Orcinus orca (killer whale): 101280135
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Entry
101280135 CDS
T05247
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00790
Folate biosynthesis
oor01100
Metabolic pathways
oor01240
Biosynthesis of cofactors
oor01523
Antifolate resistance
oor04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
101280135 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
101280135 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
101280135 (FPGS)
Enzymes [BR:
oor01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
101280135 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
101280135
NCBI-ProteinID:
XP_004269230
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Position
6:112855062..112863741
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AA seq
580 aa
AA seq
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MSRARCHLRAALFLAAVSSRGATTGVAARRVLSAWPAPQEPGMEYQDAVRTLNTLQTNAN
CLEQVKRQRDDPQTQLEAMRLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWRLYHRLEETKDDSSCVSMPGYFR
FLTLMAFHVFLQEKVDLAVMEVGIGGAYDCTNIVKKPVVCGVSSLGIDHTGLLGDTMEKI
AWQKGGIFKCGVPAFTVLQPDGPLAVLRDRAQQISCPLYLCPPLEALEEGGPLLTLGLEG
EHQQANAALALQLARCWLQQKGYRDTGELKASRPSLLGQLPLAPVFQPTSHMQHGLRDTE
WPGRTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALQSRERPGGGSEVRVLLFNSTGDR
DSAALLKLLQPCQFDYTVFCPNLTEVSSTDDADQQNFTVTLDQVLLRCLAHQQHWSRLHE
DQASPEPGGPAPLLLPPRPAHTHSASSLVFSCISHALQWISQGRDPVFQPPSPPRVLFAH
PVAGSGAVVLQEAAAIHVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1743 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgggcacgctgccacctgcgcgcggctctcttcctggcagcggtttcttcgcgt
ggtgcaacaaccggggtcgcagcgaggcgagtattgagcgcgtggcctgcgccgcaggag
cccggcatggagtatcaggatgccgtgcgcacactcaacaccctgcagaccaatgccaac
tgcttggagcaggtgaagcgccagcgggatgacccccagacacagctggaagccatgagg
ctgtacttggcacggagtgggctgcaggtggaggacttggaccaactaaacatcattcac
atcactgggaccaaggggaagggctccacctgtgccttcactgaacgtatcctccggagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggtgcgtgagcggatc
cgaatcaatgggcagcccataagccccgagctcttcaccaagcacttctggcgcctctac
caccggctggaggagaccaaggatgacagcagctgtgtctccatgcctggctacttccgc
ttcctcacactcatggccttccatgtcttcctccaagagaaggtggacctggcagtgatg
gaagtgggcatcggcggggcttacgactgcaccaacattgtcaagaagcctgtggtgtgt
ggggtctcctctcttggcatcgaccacactggccttctgggggacacgatggagaagatc
gcatggcagaaagggggcatttttaagtgtggcgtccccgccttcactgtgctccagcct
gacgggcccctggcagtgctgagggaccgcgctcagcagatctcatgtcccctctacctg
tgcccaccactagaagccctggaggaaggggggccgctgctgaccctgggcctggagggg
gagcaccagcaggccaacgccgccttggccttgcagctggctcgctgctggctgcagcag
aagggctaccgggatactggagagctgaaggcgtccaggccaagcctcctggggcagctg
cccctggcacctgtgttccagcccacgtcccacatgcagcatgggcttcgggacacggag
tggccgggccggacgcagttgctgcggcggggccccctcacttggtacctggacggcgcg
cacaccaccagcagcatgcaggcctgcgtgcgctggttccgccaggcgctgcaaagccgc
gagaggccgggcggcgggtctgaggtgcgtgtcttgctcttcaactccactggggaccgg
gattccgcggccctgctgaagctgctgcagccctgccagtttgactataccgttttctgc
cctaacctgacagaggtgtcatccacggacgacgcagaccaacagaacttcacagtgacc
ctggaccaggtgctgctccgctgccttgcgcaccagcaacactggagccgcctgcacgag
gaccaggccagcccggagcctggtgggcctgcacccctgctgctgccaccccgcccagcc
cacacccacagcgccagttctctcgtcttcagctgcatttcccacgccttgcagtggatc
agtcaaggccgggaccctgtctttcagccacccagtcccccacgggtcctctttgcccac
cctgtggcaggcagtggggccgtcgtcctccaggaggctgctgccatccacgtgctggtc
acaggcagcctgcacctggtgggcggcgtgctgaagctgctggagccctccctgtcccag
tag
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