Orcinus orca (killer whale): 101275708
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Entry
101275708 CDS
T05247
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00230
Purine metabolism
oor01100
Metabolic pathways
oor04927
Cortisol synthesis and secretion
oor04934
Cushing syndrome
oor05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
101275708 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
101275708 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
101275708 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101275708 (PDE8A)
Enzymes [BR:
oor01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
101275708 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS
PAS_9
PDE8
PAS_4
PAS_3
Response_reg
PAS_8
Band_7_C
DUF5894
Motif
Other DBs
NCBI-GeneID:
101275708
NCBI-ProteinID:
XP_012391637
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Position
2:complement(60729961..60867218)
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AA seq
840 aa
AA seq
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MGCAQSIHASESRVVYHGGNEAEDAPGPAAPPLQPGGPRLPPGQTTAASARSCGSSLVES
ELSIGSGSSIGSAVAVADIQFGPMRFHPDQLQVLLVFPKEDKQCNGFCRACEKAGFKCTV
IKEAQTALACFLDKHHDIIIIDHRNPQQLDGEVLCRSIRSSELSENTVIVGVVRRAVREE
SSVMSLIEAGFTRRYVENPSAMACYNELLQMEFGLVRPQLKLRACNSMFTALEKSQEAIE
ITSEDHIVQYANPAFETTMGYESGELIGKDLAEVPVNEKKADLLDTINSCIRIGKEWQGI
CSAKEKNGDNVQQNVKILPVIGQGGKIRHYVSIVRACNGNNKATKIAECVQSDTHTDHQS
GKHNDRRKSSLDVRTAASRTGKVSSQRRRSSTARIHSMKIEAPITKAINIISAAQESSPM
PVTEALDRVLEILRTTELYSPQFDAKDDDPHAIDLVGGLMSDVFRRPSRNEYVLSTKNLQ
QASSSVITPTSLHDIPSQITQAMENEESWDFDIFELEAATHKRPLIYLGLKIFARFGVCE
VLKCSETTLRSWLQIIEANYHASNPYHNSTHSADVLHATAYFLCKERIKQTLDPLDEVTA
LIAATVHDLDHPGRTNSFLCNAGSELAILYNDTAVLERHHAALAFQLTTGDDKCNIFKNM
ERNDYRMLRQSIIDMVLATEMTKHFEHVNKFVNSINKPLAALEEDGETDKNQEAIITMLR
TPDNRSLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDR
NTCSIPKSQISFIDYFITDMFAAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2523 nt
NT seq
+upstream
nt +downstream
nt
atgggctgtgcccagagcatccacgcttccgagagccgggttgtgtaccacggcggcaac
gaggccgaggacgcgccgggccccgcggcgccgccgttgcagcccggcgggccgcgcctc
ccacccggccagacgacggctgcctcggcccggtcctgtggctccagcctcgtggagtcc
gagctaagcatcggcagcggcagcagcatcggcagcgcggtagcagtagctgatatacag
tttggccccatgagatttcatccagatcagctccaggtacttttagtgtttcccaaagaa
gataagcagtgtaatggattctgtagggcatgtgaaaaagcagggtttaagtgtacagtt
atcaaggaggctcagacggcccttgcctgtttcctggacaaacatcatgacatcatcatc
attgaccacagaaatccccaacagctggacggggaggtgctgtgcaggtctatcagatca
tcagaactctcagaaaacacagttattgttggtgtagtacgcagggcggttagagaagag
tcatctgtaatgtccctcattgaggctggctttacaaggaggtatgtagaaaaccccagc
gccatggcctgttacaatgaactgctccagatggagtttggattggtgcgcccacagctg
aaactcagggcttgtaactcaatgttcactgcattagagaaaagtcaagaagcaattgaa
attacaagtgaagaccacattgtacagtatgcaaatccagcatttgaaacaacaatgggc
tatgagtcaggtgaattaatagggaaggatttagcagaagtgcctgtaaatgaaaaaaag
gctgatttgctcgatactataaattcatgcatcaggataggcaaggaatggcaaggaatt
tgctctgccaaagagaagaacggagataatgtacaacaaaatgtgaagatactacctgtc
atcgggcagggaggaaaaattagacactatgtgtccattgtcagagcgtgcaatggcaac
aataaggctacgaaaatagctgaatgtgttcagtctgacactcatacagatcatcagtca
ggcaaacataatgacaggaggaaaagctcactagatgtcagaactgctgcctctcgaaca
ggcaaagtttccagccagagacgacgctcctccacggcccggatacattccatgaagatc
gaggcgcccatcaccaaggcaatcaatatcatcagtgctgcccaggaaagcagtcccatg
cctgtgacagaagccttagatcgtgtgctggaaattctaagaaccactgaattatattca
ccacaattcgatgctaaggacgatgatcctcatgccatcgaccttgttgggggcttaatg
tctgacgtttttcgaagaccgtccaggaatgagtatgttctttcaacaaaaaaccttcag
caggcttccagcagtgtgatcacccccacctcccttcacgacatcccatcacagataact
caggccatggaaaatgaggaatcctgggactttgatatttttgaactggaggctgccact
cataaaaggcctttgatttatcttggtctcaaaatatttgctcgctttggagtctgtgaa
gtcttaaaatgctctgagacaacgctgagatcgtggctgcaaattatcgaagccaattat
catgcttctaacccctaccacaattctacacattctgccgacgtgcttcatgccactgcc
tattttctctgcaaggagaggataaagcaaactttagatccacttgatgaggtcactgcc
ctcattgcagccactgtccatgacctggaccatcccgggagaaccaactccttcctgtgc
aatgctgggagtgagctggccattctgtataacgacactgctgtgctcgagagacaccac
gcggccttggccttccagctgaccactggtgatgataaatgcaacatctttaaaaacatg
gagaggaatgactaccggatgctgcgccagagtattatcgacatggtcttagccacagaa
atgacaaagcactttgagcacgtcaacaaatttgtcaacagcatcaacaagcccttggca
gcattagaggaagatggggaaactgataaaaatcaagaagccataatcactatgctcaga
actccagacaaccgcagtttgatcaaacgaatgctgattaagtgtgctgatgtgtccaat
ccctgccgacccctggagcagtgcattgagtgggccgcacgtatctcagaagaatatttt
tctcagactgatgaagagaagcgacaggacttgcctgtggtgatgccagtttttgacaga
aatacctgcagcatccccaaatcccaaatctctttcattgactacttcatcacagacatg
tttgctgcttgggacgcctttgtagacctgcctgagttaatgcagcatcttgacaacaat
tttaaatactggaagggactggacgaaatgaagctgcggagcctccgcccacctcctgaa
tag
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