KEGG   Orcinus orca (killer whale): 101276321
Entry
101276321         CDS       T05247                                 
Symbol
ITGA2B
Name
(RefSeq) integrin alpha-IIb isoform X2
  KO
K06476  integrin alpha 2B
Organism
oor  Orcinus orca (killer whale)
Pathway
oor04015  Rap1 signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04510  Focal adhesion
oor04512  ECM-receptor interaction
oor04611  Platelet activation
oor04613  Neutrophil extracellular trap formation
oor04640  Hematopoietic cell lineage
oor04810  Regulation of actin cytoskeleton
oor04820  Cytoskeleton in muscle cells
oor05165  Human papillomavirus infection
oor05200  Pathways in cancer
oor05222  Small cell lung cancer
oor05410  Hypertrophic cardiomyopathy
oor05412  Arrhythmogenic right ventricular cardiomyopathy
oor05414  Dilated cardiomyopathy
oor05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oor00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101276321 (ITGA2B)
   04151 PI3K-Akt signaling pathway
    101276321 (ITGA2B)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    101276321 (ITGA2B)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101276321 (ITGA2B)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    101276321 (ITGA2B)
   04810 Regulation of actin cytoskeleton
    101276321 (ITGA2B)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    101276321 (ITGA2B)
   04611 Platelet activation
    101276321 (ITGA2B)
   04613 Neutrophil extracellular trap formation
    101276321 (ITGA2B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101276321 (ITGA2B)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    101276321 (ITGA2B)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    101276321 (ITGA2B)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    101276321 (ITGA2B)
   05410 Hypertrophic cardiomyopathy
    101276321 (ITGA2B)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    101276321 (ITGA2B)
   05414 Dilated cardiomyopathy
    101276321 (ITGA2B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:oor01009]
    101276321 (ITGA2B)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oor04147]
    101276321 (ITGA2B)
   04515 Cell adhesion molecules [BR:oor04515]
    101276321 (ITGA2B)
   04090 CD molecules [BR:oor04090]
    101276321 (ITGA2B)
Protein phosphatases and associated proteins [BR:oor01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     101276321 (ITGA2B)
Exosome [BR:oor04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   101276321 (ITGA2B)
Cell adhesion molecules [BR:oor04515]
 Integrins
  Integrin alpha subunits
   101276321 (ITGA2B)
CD molecules [BR:oor04090]
 Proteins
  101276321 (ITGA2B)
SSDB
Motif
Pfam: Integrin_A_Ig_3 Integrin_A_Ig_2 Integrin_A_Ig_1 FG-GAP FG-GAP_3 Integrin_alpha ITGAX-like_Ig_3
Other DBs
NCBI-GeneID: 101276321
NCBI-ProteinID: XP_004286027
LinkDB
Position
19:39366073..39379946
AA seq 1034 aa
MARALCPLHALWLLEWVQLLLGPGAAPPTWALNLDPVRLTFYTGPNGSYFGFSLDFYKDS
RGSVSIVVGAPRTLGRSQEETGGVFLCPWKAEGDQCTSLPFDLNDETRSAGTQTFQTFKA
RQGLGASVVSWSDIVVACAPWQHWNVLEKAEEAEKTPVGGCFVAQLQNSGRAEYSPCRAN
IMSRVYQKNYFSGDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLARAPLGDIISSYRP
GTLLWHVPTQQLTFDYSHPEYFDGYRGYSVAVGDFDGNPNTTEFVVGAPTWSWTLGAVEI
LSSYHQTLHRLHGEQMASYFGHSVAVTDVNRDGRHDLLVGAPLYMESRAGRKLAEVGRVY
LFLQTRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGASGRGQV
SVFLGQSEGLNSHPSQVLDSPFPTGSGFGFSLRGATDIDDNGYPDLLVGAYGANKVVVYR
AQPVVMATVQLLVQDSLNPAVKNCVLPLTETPVSCFNIQMCVGATGHNVPKKLHLNAELQ
LDRQKPRQGRRVLLLASQQASTVLGLDLSGRHGPTCHTTKAFLRDEADFRDKLSPIVLSL
NVSLQPEKDGLAPALMLHGDTHIQEQTRIILDCGEDDVCVPQLQLTASVTGSPLLIGADN
VLELQMEAANEGEGAYEAELAVHLPPGAHYMRALSNIEGFERIICNQKRENETKVVLCEL
GNPMKRNAQIGITMLVSVGNLEEAGEHVSFRLQIRSKNSQNPNSEMVMLDVPVRAEAHVE
LRGNSFPASLVVAAEESKRDNSSDSWGPKVEHTYELHNNGPGAVNGLRLNLRLPGQSQPS
DLLYILDIQPRGGLQCSPQPSPNPLKLDWGLPTSSPSQAYHKRDRRQALLPEQEQPSRLQ
GPVFVSCDSAPCTVVQCELQEMARGQRVMVTVLAFLSLPSLRKRPLDQFVLQSHAWFNVS
SLPYAVPALSLPSGEALVQTQLLRVLEERDIPIWWVLLGVLGGLLLLTFLVLAMWKVGFF
KRNRPPLQEDDEEE
NT seq 3105 nt   +upstreamnt  +downstreamnt
atggccagagctttgtgtccacttcatgccctctggcttctggagtgggtgcagctgctc
ttgggacccggtgctgcacctccaacctgggccttgaacctggacccggtgcgactcacc
ttctacacaggccccaatggcagctactttgggttttcattggacttctacaaggacagc
cgtgggagcgtgtccatcgtggtgggcgccccacggaccctgggccgcagccaggaggag
acaggcggcgttttcctgtgcccctggaaggccgagggcgaccagtgtacctcgctgccc
ttcgacctcaatgatgagacgcgaagcgcaggcacccaaactttccaaaccttcaaggcc
cgtcaaggactaggggcgtcggtcgttagttggagcgacatcgttgtggcctgcgccccc
tggcagcactggaacgtcctggaaaaggccgaggaggctgagaagacgcccgtaggtgga
tgcttcgtggctcagctgcagaacagcggccgcgcagagtactcaccctgccgggccaac
atcatgagccgagtttaccagaaaaattacttcagcggagacaagcgctactgtgaagcc
ggcttcagctctgtggtcactcaggctggggagctggtgcttggggcccctggcggctac
tatttcctaggtctcctggcgcgggctccacttggcgatatcatctcgagttaccgcccg
ggcaccctcttgtggcacgtgcccacccagcagctcacctttgactacagccacccagag
tacttcgacggctaccgggggtactcggtggctgtaggcgacttcgacgggaatccaaac
actacagagtttgtcgtcggtgcccctacctggagctggaccctgggagcggtggaaatt
ttgagctcgtaccaccagacgctgcaccggctgcatggagagcagatggcttcgtatttc
gggcactcagtggccgtcactgacgtcaacagggacgggaggcatgacctcttggtgggc
gcgccactgtacatggagagccgtgctggccgcaagctggccgaggtggggcgcgtgtac
ttgttcctgcagactcgaggccctcacgcgctgggcgcccccagcctcctgctgaccggc
acgcagctctatgggcgatttggctcagccatcgcgcctctgggcgacctcaaccgggat
ggctacaatgatgttgctgtggccgccccctatgggggtgccagcggtcgaggccaagtg
tcggtgttcctgggtcagagtgagggacttaactcacacccttcccaggtcctggacagc
cccttccccacaggctctggctttggcttctcccttcgaggtgccacagacatcgatgac
aatggatacccagacctgctggtgggagcttacggggccaacaaggttgttgtgtacagg
gctcagccggtggtgatggccactgtccagctgctggtgcaagattcgctgaatcctgct
gtgaagaattgtgtcctgcccctgaccgagacaccagtgagctgctttaacatccagatg
tgtgtgggagccactggacacaacgttcccaagaagctgcacctaaatgctgagctgcag
ctggaccggcagaagccccgccagggccggcgggtgctactgctggcctctcaacaggcg
agcacggtcctgggcctggatctgagcggaaggcacggccccacctgccacaccaccaag
gccttcctccgagatgaggccgacttccgggacaagctgagccccatcgtgctcagcctc
aatgtgtccctgcagcctgagaaggatggactagcccctgctctcatgttgcatggagac
acccacatccaggaacagacccgcatcattctggactgtggggaagatgacgtgtgtgtg
ccacagctccagctcactgccagcgtgacaggctccccgctcctcattggagctgataac
gtgctggagctgcagatggaagcggccaacgagggtgagggagcctacgaggccgagctg
gctgtgcacctgcctccaggcgcacactacatgcgggccctcagcaacatcgagggcttt
gagaggatcatctgtaaccagaagagggagaatgagaccaaggtggtgctgtgtgagctg
ggcaaccccatgaagaggaacgcccagataggaatcacgatgttagtgagtgtggggaac
ctggaagaggctggggagcacgtgtccttccggctgcagatcaggagcaagaacagccag
aatccaaacagtgagatggtgatgctggatgtgccagttcgggcagaggcccatgtggag
ctgagagggaactcctttccagcctccctggtggtggcagcagaagaaagcaagagagac
aacagctcggacagctggggccccaaagtggagcacacctacgagctccacaacaatggc
cctggtgctgtaaacggcctccgcctcaacctccgcctccccggccagtcccagccctcc
gaccttctctacatcctggatatacagccccggggaggccttcagtgctccccacaacca
tctcccaaccccctcaagctggactgggggctgcccacctccagcccttcccaggcctat
cacaagcgggaccgcagacaggcgctcctgccggagcaggagcagccctcgaggcttcaa
ggtccagtttttgtgagctgcgattcggcgccctgtactgtggtgcagtgtgagctgcag
gagatggcgcgcgggcagcgggtcatggtcacggtgctggccttcctgtcgctgcccagc
ctccgaaagaggcccctggatcagtttgtgctgcagtcgcacgcttggttcaacgtctcc
tcccttccctacgccgtgcccgccctcagcctgcccagcggggaagctctggtgcagaca
cagctgcttcgggtcttggaggagagagacattcccatctggtgggtgctgctaggcgtg
ctgggtggcctgctgttgctcacgttcctggtcctggccatgtggaaggttggcttcttc
aagcggaatcggccacccttacaagaagatgacgaagaggagtga

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