Orcinus orca (killer whale): 101275189
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Entry
101275189 CDS
T05247
Symbol
SHMT2
Name
(RefSeq) serine hydroxymethyltransferase, mitochondrial isoform X1
KO
K00600
glycine hydroxymethyltransferase [EC:
2.1.2.1
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00260
Glycine, serine and threonine metabolism
oor00630
Glyoxylate and dicarboxylate metabolism
oor00670
One carbon pool by folate
oor01100
Metabolic pathways
oor01200
Carbon metabolism
oor01230
Biosynthesis of amino acids
oor01240
Biosynthesis of cofactors
oor01523
Antifolate resistance
oor04981
Folate transport and metabolism
Module
oor_M00141
C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00630 Glyoxylate and dicarboxylate metabolism
101275189 (SHMT2)
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
101275189 (SHMT2)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
101275189 (SHMT2)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
101275189 (SHMT2)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
101275189 (SHMT2)
Enzymes [BR:
oor01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.1 glycine hydroxymethyltransferase
101275189 (SHMT2)
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Gene cluster
GFIT
Motif
Pfam:
SHMT
Aminotran_1_2
Motif
Other DBs
NCBI-GeneID:
101275189
NCBI-ProteinID:
XP_004276574
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Position
11:45277340..45282291
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AA seq
504 aa
AA seq
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MLPFSLLWATRPLQRCGRLVRMAIRCQHSEAAQTQTGEATKGWSGQESLSDSDPEMWELL
RREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGTEVVDEIELLCQ
RRALEAFDLNPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYDQLALTARLFRPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFEHADVVTTTTHKTLRGARSGLIFYRKGVRAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSATT
PGGLRLGAPALTSRQFREDDFRKVVGFIDEGVNIGLEVKSKTAKLQDFKSFLLKDPETSH
WLADLRQRVEQFAKAFPMPGFDEH
NT seq
1515 nt
NT seq
+upstream
nt +downstream
nt
atgttgcccttctctttgctctgggcgactcggcctctgcagagatgtggtcggctggtc
aggatggccatacggtgccagcacagcgaggcagcccagacccagactggagaagcaacc
aagggctggtcaggccaggagagtctatcggacagtgaccctgagatgtgggagctgcta
cggagagagaaggacaggcagtgtcgtggcctggagctcattgcttcagagaacttctgc
agccgagctgcgctggaggccctggggtcctgtctgaacaacaagtactcggagggttat
cctggcaagaggtactatggaggaacagaggtagtggatgaaatcgagctgctgtgtcag
cgccgggccttggaggcctttgacctgaatcctgctcagtggggagtcaatgtccagcct
tactcggggtccccagccaacctggctgcctacacagcccttctgcagcctcatgaccga
atcatggggctggacctgcctgatgggggccatctcacccatggctacatgtctgatgtt
aagcggatctcagctacatccatcttcttcgagtctatgccctataagctgaatcccaaa
accggcctcattgactatgaccagctggcactcactgctcggctcttccgacctcgactc
atcatagctggtaccagtgcctatgctcgcctcatcgactacgcccgcatgcgagaggtg
tgtgatgaggtcaaggcacacctgctggcggacatggcccacatcagtggcctggtggct
gccaaggtgatcccctcacctttcgagcatgcggatgttgtcaccaccaccactcacaag
acccttcgaggggccaggtcaggactcatcttctaccggaagggggtgcgggctgtggac
cccaagacgggccgggagatcccttacacgtttgaggaccgaatcaactttgctgtgttc
ccgtccctgcaggggggcccccacaaccatgccattgctgcagtggctgtagccctaaag
caggcctgcacccccatgttccgggagtactccctgcaggttctaaagaacgctcgggcc
atggctgatgccctgctagagcgaggctactcgctggtgtctggtggcactgacaaccac
ctagtgctggtggacctgcggcccaagggcctggatggggctcgagctgaacgggtgttg
gaactcgtatccatcacggccaacaagaacacctgtcctggagatcgaagtgctaccaca
cctgggggcctgcggctgggggccccagccttgacttctcgacagttccgtgaggatgac
ttccggaaagttgtgggctttatagatgaaggcgtcaacatcggcttggaggtgaagagc
aagaccgccaaactccaggatttcaaatccttcctgctcaaagacccagaaacaagtcat
tggctggctgacctcaggcaacgggtggagcagtttgccaaggccttccccatgcctggt
tttgatgagcactga
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