KEGG   Orcinus orca (killer whale): 101278075
Entry
101278075         CDS       T05247                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor00562  Inositol phosphate metabolism
oor01100  Metabolic pathways
oor01521  EGFR tyrosine kinase inhibitor resistance
oor01522  Endocrine resistance
oor01524  Platinum drug resistance
oor04012  ErbB signaling pathway
oor04014  Ras signaling pathway
oor04015  Rap1 signaling pathway
oor04024  cAMP signaling pathway
oor04062  Chemokine signaling pathway
oor04066  HIF-1 signaling pathway
oor04068  FoxO signaling pathway
oor04070  Phosphatidylinositol signaling system
oor04071  Sphingolipid signaling pathway
oor04072  Phospholipase D signaling pathway
oor04081  Hormone signaling
oor04140  Autophagy - animal
oor04150  mTOR signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04152  AMPK signaling pathway
oor04210  Apoptosis
oor04211  Longevity regulating pathway
oor04213  Longevity regulating pathway - multiple species
oor04218  Cellular senescence
oor04360  Axon guidance
oor04370  VEGF signaling pathway
oor04380  Osteoclast differentiation
oor04510  Focal adhesion
oor04550  Signaling pathways regulating pluripotency of stem cells
oor04611  Platelet activation
oor04613  Neutrophil extracellular trap formation
oor04620  Toll-like receptor signaling pathway
oor04625  C-type lectin receptor signaling pathway
oor04630  JAK-STAT signaling pathway
oor04650  Natural killer cell mediated cytotoxicity
oor04660  T cell receptor signaling pathway
oor04662  B cell receptor signaling pathway
oor04664  Fc epsilon RI signaling pathway
oor04666  Fc gamma R-mediated phagocytosis
oor04668  TNF signaling pathway
oor04670  Leukocyte transendothelial migration
oor04722  Neurotrophin signaling pathway
oor04725  Cholinergic synapse
oor04750  Inflammatory mediator regulation of TRP channels
oor04810  Regulation of actin cytoskeleton
oor04910  Insulin signaling pathway
oor04914  Progesterone-mediated oocyte maturation
oor04915  Estrogen signaling pathway
oor04917  Prolactin signaling pathway
oor04919  Thyroid hormone signaling pathway
oor04923  Regulation of lipolysis in adipocytes
oor04926  Relaxin signaling pathway
oor04929  GnRH secretion
oor04930  Type II diabetes mellitus
oor04931  Insulin resistance
oor04932  Non-alcoholic fatty liver disease
oor04933  AGE-RAGE signaling pathway in diabetic complications
oor04935  Growth hormone synthesis, secretion and action
oor04960  Aldosterone-regulated sodium reabsorption
oor04973  Carbohydrate digestion and absorption
oor05010  Alzheimer disease
oor05017  Spinocerebellar ataxia
oor05020  Prion disease
oor05100  Bacterial invasion of epithelial cells
oor05132  Salmonella infection
oor05135  Yersinia infection
oor05142  Chagas disease
oor05146  Amoebiasis
oor05160  Hepatitis C
oor05161  Hepatitis B
oor05162  Measles
oor05163  Human cytomegalovirus infection
oor05164  Influenza A
oor05165  Human papillomavirus infection
oor05166  Human T-cell leukemia virus 1 infection
oor05167  Kaposi sarcoma-associated herpesvirus infection
oor05168  Herpes simplex virus 1 infection
oor05169  Epstein-Barr virus infection
oor05170  Human immunodeficiency virus 1 infection
oor05171  Coronavirus disease - COVID-19
oor05200  Pathways in cancer
oor05203  Viral carcinogenesis
oor05205  Proteoglycans in cancer
oor05206  MicroRNAs in cancer
oor05207  Chemical carcinogenesis - receptor activation
oor05208  Chemical carcinogenesis - reactive oxygen species
oor05210  Colorectal cancer
oor05211  Renal cell carcinoma
oor05212  Pancreatic cancer
oor05213  Endometrial cancer
oor05214  Glioma
oor05215  Prostate cancer
oor05218  Melanoma
oor05220  Chronic myeloid leukemia
oor05221  Acute myeloid leukemia
oor05222  Small cell lung cancer
oor05223  Non-small cell lung cancer
oor05224  Breast cancer
oor05225  Hepatocellular carcinoma
oor05226  Gastric cancer
oor05230  Central carbon metabolism in cancer
oor05231  Choline metabolism in cancer
oor05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oor05415  Diabetic cardiomyopathy
oor05417  Lipid and atherosclerosis
oor05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oor00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101278075 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101278075 (PIK3CA)
   04014 Ras signaling pathway
    101278075 (PIK3CA)
   04015 Rap1 signaling pathway
    101278075 (PIK3CA)
   04370 VEGF signaling pathway
    101278075 (PIK3CA)
   04630 JAK-STAT signaling pathway
    101278075 (PIK3CA)
   04668 TNF signaling pathway
    101278075 (PIK3CA)
   04066 HIF-1 signaling pathway
    101278075 (PIK3CA)
   04068 FoxO signaling pathway
    101278075 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    101278075 (PIK3CA)
   04072 Phospholipase D signaling pathway
    101278075 (PIK3CA)
   04071 Sphingolipid signaling pathway
    101278075 (PIK3CA)
   04024 cAMP signaling pathway
    101278075 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    101278075 (PIK3CA)
   04152 AMPK signaling pathway
    101278075 (PIK3CA)
   04150 mTOR signaling pathway
    101278075 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101278075 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101278075 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    101278075 (PIK3CA)
   04218 Cellular senescence
    101278075 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101278075 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    101278075 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101278075 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101278075 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    101278075 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    101278075 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    101278075 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    101278075 (PIK3CA)
   04660 T cell receptor signaling pathway
    101278075 (PIK3CA)
   04662 B cell receptor signaling pathway
    101278075 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    101278075 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    101278075 (PIK3CA)
   04670 Leukocyte transendothelial migration
    101278075 (PIK3CA)
   04062 Chemokine signaling pathway
    101278075 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101278075 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    101278075 (PIK3CA)
   04929 GnRH secretion
    101278075 (PIK3CA)
   04915 Estrogen signaling pathway
    101278075 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    101278075 (PIK3CA)
   04917 Prolactin signaling pathway
    101278075 (PIK3CA)
   04926 Relaxin signaling pathway
    101278075 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    101278075 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    101278075 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101278075 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101278075 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    101278075 (PIK3CA)
   04722 Neurotrophin signaling pathway
    101278075 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101278075 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    101278075 (PIK3CA)
   04380 Osteoclast differentiation
    101278075 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    101278075 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    101278075 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101278075 (PIK3CA)
   05206 MicroRNAs in cancer
    101278075 (PIK3CA)
   05205 Proteoglycans in cancer
    101278075 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    101278075 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    101278075 (PIK3CA)
   05203 Viral carcinogenesis
    101278075 (PIK3CA)
   05230 Central carbon metabolism in cancer
    101278075 (PIK3CA)
   05231 Choline metabolism in cancer
    101278075 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101278075 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101278075 (PIK3CA)
   05212 Pancreatic cancer
    101278075 (PIK3CA)
   05225 Hepatocellular carcinoma
    101278075 (PIK3CA)
   05226 Gastric cancer
    101278075 (PIK3CA)
   05214 Glioma
    101278075 (PIK3CA)
   05221 Acute myeloid leukemia
    101278075 (PIK3CA)
   05220 Chronic myeloid leukemia
    101278075 (PIK3CA)
   05218 Melanoma
    101278075 (PIK3CA)
   05211 Renal cell carcinoma
    101278075 (PIK3CA)
   05215 Prostate cancer
    101278075 (PIK3CA)
   05213 Endometrial cancer
    101278075 (PIK3CA)
   05224 Breast cancer
    101278075 (PIK3CA)
   05222 Small cell lung cancer
    101278075 (PIK3CA)
   05223 Non-small cell lung cancer
    101278075 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101278075 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    101278075 (PIK3CA)
   05161 Hepatitis B
    101278075 (PIK3CA)
   05160 Hepatitis C
    101278075 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    101278075 (PIK3CA)
   05164 Influenza A
    101278075 (PIK3CA)
   05162 Measles
    101278075 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    101278075 (PIK3CA)
   05163 Human cytomegalovirus infection
    101278075 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101278075 (PIK3CA)
   05169 Epstein-Barr virus infection
    101278075 (PIK3CA)
   05165 Human papillomavirus infection
    101278075 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101278075 (PIK3CA)
   05135 Yersinia infection
    101278075 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    101278075 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101278075 (PIK3CA)
   05142 Chagas disease
    101278075 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101278075 (PIK3CA)
   05017 Spinocerebellar ataxia
    101278075 (PIK3CA)
   05020 Prion disease
    101278075 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101278075 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    101278075 (PIK3CA)
   05415 Diabetic cardiomyopathy
    101278075 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101278075 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    101278075 (PIK3CA)
   04931 Insulin resistance
    101278075 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101278075 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101278075 (PIK3CA)
   01524 Platinum drug resistance
    101278075 (PIK3CA)
   01522 Endocrine resistance
    101278075 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oor04131]
    101278075 (PIK3CA)
Enzymes [BR:oor01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101278075 (PIK3CA)
Membrane trafficking [BR:oor04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101278075 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 101278075
NCBI-ProteinID: XP_004270569
LinkDB
Position
5:61563899..61670133
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcgagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatctcaattcaccgcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgacgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcacttaggataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttctatttgttctgttaaaggccgaaagggtgctaaagaggaacattgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaggattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcgatgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctacttgtgaggtttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatttgaag
cacctgaataggcaggttgaggctatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaaatttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacagggctttctgtcgcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcattatg
gaaaatatatggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtcc
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgtaaaggaggcctgaaaggtgccctgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatctatttacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaggaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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