KEGG   Orcinus orca (killer whale): 101270961
Entry
101270961         CDS       T05247                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor00562  Inositol phosphate metabolism
oor01100  Metabolic pathways
oor04015  Rap1 signaling pathway
oor04020  Calcium signaling pathway
oor04022  cGMP-PKG signaling pathway
oor04062  Chemokine signaling pathway
oor04070  Phosphatidylinositol signaling system
oor04071  Sphingolipid signaling pathway
oor04072  Phospholipase D signaling pathway
oor04081  Hormone signaling
oor04082  Neuroactive ligand signaling
oor04261  Adrenergic signaling in cardiomyocytes
oor04270  Vascular smooth muscle contraction
oor04310  Wnt signaling pathway
oor04371  Apelin signaling pathway
oor04540  Gap junction
oor04611  Platelet activation
oor04613  Neutrophil extracellular trap formation
oor04621  NOD-like receptor signaling pathway
oor04713  Circadian entrainment
oor04720  Long-term potentiation
oor04723  Retrograde endocannabinoid signaling
oor04724  Glutamatergic synapse
oor04725  Cholinergic synapse
oor04726  Serotonergic synapse
oor04728  Dopaminergic synapse
oor04730  Long-term depression
oor04742  Taste transduction
oor04750  Inflammatory mediator regulation of TRP channels
oor04911  Insulin secretion
oor04912  GnRH signaling pathway
oor04915  Estrogen signaling pathway
oor04916  Melanogenesis
oor04918  Thyroid hormone synthesis
oor04919  Thyroid hormone signaling pathway
oor04921  Oxytocin signaling pathway
oor04922  Glucagon signaling pathway
oor04924  Renin secretion
oor04925  Aldosterone synthesis and secretion
oor04926  Relaxin signaling pathway
oor04927  Cortisol synthesis and secretion
oor04928  Parathyroid hormone synthesis, secretion and action
oor04929  GnRH secretion
oor04933  AGE-RAGE signaling pathway in diabetic complications
oor04934  Cushing syndrome
oor04935  Growth hormone synthesis, secretion and action
oor04961  Endocrine and other factor-regulated calcium reabsorption
oor04970  Salivary secretion
oor04971  Gastric acid secretion
oor04972  Pancreatic secretion
oor04973  Carbohydrate digestion and absorption
oor05010  Alzheimer disease
oor05016  Huntington disease
oor05017  Spinocerebellar ataxia
oor05022  Pathways of neurodegeneration - multiple diseases
oor05142  Chagas disease
oor05143  African trypanosomiasis
oor05146  Amoebiasis
oor05163  Human cytomegalovirus infection
oor05200  Pathways in cancer
oor05415  Diabetic cardiomyopathy
oor05417  Lipid and atherosclerosis
Module
oor_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oor00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101270961 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101270961 (PLCB4)
   04310 Wnt signaling pathway
    101270961 (PLCB4)
   04371 Apelin signaling pathway
    101270961 (PLCB4)
   04020 Calcium signaling pathway
    101270961 (PLCB4)
   04070 Phosphatidylinositol signaling system
    101270961 (PLCB4)
   04072 Phospholipase D signaling pathway
    101270961 (PLCB4)
   04071 Sphingolipid signaling pathway
    101270961 (PLCB4)
   04022 cGMP-PKG signaling pathway
    101270961 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101270961 (PLCB4)
   04081 Hormone signaling
    101270961 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101270961 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101270961 (PLCB4)
   04613 Neutrophil extracellular trap formation
    101270961 (PLCB4)
   04621 NOD-like receptor signaling pathway
    101270961 (PLCB4)
   04062 Chemokine signaling pathway
    101270961 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    101270961 (PLCB4)
   04922 Glucagon signaling pathway
    101270961 (PLCB4)
   04929 GnRH secretion
    101270961 (PLCB4)
   04912 GnRH signaling pathway
    101270961 (PLCB4)
   04915 Estrogen signaling pathway
    101270961 (PLCB4)
   04921 Oxytocin signaling pathway
    101270961 (PLCB4)
   04926 Relaxin signaling pathway
    101270961 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    101270961 (PLCB4)
   04918 Thyroid hormone synthesis
    101270961 (PLCB4)
   04919 Thyroid hormone signaling pathway
    101270961 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    101270961 (PLCB4)
   04916 Melanogenesis
    101270961 (PLCB4)
   04924 Renin secretion
    101270961 (PLCB4)
   04925 Aldosterone synthesis and secretion
    101270961 (PLCB4)
   04927 Cortisol synthesis and secretion
    101270961 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101270961 (PLCB4)
   04270 Vascular smooth muscle contraction
    101270961 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    101270961 (PLCB4)
   04971 Gastric acid secretion
    101270961 (PLCB4)
   04972 Pancreatic secretion
    101270961 (PLCB4)
   04973 Carbohydrate digestion and absorption
    101270961 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101270961 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    101270961 (PLCB4)
   04725 Cholinergic synapse
    101270961 (PLCB4)
   04728 Dopaminergic synapse
    101270961 (PLCB4)
   04726 Serotonergic synapse
    101270961 (PLCB4)
   04720 Long-term potentiation
    101270961 (PLCB4)
   04730 Long-term depression
    101270961 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    101270961 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    101270961 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    101270961 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101270961 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101270961 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101270961 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101270961 (PLCB4)
   05142 Chagas disease
    101270961 (PLCB4)
   05143 African trypanosomiasis
    101270961 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101270961 (PLCB4)
   05016 Huntington disease
    101270961 (PLCB4)
   05017 Spinocerebellar ataxia
    101270961 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    101270961 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101270961 (PLCB4)
   05415 Diabetic cardiomyopathy
    101270961 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101270961 (PLCB4)
   04934 Cushing syndrome
    101270961 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oor04131]
    101270961 (PLCB4)
Enzymes [BR:oor01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101270961 (PLCB4)
Membrane trafficking [BR:oor04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101270961 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101270961 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 101270961
NCBI-ProteinID: XP_033296197
LinkDB
Position
16:36392956..36821075
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAIGKSENDLEGRVVCVCSGTDLVNISFTYMVAENSE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKKKGQISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKSEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLEHENNKKGLVTIEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRLAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKASVTPQ
SSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTLQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCV
KLQDAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcgtttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggacaagttcta
gaatgttctctcatcaacagtgttcgactgggagccacaccaaaggatcccaaaattttg
gctgctcttgaagctattggaaaatcagaaaatgacctggaagggcgggtagtttgtgtc
tgcagtggtacagatctggtgaacatcagtttcacgtacatggtggctgaaaattcagaa
gtaactaagcaatgggtcgaaggcctgagatccatcatacacaacttcagggccaacaat
gtcagtcccatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattaccagaacctttgcatcggggaagacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgaa
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattc
ccattttatgatactaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
ttgaagaaaaaaggccaaatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctagatcgcctagagctttaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccaataataactcatggaaaagcaatgtgc
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcaggcctctgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaatctgaggttgaaaaaaaacagcttgaagctttgaaaagtatg
atggaagcaggagaatctgctgccccagtgaacatcttagaggatgacaatgaagaggaa
atagaaagtgctgagcaagaggaagaagctcaccctgaatacaaatatggaaatgaactt
tctgcagacgacttgggtcacaaggaagctattgccaatagtgttaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactatagaagatgagcaggcttgg
atggcatcttataaatatgtaggcgccaccactaatatccatccatatttgtccacaatg
atcaactatgcacagcccgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagttggtctaggctacttgaagacacatgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgagacggcccgatcgaacatttgat
cccttctctgaaacgcctgttgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagttcttatcagataaaaaaattggcacatatgtagaagtggatatgtatggg
ttgcccaccgacactatccggaaggaattccgaacacgcatggtgatgaacaatggactc
aatccagtttacaatgaagagtcatttgtatttcggaaggtgatcctccctgacctggca
gtcttgagacttgcagtgtatgatgacaacaacaaactgattggccagaggattctgcca
ctggatggcctccaagcaggctatcgacacatttctcttcgaaacgagggaaataaacct
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaaccagtgacatcgccgacgtgcccagtgac
acatcaaagaatgacaagaaagggaaagccaacacagcgaaagcaagtgtgacccctcag
agcagctcagagctcaggcccaccaccacggccgccctgggagctggcctggaggccaag
aaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctcaattctttaaagaagaaacatgcaaag
gagcacagcaccatgcagaagctacattgcacacaagttgacaaaattgtggcgcagtat
gacaaggagaagtcaactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagatcgtggcgcagcacacaaaagagtggtcagacatgatc
aacactcacagtgcagaggagcaggagatccgggatctgcacctcagccagcagtgtgag
ctactcagaaagctcctgatcaacgcccacgagcagcagaccctgcagttgaaactgtct
catgacagggaaagcaaggaaatgcgagcgcaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgggtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagcgactcgcaatgaag
cagtccaaagaaatggaccagttgaaaaaagtccagcttgagcatctcgaattcctagag
aaacagaacgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacgcaaactga

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