Orcinus orca (killer whale): 101269393 Help Entry 101269393         CDS       T05247                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism oor  Orcinus orca (killer whale) Pathway oor04020   Calcium signaling pathway oor04371   Apelin signaling pathway oor04713   Circadian entrainment oor04921   Oxytocin signaling pathway oor04970   Salivary secretion oor05010   Alzheimer disease oor05012   Parkinson disease oor05020   Prion disease oor05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:oor00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101269393 (RYR3)    04020 Calcium signaling pathway     101269393 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101269393 (RYR3)   09154 Digestive system    04970 Salivary secretion     101269393 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     101269393 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101269393 (RYR3)    05012 Parkinson disease     101269393 (RYR3)    05020 Prion disease     101269393 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     101269393 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oor04040]     101269393 (RYR3) Ion channels [BR:oor04040]  Voltage-gated cation channels   Ryanodine receptor    101269393 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  101269393 NCBI-ProteinID:  XP_049561424 LinkDB All DBs Position 2:123851688..124407301 Genome browser AA seq 4869 aa AA seqDB search MAEGAEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTALFSQ FVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEEMQHEDRQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSIAHFTGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPQRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLRKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEMLVDKLAENAHNVWAKDRIRQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRID GTMDSPPCLKVIHKTFGTQNGNATMIYCRLSVPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSDRHGWVVQCLEPLQMMALYIPEENRCVDILELCEKEDLMWFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGFLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSSTRKIRLYPDESKRHGLPGVGPRTCLKPGFRFSPACFVMTSEEHQ KQSPEIPLELLKTKALSMLTEAVRCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLVIDPSVFGEHSGDTQDGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREEMYDFHEDLLIHCGVPLEEEEVEEED ASWTGKFRALVYKIKGSSKPEKERPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSAEDHEDEEEVVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAVLALNRYICSAVLPLLTRCAPLFAGTEHYSSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEDELHLTEKIFWGILDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDT RISATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALFQQRE NEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVIAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGIKDMGLDASSMEKRFAYKF LKKILKYVDSAQEFIAHLETIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGNDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQMKGVSQNINYTTVALLPI LKSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAG AIPVAFLEPTLDCYNPLSVFNAKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKII NNNLGIDEASWMKRIAVYAQPIIGKARADLLRSHFIPTLEKLKKKAVKTVQEEEQLKADS KGDAQEAELLILDEFAILCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLWNNLHLQEKS DDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLARSPKVEE EEAEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEEGEEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKDVIDESGQHNFSKALAVTKQIFNSLTEYIQGPCVGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTGSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLTYFEPYLGRIEIMGEAKKIERVYFEISESSRTQWEKPQVKESKQQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEENEDSSYTLEVEGEEDDKAFECAS AFAVACASVKRNVANFLKRATLKNLKKQCRKVKKMTLKELVKVFFSFFWTLFVGLFHLLF AILGGIFQILWSTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVSEPGI ATELVHFVKGERGDAEIMSDLFGLQSKKEGGLKHGPEVGLGDLSEITGKDEPPTLESTVR EKRKASAAETKAAHETEGKVESEKADTEDGEKEDTAKEKQAEAGWADATKRKKRWCGQKI EKPEAFMASFFKGLEIYQTKLLHYLARNFYNLRLLALFVAFAINFILLFYKVTEEPLEEE TEDIANLWNSFNDEEEEEAVVFFVLQESTGYMAPTLRALAVIHTIISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNS FLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggggcagaaggaggcgaggacgagatccagttcctgcggactgaagatgaa gtggtcctccagtgcatcgccaacattcacaaggaacagaggaagttctgcctggcagct gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtcctggaacagtccctctctgtcagagccctacag gaaatgcttgccaacacaggtgaaaatggtggcgaaggggctgcacaagggggtggccac aggaccctgctgtacggccacgcgattctcctgcggcactccttcagcggaatgtatcta acatgtttgactacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcccgcttccaagcagaggtct gagggagaaaaggttcgaattggtgacgacctcatccttgtcagcgtatcctctgaaaga taccttcatctctcaatatcaaatggtaacatacaagtggacgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcgggaagtagcatcgaagaaggatacctacttggt gggcacgtagtacgtcttttccatggtcacgatgagtgtttgacaataccatctacagac cagaatgattcccagcacaggaggatatactacgaagctgggggagctggcacgagagcc agatctctgtggagagtggaaccccttcggataagttggagcggcagtaacatcagatgg ggccaggctttccgacttcggcatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaagatcggggaaaatcagacaccaagtccacagccttctctttc cgagcatcaaaggaaatcaaggagaaactggattccagtcacaagcgagatatagagggc atgggagtcccagaaatcaagtacggagactctgtctgctttgtccaacatatagccagt ggtctctgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggttaacactgcagagatgc cagcatgaggagtcccaggctgcccggatcatccggaacacgaccgctttattcagccag tttgtaagtggaaacagccgcacagcagcccctgtcaccctgccgatagaagaggtcctg cagaccttacacgacttgatcgcctacttccagcccccggaggaggagatgcagcatgag gacaggcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttggcccttgtgttaaactgcattgatcgcttaaatatctacaatagcatagcacac ttcacagggattgccagggaggagagtgggatggcctggaaggaaattctgaacctcctc tacaaattgctggctgctctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctgattgaaagcccagaagccttaaacctgatagcggaaggccac atcaagtcaatcatctccctgttggataagcacgggcgaaatcacaaggttctggatgtg ctgtgttccctctgtctctgcaatggggtcgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccagagaaacctgctcctgcagacgcggctcattaacgatgtgaca agtattcggccaaacatcttcctgggagtcgctgagggctcagcacagtacaagaagtgg tacttcgagctaatcatcgaccaggtggaccccttcctcacagcagagcccacacacctg cgggtgggctgggcctcttcctcaggctatgccccataccccggaggcggagaaggatgg gggggcaacggtgttggtgatgacctgtactcctacggctttgatggacttcacctttgg tcaggccgcatacccagagccgtggcctccatcaaccagcacctcctgaagtcggacgac gtggtgagctgttgcctggacctcggagcacccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgtttcctgatggggggacgtcacggagaatttaagttc ctgcctccctctggctatgccccttgctacgaagccttacttccaaaagaaaagatgaga ttggagcctgtcaaagagtataaacgtgatgctgaaggtgttcgggatctgctgggtacc acccagttcctctcccaagcttctttcattccgtgccccatagataccagtcaggttgtt ttaccacctcacctagagaagatccgagacaggctggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaacaaaaga caacacccctgccttgttgagttttcaaagctacctgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctcctggccctggggtgccacatcgctcatgtt aacccagctgctgaagaggatctcaggaaggtcaagttgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa atgttagtggataagcttgcagaaaatgcacacaatgtttgggcaaaagacagaataaga caaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccccgtctggtg ccctatgcattattggatgagcgtaccaagaagtcaaatagggatagccttcgtgaagct gttcggactttcgttggctatggctataacattgagccatcagaccaagaactagccgac ccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctcttat gcagtgagatctggaaagtggtattttgagttcgaggtagtgaccggaggagacatgcgt gtcggctgggccaggccaggctgtcggcctgacgttgagctgggggctgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgg acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacgctgaatggggagttgctgatcaccaacaaaggctctgagcttgccttcgctgac tacgagattgacaatggctttgtgcccatatgctctctgggcctgtctcagatcggacgc atgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgcgatgtggccatgtggttcagcaagcgc ctcccgacatttgtcaacgtgcccaaggatcatccgcagatagaggtggtgaggatcgat ggcaccatggacagccctccgtgcctcaaggtgatccacaagacgttcggcacgcagaac ggcaacgccaccatgatctactgccgcctgagcgtgccggtggagtgccactcctccttc agtcacagcccgtgtctggacagtgacgctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactacgcaattcgcatctttgctggacaggatccc tcctgcgtctgggtcggatgggtgactcccgactatcatttgtacagtgaaaagtttgac ttgaataaaaactgtaccgtgactgttactctgggggacgaaagaggccgggtccacgaa agtgtgaagcgcagcaactgctacatggtctggggtggggacatcgtggccacgtcccaa agagcaagtcgcagcaacgtggacctagagatcggctgcctcgtggatctggcaatgggc atgttgtccttctcggccaacgggagggaactcggcacctgctaccaggtggagcccaat accaaggtgtttccagcggtcttcctgcagcctacaagcacctctttgtttcagtttgaa cttgggaagctgaagaacgccatgcccctgtcggcagccatatttaagagtgaagagaaa aaccccgtcccgcagtgcccaccacggctggacgtccaaaccatccagcccgtcctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgggtgagcgaccgccatggc tgggtggtgcagtgcctggagcctctacagatgatggcgctctacatccccgaggagaac aggtgtgtggacatcctggagctctgcgagaaggaggacctcatgtggttccattaccac acgctgagactctacagcgccttgtgcgccctgggaaacagccgggtggcttacgccctg tgcagccacgtggacctctcccagctcttctacgccattgacaacaagtacctccctggc ttcctgcgctctggcttctatgaccttctcatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacatcatccccatcaccagcagcaccaggaaaatc cgcctgtacccggatgagtccaagaggcatgggctccctggggtgggcccgagaacgtgc ctcaagccagggttcaggttctcccccgcctgcttcgtcatgaccagcgaggaacaccag aagcagagccccgagattcccttggagcttctcaagacgaaggcgctgagcatgctgacg gaggcagtgcggtgcagtggggctcacatccgggaccccgttggggggtccgtggagttc cagttcgtgcctgtgctgaaactcatcggaaccctgctggtcatgggggtgtttgacgat gacgatgttcggcagatcctccttgtcatcgacccctccgtgtttggggagcacagtggg gacacacaggacggagcagagaaggaggaggtgacccaggtggaggagaaggctgtggag gctggggaaaaggccagcaaggaggctcccgtcaaaggcttgttgcagacccgattaccg gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcaa caccgggtggaggccatcgtggcctttggcgacatttatgtctccaagctccaggcgaat cagaagttccgctacaacgaactcatgcaggccctgaacatgtctgcggccctgactgct cggaagaccagggagttccgctcacccccgcaggagcagatcaacatgcttcttaacttt caactgggggagaactgcccgtgcccagaagagatccgggaggagatgtatgacttccac gaggaccttctcattcactgcggggttcccctggaggaagaggaagtggaagaggaagac gcctcctggactggaaaattccgtgccttggtgtataaaatcaaaggctcttccaagcca gagaaggagcggccgacagaggaggaggagagatgccctacgacgctgaaggagctcatc tcacagaccatgatctgctgggcccaggaggaccagatccaggatgcagagctggttcgg atgatgttcaacctcctgcggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccataagccaggcctccgtgagcgacaccatcagcctgctggctgcc ctgggccagattcgctgcctgcttagtgtccggatgggcaaggaggaggagctgctcatg atcaacgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctcatg cgagtccttggcatgcacgagacagtcatggaggtgatggtgaacgtgctgggtgcagag aaatctcagattgcctttccaaagatggttgctagctgttgccgcttcctgtgctatttc tgtcgaattagccgacaaaatcagaaggccatgtttgagcatctcagttacctgctggag aatagcagtgttggcctagcctccccgtccatgagaggatccaccccgctggacgtggct gcttcctctgtgatggacaacaatgagttagcgctgggcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgatgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagaaaacgccagcgtcgtggtcaagctg ctcattagacgccccgagtgcttcggcccggccctgcggggtgaaggaggaaatggtcta ctggcggccatgcaaggcgccattaagatctccgagaacccagccctcgacctcccctcg caggggtacaagagagaagtcagcgcggaggaccatgaagatgaagaagaggttgtgcac atgggcaatgcaattatgtcattttattcggctcttatagatctgctgggccgctgtgct cctgaaatgcaccttatccagacaggaaagggggaagccatccggatcaggtccatcctg cgctccctggtccccaccgaggacttggttggaatcatcagcatccccttgaaactgccc tccctgaacaaagatggatcagtcagcgaaccagatatggcggccaacttctgccccgac cacaaggcgcccatggtgctgttcttggaccgtgtttatggtataaaggatcaaactttc ctgctccacttgttggaagttgggtttttacccgacttaagagcctctgcctctttagat acagtctccctaagcaccaccgaggccgtgctggcactgaacaggtacatatgttctgcc gtgctcccgcttctcacaagatgcgcccctctctttgctggaacagagcactattcctct ttgatcgactctacactgcagacaatatacaggctttccaagggccgttccctcaccaaa gctcagagggacaccatagaggagtgtttgctggccatttgcaatcacttgaggccttcc atgttacagcaactcctgcgacgtctagtttttgatgtgccgcaactcagtgaatactgc aaaatgcctctgaagcttctgacaaatcactacgaacagtgctggaagtattactgtctg ccgtcaggctgggggagctacggtctggctgtggaggatgagctgcatctgacagagaag atcttctgggggattcttgactccctttcccataagaggtacgacccagatcttttccga atggcccttccctgtctcagtgctatagctggggccttgccaccagactatttagatacc aggatctcagccacattggagaaacagatctcagtggacgcagatggcaactttgacccc aagcctatcaacaccatgaatttctccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcactcacatgataaatgggcctgtgataagagtcagaatggatggaaatat ggaatttccctggatgaaaatgtgaagacccatccattgatcaggcctttcaagacgtta acagagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctg gctgtgggctggacggtagagaggaccaaagagggagaagccctatttcaacagcgggaa aatgagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgctccc ctggatctctccaatgttgtgctctccagagagctccaggggatggtggaggtgatagct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggc ggcagtcaccctcttttggtaccgtacgacaccttgactgccaaggaaaagttcagggac cgggagaaggcccaggacctgtttaagttcctccaagtgaacggcattgtggtttccaga ggtatcaaggatatggggctggatgcctcctccatggaaaagaggtttgcctataagttt ttgaagaagatcctgaaatatgttgattctgctcaagagtttattgcccatttggaaacc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttcttctcccactggttgaccagtacttcaccaatcaccgcctctacttcctctcg tcccctctgaagccccttagcagcagcgggtacgcctctcataaggagaaagaaatggtg gccagcctgttctgcaaactcgctgctcttgttcgacataggatttccctctttgggaac gattctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggaca gtcatgaagtcaggctcagagctggtgaaggccgggttacgagcattctttgaaaatgca gccgaagacttagagaagacttcagaaaacctgaagctcgggaagtttacccattccaga acgcagatgaaaggcgtctctcagaatataaactacaccacggtggctctgctccccatc ctgaagtccatctttgagcatgtggcccagcatcagttcggggtggatttactcttgggt gacgtgcagatttcatgctaccatatactgtgcagcctctactcccttgggacaggaaag aacatctatgttgaaaggcaacgtcctgccctcggagaatgcctggcctcactggcaggt gccataccagtggcattcctggagcccacccttgactgctacaacccactctcagtcttc aacgccaaaacccccagggagaggtctattctggggatgccagacacggtggaggagatg tgccctgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggccgagtca ggggcccggtacacggagatgccccacgtcatcgaggtgatcttgcccatgctctgcaac tacctgtcctactggtgggagcgggggcctgagcacctgccccccagcacagggccctgg tgcaccaaggtcacctctgaacacctcagtgtcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgatgaggcctcctggatgaagcgcattgcagtgtatgcccag ccaatcatcggcaaagccagggcggacctgctaagaagccacttcatcccaactctggag aagctgaagaagaaggctgtgaagaccgtgcaggaagaggagcagctgaaagccgacagc aaaggggacgcccaggaggcagagctcctcattctggatgagtttgccatcctctgcaga gacctctatgccttctaccccatgctgatccgctacgtggacaacaacagatctaactgg ctcaaaagccccgatgctgactctgaccagctcttccgcatggtggcagaggtcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaacgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggaggacaggaccaggagaggaagaagacgaagcggaggggggacttgtat tccatccagacctccctcatcgtggctgcactcaagaaaatgctgcccattggtttgaat atgtgcaccccaggcgatcaggagctgatctccctcgcaaaatcacggtacagctataag gacacagacgaagaggtgaaggaacatctgtggaataacttgcacttgcaggaaaagtct gatgacccagctgtaaagtggcaactgaacctatacaaggatgttttgaagagtgaagaa ccttccaacccagaaaagacagtggagcgtgtgcagagaatttcagcagctgtcttccac ctagagcaggtggaacagcctttgaggtccaagaaggcggtctggcacaaactgctatca aagcagcggaaacgggcagtggtggcctgtttcaggatggcgcctctctacaacctgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggatttggctagatctcccaaggtggaagaa gaagaggcggaggagacagaaaagcagccggacccacttcatcagatcatactccacttt agccgcaatgctctcacagagaggagcaaactggaagacgaccctttgtacacctcctat gccagcatgatggccaagagttgtcagagtggggaagacgaagaaggggaggaagacaag gaaaagacgtttgaagagaaagaaatggaaaagcagaaaaccctctatcagcaagctcgg ctgcatgagcgtggagccgcagagatggtccttcagatgataagcgccagcaaaggtgag atgagccccatggtggtggagactctgaagctggggatcgccattctgaatgggggcaac gctggcgtgcagcagaaaatgctagattacctaaaggagaaaaaggatgctgggttcttt caaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagagg cagaataaagctgaaggcctggggatggttactgaggaaggaacactcatcgttcgtgag cgtggtgaaaaagtactccagaatgatgagtttacacgagatctctttagattcctacag ttactttgtgaaggacataacagtgatttccagaacttcctgcggactcagatgggcaac accaccaccgtgaacgtcatcatcagtaccgtggactaccttctgcgtctgcaggaatca atcagtgacttctactggtattattcagggaaggacgtcattgatgaatctggacagcac aatttttccaaagccctggcggtcaccaagcagattttcaattctcttacggaatacatc cagggtccctgcgttgggaaccagcagagcctcgctcacagtaggctgtgggatgcagtg gtcggcttcctccatgtatttgctaacatgcagatgaaactctctcaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggaactattggcaagcagatggttgacacactggta gagtcctctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaa gacttaactggctcagacaccttcaaagaatatgaccccgatgggaaagggatcatctcc aaaaaggaattccagaaggccatggaagggcagaaacagtacacgcagtcggagattgac tttctcctttcgtgcgcagaagcggatgagaatgacatgtttaattacgttgactttgta gaccggttccacgagccggccaaggacatagggtttaacgtggcggtgttattgacaaac ctctccgaacatatgccaaatgattctcgccttaagtgtctgttggacccagccgaaagc gtactcacttactttgaaccgtacctaggacgcattgagatcatgggtgaggccaagaag attgagcgtgtttattttgagatcagtgagtccagtcgaactcagtgggagaagccccag gtgaaggagtctaagcagcagttcatctttgatgtcgtcaacgaaggcggagagcaggag aagatggagctgttcgtgaacttctgtgaagacaccatctttgagatgcagttagcctca cagatctcagaatcggactcagccgacaggccggaagaggaggaggaagaaaatgaagac tcttcctatacgttagaagttgagggcgaagaggacgacaaggcttttgagtgtgcctct gcgtttgccgtggcctgtgcctcagtgaagagaaacgtggccaactttctgaagagggcc accctgaagaacctcaagaagcagtgtaggaaggtaaagaagatgactctgaaggagctg gtgaaggtgttcttctctttcttctggacgttgttcgtggggctcttccacttgctcttc gccatactgggaggaatctttcagattctctggagcacagtgtttggagggggcctcata gaaggcgcaaagaacatcagagtcacaaagatcctgggtgacatgcctgacccaacccaa tttggtatccacgatgatgcaatggaggctgagagggcagaagtgtccgagccgggtatc gccacggaactcgtgcacttcgtaaagggggagaggggagatgcggaaattatgtcagat ctctttggactccagtcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttg ggtgacctctctgagattactggcaaggatgaaccccccacgttagagagtactgtacgg gagaaaaggaaagcatcggcagcagagacgaaagcagctcatgaaaccgaaggaaaagtg gagtctgagaaggcagacacggaagatggggagaaagaggacacagccaaagaaaagcag gccgaagccgggtgggcagatgcgaccaaaaggaagaagcgatggtgtggccagaaaatt gagaagcctgaagccttcatggccagtttctttaaagggctggaaatctatcagaccaag ctgctgcactacctggccaggaatttctacaacctgaggctccttgctctgtttgtagcc ttcgctatcaacttcatcctgctcttttacaaggtcaccgaggaacctttagaagaagag acagaagacattgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcagtg gtattctttgtcctgcaggagagcactggatatatggccccaacattgcgagccctggcc gttatccacaccatcatttctttagtctgcgtggtgggctattactgcctgaaggttcct ttggtggtattcaaaagagaaaaagaaatcgccaggaagctggagtttgatggcctgtat atcaccgaacagccttctgaagatgacatcaaggggcaatgggatcgcttggtaatcaac acaccatcttttcctaataactactgggacaagtttgtaaagagaaaggtgatcaacaag tatggagatctctacggagcagaacgcattgctgaactcctggggttggacaaaaatgcc ctcgactttagcccagtagaagagaccaaagcagaggcagcctccctggtgtcatggcta agttccatcgacatgaagtaccatatctggaagctgggagttgtttttacggacaattcc tttctctacctcgcctggtacacgaccatgtcagtcctgggccactacaacaacttcttc ttcgctgctcatctgctggatatcgcgatgggcttcaagactctgaggactattctgtca tctgtcactcacaatggcaaacagttggtcctgactgtcggtctcctggccgtggtggtt tacctctataccgtggtggcgttcaacttcttccgcaagttctacaacaaaagtgaagac gacgatgagcccgacatgaagtgtgatgacatgatgacgtgttacctgttccacatgtac gtgggagtgagagctggaggtggcattggcgatgaaattgaagaccccgctggggacccg tacgaaatgtaccgcatcgtctttgacattacattcttcttcttcgtcattgtcatcctg ctggccatcatccaaggtcttattattgatgcttttggggagctgagagaccagcaggaa caagtacgagaggatatggagactaaatgtttcatctgtgggatcggcaatgactacttt gacacgacccctcatggttttgaaacacacaccttacaagagcacaacttagccaactac ttgttcttcctgatgtatttgattaataaagatgaaacagagcacacaggtcaggaatct tatgtctggaagatgtaccaagaaaggtgttgggatttcttccctgctggtgactgcttc cggaaacagtacgaagatcagcttggataa

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