Orcinus orca (killer whale): 101275383 Help Entry 101275383         CDS       T05247                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism oor  Orcinus orca (killer whale) Pathway oor01521   EGFR tyrosine kinase inhibitor resistance oor04151   PI3K-Akt signaling pathway oor04217   Necroptosis oor04380   Osteoclast differentiation oor04550   Signaling pathways regulating pluripotency of stem cells oor04620   Toll-like receptor signaling pathway oor04621   NOD-like receptor signaling pathway oor04630   JAK-STAT signaling pathway oor04658   Th1 and Th2 cell differentiation oor04659   Th17 cell differentiation oor05140   Leishmaniasis oor05145   Toxoplasmosis oor05152   Tuberculosis oor05160   Hepatitis C oor05161   Hepatitis B oor05162   Measles oor05163   Human cytomegalovirus infection oor05164   Influenza A oor05165   Human papillomavirus infection oor05166   Human T-cell leukemia virus 1 infection oor05167   Kaposi sarcoma-associated herpesvirus infection oor05168   Herpes simplex virus 1 infection oor05169   Epstein-Barr virus infection oor05171   Coronavirus disease - COVID-19 oor05200   Pathways in cancer oor05203   Viral carcinogenesis oor05212   Pancreatic cancer oor05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:oor00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101275383 (JAK1)    04151 PI3K-Akt signaling pathway     101275383 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101275383 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101275383 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     101275383 (JAK1)    04621 NOD-like receptor signaling pathway     101275383 (JAK1)    04658 Th1 and Th2 cell differentiation     101275383 (JAK1)    04659 Th17 cell differentiation     101275383 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     101275383 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101275383 (JAK1)    05203 Viral carcinogenesis     101275383 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101275383 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     101275383 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101275383 (JAK1)    05161 Hepatitis B     101275383 (JAK1)    05160 Hepatitis C     101275383 (JAK1)    05171 Coronavirus disease - COVID-19     101275383 (JAK1)    05164 Influenza A     101275383 (JAK1)    05162 Measles     101275383 (JAK1)    05168 Herpes simplex virus 1 infection     101275383 (JAK1)    05163 Human cytomegalovirus infection     101275383 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     101275383 (JAK1)    05169 Epstein-Barr virus infection     101275383 (JAK1)    05165 Human papillomavirus infection     101275383 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     101275383 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101275383 (JAK1)    05140 Leishmaniasis     101275383 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101275383 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oor01001]     101275383 (JAK1) Enzymes [BR:oor01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101275383 (JAK1) Protein kinases [BR:oor01001]  Non-receptor tyrosine kinases   JAK family [OT]    101275383 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  101275383 NCBI-ProteinID:  XP_012392828 LinkDB All DBs Position 1:157015252..157155163 Genome browser AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTDVNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDENIKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNSYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDNGNILCYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLENKHKKDEEKNKIQ EEWNNFSYFPEITDIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSELLGVQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCLPKPREISNLLVATKKAQEWQPVLPVSQLSFYRILKKDIMQGEHLGRGTRTHIYSGT LMDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGTDSECGPFIKLSDPGIPVTVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKSIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPEEVYQLMRKCWEFQPSIRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatttaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagactgacgtgaatctggaggcccctgagccaggggtggaagtgctcttc tatctgtcggatagggagcccctccggttgggcggcggagagtacacagcggaggagctg tgcatcagggcggcgcaggaatgctgtatatctcctctgtgtcacaacctctttgccctg tatgatgagaacatcaagctctggtatgctccgaatcgcaccatcaccgtcgacgacaag atgtcactccggctccactaccggatgaggttctatttcaccaactggcacgggaccaat gataacgagcagtcagtatggcgacattctccaaagaagcagaagaatagctacgagaaa aaaaaagttccagatgcaacccctctccttgacgccagctcattggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcatgatattgagaacgagtgtctgggaatggccgtcctggccatctcccactat gccatgatgaagaagatgcagttgccagaacttcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggatttcctaaaggagtttaacaacaagaccatttgtgacagcagt gtgtccacacacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatccgaatgataatggaaacattctctgctatgaagtgatggtgactggaaat cttggaatccagtggaggcagaaaccaaatgttgttcctgttgaaaaggaaaaaaataaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggagaaaaataaaatccag gaagagtggaacaatttttcttacttccctgagatcactgacattgtaatcaaggagtct gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctgtcttcccacgag gaggcgttgtcctttgtgtccctcgtggacggctacttccggctcacagcagatgcccat cattacctctgcacggacgtggctcccccgttgatcgtccacaacatacagaatggctgt cacggtccaatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggag ggaatgtacgtgctgcggtggagctgcaccgacttcgacaacatcctcatgaccgtcact tgctttgaaaagtctgagttgctgggtgtccagaagcagttcaagaactttcagattgag gtgcagaagggccgctacagcctgcatggctcagaccgaagcttccccagccttggagac ctcatgagccacctgaagaagcagatcctgcgcacagacaacatcagctttgtgctgaag cgctgctgcctgcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc caggagtggcagcctgtcctccccgtgagccagctgagtttttatcggatcctcaagaaa gatattatgcagggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctcatggattacaaggatgacgaaggaacttccgaagagaagagaataaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgagacaggtctcccataaacacatcgtgtacctctatggcgtttgtgtccgagacgtg gagaatatcatggtggaagagtttgtggagggagggcccctggatctcttcatgcaccgg aaaagtgatgtcctcaccacaccctggaagttcaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagatctggtccacggaaatgtgtgcactaaaaacctcctc ctggcccgcgagggcactgacagcgagtgcggccccttcatcaagctcagtgaccccggc atccccgtcactgtgctgtccaggcaagagtgcatagaacgaatcccatggatcgctcct gagtgtgttgaagactccaagaacctgagtgtggccgctgacaagtggagctttggaacc acgctctgggagatctgctacaatggcgagattcccttgaaagacaagacactgattgag aaagagaggttctatgaaagccggtgcaggccagtgaccccgtcttgtaaggagctagct gaccttatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatc atgagagacatcaataagctggaggagcagaatccagacatcgtatcagaaaaaaagcca gcaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg ggagagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaataca ggggagcaggtggccgtcaaatccctgaagcctgagagcggagggaaccacatagctgat ctgaagaaggaaattgaaatcttaagaaacctttatcatgagaacattgtgaagtataaa ggcatctgcacagaagacggaggaaacggtattaagctcatcatggaatttctgccttca ggaagtcttaaggagtatcttccaaagaataagaacaaaattaacctcaaacagcagtta aaatatgccattcagatttgtaaggggatggactatttgggttctcggcaatacgttcac cgtgacttagcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattggggac tttggtctaaccaaatccattgaaactgataaggagtactacacagtcaaggacgatcgg gacagccctgtgttttggtatgctccagaatgtttaattcagtgtaagttttatatcgcc tctgatgtctggtcttttggagtaactctgcatgagctgcttacttactgtgattcagat tccagtcccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagta acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacctaactgtcca gaagaggtttatcagcttatgagaaaatgctgggaattccaaccatccattcggacaacc tttcagaaccttattgagggatttgaagcgcttctaaaataa

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