Orcinus orca (killer whale): 101280520
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Entry
101280520 CDS
T05247
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00220
Arginine biosynthesis
oor00330
Arginine and proline metabolism
oor01100
Metabolic pathways
oor04020
Calcium signaling pathway
oor04022
cGMP-PKG signaling pathway
oor04066
HIF-1 signaling pathway
oor04071
Sphingolipid signaling pathway
oor04151
PI3K-Akt signaling pathway
oor04370
VEGF signaling pathway
oor04371
Apelin signaling pathway
oor04611
Platelet activation
oor04915
Estrogen signaling pathway
oor04921
Oxytocin signaling pathway
oor04926
Relaxin signaling pathway
oor04931
Insulin resistance
oor04933
AGE-RAGE signaling pathway in diabetic complications
oor05415
Diabetic cardiomyopathy
oor05417
Lipid and atherosclerosis
oor05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
101280520 (NOS3)
00330 Arginine and proline metabolism
101280520 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
101280520 (NOS3)
04371 Apelin signaling pathway
101280520 (NOS3)
04066 HIF-1 signaling pathway
101280520 (NOS3)
04020 Calcium signaling pathway
101280520 (NOS3)
04071 Sphingolipid signaling pathway
101280520 (NOS3)
04022 cGMP-PKG signaling pathway
101280520 (NOS3)
04151 PI3K-Akt signaling pathway
101280520 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101280520 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
101280520 (NOS3)
04921 Oxytocin signaling pathway
101280520 (NOS3)
04926 Relaxin signaling pathway
101280520 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101280520 (NOS3)
05418 Fluid shear stress and atherosclerosis
101280520 (NOS3)
05415 Diabetic cardiomyopathy
101280520 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
101280520 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
101280520 (NOS3)
Enzymes [BR:
oor01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
101280520 (NOS3)
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
DEC-1_N
Motif
Other DBs
NCBI-GeneID:
101280520
NCBI-ProteinID:
XP_004281233
LinkDB
All DBs
Position
9:complement(6112332..6130344)
Genome browser
AA seq
1205 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCSKQGPASPAPEPSRAPAPAPPPAPDHSPAPNSPQ
LTRPPEGPKFPRVKNWEAGSITYDTLCAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQGPP
PPEQLLSQARDFINQYYSSIKRSGSQAHKERLQEVEAEVAATGTYQLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHVKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQTPDE
APELFVLPPELVLEVPLEHPTLEWFSALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYM
STEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIV
DHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPD
PWKGSTAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAQA
AAQDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLLVENLQSSKSTRAT
ILVRLDTGSQEGLQYQPGDHIGICPPNRPGLVEALMSRVEDPPPPTESVAVEQLEKGSPG
GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYREEVQDAQQRGVFGRVLTAFS
REPNSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHMRGAVPWAFDPPGP
DTAGP
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtgggccaggagcccgggccaccctgcggcctggggctaggg
ctgggcctcgggctgtgcagcaaacagggcccggcctccccagcgcccgagcccagccgg
gcaccagcacccgcacccccgcccgcgccagaccacagcccggctcccaacagcccccag
ctaacccggcctccagaggggcccaagttccctcgcgtgaagaactgggaggcggggagc
atcacctacgacactctgtgcgcgcagtcacagcaggacgggccctgcacccccagacgc
tgcctgggctccctggtgtttccacggaaactgcagagccgaccctcccagggccctccg
ccccctgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatc
aagaggagcggctcccaggctcacaaggagcggcttcaggaagtggaagccgaggtggcg
gccacaggcacctaccagcttcgtgagagcgagctggtgttcggggccaagcaggcctgg
cgcaacgccccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgacgcg
cgggattgcagctctgcacaggagatgttcacctacatctgcaaccacgtcaagtacgcc
accaaccggggcaacctccgttcggccatcacggtgttcccccagcgcgctccgggccgc
ggagacttccgcatctggaacagccaactggtgcgctacgcgggctacaggcagcaggac
ggctccgtgaggggggacccagccaacgtggagatcaccgagctctgcatccagcacggc
tggaccccaggaaacggccgctttgatgtgctgcccctgctgctccagaccccagatgag
gctccagagctctttgttctgccccccgaactggtcctcgaggtccccctggagcacccc
acgctggagtggttctcggccctgggcctgcgctggtacgccctcccagcagtgtccaac
atgctgctggaaattgggggcctggagttccctgcagcccccttcagcggctggtacatg
agcacggagattggcatgcgggacctgtgtgatccccaccgctacaacatcctggaggac
gtggccgtctgcatggacctggatacccggaccacctcatccctgtggaaagacaaggca
gccgtggaaatcaacttggctgtgctgcacagttaccagcttgccaaagtgaccatcgtg
gaccaccacgctgccacggcctccttcatgaagcacctggagaacgagcagaaggccagg
gggggctgccctgccgactgggcctggatcgtgccccccatctcgggcagcctcacccca
gtcttccatcaggagatggtcaactatgtcctgtcccccgctttccgctaccagccagac
ccctggaaggggagcacagccaagggcaccggcatcaccaggaagaagacctttaaggaa
gtggccaatgcggtgaagatctctgcctcactcatgggcaccgtgatggcgaagcgagtg
aaggcgacgattctgtacgcctccgagaccggccgggcccagagctacgcacagcagctg
gggaggctcttccggaaggccttcgaccctcgggtcctgtgcatggatgagtatgacgtg
gtgtccctggagcacgagacgctggtgttggtggtgaccagcacctttgggaacggtgat
cccccagagaatggagagagttttgcggcagccctgatggagatgtcgggcccctacaac
agctcccctcggccagagcaacacaagagttacaaaatccgcttcaacagcgtctcctgc
tcagacccgctggtgtcctcctggcggcggaagaggaaggagtccagtaacaccgacagc
gcaggggcgctggggaccctcaggttctgtgtgtttgggctgggctcccgggcgtacccc
catttctgcgcctttgctcgtgcggtggacacgcggctggaagagctgggaggggagcgg
ctgcttcagctgggccagggcgatgagctgtgcggccaggaggaggccttccgtggctgg
gcccaggctgccttccaggcctcctgtgagacgttctgcgtgggggaggatgcccaggcc
gcggcccaggacatcttcagccccaaacggagctggaaacgccagaggtaccggctgagc
gcccaggccgagggcctccagctgctgccaggcctgatccacgtgcacaggcggaagatg
ttccaggccacagtcctcttggtggaaaacctacaaagcagcaagtccacccgggccacg
atcctggtgcgcctggacactggaagccaggaggggctccagtaccagccgggggaccac
ataggcatctgcccgcccaaccggccggggctcgtggaggcgctgatgagccgcgtggag
gacccgccgccacccaccgagtctgtggcagtggagcaactggagaagggcagcccaggt
ggccctcctcccggctgggtgcgggacccccggctgcccccgtgtacgctgcgccaggct
ctcacctttttcctggacatcacctccccgcccagccctcaacttcttcgtctgctcagc
accctggctgaagagcccagtgaacagcaagagctcgagaccctcagccaggacccccgg
cgctacgaggagtggaagtggttccgctgccccaccctgctggaggtgctcgagcagttt
ccatccgtggcactgcctgccccactgcttctcacccagctgcccctgctccagccccgg
tactactcggtcagctcagcacccagcacccatccaggagagatccacctcacagtagct
gtgctggcatacaggacccaagatgggctgggtcccctgcactatggagtctgctccacg
tggctgagccaactcaaggctggagaccccgtaccctgcttcatcaggggggctccctcc
ttccggctaccgcctgatcccagcttgccctgcatcctcgtgggcccgggcactggcatc
gcccccttccggggattttggcaggagcggctacatgacatcgagagcaaagggctgcag
cctgcccccatgaccttggtgttcggctgccggtgctcccagctcgaccatctctaccgc
gaggaggtgcaggatgcccagcagcgcggggtgtttggccgcgtcctcaccgccttctcc
cgggaacccaacagccctaagacctacgtgcaggacatcctgcggacggagctggctgct
gaggtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcacc
atggcaaccagcgtcctgcagacagtgcagcgcatcctggcgacagagggcgacatggag
ctggatgaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggac
attttcgggctcacgctgcgcacccaggaagtgacaagccgcatacgcacccagagcttt
tccttgcaggagcggcatatgcggggcgcagtgccctgggcgttcgacccgcccggccca
gacaccgctggcccctga
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