggaagattcttagactcatggagcaaggtgcatttgcaaggcctggaacacccatagag aagttggaagaagaaactagtgatgatgaagaagagcagaaaggagtgatcactgaagaa agtaacactgttaaacaaggacttcttcaaatgaagcttccagaagctgtcaaacttgag ctctgccacctgctatcctacctgtgtcactgccaggttcgccacagggtagaagctgtg attgctttctccgacagctttgttggccagctgcaggagaaccagcggtttcgctacaac caggtcatgcaggcgctcaacatgtctgctgccctcactgctcgcaagacaaaggagttc cggttacctccacaggagcagatcaatatgctgctgagcttcagagaagatacgcagcag gagaactctccgtgtccagtggaaatccaggagcttcttcaagacttccatcacctcctc aagacacactgtggcattgatttggccagcacctcagaggatgaagaggatgcagagatg tctctaaaagaacgacttctcggtcttgtggcgagagtcattggccgtaataagtcatca gtggatatagacgggtgttcttcacacagccctaagtccctcaaaaagatgatttctgaa acaatggtgcgctgggctcaagagagtgagattgaggaccctgaactagtcagtgctatc ttctcattgctgcaccgccagtatcagggcctcaggtccctaatggaaagacccttattc aaagcttataccatcaagcagtcgtcactggaggacaccatggcactcttgtcctccttg ggccaaatccgctccctcctcagtgttcgcatggggaaagaggaagagaggttgatgatc agacgactaggagatatcatgaataataaagttttctaccaacatccaaacctaatgagg gcattgtcgatgcatgagactgtgatggaggtgatggtcaatgttcttggagaagggcaa ataaaggagattacctttcctaagatggttgccagctgctgtcgattcctgtgctatttt tgccgtatcagccgacacaatcagggagccttgtttgaccacctcagctacttattggaa aacagcagtgtcgggctagcttcgccgtccatgcgtggatccactcctctggatgtggct gcagcttcggttatggataataatgaattggccttagcactgagggaatcagacctggag aaggtggttcagtgccttgctggctgtggtctccagagctgtccaatgctagtggcaaaa ggttattgcgatatagggtggaaccctgtggagggcgagcgttatctggattttctacgt tttgctgtcttttgcaatggtgagagtgtcgaggagaatgcttatgtggtgttgaggctg ttgattcgtcgacctgagtgttttggccccgcgctgcgaggtgatgggggaaatggtctc ttagcagccatggaagaagccatcaagatctctgaagacccttctatggatggtccttgt actacttatcagtcaaacagagcgctagatgttgtccaagacagtgatgatgatgtcatt cacatggggcacgccatcatgaccttctactcagctcttattgacttgctcggtcgctgt gctccggagatgcatttaattcaaggaggcaaaggagaggcaatccgtatcagggccatt ctgaggtctctcatccctattcaggatcttcagggagtcatcagcatctcctttcaaatc ccttcagtctctaaagatggtacattggttgagcctgacctatctacagtgttctgccca gaccacaaggcagccatggtgctgttcctggatcgggtttatggcgttgagagtcagagt tttcttctccaccttctagaagttggctttctgcctgaccttcaggcagctgtctctctt gacactgctgacctaggatccactgatatggctctggccctcaatagatacttgtgtact gttgttcttccccttctcaccaaatattcagttcttttccatgatttagaggaccacatc ttgctggttgattctctcattcaggcagtctaccgcctctcgagggctcttagcttgacc aaggctcagagagacaccacagaagagtgtctgttggctttgtgcagtaaactccagcca cctatgatgcagcctctccttcgtcggcttgtctttgatgtccttcatctgacagaccac agcaaaatgcctctaaagctcttgaccagtcactatgagcaaaggtggaagtactactcc cagtctggcaggcagggtgagcaaggttgtgcatctgaagaagaactctatctgtctaca aagttgttctggggggtgttcaaggccttagccaagaagccccagatgcttcagttatcg agtctatgtgtgcagtgcctctctgcagtggccctggccctgcctcctgatcatatggaa caaaactgcttgtcgcacattgagagaataacctccatggatacagacggacactttgac tcccagcctgtagatacatccaatgtgtcagtgccagagaggctggagtttgttgtgaac aagtatgccgagcatactcatgaaaagtggtcactggaaaagtttgtcagtggctgggtt catggagagcacctatgtgagaacaccaaagttcaccctcgcctcaagccgtacagggct ctggctgaaaaggagaaggaggcataccgctgggctatcaaagagacaataaagactatg ctggcctttggctggaacatagaaaggaccaaagaaggagatgcgttcagcatgcatcca tgcacacgcagggtctctcagtctggacagctgtcatttgaaggtgcatcaaccttcagc cccaaacctgtggacatgagctgcatcaccttatcatgggaccaatgtgccatggctgaa cagctggctgaaaactaccacaatgcctgggctaagacgaagaaattagaacttgagagt aaaggaggaggtagccattcgctgcttgtaccttatgataccttgagtgccaaagagaag gctaaattcagagaaagagctcaggatgtcctcaagttccttcagctcaatggctacact gtgtggagagatcggaagtcagtggaaatggactttccagccatagccaactgctttgca tacacgctgcttcagcggctcctgtctcacactgaggaggcccaagagaaccttttaaag cttgagctgatgcaagccagaggacagatgtctaagggagagagggctccacacgagcaa ccagtcattttttttcacaaggttatccttcctcttttggaacagtatgttaaaagccac cgtctgtatttcctgtctgcttcctcaagtgataatagaagccatgcctcgagaaaggaa aaggagatgattgcatgcctcttttgtaagcttgcagctcttgtaagacacaggatctca gtctttggaagagaagcctcgtcagttgcaagctccctccacgttttggctcaggctctt gatgccaggactttaatgaagtcagcaccagagtctattcagacatctctgcattccttt tttaaggcagcggcgtctgatttagagatgactgtggaaaccctttctgagagcttagtt tcactgcctcagagtaggagtcagctggcaagaggagtagccaaggttctcaactacaca acctccatccttctccctacactcacttctctattccttcatcttggaaaccagaaccat ggagtagatctcctggctggtggtatacaggtatcctgctacaggatcttaaacagcctc tatgctcttggaaccagtagcagcatctacatggaggggcataggtcagcagcaggtgct tgtctggcagccttgacaggagctttccccgtgtgtttcctggagccagatctaaaccaa aacaacccttactccatctacaatatgatgactgctactcagataaaagaccagggattg ccagatcaggtggaggacatgtgtcccctcctaccttctctgggacaggcgctgagggaa gtggaggagctggccggtgctggagctcaccaggcccactacatccatgttgcagaggtt actttgcccatgttgtgcagttacatttcccactggtggaacttgggtcctgagggccag ccagaaaggccagtgtgtacctctgtcgttcctaagcatgctagtgacctacttggcaac atcctgcgtatcatccacaatcatgtgggtgctagccagggtgactggatgaaacagctg gcagttttttctcagccagtcatatgcaaagtccatcctgagctgttaaagagccacttc ctgccactaatggagaagctgagaaagaggacagaatgtgtgttggcagaggaggagcag atgaaagcagaaggtggagatacctctgatgcggagttgcagatacaagaaaagttcgct atgctagtccgagacctctacgccttctttcccctcctcatcccatttgtggatactcat cgagccaggtggctgaaagacctgaaccctgaggctgagcagctgttcagcatggtggca gaggtctttatattctgggccaaatcccataatttcaaatgggaggaacagaattatgtt gttcaaaatgaaatcaacaacttgtctttcttggccaataatgacaaaacattcaagctt gacaatgagaagaggaagatgaggaggaagaggggttgttattccaccaacacctctctc attgtagctttaatgaagaggctgacccctgtgggactcagggtttgttttccgagcgat cacagtctcatcatcttggctaagaatgccttctctcagaagaccactgagaatgagatc cgagatcatattttcaattgcgttgtacatcttcagaatcagggatcagacagtttaaga cagaagattcttacagagctcccaaaccaacccgggtacatcagtgatgcagaaaagact gttgacaggattatggaaatagctcgagtcctttattatcttgaccaggtggaacaccca ctgagaaacaaaaaacctgccagacacacagttttatcgaaacagaggaaacgtgcagtg gtggcctgcctgagaatgactccactctataacctacccaggcatcgagctgttaacctg ttccttcaagcctacaataaatcctggatatctgctgaggagcacagctttgaagagaca cttgtggagaatttagctaagaggggggtaatggaaccgtatgtaggtggaagaggtgaa gaaaaggatgtgaaggaaggtgccaaaccaatcgatcctctcctacaactcattacactc ttcagtcgaagcgccctgacagaaagcagtaagcttgaaattgacagtctctataagtcc tacgctgctattatggccaagagttgtagcagagagggcgaagaggaagagcaggaggtg gaaagctttgaagagaaggagatggagaaacagaagttgctgtaccagcaagccaggtta cattgtcgtggagcttctgagatggtcctgcaaactatcagtgccagcaaaggtgccata ggctccatgattgcccctacgctgaagttaggcattgctattctcagcggaggaaatgcc actgttcagcagaaaatgctggattatctaaaagagaagcgagatgtgggcttctttcag agcatgtctgggctcatgcagtcatgcagtgttttggatctgaatgcctttgagaggcag aacaaagcagagggattaggcatggccacggacgagagctcaggagaaaaggtgatgcct gacaaagacctaacctgcgacctgttccgtttccttcagctgctctgtgaaggacacaac tcagatttccagaattacttgagaacacaaacaggcaacaacaccactgtcaacatcatt atatccaccgtagactatttactaaggatacaggagtccatcagtgacttctactggtac tactcgggtaaggatgcgattgattcacaaggtcaacacaacttctccaaggccattgaa gtggccaaacaggtcttcaacacactcactgagtacatacagggcccgtgtactgggaac cagcagagtctagctcatagtcgtctttgggacgctgttgtgggattcctccatgtcttt gcgcacctgcagatgaagctctctcaggattcaaggcaaatagagcttctgaaggagctc atggatttacagaaagatatggttgtgtttttgctttccatgttagaaggtaatgttgtc aatggaactactggaaagcaaatggtggatatgttggtggaatcgtcaagcaatgtggaa atgattctcaaattttttgacatgttcctcaaacttaaagacctcacctcctcagaagcc ttcacagaacatgatcctgatcgtcagggaagcatatccaggaaggacttccagaaagcc atggaaaactgcaagcatctctcgcagactgagatccacttcttgctttcgtgcatggag actgatgatggtgaaattgtgaactatgaggcctttgtggatcgcttccatgagccagca aaagacattggcttcagcatcactgttctcctcaccaatttgtcagaacacatgcccaac gattcaagactaaagacattcttggaactggcagaaagtgtcttgacttactttgagccc tgtctaggacgcatagagatcctcggcagtgggaagcgcttcgaacgcgtctactttgag atcagtgaatatagccgtacgcagtgggagaagccacaggttaaagagtcgaagaggcag ttcatttttgatgtcgtcaacgagggcgcagagagagagaaaatggaaatgtttgtcaat ttctgtgaggacaccatttttgagatgcagcttgctgctcagatatctggctctaacact ggagaaaggaatactgggaaacaagtcgaggataaacgacacctggacgatcagggaatg tttttcatgattcattggtggctatttctgtcaactctactttctctgacaaacctaaag acactgatgaagatgaccctgaaggatatcctcacgtcggctgctctattcgtccgattc atttgtatggctcaggtacggtgcatttatgttttatttcgcagcatcttgtacgtgctg tacattgcttttgtgagtggtgggctcatagagggagccaaaaggatgaggatatccgac ttgcttggcggtatccttgaaccaactcttgatgaggtcacggaggtgccaagtggtgtg gatcagccgaggaggtactctgccagtttctcgtcccacagagaattgagggagattggg cagatgggagctgtgacctcccccagagaggtggatgtactgtcaggcatttttggcctg aaactaaagaaagaggaaggtcgatacaaacttgtagcacaagacctcactgccagtctg gatgacctgttcagcacaagttccaggaccagtgcttcctctgatattgaaaagcatcag ataacgcagcaaattaaggatcacacaaccacagaggaaaaaaatgaagacaaaaaaatg aagacagaagagaagaagtctgagaagaaaattggaaatgagaaagcaaaggcaagaggg agagccaagatattctcaaataagttaaaagaaccacagagccaacaatctgccctttgg gagacaattggcactcataacaagagcctgctgaactattttgcaaggaacttttataat ctgcgcttgctggctctttttgtcacctttgcaatcaatttcatccttctgttctacaag gtaacatcgttccctaacctgaaagaagaggaaggaatgaccacatctgtttacggtgaa gacctgaactctgatgctgacaacagcgagggcagagtgtattttgtacttgaaaaaaac agtggatacatggagccctctctcaatttcctggctgtagcacacacaatcatctccttc tgttgtattattggttattactgcctcaaggtaccattagtaatcttcaaacgtgagaag gaagtggcacgaaggctggagtttgatgggctctatgtgacaaaacagcctcctgaggaa gacatcaaaggccaatgggaccgactggtcattaacaccccatcatttccaagcaattac tgggataaatttgtgaggagaaaggtgatggataagtacggtgacttttatggctgcgag aagataagtgaactcctaggtctggacaaggctactttagaccttagttctgaaacaaaa acaaagaagaggctcaagagagacgctgcctggagtgctctatgcaactccattgacatg aagtatcaggtgtggaaactaggtgtagttttcactgacaattccttcttgtacttggca tggtacatgaccatgtcgtttctgggacattataacaacttcttctttgctgcccacctt ttggatatcgctatgggttttaagacgcttcgtaccatcctctcctctgtcacacataat ggcaaacagttggtccttactgtgggcctcttggctgttgtggtgtacctctacactgtt gtagccttcaacttcttcagaaagttctacaacaaaagtgatgacaaggacatccaagac atgaagtgcaatgacatgcttacttgttacatgttccacatgtatgtgggagtgcgtgca ggcggtggaattggtgatgagatcgaggatcctgctggagatgagtttgaggtggaacgg attgtctttgatattacgtttttcttctttgtcattgtcatcctcctggccattatccag gggttgataattgatgcctttggagagcttcgtgaccaacaggaacaggtgaaggaggat atggagacgaaatgttttatatgtggaataggaagtgaatactttgatacagttcctcat ggctttgagactcacacgcttcaggagcacaacctggccaactatctattttttctgatg taccttattaacaaggatgagacagaacacacggggcaggaatcttatgtgtggaaaatg taccaggagcgttgctgggaattctttcctgtgggagactgtttccgtaagcaatatgag gatcaactggatccttaccctccggtctttgctgttcccccctcctgcgttccttctgct cccctgcaattcctcgtatcgagctctttcccaccatcattgtcagctgtggtatag

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