Orcinus orca (killer whale): 101281886
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Entry
101281886 CDS
T05247
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00310
Lysine degradation
oor01100
Metabolic pathways
oor05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
101281886 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
101281886 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
oor03036
]
101281886 (DOT1L)
Enzymes [BR:
oor01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
101281886 (DOT1L)
Chromosome and associated proteins [BR:
oor03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
101281886 (DOT1L)
HMT complexes
Dot1-containing complex
101281886 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
101281886
NCBI-ProteinID:
XP_049564472
LinkDB
All DBs
Position
3:1423054..1478128
Genome browser
AA seq
1748 aa
AA seq
DB search
MAGGRVTGSLPGASPSFTHPSGTLGAGTDQLGEGSYAGELTLLGSRGAHVCTRIPARVHA
CMQVHTTHIHTQAHTHAPAHMRHHWGQRHGRRGGAQVDQLALPVPQWKGTTQPMKLNTRP
STGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDL
GSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGD
FLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSR
NLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAAR
RRQQRENKSNTTTPTKVPESKTAMPADTPMDSGAEEEKAGATTVKKPSPSKARKKKLNKK
GRKMAGRKRGRPKKMSTANPERKPKKTQSALDLLHAQTVSRAASPSPQGAPYQLPPSTQR
RPPEQLLLAPAPPALHRLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTRLLGAV
QQLFGHCQAQKEEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGN
RELRSQSLRLLKARCEELKLDWSTLSLEGLLKEKQALKSQISEKQRHCLELQISIVELEK
SQRQQELLQLKSCVPPDDALSLHLRGKGGLGREPEAEPGRPHLELDCARFSLPHLSNMSP
ELSMNGHAAGYELCGALSRPSPKQNTPQYLASPLDQEVVPCTPNHSGRPRLEKLSGLALP
DYTRLSPAKLVLRRHLSQDHTANSRATASELHSRAEHAKENDLPYQSPGIANGIKLSPQD
PRPSSPAALQMTGEKSSEKREQAGPVVCLQGLKERTYASSGEAITSLPVSIPLSTVQPSK
LPVSIPLASVVLPSRAEKVRSTPSPVPQARESSSTLEKQMGAGTHGSGCNAAGSRSLALA
PAGFAYAGSVAISGALAGSPAPLVSGAELPALDESSSSGSLFATVGSRSSTPQHPPLLAQ
PRNCGSASPAPQLCASPRLGAQGPLPDTSKGDLPSEAGFSDPESEAKRRIVFTISAGSSS
AKQSPSSKHSPLSSGTRGDGGQSHGQDSRKRGRRKRAAAGTPGFSSGVSPKRRALPSVAG
LFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQT
NGAHYSPLTSDEEQGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKVPASEPV
NSSKWKSTFSPISDLGLAKAADSPLQAASALSHNSLFAFRPGLEEPGAADAKLAAHPRKS
FPGALPGAGGLSPSSHPASSFALGGGLAADLSLHSFSDGASLSHKAPEAAGLGTPLSFPG
PRGKEGGAADPGSFVNKRQLDGLAPKGEGGPPVCGPADKASAMHGKAGKGRDREPDVKNG
HNLFMAAAAAAAAAAATPPGGLLSGPGLAPAASSAGGTAPSAQTHRPFLGAFAPGPQFAL
GPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAATRLTNSHAMGSFSPGVAGGAVGGAFNH
AVPPASAHPFGASFGSGAACRSATLSLTPLQAVASTPASSFQAPPPAEPRPPPPPPHLGR
PPPGPPALHAPPPPNAALPPPPALLPANSEPVLLQNLASLPANQAFLPASSAASVPPANA
SLSIKLASLPHKVSRPSFTVHHPPLPGLALAQAAPVIPQASSTGPPAVWVSLGMPPPYAA
RLAGVKPR
NT seq
5247 nt
NT seq
+upstream
nt +downstream
nt
atggcaggcgggcgggtgacagggagcctccctggggcttctccatccttcacccacccc
tcgggcactctgggcgctgggacagaccagctaggagaggggagctatgctggggagctc
acactgcttgggtccaggggtgcacacgtgtgcacacgtatccctgcacgggtacatgca
tgcatgcaggttcatactacacacatccacacacaggctcacacacatgctcccgcacac
atgcgtcaccattgggggcagcggcacggccggcggggcggggcccaggtggaccaactg
gcgctccctgtgccgcagtggaagggcaccacgcagcccatgaagctgaacacgcggccg
tccacggggctcctgcgccacatcctgcagcaggtctacaaccactcggtgaccgacccc
gagaaactcaacaactatgagcccttctccccggaggtgtacggggagacttccttcgac
ctggtcgcccagatgatcgacgagatcaagatgaccgaagacgacctgtttgtggacctg
ggtagcggagtgggccaggttgtgctgcaggtcgctgcggctaccaactgcaaacatcac
tatggtgtcgagaaagctgacatcccggccaagtacgcggagaccatggaccgagagttc
aggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagaggagat
ttcctctcggaggagtggagagagcggatcgccaacacgagtgttatatttgtgaataac
tttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaacatgaaggaa
ggtggcagaatcgtgtcctcgaagccctttgcacctctgaacttcagaataaacagtaga
aacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgcctctaaaaggctcg
gtgtcgtggacggggaagccggtgtcttactacctgcacaccatcgaccgcaccatactt
gaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggcagctcgg
cgccggcagcagcgggagaacaagagcaacacgaccacccccaccaaggtgcccgagagc
aagacggccatgcccgccgacacccccatggactctggtgctgaggaagagaaagccggg
gcgaccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaacaagaag
ggccggaagatggccggccggaagcgcggacgtcccaagaagatgagcaccgccaacccc
gagcgcaagcccaagaagacccagagcgcactggacctgctgcacgcccagactgtgtcg
cgggcggcgtcaccctcgccgcagggcgccccctaccagctacctcccagcacgcagcga
cgcccccctgagcagctgctgctggcgcccgccccgcctgccctacaccggctgctagaa
tccttcaagattcagtacctacagttcctggcgtacacaaagacccctcagtacaaggcc
aacctgcagcagctgctggaccaggagaaggagaagaacacccggttgctgggcgccgtg
cagcagctgttcggccactgccaagctcagaaggaggagatcaagaggcttttccagcag
aaactggatgagctgggagtgaaggcgctgacctacaacgacctgatccaagcgcagaag
gagatctcagctcacaaccagcagctgagggagcagacggagcagctggagaagggcaac
cgggagctgaggagccagagcctgcggctgctcaaggcacggtgcgaggagctgaagctg
gactggtccacgctgtcccttgagggcctgctgaaggagaagcaggccctgaagagccag
atctcggagaagcagaggcactgcctggagctgcagatcagcattgtggagctggagaag
agccagcggcagcaggagctcctgcagctgaagtcctgcgtgccgcccgacgacgccctg
tccctgcacctgcgcgggaagggtggcctgggccgagagccggaggccgagcccggccgg
ccacacctggagctggactgtgccaggttctccctgccccacttgagcaacatgagcccg
gagctgtccatgaacggccacgcggccggctatgagctctgcggcgcgctgagccggccc
tcgcccaagcagaacaccccccagtacctggcctcccccctggaccaggaggtcgtgccc
tgcaccccgaaccacagtggccggccgaggctcgagaagttgtccggcctggccctgccc
gactacaccaggctctccccggccaagctggtgctgcggcgccacctgagccaggaccac
acagccaacagcagggcgaccgccagcgagctgcactcacgagctgagcatgccaaggag
aacgacctcccgtaccagagccccggcatcgccaacggcatcaaactgagcccacaggac
cctcggccctcatcccctgcggccttgcagatgacgggagagaagagcagtgagaagcgg
gagcaggctggcccggtggtgtgtctgcagggtttgaaggagcgcacctacgccagcagt
ggggaggccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcctagcaag
ctgccagtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaaggtgaga
agcacccccagccccgtgccgcaggcccgagagtcctcgtccacactggagaagcagatg
ggtgctggcacccacggctccgggtgcaacgctgctgggagcagaagcctcgccctggcc
cccgcaggctttgcctacgccggctcagtggccatcagtggggccctggcaggcagcccg
gcaccactcgtctctggagccgagctccccgccctggacgagtcctccagctccggaagc
ctctttgccactgtggggtcccgcagctccacccctcagcacccccccctgctggcgcag
ccccgcaactgcggctcggcctcgcccgccccccagctctgcgccagtccccggctcggc
gcccagggcccgctccccgacaccagcaaaggagacctgccctctgaggccggcttctcg
gatcccgagagtgaagccaagagaaggatcgtcttcaccatctcggccggctctagcagc
gccaaacagtcaccttccagcaagcacagccctctgtcctcgggcacccgcggtgacggc
ggccagagccacgggcaggacagccgcaagaggggcaggaggaagcgggcagcggcgggg
acccccggcttcagctcgggcgtgtcccccaagcgccgggccctgccgtccgtcgccggc
ctcttcacccagtcttcagggtcccccctgaacctcaactccatggtcagcaacatcaac
cagcccttggaaatcacggccatctcgtcccccgagagctccctgaagagctcgcctgtc
ccttaccaggacaacgaccagccgcccgtgctcaagaaggagaagcccctgagccagacc
aacggggcccactattccccgctgacctcggatgaggagcagggctctgaggacgagccc
agcagtgccagaattgagagaaaaattgcaaccatctccttagaaagcaaatctcctccg
aaaaccttggaaaatgggggcggcctggcgggaaggaaggtgccagccagcgagccggtc
aacagcagcaagtggaagtccaccttctcgcccatctccgacctcggcctggccaaggca
gccgacagcccgctgcaggccgcctccgctctgagccacaactccctgttcgctttccgg
cccggcctggaggaacctggcgcggctgatgccaagctggctgcccaccccaggaagagc
ttcccaggcgcgctgccgggggcgggcgggctgagccccagcagccatcccgccagcagc
ttcgccctgggcgggggcctggcggccgacctcagtttacacagcttcagcgatggtgct
tctctctcccacaaggcccccgaggcggccggcctgggcacccccctgagctttcccggc
ccgcggggcaaggagggcggcgccgcagaccccggctccttcgtgaacaagagacagctg
gacggactggccccgaagggcgaggggggcccacctgtgtgcgggcccgcggacaaggcc
tcagcgatgcacggcaaggcgggcaagggccgtgaccgcgagcccgacgtcaagaacggc
cacaacctcttcatggccgctgctgctgctgccgccgccgccgctgccaccccccccggg
ggcctcctcagcggcccgggccttgccccggcggcgtcctcggcagggggcacggccccg
tccgcccagacccaccgccccttcctgggcgccttcgcccccggcccgcagttcgcactg
ggccccatgtccctgcaggccaacctgggtccgtctgtgctgcagtccctgttcagctcc
gtgcccgccgccggcctggtgcacgtctcaaccgccgccaccagactgaccaactcgcac
gccatgggcagcttctcccccggggtggccggcggtgcagtcggaggtgcctttaaccac
gcggtgcctcccgcctccgctcatccgtttggagccagtttcggcagtggggctgcatgt
cgcagcgccacgctgagcctaaccccgctgcaggcggtggccagcaccccggcctcttcc
tttcaggccccgccccctgcggagccgaggccgcccccgccccctccgcacctgggccgg
ccccctccggggccgcccgccctccacgccccgccccctcctaacgccgccttgcctccg
ccccccgcgctgctcccggctaactctgagcccgtgctcctgcagaacctcgcgtccctc
ccagctaaccaagctttcttacctgcctcctctgctgcctctgtgccgcctgctaacgcc
tctctgtccatcaagctcgcctcacttccgcacaaggtgtcccgcccctccttcacggtg
caccacccgcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcaggcc
agctccacggggccgcccgccgtgtgggtttcccttggcatgccacctccgtatgccgcg
cgccttgcgggggttaagccgcgataa
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